Cited by 1,284Inflammation biomarkers and pathwaysImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

Bouchon, Axel, Dietrich, Jes, Colonna, Marco·2000·The Journal of Immunology

DOI 10.4049/jimmunol.164.10.4991

Open this paper in CoChat — free account

Abstract

We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.164.10.4991

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009
NK CELL RECEPTORS
Lanier, L. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.359 · Cited by 1,641
Recognition of Gram-negative bacteria and endotoxin by the innate immune system
Ulevitch, R. J., & Tobias, P. S. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80004-1 · Cited by 567
NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily
Cantoni, C., Bottino, C., Vitale, M., Pessino, A. M., Augugliaro, R., Malaspina, A., Parolini, S., Moretta, L., Moretta, A., & Biassoni, R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.787 · Cited by 450
A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing
Cella, M., Döhring, C., Samaridis, J., Dessing, M., Brockhaus, M., Lanzavecchia, A., & Colonna, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.10.1743 · Cited by 430
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells
Bakker, A. B. H., Baker, E. G., Sutherland, G. R., Phillips, J. H., & Lanier, L. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9792 · Cited by 210
Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain.
Nakajima, H., Samaridis, J., Ångman, L., & Colonna, M. (1999) · PubMed · Cited by 173
Cutting Edge: Signal-Regulatory Protein β1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells
Dietrich, J., Cella, M., Seiffert, M., Bühring, H., & Colonna, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.9 · Cited by 172
Cutting Edge: Human Myeloid Cells Express an Activating ILT Receptor (ILT1) That Associates with Fc Receptor γ-Chain
Nakajima, H., Samaridis, J., Ångman, L., & Colonna, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.5 · Cited by 152
Biochemical Nature and Cellular Distribution of the Paired Immunoglobulin-like Receptors, PIR-A and PIR-B
Kubagawa, H., Chen, C., Ho, L. H., Shimada, T., Gartland, L., Mashburn, C. B., Uehara, T., Ravetch, J. V., & Cooper, M. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.309 · Cited by 148

Flagged first, then by citations

Show all 13 references

Research works printed but not linked: 13

1999, Curr. Opin. Immunol., 19
1995, Semin. Cell Biol., 345
1999, J. Immunol., 5
1998, J. Immunol., 4042
1999, J. Exp. Med., 309
2000, J. Immunol., 9
1999, Proc. Natl. Acad. Sci. USA, 9792
1998, Annu. Rev. Immunol., 359
1999, J. Exp. Med., 787
1991, Trends Biotechnol., 109
1997, J. Exp. Med., 1743
1997, The Leukocyte Antigen Facts Book
1994, Cell, 301

Sorted by citations

Items 901–1,000 of 1,000

CD antigens 2001
Mason, D. Y., André, P., Bensussan, A., et al. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.5.685 · Cited by 5
Building up an infection control strategy based on the e-health concept
Palos, C., Pedroso, A., Mapril, J., & Alves, C. (2010) · Critical Care · doi:10.1186/cc9154 · Cited by 5
Clinical effects of adsorption of lipopolysaccharide in the treatment of Gram-negative severe sepsis
Кулабухов, В. В., Chizhov, A., Клеузович, А. А., & Kudryavtsev, A. N. (2010) · Critical Care · doi:10.1186/cc9131 · Cited by 5
TREM1 deficiency attenuates LPS-induced sepsis-associated acute kidney injury by modulating macrophage polarization
Xu, Y., Fan, Y., Peng, J., Zhang, X., Luo, Q., Shui, K., Li, T., Qin, J., Zhang, H., Nie, R., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003836 · Cited by 6
Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors
Yao, R., Zhang, Y., Yu, W., Chen, X., Shi, H., Luo, R., Fang, C., Zhao, X., Zhu, X., Lai, Y., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120846 · Cited by 4
The role of the triggering receptor expressed on myeloid cells family in metabolic syndrome: A review
Li, Y., Wang, Y., Li, H., Gao, R., Zhang, W., & Yang, X. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112509 · Cited by 4
TREM-1 as a novel immunotherapeutic target to treat pancreatic ductal adenocarcinoma
Gross, L., Mutisheva, I., Hillen, H., et al. (2025) · Molecular Therapy Oncology · doi:10.1016/j.omton.2025.201034 · Cited by 4
“24,25 Possible ligands for TREM-1 are either endogenous danger signals released by necrotic cells, such as HMGB1 and Hsp70, 26 or peptido-glycan (PGN) recognition protein 1 (PGLYRP1) complexed with PGN. 27 TREM-1 activation triggers an oxidative burst, 28,29 along with the release of…”
[Expression of TREM-1 in patients with invasive cervical cancer and precursor lesions].
Anaya‐Prado, R., Norzgaray-Ibarra, F. G., Bravo‐Cuéllar, A., et al. (2017) · PubMed · Cited by 4
Protective effects of Panax notoginseng saponins in a rat model of severe acute pancreatitis occur through regulation of inflammatory pathway signaling by upregulation of miR-181b
Liu, M.-W., Huang, Y.-Q., Qu, Y.-P., et al. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738418818630 · Cited by 4
IL-1R2-based biomarker models predict melioidosis mortality independent of clinical data
Kaewarpai, T., Wright, S. W., Yimthin, T., et al. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1211265 · Cited by 4
Who is who within the universe of TREM-like transcripts (TREML)?
Ertel, M. V., da Silva, A. B. A., de Sousa, D. F., dos Santos, C. J., da Silva, T. M., Silva‐Sales, M., Matos, A. D. O., & Sales‐Campos, H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122696 · Cited by 4
Could TREM-1 be a novel marker in the diagnosis of fibromyalgia?: A cross-sectional study
Baykara, R. A., Kıran, T. R., Otlu, Ö., Erdem, M., & Taş, N. P. (2024) · Medicine · doi:10.1097/md.0000000000038806 · Cited by 4
“[35] In many rheumatological diseases, the etiopathogenesis of which has been investigated immunologically and which can be treated with biological agents, TREM-1 levels have been detected to be higher compared to the control group.”
Background
Correlation between Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Endoscopic Activity in Intestinal Behçet's Disease
Lee, H. J., Shin, H. S., Jang, H. W., et al. (2014) · Yonsei Medical Journal · doi:10.3349/ymj.2014.55.4.960 · Cited by 4
Toll-like receptor 4 plays an important role to enhance bacterial clearance from the nose in synergy with triggering receptor expressed on myeloid cells (TREM)-1 expression on polymorphonuclear neutrophils
Moriyama, M., Hirano, T., Kawano, T., Kadowaki, Y., Kodama, S., & Suzuki, M. (2018) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2018.06.025 · Cited by 4
Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice
McQueen, B., Kollipara, A., Gyorke, C. E., et al. (2021) · Infection and Immunity · doi:10.1128/iai.00072-21 · Cited by 4
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory mediators in malaria by Plasmodium vivax during enteroparasites coinfection
de Jesus, M. C. S., Barbosa, J. H. R., Menezes, R. A. D. O., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270007 · Cited by 4
“Among these, the Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) is a receptor expressed in macrophages, monocytes, and neutrophils that is known to increase inflammatory responses of myeloid cells in innate and adaptive responses that were initiated by the Toll-like receptors [14, 15].”
Background
High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice
Liu, M., Wu, W., Zhao, Q. C., et al. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00057 · Cited by 4
Diagnostic Value of Endotracheal Tube-Aspirate Soluble Triggering Receptor Expressed on Myeloid Cells-1 Concentration for Neonatal Ventilator-Associated Pneumonia
Zhou, J., Zhou, J., Yan, H., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.664801 · Cited by 4
Hepatitis B Virus Flares After Nucleot(s)ide Analogue Cessation Are Associated With Activation of Toll-Like Receptor Signaling Pathways
Hall, S., Burns, G. S., Mooney, B. J., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac375 · Cited by 4
Innate Immune System in Sepsis Immunopathogenesis and Its Modulation as a Future Therapeutic Approach
Kumar, V. (2012) · InTech eBooks · doi:10.5772/25590 · Cited by 4
Guía de práctica clínica para el diagnóstico y tratamiento de la sepsis en el servicio de urgencias de adultos
Tobón, F. A. R., López, A. I. H., Osorno, S. C., & Barragán, F. A. J. (2007) · IATREIA · doi:10.17533/udea.iatreia.4404 · Cited by 4
The Pathophysiological Relevance of Monocyte-platelet Interactions in Inflammatory Disease
Stephen, J., & Dransfield, I. (2010) · Journal of Experimental & Clinical Medicine · doi:10.1016/j.jecm.2010.08.002 · Cited by 4
Diagnostic Utility of Pleural Fluid Soluble Triggering Receptor Expressed on Myeloid Cells 1 Protein in Patients with Exudative Pleural Effusion
Sim, Y. S., Lee, J. H., Chun, E. M., et al. (2007) · Tuberculosis & respiratory diseases · doi:10.4046/trd.2007.62.6.499 · Cited by 4
Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity
Геннадьевна, М. В., Головкин, А. С., Grigoryev, E. V., et al. (2011) · General Reanimatology · doi:10.15360/1813-9779-2011-3-70 · Cited by 4
Expression pattern of soluble triggering receptor expressed on myeloid cells-1 in mice with Acinetobacter baumannii colonization and infection in the lung
Hu, C., Jiang, J., Li, Z., et al. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.03.41 · Cited by 4
Cardiovascular hyporesponsiveness in sepsis is associated with G-protein receptor kinase expression via a nitric oxide-dependent mechanism
Dal-Secco, D., Olivon, V. C., Corrêa, T., Celes, M., Abreu, M. V. A., Rossi, M., de Oliveira, A. L., Cunha, F. Q., & Assreuy, J. (2010) · Critical Care · doi:10.1186/cc9137 · Cited by 4
Two chromogranin A-derived peptides, chromofungin and catestatin, induce neutrophil activation via a store-operated channel-dependent mechanism
Metz‐Boutigue, M., Zhang, D., Lavaux, T., Schneider, F., & Aunis, D. (2010) · Critical Care · doi:10.1186/cc9135 · Cited by 4
Inflammation and Immunity
Galley, H. F. (2006) · doi:10.1002/9780470755297.ch11 · Cited by 4
Roles of Triggering Receptor Expressed on Myeloid Cells-1: More than Just Pneumonia
Han, J., & Li, L. (2024) · Advances in Human Biology · doi:10.4103/aihb.aihb_173_22 · Cited by 3
A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection
Rickert, D. M., Cardozo, S., Carbonetti, N. H., Goldman, W. E., Scanlon, K. M., & Skerry, C. M. (2026) · eLife · doi:10.7554/elife.108947.3 · Cited by 3
Differential downstream signaling in microglia lacking Alzheimer’s-related TREM2 or its adaptor TYROBP/DAP12
Quipildor, G. F., Belfiore, R., Althobaiti, K., Najarzadeh, Z., Glabe, C. C., Readhead, B. P., Gandy, S., Salton, S. R., & Ehrlich, M. E. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-025-00012-x · Cited by 6
Hypoxia and Gene Expression
Bosco, M. C., & Varesio, L. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-9167-5_5 · Cited by 3
Sepsis-3: renewed determinations, potential problems and further practical foot steps
Кryvoruchko, І. А., Boyko, V. V., Іvanova, Y. V., et al. (2019) · Klinicheskaia khirurgiia · doi:10.26779/2522-1396.2019.06.60 · Cited by 3
Pathological Roles of INPP5D in Alzheimer’s Disease
Chu, Y. N., Akahori, A., Takatori, S., & Tomita, T. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-31978-5_30 · Cited by 3
Higher soluble TREM-1 levels are associated with cognitive impairment after acute ischemic stroke
Chen, Z., Yi, X., Fu, W., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1463065 · Cited by 3
Role of triggering receptor expressed on myeloid cells 1/2 in secondary injury after cerebral hemorrhage
Yi, F., Wu, H., & Zhao, H. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v13.i9.100312 · Cited by 3
TREM ‐1 Pathway Biomarkers for Classification of Periodontal Diseases and Monitoring of Treatment Response in Grade B and C Periodontitis
Silbereisen, A., Lira‐Junior, R., Afacan, B., et al. (2025) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.14195 · Cited by 3
“…protein 1 (PGLYRP1), a neutrophil-derived bactericidal protein, is one of the ligands that can activate the TREM-1 signalling pathway, which works in synergy with Toll-like receptor activation (Bouchon et al. 2000; Dziarski and Gupta 2010; Nylund et al. 2018; Read et al. 2015; Tammaro et al. 2017).”
Age‐Specific Biomarkers TREM1 and KLF4 in Ischemic Stroke: From Transcriptomic Discovery to Therapeutic Drug Screening
Zhou, X., Bi, J., Chen, H., Wang, Y., Li, Y., Huang, D., Ma, X., Cai, W., Jiang, D., & Guan, T. (2025) · The FASEB Journal · doi:10.1096/fj.202501934rr · Cited by 3
DNAX-Activating Protein of 12 kDa Impairs Host Defense in Pneumococcal Pneumonia
Hommes, T. J., Hoogendijk, A. J., Dessing, M. C., Veer, C. V. ′., Florquin, S., de Vos, A. F., & van der Poll, T. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000686 · Cited by 3
Integrating classifiers across datasets improves consistency of biomarker predictions for sepsis
Saraiva, J., Oswald, M., Biering, A., Assmann, C., Klassert, T. E., Blaess, M. F., Czakai, K., Claus, R. A., Löffler, J., Slevogt, H., et al. (2016) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2016.12.109 · Cited by 3
Human peptidoglycan recognition protein 1 in innate immunity
(2018) · Cogent Biology · doi:10.1080/23312025.2018.1450917 · Cited by 3
“Triggering receptor expressed on myeloid cells 1 (TREM-1) is expressed on neutrophils and most monocytes or macrophages constitutively and potently amplifies inflammation [20].”
Background
Soluble Triggering Receptor on Myeloid Cell-1 and its Predictive Factors in Patients With End-Stage Kidney Disease on Hemodialysis
Montañez-Fernández, J. L., Cueto-Manzano, A. M., Campos, E. R., et al. (2021) · ASAIO Journal · doi:10.1097/mat.0000000000001541 · Cited by 3
TREM-1 Expression on the Surface of Neutrophils in Patients With Visceral Leishmaniasis Is Associated With Immunopathogenesis
Bomfim, L. G. S., Magalhães, L. S., Rodrigues, L. S., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.863986 · Cited by 3
Translocated HMGB3 is involved in papillary thyroid cancer progression by activating cytoplasmic TLR3 and transmembrane TREM1
Zhao, Y., Lv, H., Deng, X., et al. (2023) · Cell Cycle · doi:10.1080/15384101.2024.2302244 · Cited by 3
“TREM1, an immunoglobulin (Ig) superfamily receptor, is primarily expressed on myeloid cells regulating its differentiation through the release of inflammatory mediators [57].”
Background
Extracellular Cold-Inducible RNA-Binding Protein and Hemorrhagic Shock: Mechanisms and Therapeutics
Rashid, N., Hu, Z., Jacob, A., & Wang, P. (2024) · Biomedicines · doi:10.3390/biomedicines13010012 · Cited by 3
HBCOC attenuates cerebral ischemia-reperfusion injury in mice by inhibiting the inflammatory response and autophagy via TREM-1/ERK/NF-κB
Li, R., Li, Q., Yang, C., Liu, H., Xiao, Y., Yang, P., Gong, G., & Wu, W. (2025) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2025.108280 · Cited by 3
Identification of early biomarkers in a rabbit model of primary Candida pneumonia
Lu, G., Wang, C., Wu, C., et al. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4320-9 · Cited by 3
Preparation and Characterization of Monoclonal Antibody Against Protein TREM-Like Transcript-1 (TLT-1)
Lu, Y., Yen, C.-Y., Ho, H., et al. (2006) · Hybridoma · doi:10.1089/hyb.2006.25.20 · Cited by 3
Physiopathologie du choc septique
Lemaout, C., Gonzalez, H., Aboab, J., & Annane, D. (2006) · La Presse Médicale · doi:10.1016/s0755-4982(06)74628-0 · Cited by 3
Keratinocytes and Activation of TREM-1 Pathway in Cutaneous Leishmaniasis Lesions
Nunes, S., Ampuero, M. R., Bonyek-Silva, Í., Lima, R., Lima, F. R., Arruda, S. M., Khouri, R., Oliveira, P. R. S., Barral, A. M. P., Boaventura, V. S., et al. (2021) · Microbiology Research · doi:10.3390/microbiolres12040056 · Cited by 3
“TREM-1 has emerged as a key molecule during inflammatory diseases, promoting complex effects on cells of the immune system and exacerbating the host response [7,8].”
Background
TREM-1 is required for enhanced OpZ-induced superoxide generation following priming
Murthy, S., Baruah, S., Bowen, J. L., Keck, K., Wagner, B. A., Buettner, G. R., Sykes, D. B., & Klesney-Tait, J. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0421-212r · Cited by 3
Dengue Virus Increases the Expression of TREM-1 and CD10 on Human Neutrophils
Ruiz‐Pacheco, J. A., Muñoz-Medina, E. J., Díaz, L., et al. (2023) · Viral Immunology · doi:10.1089/vim.2022.0124 · Cited by 3
“In turn, TREM-1 expression can be upregulated by invading pathogens or self-molecules, and differentially affected by cytokines (Bleharski et al, 2003; Bouchon et al, 2000; Wu et al, 2012).”
Signal Transduction Changes in fMLP, TLRs, TREM-1 and GM-CSF Receptors in PMN with Aging
Fortin, C. F., Larbi, A., Dupuis, G., & Fülöp, T. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_23 · Cited by 3
Mining metastasis related genes by primary-secondary tumor comparisons from large-scale databases
Kim, S., & Lee, D. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-s3-s2 · Cited by 3
“TREM2 (triggering receptor expressed on myeloid cells 2, 1405 metastasis score, 3rd ranked) is also known to have a role in chronic inflammations and stimulate production of constitutive chemokines and cytokines [19].”
Background
La génétique de la maladie d’Alzheimer
Halla, S. B., Moutawakil, B. E., Kadmiri, N. E., & Nadifi, S. (2019) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2018.11.006 · Cited by 4
Chromogranin A expression in plasma of critically ill patients
Lavaux, T., Schneider, F., Bach, C., Herbrecht, J.-É., Aunis, D., & Metz-Boutigue, M. H. (2010) · Critical Care · doi:10.1186/cc9140 · Cited by 3
Sepsis induces platelet mitochondrial uncoupling and a gradual increase in respiratory capacity that is negatively associated with clinical outcome
Sjövall, F., Morota, S., Hansson, M., Friberg, H., Gnaiger, E., & Elmér, E. (2010) · Critical Care · doi:10.1186/cc9114 · Cited by 3
Soluble Triggering Receptor Expressed on Myeloid Cells in Patients With Suspected Meningitis, Peritonitis, or Pleuritis
Lourens, N. A., Bösenberg, L. H., Tintinger, G. R., et al. (2008) · Infectious Diseases in Clinical Practice · doi:10.1097/ipc.0b013e318167652d · Cited by 3
“tuberculosis (3), Pseudomonas aeruginosa (2), and Salmonella species (1).”
Background
Soluble TLT-1 is a naturally occurring TREM-1 inhibitor and protects mice from hyperresponsiveness and death during sepsis
Derive, M., Bouazza, Y., Massin, F., Alauzet, C., Lévy, B., Bollaërt, P., & Gibot, S. (2010) · Critical Care · doi:10.1186/cc9146 · Cited by 3
CCR2 drives neutrophil infiltration and elicits tissue damage in remote organs during sepsis
Souto, F., Alves‐Filho, J., Turato, W. M., Nascimento, D., Auxiliadora‐Martins, M., Basile-Filho, A., & Cunha, F. Q. (2010) · Critical Care · doi:10.1186/cc9126 · Cited by 3
Severity of illness scoring systems in community-acquired Legionella pneumonia
Simonsen, Ø., & Ringstad, J. (2010) · Critical Care · doi:10.1186/cc9128 · Cited by 3
Serum procalcitonin as a diagnostic tool of bacteremia
Gartzonika, C., Priavali, E., Zotos, N., Kallinteri, A., Katsoula, I., Sakkas, H., Papapetrou, E., Kapsali, E., Vrioni, G., Mavridis, A. K., et al. (2010) · Critical Care · doi:10.1186/cc9117 · Cited by 3
A fast and accurate diagnostic test for severe sepsis using model-based insulin sensitivity and clinical data
Parente, J. D., Lee, D., Lin, J., Chase, J. G., & Shaw, G. (2010) · Critical Care · doi:10.1186/cc9116 · Cited by 3
Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancerPreprint
Costa, D. B. V., Francescone, R., Franco‐Barraza, J., Luong, T., Graves, M., de Aquino, A. M., Steele, N. G., Gardiner, J. C., dos Santos, S. A. A., Ogier, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594354 · Cited by 3
Two Genes Behind PLOSL : Molecular and Pathological Characteristics of the Disease
Paloneva, J. (2003) · Työväentutkimus Vuosikirja · Cited by 3
TREM-1 as a Marker of Multiple Organ Failure in Cardiac Surgery
Khutornaya, M. V., Sinitsky, M. Y., Sinitskaya, А. V., et al. (2023) · Immunological Investigations · doi:10.1080/08820139.2023.2215276 · Cited by 2
“TREM-1 was described in 2000 by Bouchon and colleagues in the context of septic shock pathophysiology (Bouchon et al. 2000) and has been primarily reported as an informative marker of sepsis (Oku et al.”
Background
Blocking triggering receptors expressed on myeloid cell-1 alleviates alveolar epithelial cell senescence by inhibiting oxidative stress in pulmonary fibrosis
Zhong, W., Xiong, J., Zhang, C., et al. (2025) · Histochemistry and Cell Biology · doi:10.1007/s00418-025-02374-5 · Cited by 2
“These findings suggest that AEC senescence is a pivotal factor in the pathogenesis of PF. TREM-1 is expressed mainly on the surface of myeloid cells such as neutrophils or monocytes/ macrophages (Bouchon et al. 2000).”
TREM-1-Linked Inflammatory Cargo in SARS-CoV-2-Stimulated Macrophage Extracellular Vesicles Drives Cellular Senescence and Impairs Antibacterial Defense
Silva-Neto, P. V. D., de Carvalho, J. C. S., Toro, D. M., Oliveira, B., Cominal, J. G., Castro, R. C., Almeida, M., Prado, C. M., Arruda, E., Frantz, F. G., et al. (2025) · Viruses · doi:10.3390/v17050610 · Cited by 2
“During SARS-CoV-2 infection, TREM-1 activation exacerbates acute inflammation, contributes to tissue damage, and intensifies the cytokine storm [8–10].”
Synthesis, Characterization, Molecular Dynamic Simulation and Neuroprotective Effects of Synthetic Isoxazolone Derivatives in Ethanol‐Induced Neurodegeneration
Awan, M. N., Albaqami, F. F., Nadeem, H., Zulfiqar, I., Rehman, N. U., Ayaz, M., Khan, M. F., & Shah, F. A. (2025) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.70051 · Cited by 2
TREM-1 inhibitor specificity and timing of treatment initiation can impact its therapeutic efficacy in cancer and inflammatory disease
Sigalov, A. B. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1689771 · Cited by 2
Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial
Theobald, V., Gregorius, J., Berger, M. M., Decker, S., Feißt, M., Herbstreit, F., Nußhag, C., Skarabis, A., Schmidt, K. D., Schmitt, F. C. F., et al. (2026) · Critical Care · doi:10.1186/s13054-026-06025-6 · Cited by 3
“Consistently, TREM-1 was first found to be expressed on the surface of monocytes and neutrophils [11], but it is also expressed on non-immune cells like hepatic endothelial cells and gastric epithelial cells.”
The role of DAP12 in immune-related inflammatory diseases
Lu, J., Shi, L., Jin, G., Yang, Y., Zhu, F., & Zhou, G. (2026) · Inflammation Research · doi:10.1007/s00011-026-02256-z · Cited by 3
Revisiting TREM2: from multi-omics signaling networks to clinical translation
Yang, J., Wan, D., Ren, L., Lv, Y., & Zhao, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1782384 · Cited by 2
EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS
Матвеева, В. Г., Головкин, А. С., Chernova, M. N., et al. (2014) · Medical Immunology (Russia) · doi:10.15789/1563-0625-2013-5-439-448 · Cited by 2
Toxicogenomic Approach to Risk Assessment of Welding Fumes
Rim, K.-T. (2012) · Journal of Clinical Toxicology · doi:10.4172/2161-0495.s5-004 · Cited by 2
“It has been reported that treating macrophages with an agonistic Trem1 antibody induces the activation of recognition receptors, such as the TLR or NLR family, and increases cytokine and chemokine secretion [8,9].”
Background
The Role of Soluble Triggering Receptor 1 Expressed on Myeloid Cell (STREM-1) as an Early Biomarker in Diagnosis of Sepsis
Yasin, H. M. M., Aly, N. K., & Abdelaziz, S. Y. (2020) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2020.67677 · Cited by 2
Molecular and Histological Profiling Reveals an Innate-Shaped Immune Microenvironment in Solitary Juvenile Polyps
Zysset, D., Montani, M., Spalinger, J. H., et al. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000361 · Cited by 2
“In addition, in our cohort, the pediatric IBD samples showed significantly increased CXCL8 mRNA levels in comparison with non-IBD control samples.”
BackgroundInfluential
Regulation of TREM1-Mediated Inflammation in Hepatocellular Carcinoma Cells
Rai, V., & Agrawal, D. K. (2021) · Reports — Medical Cases Images and Videos · doi:10.3390/reports4020017 · Cited by 2
“TREM-1 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily and family related to the natural killer cell receptor, expressed on monocytes, neutrophils, macrophages, and fibroblasts [16,17].”
Background
Recombinant P40 protein of Schistosoma japonicum inhibits TREM-1 expression in RAW264.7 cells via FOXO3a
Shen, P., Zhang, T., Chen, G., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112826 · Cited by 2
Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guérin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1
Li, P., Wang, R., Dong, W., Wang, G., Zhang, A., Chen, H., & Tan, C. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106535 · Cited by 2
Triggering Receptor Expression on Myeloid Cells-1 (TREM1) Promoter Hypomethylation and Its Overexpression Associated With Poor Survival of Cancer Patients: A Pan-Cancer Analysis
Ruskin, P., Pandi, C., Kannan, B., Pandi, A., Girija, A. S. S., Jayaseelan, V. P., & Arumugam, P. (2024) · Cureus · doi:10.7759/cureus.64640 · Cited by 2
“Certain other inflammatory disorders such as pancreatitis, gastric ulcers, psoriasis, ulcerative colitis, and vasculitis situations when TREM1 may be over-expressed [9,27-29].”
Background
Triggering receptor expressed on myeloid cells-1 aggravates obliterative bronchiolitis via enhancing the proinflammatory phenotype of macrophages
Wan, J., Yang, F., Tong, S., Zhou, T., & Wang, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113274 · Cited by 2
Immune Sensors, Regulators, and Effectors of Brain Health
Acıoğlu, Ç., & Elkabes, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-68237-7_3 · Cited by 2
Could Be Systems-Directed Therapy Approaches Promising in Glioblastoma Patients?
Grauer, O. M., & Hau, P. (2010) · Springer eBooks · doi:10.1007/978-90-481-9531-2_8 · Cited by 2
Epithelial to Mesenchymal Transition in Microbial Pathogenesis
Chargui, A., Sanda, M., Brest, P., Hofman, P. M., & Valrie, V.-C. (2012) · InTech eBooks · doi:10.5772/34135 · Cited by 2
Lyar Is a New Ligand for Retinal Pigment Epithelial Phagocytosis
Guo, F., Ding, Y., Caberoy, N. B., Alvarado, G., Liu, R., Shen, C., Yu, J., Zhou, Y., Salero, E., LeBlanc, M. E., et al. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25089 · Cited by 2
“Despite identification of TREM2 as a phagocytic receptor 14 years ago [Bouchon et al., 2000], its ligand(s) remains elusive.”
Biomarkers in fever and neutropenia: A solution in search of a problem?*
Gea‐Banacloche, J. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31820f6d6d · Cited by 2
Diagnostic non bactériologique des pneumopathies acquises sous ventilation mécanique
Gibot, S., & Bollaert, P. (2005) · Réanimation · doi:10.1016/j.reaurg.2005.03.007 · Cited by 2
“Son expression est spécifiquement up-régulée à la surface des phagocytes en cas d’agression bactérienne [47,48].”
Maladies démyélinisantes d’origine génétique
Labauge, P. M., & Boespflug‐Tanguy, O. (2010) · La Presse Médicale · doi:10.1016/j.lpm.2009.11.011 · Cited by 2
Inflammation, Immune System and Alzheimer's disease: A Review of the Findings from the Major GWAS Studies
Reitz, C., & Tosto, G. (2013) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000060 · Cited by 2
“The TREM2 gene istranslated into a type-I membrane protein with an extracellular Iglike domain and was first described as potentially involved in chronic inflammation response [49].”
Background
[Role of triggering receptor expressed on myeloid cells-1 in the pathogenesis of Kawasaki disease].
Zhao, J., & Wang, Q. (2016) · PubMed · doi:10.7499/j.issn.1008-8830.2016.06.011 · Cited by 2
Expression of TREM-1 in maternal leukocytes in preterm, prelabour rupture of the membranes
Anaya‐Prado, R., Barba-Anaya, M. F., Sánchez-González, J. M., Anaya-Fernandez, M. M., Zavalza-Gómez, A. B., Gil-Villarreal, F., Bravo‐Cuéllar, A., & Grijalva-Solis, A. D. C. (2016) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2016.1217834 · Cited by 2
“Since TREM-1 has been identified as a the first activator in the inflammatory response and different studies have demonstrated that the expression of this molecule is directly proportional to the degree of inflammation and inversely proportional to the final prognosis of different acute processes, it could be interest…”
BackgroundInfluential
New markers in prognosis of severe community-acquired pneumonia
Borovac, D. N., Pejčić, T., Petković, T., et al. (2011) · Cited by 2
Identification of gene expression markers and development of evaluation method using cell-based and RT-PCR-based assay for skin sensitising potential of chemicals
Nishikawa, M., Iwaki, M., Tashiro, K., & Kurose, K. (2020) · Xenobiotica · doi:10.1080/00498254.2020.1767320 · Cited by 2
THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES
Kutlu, Y., Toprak, İ. D., Gökden, Y., et al. (2021) · Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi · doi:10.26650/iuitfd.2020.0090 · Cited by 2
Role of caspases, apoptosis and additional factors in pathology of Alzheimer's disease
Gupta, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820122-0.00001-7 · Cited by 2
Role of soluble triggering receptors expressed on myeloid cells‐1 and 25‐hydroxy vitamin D as early diagnostic markers of neonatal Ventilator‐associated pneumonia: A prospective cohort study
El-Sheikh, M. R., Elmahdy, H. S., Nassar, M. A. E., et al. (2022) · Pediatric Pulmonology · doi:10.1002/ppul.26016 · Cited by 2
“As one of the immunoglobulin super receptor family (Ig‐superfamily, Ig‐SF), sTREM‐1 induces chemokines and releases proinflammatory cytokines during acute infection.(20) The sTREM‐1 levels can increase in MV even without VAP due to the MV‐induced lung injury.”
Background
The Macrophages and Intestinal Symbiosis
Kloc, M., Uosef, A., Elshawwaf, M., Abdelshafy, A. A. A., Elsaid, K. M., Kubiak, J. Z., & Ghobrial, R. M. (2020) · Results and problems in cell differentiation · doi:10.1007/978-3-030-51849-3_23 · Cited by 2
Untitled work
Daws (2001) · doi:10.1002/1521-4141(200103)31:3
Untitled work
Kalina (2002) · doi:10.1002/1521-4141(200209)32:9

Authors: Bouchon, A., Dietrich, J., & Colonna, M.
Affiliations: Basel Institute for Immunology , Basel ,
ORCID: Dietrich, Jes
Colonna, Marco
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2000-05
Volume: 164
Issue: 10
Pages: 4991-4995
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.164.10.4991
OpenAlex: W2149698238
Semantic Scholar: c6fffd66acdcb27c928605f7aca443056a3a6c3f
Cited by: 1,284
References: 13
Citations by year: 2026: 38 · 2025: 47 · 2024: 73 · 2023: 87 · 2022: 51 · 2021: 65 · 2020: 83 · 2019: 49 · 2018: 55 · 2017: 51 · 2016: 59 · 2015: 47 · 2014: 48 · 2013: 68 · 2012: 50
FWCI: 6.50
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: TREM-1, neutrophils, monocytes, inflammation, IL-8 secretion, MCP-1, TNF-α, neutrophil degranulation, calcium mobilization, phospholipase C-gamma, myeloid cell activation
MeSH terms: Triggering Receptor Expressed on Myeloid Cells-1, Amino Acid Sequence, Fungi, Multigene Family, Gram-Negative Bacteria, Gram-Positive Bacteria, Humans, Immunoglobulins, Inflammation, Macrophage Activation, Membrane Glycoproteins, Membrane Proteins, Molecular Sequence Data, Molecular Weight, Monocytes, Neutrophils, Phosphorylation, Receptors, Immunologic, Tyrosine, Biomarkers, Up-Regulation, Cytokines, Neutrophil Activation, Chemokines, Calcium Signaling, Adaptor Proteins, Signal Transducing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks