Cited by 1,284Inflammation biomarkers and pathwaysImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

Bouchon, Axel, Dietrich, Jes, Colonna, Marco·2000·The Journal of Immunology

DOI 10.4049/jimmunol.164.10.4991

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Abstract

We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.

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Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009
NK CELL RECEPTORS
Lanier, L. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.359 · Cited by 1,641
Recognition of Gram-negative bacteria and endotoxin by the innate immune system
Ulevitch, R. J., & Tobias, P. S. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)80004-1 · Cited by 567
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Cantoni, C., Bottino, C., Vitale, M., Pessino, A. M., Augugliaro, R., Malaspina, A., Parolini, S., Moretta, L., Moretta, A., & Biassoni, R. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.787 · Cited by 450
A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing
Cella, M., Döhring, C., Samaridis, J., Dessing, M., Brockhaus, M., Lanzavecchia, A., & Colonna, M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.10.1743 · Cited by 430
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells
Bakker, A. B. H., Baker, E. G., Sutherland, G. R., Phillips, J. H., & Lanier, L. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9792 · Cited by 210
Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain.
Nakajima, H., Samaridis, J., Ångman, L., & Colonna, M. (1999) · PubMed · Cited by 173
Cutting Edge: Signal-Regulatory Protein β1 Is a DAP12-Associated Activating Receptor Expressed in Myeloid Cells
Dietrich, J., Cella, M., Seiffert, M., Bühring, H., & Colonna, M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.9 · Cited by 172
Cutting Edge: Human Myeloid Cells Express an Activating ILT Receptor (ILT1) That Associates with Fc Receptor γ-Chain
Nakajima, H., Samaridis, J., Ångman, L., & Colonna, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.5 · Cited by 152
Biochemical Nature and Cellular Distribution of the Paired Immunoglobulin-like Receptors, PIR-A and PIR-B
Kubagawa, H., Chen, C., Ho, L. H., Shimada, T., Gartland, L., Mashburn, C. B., Uehara, T., Ravetch, J. V., & Cooper, M. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.2.309 · Cited by 148

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Research works printed but not linked: 13

1999, Curr. Opin. Immunol., 19
1995, Semin. Cell Biol., 345
1999, J. Immunol., 5
1998, J. Immunol., 4042
1999, J. Exp. Med., 309
2000, J. Immunol., 9
1999, Proc. Natl. Acad. Sci. USA, 9792
1998, Annu. Rev. Immunol., 359
1999, J. Exp. Med., 787
1991, Trends Biotechnol., 109
1997, J. Exp. Med., 1743
1997, The Leukocyte Antigen Facts Book
1994, Cell, 301

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Background
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Anfossi, N., Lucas, M., Diefenbach, A., Bühring, H., Raulet, D. H., Tomasello, E., & Vivier, É. (2003) · European Journal of Immunology · doi:10.1002/eji.200324573 · Cited by 18
Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
Nichols, K. E., Haines, K. M., Myung, P. S., et al. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703312 · Cited by 18
“For example, several new receptor families have been identified recently in myeloid cells, including the Ig-like receptors (also known as leukocyte Ig-like and monocytemacrophage inhibitory receptors) [51], signal regulatory proteins [52, 53], the mouse-paired Ig receptors [54], and the triggering receptors expressed…”
Background
TREM2 in neurodegeneration and diseases
Abdulkhaliq, A. A., Alasiri, G., Kim, B., Khan, J., Ajoolabady, A., Yousof, S. M., Ren, J., Tuomilehto, J., Borai, A., Alrfaei, B. M., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03505-7 · Cited by 16
TREM1 induces microglial ferroptosis through the PERK pathway in diabetic-associated cognitive impairment
Zhao, Y., Guo, H., Li, Q., Wang, N., Yan, C., Zhang, S., Dong, Y., Liu, C., Gao, W., Zhu, Y., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115031 · Cited by 17
A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity
Zhang, L., Yang, J., Zhou, Z., Ren, Y., Chen, B., Tang, A., Zhang, K., Li, C., Zhou, H., Fung, K.-M. A., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2427073122 · Cited by 18
“Activation of the TREM1/DAP12 pathway promotes the recruitment of tyrosine kinases, activating downstream signaling pathways such as extracellular signal - regulated kinases (ERK) ( 20 ).”
Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) Contributes to Bordetella pertussis Inflammatory Pathology
Gallop, D., Scanlon, K. M., Ardanuy, J., Sigalov, A. B., Carbonetti, N. H., & Skerry, C. (2021) · Infection and Immunity · doi:10.1128/iai.00126-21 · Cited by 21
“The engagement of TREM-1 by its ligands amplifies the expression of inflammatory factors, such as tumor necrosis factor-a (TNF-a) and C-C motif chemokine ligand 2 (CCL2) (13).”
BackgroundInfluential
Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease: miRNA and mRNA Regulation
Wang, L., Zhao, H., Raman, I., et al. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s337894 · Cited by 17
“TREM-1 is considered to amplify both infectious and non-infectious inflammation(28) and to elicit the release of TNF-α, IL-8 myeloperoxidase, and nitric oxide by innate immune cells.(29) According to previous reports, levels of soluble TREM-1 in the serum of patients with stable COPD and AECOPD significantly increase.”
Background
Bacillus -Based Direct-Fed Microbial Reduces the Pathogenic Synergy of a Coinfection with Salmonella enterica Serovar Choleraesuis and Porcine Reproductive and Respiratory Syndrome Virus
Zuckermann, F. A., Husmann, R. J., Chen, W., Roady, P. J., Pfeiff, J., Leistikow, K. R., Duersteler, M., Son, S., King, M. R., & Augspurger, N. R. (2022) · Infection and Immunity · doi:10.1128/iai.00574-21 · Cited by 19
Inhibition of TREM-1 alleviates neuroinflammation by modulating microglial polarization via SYK/p38MAPK signaling pathway after traumatic brain injury
Zhao, T., Zhou, Y., Zhang, D., Han, D., Ma, J., Li, S., Li, T., Hu, S., & Li, Z. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148907 · Cited by 18
Inhibition of TREM-1 ameliorates angiotensin II-induced atrial fibrillation by attenuating macrophage infiltration and inflammation through the PI3K/AKT/FoxO3a signaling pathway
Chen, X., Yu, L., Meng, S., Zhao, J., Huang, X., Wang, Z., Zhou, Z., Huang, Y., Hong, T., Duan, J., et al. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111458 · Cited by 17
Diagnostic role of soluble triggering receptor expressed on myeloid cell-1 in patients with sepsis
Wang, H., & Chen, B. (2011) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.1920-8642.2011.03.006 · Cited by 17
The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases
Teixeira, M. K. S., Lira‐Junior, R., Lourenço, E., Telles, D. D. M., Boström, E. A., Figueredo, C. M., & Bostancı, N. (2019) · Clinical Oral Investigations · doi:10.1007/s00784-019-03047-z · Cited by 18
Association of TREM-1, IL-1β, IL-33/ST2, and TLR Expressions With the Pathogenesis of Ocular Toxoplasmosis in Mouse Models on Different Genetic Backgrounds
Zhang, Y., He, J. G., Zheng, H., Huang, S., & Lü, F. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02264 · Cited by 18
“Triggering receptor expressed on myeloid cells (TREM)-1, a cell surface receptor expressed at high levels on several immune cells such as polymorphonuclear neutrophils, macrophages, and monocytes, plays a vital role in innate and adaptive immune responses (Bouchon et al., 2000).”
Background
Inhibition of Triggering Receptor Expressed on Myeloid Cell-1 Alleviates Acute Gouty Inflammation
He, Y., Yang, Q., Wang, X., Jia, A., Xie, W., & Zhou, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/5647074 · Cited by 17
“The levels of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, and MCP-1) in cultural supernatants were detected by ELSIA post MSU with a specific inhibitor, including TREM-1, TLR-4, and MyD88.”
BackgroundResultInfluential
Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer’s Risk Variant
Tambini, M. D., & D'adamio, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-60800-1 · Cited by 16
The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
Kung, C., Su, C.-M., Hsiao, S.-Y., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11111979 · Cited by 17
TREM‐2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis
Bucová, M., Suchánková, M., Tibenská, E., Tedlová, E., Demian, J., Majer, I., Novosadova, H., & Tedla, M. (2015) · Mediators of Inflammation · doi:10.1155/2015/181986 · Cited by 17
Triggering receptor (TREM‐1) expressed on myeloid cells predicts bacteremia better than clinical variables in community‐acquired pneumonia
Ruiz-González, A., Esquerda, A., Falguera, M., et al. (2010) · Respirology · doi:10.1111/j.1440-1843.2010.01905.x · Cited by 17
Cloning of porcine triggering receptor expressed on myeloid cells-1 (TREM-1) and its induction by lipopolysaccharide, peptidoglycan, and Salmonella enterica serovar Typhimurium infection
Ramanathan, B., Minton, J. E., Ross, C. R., & Blecha, F. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.05.007 · Cited by 17
Role of Triggering Receptor Expressed on Myeloid Cells-1/3 in Klebsiella -Derived Pneumosepsis
Hommes, T. J., Dessing, M. C., Veer, C. V. ′., Florquin, S., Colonna, M., de Vos, A. F., & van der Poll, T. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0485oc · Cited by 19
Significance of sTREM-1 in early prediction of ventilator-associated pneumonia in neonates: a single-center, prospective, observational study
Zhao, X., Xu, L., Yang, Z., Sun, B., Wang, Y., Li, G. L., Feng, C., Pan, T., Tian, Y., & Feng, X. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05196-z · Cited by 17
“showed for the first time that TREM-1, as a member of the novel immunoglobulin super receptor family (Igsuperfamily, Ig-SF), triggers the release of chemokines and pro-inflammatory cytokines [23].”
Background
Tissue-resident CCR2+ macrophage TREM-1/3 signaling is necessary for monocyte and neutrophil recruitment to injured hearts
Terada, Y., Li, W., Amrute, J., Bery, A. I., Liu, C., Nunna, V., Frye, C. C., Dun, H., Koenig, A. L., Luehmann, H. P., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115380 · Cited by 16
Exploring the Roles of Liver X Receptors in Lipid Metabolism and Immunity in Atherosclerosis
Endo‐Umeda, K., & Makishima, M. (2025) · Biomolecules · doi:10.3390/biom15040579 · Cited by 20
“TREM2 has been identified as a cell surface receptor associated with an adaptor protein called DNAX activation protein 12 [31].”
Malaria-derived exosomes exacerbate liver injury during blood stage of Plasmodium berghei infection
Zhang, X., Zhang, M., Wang, Q. R., Hou, X., Zhou, T., Liu, J., Wang, Q., Liu, W., Liu, X., Jin, X., et al. (2023) · Acta Tropica · doi:10.1016/j.actatropica.2023.106815 · Cited by 18
Plasma IL-6, TREM1, uPAR, and IL6/IL8 biomarkers increment further witnessing the chronic inflammation in type 2 diabetes
Sater, M. S., AlDehaini, D. M. B., Malalla, Z. H. A., Ali, M. E., & Giha, H. A. (2023) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2022-0103 · Cited by 16
Contribution of Complement, Microangiopathy and Inflammation in Idiopathic Inflammatory Myopathies
Honda, M., Shimizu, F., Sato, R., & Nakamori, M. (2023) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-230168 · Cited by 16
Different effects of sonoporation on cell morphology and viability
Zhang, J.-Z., Saggar, J. K., Zhou, Z., & Hu, B. Q. (2012) · Bosnian Journal of Basic Medical Sciences · doi:10.17305/bjbms.2012.2497 · Cited by 16
Effects of Porphyromonas gingivalis LPS and LR 12 peptide on TREM ‐1 expression by monocytes
Dubar, M., Carrasco, K., Gibot, S., et al. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12925 · Cited by 16
A Gene Expression–based Model to Predict Metabolic Response After Two Courses of ABVD in Hodgkin Lymphoma Patients
Luminari, S., Donati, B., Casali, M., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2356 · Cited by 16
Proteomic Characterization of the Cellular Effects of AhR Activation by Microbial Tryptophan Catabolites in Endotoxin-Activated Human Macrophages
Walter, K., Großkopf, H., Karkossa, I., von Bergen�, M., & Schubert, K. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910336 · Cited by 18
Upstream stimulatory factor 2 (USF2) induced upregulation of triggering receptor expressed on myeloid cells 1 (TREM1) promotes endometritis by regulating toll-like receptor (TLR) 2/4-nuclear factor-kappaB (NF-κB) signaling pathway
Zhang, M., Yin, C., Chen, Y., Wang, J., & Jiang, J. (2022) · Bioengineered · doi:10.1080/21655979.2022.2030619 · Cited by 16
“20 years ago and is described as an activating receptor of the immune globulin superfamily expressed on human myeloid cells, including neutrophils, macrophages, and endothelial cells [8].”
Background
TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen
the Hellenic Sepsis Study Group, Poukoulidou, T., Spyridaki, A., et al. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-309 · Cited by 16
Preterm Newborns are Provided with Triggering Receptor Expressed on Myeloid Cells-1
Garofoli, F., Borghesi, A., Mazzucchelli, I., et al. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300439 · Cited by 16
Lipopolysaccharide induces TREM‐1‐dependent HIF‐1α expression in human keratinocyte cell line
Tu, C., Wang, S., Xiao, H., Wang, W., Dong, Y., Xiao, S., & Wang, X. (2016) · Cell Biology International · doi:10.1002/cbin.10693 · Cited by 16
“The protein triggering receptor expressed onmyeloid cells1 (TREM-1), a member of the immunoglobulin superfamily, is constitutively expressed on monocytes and neutrophils (Bouchon et al., 2000).”
Background
Reticulocalbin-1 Facilitates Microglial Phagocytosis
Ding, Y., Caberoy, N. B., Guo, F., LeBlanc, M. E., Zhang, C., Wang, W., Wang, F., Chen, R., & Li, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126993 · Cited by 16
“For instance, despite identification of TREM2 as a phagocytic receptor 14 years ago [8], its ligand(s) remains elusive [9].”
Background
Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats
Aydın, E., Yildirim, Y., Aydın, F. Y., et al. (2020) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/0037-8682-0016-2020 · Cited by 15
Alternatives to amyloid for Alzheimer's disease therapies—a symposium report
Cable, J., Holtzman, D. M., Hyman, B. T., Tansey, M. G., Colonna, M., Kellis, M., Brinton, R. D., Albert, M., Wellington, C. L., Sisodia, S. S., et al. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14371 · Cited by 13
Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice
Yamaga, S., Murao, A., Ma, G., Brenner, M., Aziz, M., & Wang, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1151250 · Cited by 15
Proteins and an Inflammatory Network Expressed in Colon Tumors
Zhu, W., Fang, C., Gramatikoff, K., Niemeyer, C. C., & Smith, J. W. (2011) · Journal of Proteome Research · doi:10.1021/pr101190f · Cited by 15
Correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) expression and endoscopic activity in inflammatory bowel diseases
Jung, Y. S., Park, J. J., Kim, S. W., Hong, S. P., Kim, T. I., Kim, W. H., & Cheon, J. H. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.05.011 · Cited by 15
Monosodium urate crystal-induced triggering receptor expressed on myeloid cells 1 is associated with acute gouty inflammation
Lee, J. J., Lee, S.-Y., Lee, J., et al. (2015) · Lara D. Veeken · doi:10.1093/rheumatology/kev316 · Cited by 15
Control of Pathogenic CD4 T Cells and Lethal Immunopathology by Signaling Immunoadaptor DAP12 during Influenza Infection
McCormick, S. M., Shaler, C. R., Small, C.-L. N., Horvath, C. N., Damjanovic, D., Brown, E. G., Aoki, N., Takai, T., & Xing, Z. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101050 · Cited by 15
Triggering Receptor Expressed on Myeloid Cells-1 Signaling: Protective and Pathogenic Roles on Streptococcal Toxic-Shock-Like Syndrome Caused by Streptococcus suis
Han, L., Fu, L., Peng, Y., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00577 · Cited by 15
Triggering Receptors Expressed on Myeloid Cells 1 : Our New Partner in Human Oncology?
Müller, M., Haghnejad, V., Lopez, A., Tiotiu, A. I., Renaud, S., Derive, M., & Bronowicki, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.927440 · Cited by 15
Activation of Triggering Receptor Expressed on Myeloid Cells-1 Protects Monocyte from Apoptosis through Regulation of Myeloid Cell Leukemia-1
Cai, M.-T., Chen, Q., Chen, C., Liu, X., Hou, J., Zeng, C., Shu, Q., & Fang, X. (2013) · Anesthesiology · doi:10.1097/aln.0b013e31828744a5 · Cited by 15

Authors: Bouchon, A., Dietrich, J., & Colonna, M.
Affiliations: Basel Institute for Immunology , Basel ,
ORCID: Dietrich, Jes
Colonna, Marco
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2000-05
Volume: 164
Issue: 10
Pages: 4991-4995
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.164.10.4991
OpenAlex: W2149698238
Semantic Scholar: c6fffd66acdcb27c928605f7aca443056a3a6c3f
Cited by: 1,284
References: 13
Citations by year: 2026: 38 · 2025: 47 · 2024: 73 · 2023: 87 · 2022: 51 · 2021: 65 · 2020: 83 · 2019: 49 · 2018: 55 · 2017: 51 · 2016: 59 · 2015: 47 · 2014: 48 · 2013: 68 · 2012: 50
FWCI: 6.50
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: TREM-1, neutrophils, monocytes, inflammation, IL-8 secretion, MCP-1, TNF-α, neutrophil degranulation, calcium mobilization, phospholipase C-gamma, myeloid cell activation
MeSH terms: Triggering Receptor Expressed on Myeloid Cells-1, Amino Acid Sequence, Fungi, Multigene Family, Gram-Negative Bacteria, Gram-Positive Bacteria, Humans, Immunoglobulins, Inflammation, Macrophage Activation, Membrane Glycoproteins, Membrane Proteins, Molecular Sequence Data, Molecular Weight, Monocytes, Neutrophils, Phosphorylation, Receptors, Immunologic, Tyrosine, Biomarkers, Up-Regulation, Cytokines, Neutrophil Activation, Chemokines, Calcium Signaling, Adaptor Proteins, Signal Transducing

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Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

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