The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface
Open accessAbstract
Follicular dendritic cells (FDCs) present in lymphoid follicles play a critical role in germinal center reactions. They trap native Ags in the form of immune complexes providing a source for continuous stimulation of specific B lymphocytes. FDCs have been reported to express MHC class II molecules, suggesting an additional role in the presentation of not only native, but also processed Ag in the form of peptide-loaded MHC class II. Adoptive bone marrow transfer experiments have shown that MHC class II molecules are only passively acquired. Up to now the origin of these MHC class II molecules was not clear. Here we show by cryoimmunogold electron microscopy that MHC class II molecules are not present at the plasma membrane of FDCs. In contrast, microvesicles attached to the FDC surface contain MHC class II and other surface proteins not expressed by FDCs themselves. The size and marker profiles of these microvesicles resemble exosomes. Exosomes, which are secreted internal vesicles from multivesicular endosomes, have been shown earlier to stimulate proliferation of specific T lymphocytes in vitro, but their target in vivo remained a matter of speculation. We demonstrate here that isolated exosomes in vitro bind specifically to FDCs and not to other cell types, suggesting that FDCs might be a physiological target for exosomes.
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Cited by
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Extracellular vesicles: Exosomes, microvesicles, and friends
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Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
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Biological properties of extracellular vesicles and their physiological functions
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Metadata
- Authors
- Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C., & J. Geuze, H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08-01
- Volume
- 165
- Issue
- 3
- Pages
- 1259-1265
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2132603657
- Cited by
- 451
- References
- 39
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C., & J. Geuze, H. (2000). Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface. The Journal of Immunology. https://doi.org/10.4049/jimmunol.165.3.1259
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