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Cited by 185T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

Th1 and Th2 CD4+ T Cells Provide Help for B Cell Clonal Expansion and Antibody Synthesis in a Similar Manner In Vivo

Smith, Karen M, Pottage, Lindsay, Thomas, Elaine R, Leishman, Andrew J, Doig, Tamsin N, Xu, Damo, Liew, Foo Y, Garside, Paul·2000·The Journal of Immunology
DOI 10.4049/jimmunol.165.6.3136
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Abstract

The relative ability of Th1 and Th2 T cells to help B cells remains controversial as do the mechanisms by which both T cell subsets provide help in vivo. Whether this help affects the clonal expansion and/or differentiation of B cells has been difficult to assess due to the low frequency of Ag-specific T and B lymphocytes. We have employed a novel technique to directly monitor the clonal expansion of Ag-specific T and B lymphocytes in vivo. OVA-specific TCR transgenic T lymphocytes were polarized toward a Th1 or Th2 phenotype in vitro. These cells were then transferred into syngeneic recipients, along with B cell receptor transgenic hen egg lysozyme-specific B lymphocytes. Our results indicate that Th1 and Th2 cells support B cell responses to a similar extent in vivo and that they achieve this in the same manner by migrating into B cell follicles to promote CD154-dependent B cell clonal expansion and Ab production.

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Crossref · 10.4049/jimmunol.165.6.3136

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  • Th17 cells are an independent T helper cell subset.

    “Th17 cells were established as an independent T helper cell subset with the discovery of signature cytokines IL-17A, IL-17F, and IL-22, lineage-specific differentiation factors, and dedicated or “master” transcription factors”

    From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [15]

  • TGF-β and IL-6 are required to polarize naïve T cells into Th17 cells.

    “In 2006, the cytokines TGF-β and IL-6 were described as differentiation factors required to polarize naïve T cells into Th17 cells”

    From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [15]

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Authors
Smith, K. M., Pottage, L., Thomas, E. R., Leishman, A. J., Doig, T. N., Xu, D., Liew, F. Y., & Garside, P.
Affiliations
Western Infirmary (GB)
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2000-09
Volume
165
Issue
6
Pages
3136-3144
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.165.6.3136
OpenAlex
W2143242765
Cited by
185
References
50
Citations by year
2026: 4 · 2025: 8 · 2024: 2 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 3 · 2016: 11 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
3.65
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
Th1 cells, Th2 cells, CD4+ T cells, B cell clonal expansion, antibody production, CD154, B cell follicles, T cell polarization, TCR transgenic T cells, hen egg white lysozyme, ovalbumin-specific T cells
MeSH terms
Animals, Antibodies, Monoclonal, Antibody Formation, B-Lymphocytes, Cell Differentiation, Cell Movement, Cells, Cultured, Clone Cells, Ligands, Lymphocyte Cooperation, Lymphocyte Activation, Male, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Ovalbumin, Immunophenotyping, Cytokines, Cell Polarity, Th1 Cells, Th2 Cells, Epitopes, T-Lymphocyte, CD40 Antigens, Adoptive Transfer, CD40 Ligand, Mice

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