Granulocyte Macrophage Colony-Stimulating Factor

McQualter, Jonathan L.; Darwiche, Rima; Ewing, Christine; Onuki, Manabu; Kay, Thomas W.; Hamilton, John A.; Reid, Hugh H.; Bernard, Claude C.A.

doi:10.1084/jem.194.7.873

Cited by 477Multiple Sclerosis Research StudiesT-cell and B-cell ImmunologyNeuroinflammation and Neurodegeneration Mechanisms

Granulocyte Macrophage Colony-Stimulating Factor

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McQualter, Jonathan L., Darwiche, Rima, Ewing, Christine, Onuki, Manabu, Kay, Thomas W., Hamilton, John A., Reid, Hugh H., Bernard, Claude C.A.·2001·The Journal of Experimental Medicine

DOI 10.1084/jem.194.7.873PMC PMC2193476

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Abstract

Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expressed on the myelin surface, is able to induce a paralytic MS-like disease with extensive CNS inflammation and demyelination in several strains of animals. Although not well understood, the egress of immune cells into the CNS in EAE is governed by a complex interplay between pro and antiinflammatory cytokines and chemokines. The hematopoietic growth factor, granulocyte macrophage colony-stimulating factor (GM-CSF), is considered to play a central role in maintaining chronic inflammation. The present study was designed to investigate the previously unexplored role of GM-CSF in autoimmune-mediated demyelination. GM-CSF(-/)- mice are resistant to EAE, display decreased antigen-specific proliferation of splenocytes, and fail to sustain immune cell infiltrates in the CNS, thus revealing key activities for GM-CSF in the development of inflammatory demyelinating lesions and control of migration and/or proliferation of leukocytes within the CNS. These results hold implications for the pathogenesis of inflammatory and demyelinating diseases and may provide the basis for more effective therapies for inflammatory diseases, and more specifically for multiple sclerosis.

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GM-CSF is essential for the development and progression of EAE; mice deficient in GM-CSF are resistant to EAE induction, and blockade of GM-CSF in wild-type mice suppresses ongoing disease.
“GM-CSF is essential for the development and progression of EAE. Mice deficient in GM-CSF are resistant to EAE induction, and blockade of GM-CSF in wild-type mice suppresses ongoing disease (McQualter et al., 2001; Codarri et al., 2011).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as McQualter et al., 2001

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Grauer, O. M., Wesseling, P., & Adema, G. J. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00315.x · Cited by 4,025 · see citing works
Chemokines and disease
Gerard, C., & Rollins, B. J. (2001) · Nature Immunology · doi:10.1038/84209 · Cited by 1,357 · see citing works
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.
Stanley, E. G., Lieschke, G. J., Grail, D., Metcalf, D., HODGSON, G. S., Gall, J. A. M., Maher, D. W., Cebon, J. S., Sinickas, V., & Dunn, A. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5592 · Cited by 880 · see citing works
Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy.
Lassmann, H., Brück, W., & Lucchinetti, C. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(00)01909-2 · Cited by 691 · see citing works
The Hemopoietic Colony-stimulating Factors
Metcalf, D., & Nicola, N. A. (1995) · Cambridge University Press eBooks · doi:10.1017/cbo9780511663376 · Cited by 547 · see citing works
Brain Dendritic Cells and Macrophages/Microglia in Central Nervous System Inflammation
Fischer, H., & Reichmann, G. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2717 · Cited by 408 · see citing works
Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes
Aloisi, F., Ria, F., & Adorini, L. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01512-1 · Cited by 390 · see citing works
Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice.
Tran, E., Hoekstra, K., van Rooijen, N., Dijkstra, C., & Owens, T. (1998) · Journal of Immunology · doi:10.4049/jimmunol.161.7.3767 · Cited by 373 · see citing works
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
Lang, R. A., Metcalf, D., Cuthbertson, R. A., Lyons, I. G., Stanley, E. G., Kelso, A., Kannourakis, G., Williamson, D. J., Klintworth, G. K., Gonda, T. J., et al. (1987) · Cell · doi:10.1016/0092-8674(87)90136-x · Cited by 366 · see citing works
Chemokine expression in murine experimental allergic encephalomyelitis
Godiska, R., Chantry, D., Dietsch, G. N., et al. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00008-p · Cited by 355 · see citing works
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.
Gijbels, K., Galardy, R. E., & Steinman, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117578 · Cited by 339 · see citing works
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
Miller, S. D., Vanderlugt, C. L., Lenschow, D. J., Pope, J. G., Karandikar, N. J., Canto, M. C. D., & Bluestone, J. A. (1995) · Immunity · doi:10.1016/1074-7613(95)90063-2 · Cited by 315 · see citing works
Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells.
Morrissey, P. J., Bressler, L. R., Park, L. S., Alpert, A., & Gillis, S. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.4.1113 · Cited by 282 · see citing works
Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes.
Arnaout, M. A., Wang, E. A., Clark, S. C., et al. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112615 · Cited by 277 · see citing works
Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis
Bernard, C. C. A., Johns, T. G., Slavin, A., Ichikawa, M., Ewing, C., Liu, J., & Bettadapura, J. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050092 · Cited by 270 · see citing works
Self-citation
Assessment of Animal Models for MS and Demyelinating Disease in the Design of Rational Therapy
Steinman, L. (1999) · Neuron · doi:10.1016/s0896-6273(00)81107-1 · Cited by 245 · see citing works
The influence of granulocyte/macrophage colony‐stimulating factor on dendritic cell levels in mouse lymphoid organs
Vremec, D., Lieschke, G. J., Dunn, A. R., Robb, L. G., Metcalf, D., & Shortman, K. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270107 · Cited by 240 · see citing works
Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1α and monocyte chemotactic protein-1
Kennedy, K. J., Strieter, R. M., Kunkel, S. L., Lukacs, N. W., & Karpus, W. J. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00187-8 · Cited by 239 · see citing works
Protection from Collagen-Induced Arthritis in Granulocyte-Macrophage Colony-Stimulating Factor-Deficient Mice
Campbell, I. K., Rich, M. J., Bischof, R. J., Dunn, A. R., Grail, D., & Hamilton, J. A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3639 · Cited by 233 · see citing works
Self-citation
Stimulation of macrophage plasminogen activator activity by colony‐stimulating factors
Hamilton, J. A., Stanley, E. R., Burgess, A. W., & Shadduck, R. K. (1980) · Journal of Cellular Physiology · doi:10.1002/jcp.1041030309 · Cited by 222 · see citing works
Self-citation
Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor
Clements, J. M., Cossins, J. A., Wells, G., Corkill, D. J., Helfrich, K., Wood, L. M., Pigott, R., Stabler, G., Ward, G. A., Gearing, A. J. H., et al. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00210-x · Cited by 205 · see citing works
Th1 and Th2 CD4+ T Cells Provide Help for B Cell Clonal Expansion and Antibody Synthesis in a Similar Manner In Vivo
Smith, K. M., Pottage, L., Thomas, E. R., Leishman, A. J., Doig, T. N., Xu, D., Liew, F. Y., & Garside, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3136 · Cited by 185 · see citing works
Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis.
Johns, T. G., de Rosbo, N. K., Menon, K. N., Abo, S., Gonzales, M. F., & Bernard, C. C. A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5536 · Cited by 181 · see citing works
Self-citation
A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte‐macrophage colony stimulating factor.
Johnson, G. R., Gonda, T. J., Metcalf, D., Hariharan, I. K., & Cory, S. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03396.x · Cited by 180 · see citing works
Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.
Alvaro-Gracia, J. M., Zvaifler, N. J., & Firestein, G. S. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.170.3.865 · Cited by 162 · see citing works
Profile of Cerebrospinal Fluid and Serum Cytokines in Patients with Relapsing-Remitting Multiple Sclerosis. A Correlation with Clinical Activity
Carrieri, P. B., Provitera, V., Rosa, T. D., Tartaglia, G. G., Gorga, F., & Perrella, O. (1998) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923979809034820 · Cited by 155 · see citing works
Functional Maturation of Adult Mouse Resting Microglia into an APC Is Promoted by Granulocyte-Macrophage Colony-Stimulating Factor and Interaction with Th1 Cells
Aloisi, F., Simone, R. D., Cabezas, S. C., Penna, G., & Adorini, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.1705 · Cited by 153 · see citing works
Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor.
Park, L. S., Friend, D. J., Gillis, S. A., et al. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35642-9 · Cited by 146 · see citing works
Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis
Juedes, A. E., & Ruddle, N. H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.5168 · Cited by 145 · see citing works
Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune Encephalomyelitis in the “Resistant” Brown Norway Rat: Disease Susceptibility Is Determined by MHC and MHC-Linked Effects on the B Cell Response
Stefferl, A., Brehm, U., Storch, M. K., Lambracht‐Washington, D., Bourquin, C., Wonigeit, K., Lassmann, H., & Linington, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.40 · Cited by 143 · see citing works
Treatment with Anti-Granulocyte Antibodies Inhibits the Effector Phase of Experimental Autoimmune Encephalomyelitis
McColl, S. R., Staykova, M. A., Wozniak, A., Fordham, S., Bruce, J., & Willenborg, D. O. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.11.6421 · Cited by 142 · see citing works
Essential roles for granulocyte-macrophage colony-stimulating factor (GM-CSF) and G-CSF in the sustained hematopoietic response of Listeria monocytogenes-infected mice.
Zhan, Y., Lieschke, G., Grail, D., Dunn, A., & Cheers, C. (1998) · Blood · doi:10.1182/blood.v91.3.863 · Cited by 141 · see citing works
Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein
Slavin, A., Ewing, C., Liu, J., Ichikawa, M., Slavin, J., & Bernard, C. C. A. (1998) · Autoimmunity · doi:10.3109/08916939809003872 · Cited by 137 · see citing works
Self-citation
Synergistic activation of human monocytes by granulocyte-macrophage colony-stimulating factor and IFN-gamma. Increased TNF-alpha but not IL-1 activity.
Hart, P. H., Whitty, G. A., Piccoli, D. S., et al. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.5.1516 · Cited by 136 · see citing works
Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-β1 (TGF-β1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia
Wei, R., & Jonakait, G. M. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00248-3 · Cited by 126 · see citing works
Colony stimulating factors, cytokines and monocyte-macrophages-some controversies
Hamilton, J. A. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90319-g · Cited by 119 · see citing works
Self-citation
Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats
Huitinga, I., Ruuls, S. R., JUNG, S., van Rooijen, N., Hartung, H. ‐., & Dijkstra, C. D. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03675.x · Cited by 111 · see citing works
Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
Campbell, I. K., Bendele, A. M., Smith, D. A., & Hamilton, J. A. (1997) · Annals of the Rheumatic Diseases · doi:10.1136/ard.56.6.364 · Cited by 110 · see citing works
Self-citation
Multiple sclerosis: an autoimmune disease of multifactorial etiology
Bernard, C. C. A., & de Rosbo, N. K. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90058-m · Cited by 97 · see citing works
Self-citation
Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs
Hamilton, J. A. (1993) · The Lancet · doi:10.1016/0140-6736(93)91653-4 · Cited by 92 · see citing works
Self-citation
T cell functions in granulocyte/macrophage colony-stimulating factor deficient mice
Wada, H., Noguchi, Y., Marino, M. W., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12557 · Cited by 90 · see citing works
Microglial phagocytosis is modulated by pro-and anti-inflammatory cytokines
von Zahn, J., Möller, T., Kettenmann, H., & Nolte, C. (1997) · Neuroreport · doi:10.1097/00001756-199712220-00003 · Cited by 76 · see citing works
Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent.
Martiney, J., Rajan, A. J., Charles, P., Cerami, A., Ulrich, P., Macphail, S., Tracey, K., & Brosnan, C. (1998) · Journal of Immunology · doi:10.4049/jimmunol.160.11.5588 · Cited by 73 · see citing works
Local Transgenic Expression of Granulocyte Macrophage-Colony Stimulating Factor Initiates Autoimmunity
Biondo, M., Nasa, Z., Marshall, A. C. J., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.2090 · Cited by 73 · see citing works
Regulation of human monocyte adherence by granulocyte-macrophage colony-stimulating factor.
Gamble, J. R., Elliott, M. J., Jaipargas, E., Lopez, A. F., & Vadas, M. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7169 · Cited by 69 · see citing works
Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein
Hilton, A. A., Slavin, A., Hilton, D. J., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65010309.x · Cited by 63 · see citing works
The Hemopoietic Colony-stimulating Factors: From Biology to Clinical Applications
Metcalf, D., & Nicola, N. A. (1995) · Medical Entomology and Zoology · Cited by 60 · see citing works
Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T- and B-cell epitopes
de Rosbo, N. K., Brok, H., Bauer, J., Kaye, J. F., Hart, B. A. ‘., & Ben‐Nun, A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00306-4 · Cited by 60 · see citing works
Minireview: Autoimmune responses to myelin proteolipid protein
Sobel, R. A., Greer, J. M., & Kuchroo, V. K. (1994) · Neurochemical Research · doi:10.1007/bf00968701 · Cited by 59 · see citing works
Immune cell entry to the CNS — a focus for immunoregulation of EAE
Owens, T., Tran, E., Hassan‐Zahraee, M., & Krakowski, M. L. (1998) · Research in Immunology · doi:10.1016/s0923-2494(99)80005-4 · Cited by 48 · see citing works
Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55
Ichikawa, M., Johns, T. G., Liu, J., & Bernard, C. C. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.2.919 · Cited by 47 · see citing works
Self-citation
Induction of Chemokine Secretion and Enhancement of Contact-Dependent Macrophage Cytotoxicity by Engineered Expression of Granulocyte-Macrophage Colony-Stimulating Factor in Human Colon Cancer Cells
Shinohara, H., Yano, S., Bucana, C. D., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2728 · Cited by 45 · see citing works
IgG Subclass Switching Is Associated with the Severity of Experimental Autoimmune Encephalomyelitis Induced with Myelin Oligodendrocyte Glycoprotein Peptide in NOD Mice
Ichikawa, M., Koh, C., Inaba, Y., et al. (1999) · Cellular Immunology · doi:10.1006/cimm.1998.1414 · Cited by 36 · see citing works
Suppression of Experimental Autoimmune Encephalomyelitis by Intravenously Administered Polyclonal Immunoglobulins
Achiron, A., Mor, F., Margalit, R., et al. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0433 · Cited by 36 · see citing works
Frontiers in multiple sclerosis : clinical research and therapy
Abramsky, O., & Ovadia, H. (1997) · Martin Dunitz eBooks · Cited by 21 · see citing works
Frontiers in Multiple Sclerosis: Clinical Research and Therapy
Skorin, L. (1997) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.1997.97.3.131 · Cited by 20 · see citing works
Do antibodies to myelin basic protein isolated from multiple sclerosis cross-react with measles and other common virus antigens?
Bernard, C. C. A., Townsend, E., Randell, V. B., et al. (1983) · PubMed · Cited by 19 · see citing works
Self-citation
Development of dendritic cells in culture from human and murine thymic precursor cells.
Ka, K., Lucas, K., Hochrein, H., et al. (2001) · PubMed · Cited by 13 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Sobel R.A. Greer J.M. Kuchroo V.K. Minireviewautoimmune responses to myelin proteolipid protein Neurochem. Res. 19 1994 915 921 7528354
Bernard C.C. Kerlero de Rosbo N. Multiple sclerosisan autoimmune disease of multifactorial etiology Curr. Opin. Immunol. 4 1992 760 765 1281641

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Seo, J., Hasan, M., Han, J., Kim, N., Lee, J. E., Lee, K. M., Park, J.-H., Kim, H. J., Son, J. J., Lee, J., et al. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1732-9 · Cited by 3 · see citing works
Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
(2022) · doi:10.1111/ejn.15817/v2/decision1
Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
(2021) · doi:10.1111/ejn.15817/v1/decision1
Cutting Edge: C3, a Key Component of Complement Activation, Is Not Required for the Development of Myelin Oligodendrocyte Glycoprotein Peptide-Induced Experimental Autoimmune Encephalomyelitis in Mice
Calida, D. M., Constantinescu, C. S., Purev, E., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.723 · Cited by 89 · see citing works
Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"
(2021) · doi:10.1111/ejn.15817/v1/review2

Authors: McQualter, J. L., Darwiche, R., Ewing, C., Onuki, M., Kay, T. W., Hamilton, J. A., Reid, H. H., & Bernard, C. C. A.
Affiliations: La Trobe University (AU)
The Royal Melbourne Hospital (AU)
ORCID: McQualter, Jonathan L.
Kay, Thomas W.
Hamilton, John A.
Reid, Hugh H.
Bernard, Claude C.A.
Venue: The Journal of Experimental Medicine
Publisher: Rockefeller University Press
Published: 2001-09-24
Volume: 194
Issue: 7
Pages: 873-882
ISSN: 0022-1007 (ISSN-L)
1540-9538
DOI: 10.1084/jem.194.7.873
PMC: PMC2193476
OpenAlex: W2166787544
Cited by: 477
References: 58
Citations by year: 2026: 4 · 2025: 12 · 2024: 9 · 2023: 16 · 2022: 21 · 2021: 23 · 2020: 30 · 2019: 21 · 2018: 26 · 2017: 19 · 2016: 23 · 2015: 33 · 2014: 22 · 2013: 24 · 2012: 19
FWCI: 12.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Experimental Medicine (publishedVersion)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-sa)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: GM-CSF, experimental autoimmune encephalomyelitis, multiple sclerosis, myelin oligodendrocyte glycoprotein, demyelination, neuroinflammation, leukocyte migration, splenocyte proliferation, chemokines, cytokines, hematopoietic growth factors
MeSH terms: Animals, Autoantibodies, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Immunity, Innate, Immunotherapy, Mice, Mutant Strains, Multiple Sclerosis, Myelin Proteins, T-Lymphocytes, Granulocyte-Macrophage Colony-Stimulating Factor, Mice, Inbred NOD, Myelin-Associated Glycoprotein, Mice, Myelin-Oligodendrocyte Glycoprotein

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