Generation of Macrophages from Early T Progenitors In Vitro
Open accessAbstract
Early T progenitors in the thymus have been reported to have the capacity to develop into B cells, thymic dendritic cells, and NK cells. Here we describe conditions that induce early T progenitors to develop into macrophages. Initially, we observed that early T progenitors could be induced to develop into macrophages by cytokines produced from a thymic stromal cell line, TFGD, and later we found that the cytokine mixture of M-CSF plus IL-6 plus IL-7 also induced macrophage differentiation from pro-T cells. M-CSF by itself was unable to induce macrophage differentiation from early T progenitors. To correlate this observation with the developmental potential of early T progenitors, mouse embryonic thymocytes were sorted into four populations, pro-T1 to pro-T4, based on the expression of CD44 and CD25, and then cultured with TFGD culture supernatant. We found that pro-T1 and pro-T2 cells, but not pro-T3 and pro-T4 cells, generate macrophages. Limiting dilution analysis of the differentiation capability of sorted pro-T2 cells also confirmed that pro-T2 cells could generate macrophages. These results suggest that T cells and thymic macrophages could originate from a common intrathymic precursor.
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ETP and DN2 cells can generate myeloid cells if removed from the thymus, whereas pro-T cells past PU.1 expression (DN3 or later) do not make myeloid cells under these conditions.
“Whereas ETP and DN2 cells can generate myeloid cells if removed from the thymus, pro-T cells that have differentiated past the stage of PU.1 expression in the thymus (i.e., from the DN2 stage to the DN3 stage or later) do not make myeloid cells under these conditions”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [52]
The Results section ('Both Pro-T1 and T2 cells can generate macrophages'; page not supplied) reports that pro-T1 and pro-T2 cells generated macrophages in culture, whereas pro-T3 and pro-T4 cells did not under those conditions. The paper does not establish the claim's PU.1-expression boundary or test stages later than pro-T4. (LLM, conf=0.86)
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- Authors
- Lee, C.-K., Kim, J. K., Kim, Y., Lee, M.-K., Kim, K., Kang, J.-K., Hofmeister, R., Durum, S. K., & Han, S. S.
- Affiliations
- Chungbuk National University (KR)
- Corresponding author
- Kim, Youngsoo
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05
- Volume
- 166
- Issue
- 10
- Pages
- 5964-5969
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1531474592
- Cited by
- 56
- References
- 34
- Citations by year
- 2021: 2 · 2020: 2 · 2019: 2 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- macrophage differentiation, pro-T cells, thymus, macrophage colony-stimulating factor, interleukin-6, IL-7, thymic stromal cells, CD44, CD25, common precursor, T cell development
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Cell Separation, Cell-Free System, Cells, Cultured, Drug Combinations, Fetus, Macrophages, Mice, Inbred C57BL, Stem Cells, Thymus Gland, Tumor Cells, Cultured, Interleukin-6, Interleukin-7, Immunophenotyping, Macrophage Colony-Stimulating Factor, T-Lymphocyte Subsets, Culture Media, Conditioned, Cell Culture Techniques, Mice
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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