The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells
Abstract
The mechanism of tumor-associated T cell dysfunction remains an unresolved problem of tumor immunology. Development of T cell defects in tumor-bearing hosts are often associated with increased production of immature myeloid cells. In tumor-bearing mice, these immature myeloid cells are represented by a population of Gr-1+ cells. In this study we investigated an effect of these cells on T cell function. Gr-1+ cells were isolated from MethA sarcoma or C3 tumor-bearing mice using cell sorting. These Gr-1+ cells expressed myeloid cell marker CD11b and MHC class I molecules, but they lacked expression of MHC class II molecules. Tumor-induced Gr-1+ cells did not affect T cell responses to Con A and to a peptide presented by MHC class II. In sharp contrast, Gr-1+ cells completely blocked T cell response to a peptide presented by MHC class I in vitro and in vivo. Block of the specific MHC class I molecules on the surface of Gr-1+ cells completely abrogated the observed effects of these cells. Thus, immature myeloid cells specifically inhibited CD8-mediated Ag-specific T cell response, but not CD4-mediated T cell response. Differentiation of Gr-1+ cells in the presence of growth factors and all-trans retinoic acid completely eliminated inhibitory potential of these cells. This may suggest a new approach to cancer treatment.
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Cites
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Cited by
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994
Myeloid-derived-suppressor cells as regulators of the immune system
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Self-citationSubsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
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Metadata
- Authors
- Gabrilovich, D. I., Velders, M. P., Sotomayor, E. M., & Kast, W. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-05-01
- Volume
- 166
- Issue
- 9
- Pages
- 5398-5406
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2134653497
- Cited by
- 538
- References
- 30
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gabrilovich, D. I., Velders, M. P., Sotomayor, E. M., & Kast, W. M. (2001). Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.166.9.5398
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