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Cited by 459

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation

Open access
Mattei, Fabrizio, Schiavoni, Giovanna, Belardelli, Filippo, Tough, David F·2001·The Journal of Immunology
DOI 10.4049/jimmunol.167.3.1179
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Abstract

Cytokines that are induced by infection may contribute to the initiation of immune responses through their ability to stimulate dendritic cells (DCs). In this paper, we have addressed the role of IL-15 in DC activation, investigating its expression by DCs in response to three different signals of infection and examining its ability to stimulate DCs. We report that the expression of both IL-15 and the IL-15 receptor α-chain are increased in splenic DCs from mice inoculated with dsRNA (poly(I:C)), LPS, or IFN-αβ, and in purified murine splenic DCs treated with IFN-αβ in vitro. Furthermore, IL-15 itself was able to activate DCs, as in vivo or in vitro exposure of splenic DCs to IL-15 resulted in an up-regulation of costimulatory molecules, markedly increased production of IFN-γ by DC and an enhanced ability of DCs to stimulate Ag-specific CD8+ T cell proliferation. The magnitude of all of the IL-15-induced changes in DCs was reduced in mice deficient for the IFN-αβ receptor, suggesting a role for IFN-αβ in the stimulation of DCs by IL-15. These results identify IL-15 as a stimulatory cytokine for DCs with the potential for autocrine activity and link its effects to expression of IFN-αβ.

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Metadata

Authors
Mattei, F., Schiavoni, G., Belardelli, F., & Tough, D. F.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2001-08-01
Volume
167
Issue
3
Pages
1179-1187
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.167.3.1179
OpenAlex
W2160915452
Cited by
459
References
68
FWCI
9.13
Type
journal article
Language
en
Open access
bronze

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