The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells
Open accessAbstract
IL-15 and IL-15Rα are required for generation of memory-phenotype CD8 T cells in unimmunized mice. However, the role of IL-15 in primary expansion and generation of Ag-specific memory CD8 T cells in vivo has not been investigated. We characterized the CD8 T cell response against vesicular stomatitis virus (VSV) in IL-15−/− and IL-15Rα−/− mice. Surprisingly, IL-15 was required for primary expansion of VSV-specific CD8 T cells. The generation of VSV-specific memory CD8 T cells was also impaired without IL-15 signaling, and this defect correlated with a decrease in memory CD8 T cell turnover. Despite minimal proliferation without IL-15, a subset of memory cells survived long-term. IL-15Rα expression was low on naive CD8 T cells, up-regulated on Ag-specific effector cells, and sustained on memory cells. Thus, IL-15 was important for the generation and the subsequent maintenance of antiviral memory CD8 T cells.
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Citations
Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
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“VSV-Nspecific CD8 T cells were detected using H-2K b tetramers containing the N protein-derived peptide RGYVYQGL (14) and were generated as previously described (15, 16).”
MethodPreferential Localization of Effector Memory Cells in Nonlymphoid Tissue
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Self-citationCounting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
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Determination of lymphocyte division by flow cytometry
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Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
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Self-citationCloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
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IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation
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Self-citationPotent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15
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Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.
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Cited by
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
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CD4+ T cell help in cancer immunology and immunotherapy
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Enhancing CD8 T-cell memory by modulating fatty acid metabolism
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Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
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Metadata
- Authors
- Schluns, K. S., Williams, K., Ma, A., Zheng, X. X., & Lefrançois, L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-05
- Volume
- 168
- Issue
- 10
- Pages
- 4827-4831
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1505315838
- Cited by
- 521
- References
- 26
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schluns, K. S., Williams, K., Ma, A., Zheng, X. X., & Lefrançois, L. (2002). Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.168.10.4827
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
