The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells
Open accessAbstract
Host resistance to the intracellular protozoan Toxoplasma gondii is highly dependent on early IL-12 production by APC. We demonstrate here that both host resistance and T. gondii-induced IL-12 production are dramatically reduced in mice lacking the adaptor molecule MyD88, an important signaling element used by Toll-like receptor (TLR) family members. Infection of MyD88-deficient mice with T. gondii resulted in uncontrolled parasite replication and greatly reduced plasma IL-12 levels. Defective IL-12 responses to T. gondii Ags (soluble tachyzoite Ag (STAg)) were observed in MyD88−/− peritoneal macrophages, neutrophils, and splenic dendritic cells (DC). In contrast, DC from TLR2- or TLR4-deficient animals developed normal IL-12 responses to STAg. In vivo treatment with pertussis toxin abolished the residual IL-12 response displayed by STAg-stimulated DC from MyD88−/− mice. Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways.
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Cites
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Kiefer, F., Brumell, J., Al-Alawi, N., Latour, S., Cheng, A., Veillette, A., Grinstein, S., & Pawson, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4209 · Cited by 376
Hunter, C. A., Chizzonite, R., & Remington, J. S. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4347 · Cited by 245
Cited by
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2079 · Cited by 2,667
TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein
Yarovinsky, F., Zhang, D., Andersen, J. F., Bannenberg, G. L., Serhan, C. N., Hayden, M. S., Hieny, S., Sutterwala, F. S., Flavell, R. A., Ghosh, S., et al. (2005) · Science · doi:10.1126/science.1109893 · Cited by 1,048
Self-citationMyD88: a central player in innate immune signaling
Deguine, J., & Barton, G. M. (2014) · F1000Prime Reports · doi:10.12703/p6-97 · Cited by 692
Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4
Watford, W. T., Hissong, B. D., Bream, J. H., Kanno, Y., Muul, L., & O'Shea, J. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00211.x · Cited by 572
Innate immunity to Toxoplasma gondii infection
Yarovinsky, F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3598 · Cited by 462
Metadata
- Authors
- Scanga, C. A., Aliberti, J., Jankovic, D., Tilloy, F., Bennouna, S., Denkers, E. Y., Medzhitov, R., & Sher, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06
- Volume
- 168
- Issue
- 12
- Pages
- 5997-6001
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1793115003
- Cited by
- 487
- References
- 3
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Scanga, C. A., Aliberti, J., Jankovic, D., Tilloy, F., Bennouna, S., Denkers, E. Y., Medzhitov, R., & Sher, A. (2002). Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.168.12.5997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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