The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
T Cell Antigen Receptor Engagement and Specificity in the Recognition of Stress-Inducible MHC Class I-Related Chains by Human Epithelial γδ T Cells
Open accessAbstract
Human γδ T cells with the TCR variable region Vδ1 occur mainly in epithelia and respond to stress-induced expression of the MHC class I-related chains A and B, which have no function in Ag presentation. MIC function as ligands for NKG2D-DAP10, an activating receptor complex that triggers NK cells, costimulates CD8 αβ and Vγ9Vδ2 γδ T cells, and is required for stimulation of Vδ1 γδ T cells. It is unresolved, however, whether triggering of Vδ1 γδ TCRs is also mediated by MIC or by unidentified cell surface components. Soluble MICA tetramers were used as a binding reagent to demonstrate specific interactions with various Vδ1 γδ TCRs expressed on transfectants of a T cell line selected for lack of NKG2D. Tetramer binding was restricted to TCRs derived from responder T cell clones classified as reactive against a broad range of MIC-expressing target cells and was abrogated when TCRs were composed of mismatched γ- and δ-chains. These results and the inability of Vδ1 γδ T cells to respond to target cells expressing the ULBP/N2DL ligands of NKG2D, which are highly divergent from MIC, indicate that MIC delivers both the TCR-dependent signal 1 and the NKG2D-dependent costimulatory signal 2. This dual function may serve to prevent erroneous γδ T cell activation by cross-reactive cell surface determinants.
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Citations
Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1×
“Tetramers of polymorphic MHC class I- or class II-peptide complexes have been widely used as high avidity binding reagents to detect Ag-specific T cells (31, 32, 35, 36).”
MethodActivation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., & Spies, T. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 2,999
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Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
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Self-citationAn Activating Immunoreceptor Complex Formed by NKG2D and DAP10
Wu, J., Song, Y., Bakker, A. B. H., Bauer, S., Spies, T., Lanier, L. L., & Phillips, J. H. (1999) · Science · doi:10.1126/science.285.5428.730 · Cited by 1,039
Self-citationBroad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
Groh, V., Rhinehart, R., Secrist, H., Bauer, S., Grabstein, K. H., & Spies, T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6879 · Cited by 1,028
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Self-citationNatural and synthetic non-peptide antigens recognized by human γδ T cells
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Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells
Groh, V., Rhinehart, R., Randolph-Habecker, J., Topp, M. S., Riddell, S. R., & Spies, T. (2001) · Nature Immunology · doi:10.1038/85321 · Cited by 951
Self-citationREGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
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Cited by
Overview of the immune response
Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease
Hüe, S., Mention, J.-J., Monteiro, R. C., Zhang, S., Cellier, C., Schmitz, J., Verkarre, V., Fodil, N., Bahram, S., Cerf-Bensussan, N., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.018 · Cited by 759
γδ T Cells Link Innate and Adaptive Immune Responses
Holtmeier, W., & Kabelitz, D. (2005) · Chemical Immunology and Allergy · doi:10.1159/000086659 · Cited by 305
Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis
Davis, M. M., Altman, J. D., & Newell, E. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3020 · Cited by 124
Characterization of γδ T cells in patients with non-small cell lung cancer
Bao, Y., Guo, L., & Mo, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6191 · Cited by 14
Metadata
- Authors
- Wu, J., Groh, V., & Spies, T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-08-01
- Volume
- 169
- Issue
- 3
- Pages
- 1236-1240
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2141661308
- Cited by
- 257
- References
- 43
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, J., Groh, V., & Spies, T. (2002). T Cell Antigen Receptor Engagement and Specificity in the Recognition of Stress-Inducible MHC Class I-Related Chains by Human Epithelial γδ T Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.169.3.1236
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