The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing
Abstract
The healing of cutaneous wounds is dependent on the progression through distinct, yet overlapping phases of wound healing, including hemostasis, inflammation, proliferation, and resolution/remodeling. The failure of these phases to occur in a timely, progressive fashion promotes pathologic wound healing. The macrophage (MΦ) has been demonstrated to play a critical role in the inflammatory phase of tissue repair, where its dynamic plasticity allows this cell to mediate both tissue-destructive and -reparative functions. The ability to understand and control both the initiation and the resolution of inflammation is critical for treating pathologic wound healing. There are now a host of studies demonstrating that metabolic and epigenetic regulation of gene transcription can influence MΦ plasticity in wounds. In this review, we highlight the molecular and epigenetic factors that influence MΦ polarization in both physiologic and pathologic wound healing, with particular attention to diabetic wounds.
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Cites
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Cited by
Immunology of Acute and Chronic Wound Healing
Raziyeva, K., Kim, Y., Zharkinbekov, Z., Kassymbek, K., Jimi, S., & Saparov, A. (2021) · Biomolecules · doi:10.3390/biom11050700 · Cited by 1,049
Therapeutic strategies for enhancing angiogenesis in wound healing
Veith, A. P., Henderson, K., Spencer, A., Sligar, A. D., & Baker, A. B. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.010 · Cited by 1,021
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Yu, Y., Li, P., Zhu, C., Ning, N., Zhang, S., & Vancso, G. J. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201904402 · Cited by 363
Yang, Y., Zhao, X., Yu, J., Chen, X., Wang, R., Zhang, M., Zhang, Q., Zhang, Y., Wang, S., & Cheng, Y. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.04.007 · Cited by 180
Metadata
- Authors
- Boniakowski, A. E., Kimball, A. S., Jacobs, B. N., Kunkel, S. L., & Gallagher, K. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-01
- Volume
- 199
- Issue
- 1
- Pages
- 17-24
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2640452423
- Cited by
- 537
- References
- 109
- FWCI
- 20.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boniakowski, A. E., Kimball, A. S., Jacobs, B. N., Kunkel, S. L., & Gallagher, K. A. (2017). Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1700223
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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