The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Immunology of Acute and Chronic Wound Healing
Open accessAbstract
Skin wounds greatly affect the global healthcare system, creating a substantial burden on the economy and society. Moreover, the situation is exacerbated by low healing rates, which in fact are overestimated in reports. Cutaneous wounds are generally classified into acute and chronic. The immune response plays an important role during acute wound healing. The activation of immune cells and factors initiate the inflammatory process, facilitate wound cleansing and promote subsequent tissue healing. However, dysregulation of the immune system during the wound healing process leads to persistent inflammation and delayed healing, which ultimately result in chronic wounds. The microenvironment of a chronic wound is characterized by high quantities of pro-inflammatory macrophages, overexpression of inflammatory mediators such as TNF-α and IL-1β, increased activity of matrix metalloproteinases and abundance of reactive oxygen species. Moreover, chronic wounds are frequently complicated by bacterial biofilms, which perpetuate the inflammatory phase. Continuous inflammation and microbial biofilms make it very difficult for the chronic wounds to heal. In this review, we discuss the role of innate and adaptive immunity in the pathogenesis of acute and chronic wounds. Furthermore, we review the latest immunomodulatory therapeutic strategies, including modifying macrophage phenotype, regulating miRNA expression and targeting pro- and anti-inflammatory factors to improve wound healing.
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1 retracted
RETRACTED: Mast Cells in Skin Scarring: A Review of Animal and Human Research
Ud‐Din, S., Wilgus, T. A., & Bayat, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.552205 · Cited by 58
RetractedWound Healing: A Cellular Perspective
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Wound healing: cellular mechanisms and pathological outcomes
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Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
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Type 2 immunity in tissue repair and fibrosis
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Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
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Cited by
Anti‐inflammatory hydrogel dressings and skin wound healing
Huang, C., Dong, L., Zhao, B., Lu, Y., Huang, S., Yuan, Z., Luo, G., Xu, Y., & Qian, W. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.1094 · Cited by 445
Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches
Cavallo, I., Sivori, F., Mastrofrancesco, A., Abril, E., Pontone, M., Di Domenico, E. G., & Pimpinelli, F. (2024) · Biology · doi:10.3390/biology13020109 · Cited by 213
Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
Hofmann, E., Fink, J., Pignet, A.-L., Schwarz, A., Schellnegger, M., Nischwitz, S. P., Holzer-Geissler, J. C. J., Kamolz, L.-P., & Kotzbeck, P. (2023) · Biomedicines · doi:10.3390/biomedicines11041056 · Cited by 104
The macrophage polarization in inflammatory dermatosis and its potential drug candidates
Sun, Q., Hu, S., Lou, Z., & Gao, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114469 · Cited by 66
MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization
Chang, L., Gao, J., Yu, Y., Liao, B., Zhou, Y., Zhang, J., Ma, X., Hou, W., Zhou, T., & Xu, Q. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111045 · Cited by 20
Metadata
- Authors
- Raziyeva, K., Kim, Y., Zharkinbekov, Z., Kassymbek, K., Jimi, S., & Saparov, A.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2021-05-08
- Volume
- 11
- Issue
- 5
- Pages
- 700
- ISSN
- 2218-273X (ISSN-L)
- OpenAlex
- W3163579061
- Cited by
- 1,049
- References
- 168
- FWCI
- 53.75
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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