The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Postsecretory Processing Generates Multiple Cathelicidins for Enhanced Topical Antimicrobial Defense
Open accessAbstract
The production of antimicrobial peptides and proteins is essential for defense against infection. Many of the known human antimicrobial peptides are multifunctional, with stimulatory activities such as chemotaxis while simultaneously acting as natural antibiotics. In humans, eccrine appendages express DCD and CAMP, genes encoding proteins processed into the antimicrobial peptides dermcidin and LL-37. In this study we show that after secretion onto the skin surface, the CAMP gene product is processed by a serine protease-dependent mechanism into multiple novel antimicrobial peptides distinct from the cathelicidin LL-37. These peptides show enhanced antimicrobial action, acquiring the ability to kill skin pathogens such as Staphylococcus aureus and Candida albicans. Furthermore, although LL-37 may influence the host inflammatory response by stimulating IL-8 release from keratinocytes, this activity is lost in subsequently processed peptides. Thus, a single gene product encoding an important defense molecule alters structure and function in the topical environment to shift the balance of activity toward direct inhibition of microbial colonization.
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Cites
Antimicrobial peptides of multicellular organisms
Zasloff, M. (2002) · Nature · doi:10.1038/415389a · Cited by 8,457
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationβ-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citationDermcidin: A novel human antibiotic peptide secreted by sweat glands
Schittek, B., Hipfel, R., Sauer, B., Bauer, J., Kalbacher, H., Stevanovic, S., Schirle, M., Schroeder, K., Blin, N., Meier, F., et al. (2001) · Nature Immunology · doi:10.1038/ni732 · Cited by 730
Heilborn, J. D., Nilsson, M. F., Sørensen, O., Ståhle-Bäckdahl, M., Kratz, G., Weber, G., & Borregaard, N. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12069.x · Cited by 572
Dorschner, R. A., Pestonjamasp, V. K., Tamakuwala, S., Ohtake, T., Rudisill, J., Nizet, V., Agerberth, B., Gudmundsson, G. H., & Gallo, R. L. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01340.x · Cited by 567
Self-citationDeficiency of antibacterial peptides in patients with morbus Kostmann: an observation study
Pütsep, K., Carlsson, G., Boman, H. G., & Andersson, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11201-3 · Cited by 499
Cole, A. M., Shi, J., Ceccarelli, A., Kim, Y.-H., Park, A., & Ganz, T. (2001) · Blood · doi:10.1182/blood.v97.1.297 · Cited by 146
Cited by
Antimicrobial host defence peptides: functions and clinical potential
Mookherjee, N., Anderson, M. A., Haagsman, H. P., & Davidson, D. J. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0058-8 · Cited by 1,502
LL-37, the only human member of the cathelicidin family of antimicrobial peptides
Dürr, U. H. N., Sudheendra, U. S., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.03.030 · Cited by 1,049
Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea
Yamasaki, K., Di Nardo, A., Bardan, A., Murakami, M., Ohtake, T., Coda, A., Dorschner, R. A., Bonnart, C., Descargues, P., Hovnanian, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1616 · Cited by 852
Self-citationAntimicrobial peptides: General overview and clinical implications in human health and disease
Guaní-Guerra, E., Santos-Mendoza, T., Lugo-Reyes, S. O., & Terán, L. M. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.004 · Cited by 549
Antimicrobial peptides and the skin immune defense system
Schauber, J., & Gallo, R. L. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.027 · Cited by 477
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Metadata
- Authors
- Murakami, M., Lopez-Garcia, B., Braff, M., Dorschner, R. A., & Gallo, R. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-01
- Volume
- 172
- Issue
- 5
- Pages
- 3070-3077
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1602448053
- Cited by
- 308
- References
- 9
- FWCI
- 20.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Murakami, M., Lopez-Garcia, B., Braff, M., Dorschner, R. A., & Gallo, R. L. (2004). Postsecretory Processing Generates Multiple Cathelicidins for Enhanced Topical Antimicrobial Defense. The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.5.3070
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