Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin Mediates Binding and Internalization of Aspergillus fumigatus Conidia by Dendritic Cells and Macrophages
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Aspergillus fumigatus is responsible for a large percentage of nosocomial opportunistic fungal infections in immunocompromised hosts, especially during cytotoxic chemotherapy and after bone marrow transplantation, and is currently a major direct cause of death in leukemia patients. Dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is a type II C-type lectin that functions as an adhesion receptor and is used by viral and bacterial pathogens to gain access to human DC. We report that DC-SIGN specifically interacts with clinical isolates of A. fumigatus. DC-SIGN-dependent binding of A. fumigatus conidia can be demonstrated with stable transfectants and monocyte-derived DC and is inhibited by anti-DC-SIGN Abs. Binding and internalization of A. fumigatus conidia correlates with DC-SIGN cell surface expression levels and is abolished in the presence of A. funigatus-derived cell wall galactomannans. The clinical relevance of this interaction is emphasized by the presence of DC-SIGN in lung DC and alveolar macrophages, and further illustrated by the DC-SIGN-dependent attachment of A. fumigatus conidia to the cell membrane of IL-4-treated monocyte-derived macrophages. Our results suggest the involvement of DC-SIGN in the initial stages of pulmonary infection as well as in fungal spreading during invasive aspergillosis.
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Certain macrophage receptors have been shown to facilitate engulfment of resting and germinating conidia: DC-SIGN, Dectin-1, an unidentified macrophage glycoprotein-scavenger receptor recognizing FleA, and soluble PRR including PTX3 and surfactant D.
“Despite the lack of specificity of the phagocytosis process, certain macrophage receptors have been shown to facilitate engulfment of resting and germinating conidia: the C-type lectin II receptor DC-SIGN (CD209) (235), Dectin-1 (236), an unidentified macrophage glycoprotein-scavenger receptor recognizing the Aspergillus FleA fucose-binding lectin (214), and soluble pattern recognition receptors (”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [235]
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Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,244 · see citing works
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129 · see citing works
Steinman, R. M., Hawiger, D., & Nussenzweig, M. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141040 · Cited by 3,124 · see citing works
<i>Aspergillus fumigatus</i> and Aspergillosis
Latgé, J.-P. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.310 · Cited by 2,307 · see citing works
Geijtenbeek, T. B. H., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Adema, G. J., van Kooyk, Y., & Figdor, C. G. (2000) · Cell · doi:10.1016/s0092-8674(00)80693-5 · Cited by 1,701 · see citing works
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
Geijtenbeek, T. B. H., van Vliet, S. J., Koppel, E. A., Sánchez‐Hernández, M., Vandenbroucke‐Grauls, C. M. J. E., Appelmelk, B. J., & van Kooyk, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021229 · Cited by 1,058 · see citing works
Weitzman, I., & Summerbell, R. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.2.240 · Cited by 968 · see citing works
DC-SIGN: escape mechanism for pathogens
van Kooyk, Y., & Geijtenbeek, T. B. H. (2003) · Nature reviews. Immunology · doi:10.1038/nri1182 · Cited by 930 · see citing works
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Tassaneetrithep, B., Burgess, T. H., Granelli‐Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M. A., Pattanapanyasat, K., Sarasombath, S., Birx, D. L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021840 · Cited by 892 · see citing works
Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR
Feinberg, H., Mitchell, D. A., Drickamer, K., & Weis, W. I. (2001) · Science · doi:10.1126/science.1066371 · Cited by 678 · see citing works
Glucocorticoids and invasive fungal infections
Lionakis, M. S., & Kontoyiannis, D. P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14904-5 · Cited by 667 · see citing works
C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans
Alvarez, C. P., Lasala, F., Carrillo, J., Pello, Ó. M., Corbí, A. L., & Delgado, R. B. (2002) · Journal of Virology · doi:10.1128/jvi.76.13.6841-6844.2002 · Cited by 653 · see citing works
DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells
Tailleux, L., Schwartz, O., Herrmann, J., Pivert, E., Jackson, M., Amara, A., Legrès, L., Dreher, D., Nicod, L. P., Gluckman, J. C., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021468 · Cited by 643 · see citing works
Engering, A. J., Geijtenbeek, T. B. H., van Vliet, S. J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J. A. M., Figdor, C. G., Piguet, V., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.5.2118 · Cited by 630 · see citing works
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection
Kwon, D. S., Gregorio, G., Bitton, N., Hendrickson, W. A., & Littman, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00259-5 · Cited by 523 · see citing works
Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515 · see citing works
DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking
Geijtenbeek, T. B. H., Krooshoop, D. J. E. B., Bleijs, D. A., van Vliet, S. J., van Duijnhoven, G. C. F., Grabovsky, V., Alon, R., Figdor, C. G., & van Kooyk, Y. (2000) · Nature Immunology · doi:10.1038/79815 · Cited by 498 · see citing works
Soilleux, E. J., Morris, L. S., Leslie, G. J., Chehimi, J., Luo, Q., Levroney, E. L., Trowsdale, J., Montaner, L. J., Doms, R. W., Weissman, D., et al. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.3.445 · Cited by 458 · see citing works
Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR
Pöhlmann, S., Zhang, J., Baribaud, F., Chen, Z., Leslie, G. J., Lin, G. G.-H., Granelli‐Piperno, A., Doms, R. W., Rice, C. M., & McKeating, J. A. (2003) · Journal of Virology · doi:10.1128/jvi.77.7.4070-4080.2003 · Cited by 389 · see citing works
Curtis, B. M., Scharnowske, S., & Watson, A. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8356 · Cited by 385 · see citing works
Cambi, A., Gijzen, K., de Vries, I. J. M., Torensma, R., Joosten, B., Adema, G. J., Netea, M. G., Kullberg, B. J., Romani, L. R., & Figdor, C. G. (2003) · European Journal of Immunology · doi:10.1002/immu.200310029 · Cited by 375 · see citing works
DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2
Lozach, P., Lortat‐Jacob, H., de Lavalette, A. D. L., Staropoli, I., Foung, S. K. H., Amara, A., Astoul, C. H., Fieschi, F., Schwartz, O., Virelizier, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301284200 · Cited by 375 · see citing works
Bozza, S., Gaziano, R., Spreca, A., Bacci, A., Montagnoli, C., Francesco, P. D., & Romani, L. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1362 · Cited by 331 · see citing works
Invasive Aspergillosis in 2002: An Update
Kontoyiannis, D. P., & Bodey, G. P. (2002) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-002-0699-z · Cited by 327 · see citing works
Relloso, M., Puig‐Kröger, A., Pello, Ó. M., Rodríguez‐Fernández, J. L., de la Rosa, G., Longo, N., Navarro, J., Muñoz‐Fernández, M. Á., Sánchez‐Mateos, P., & Corbí, A. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.2634 · Cited by 301 · see citing works
Toll-like Receptor (TLR) Signaling in Response toAspergillus fumigatus
Mambula, S. S., Sau, K., Henneke, P., Golenbock, D. T., & Levitz, S. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201683200 · Cited by 297 · see citing works
Netea, M. G., Warris, A., van der Meer, J. W. M., Fenton, M. J., Verver-Jansen, T. J. G., Jacobs, L., Andresen, T. K., Verweij, P. E., & Kullberg, B. J. (2003) · The Journal of Infectious Diseases · doi:10.1086/376456 · Cited by 284 · see citing works
Phagocytosis and Intracellular Fate of<i>Aspergillus fumigatus</i>Conidia in Alveolar Macrophages
Ibrahim-Granet, O., Philippe, B., Boleti, H., Boisvieux-Ulrich, E., Grenet, D., Stern, M., & Latgé, J. P. (2003) · Infection and Immunity · doi:10.1128/iai.71.2.891-903.2003 · Cited by 277 · see citing works
Dual function of C-type lectin-like receptors in the immune system
Cambi, A., & Figdor, C. G. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.08.004 · Cited by 260 · see citing works
Th1 and Th2 cytokines in mice with invasive aspergillosis
Cenci, E., Perito, S., Enssle, K.-H., Mosci, P., Latgé, J., Romani, L. R., & Bistoni, F. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.564-570.1997 · Cited by 216 · see citing works
Cenci, E., Mencacci, A., Sero, G. D., Bacci, A., Montagnoli, C., d’Ostiani, C. F., Mosci, P., Bachmann, M. F., Bistoni, F., Köpf, M., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/315142 · Cited by 204 · see citing works
Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN
Park, C. G., Takahara, K., Umemoto, E., Yashima, Y., Matsubara, K., Matsuda, Y., Clausen, B. E., Inaba, K., & Steinman, R. M. (2001) · International Immunology · doi:10.1093/intimm/13.10.1283 · Cited by 190 · see citing works
Wasylnka, J. A., & Moore, M. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3156-3163.2002 · Cited by 188 · see citing works
Aspergillus fumigatus antigens activate innate immune cells via toll‐like receptors 2 and 4
Braedel-Ruoff, S., Radsak, M. P., Einsele, H., Latgé, J., Michan, A., Loeffler, J., Haddad, Z., Grigoleit, U., Schild, H., & Hebart, H. F. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.04922.x · Cited by 180 · see citing works
Colmenares, M., Puig‐Kröger, A., Pello, Ó. M., Corbí, A. L., & Rivas, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205270200 · Cited by 162 · see citing works
Subset of DC-SIGN+ dendritic cells in human blood transmits HIV-1 to T lymphocytes
Engering, A. J., van Vliet, S. J., Geijtenbeek, T. B. H., & van Kooyk, Y. (2002) · Blood · doi:10.1182/blood-2001-12-0179 · Cited by 141 · see citing works
Oligolysine-based Oligosaccharide Clusters
Frison, N., Taylor, M. E., Soilleux, E. J., Bousser, M.-T., Mayer, R., Monsigny, M. L. P., Drickamer, K., & Roche, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302483200 · Cited by 116 · see citing works
Mummidi, S., Catano, G., Lam, L., Hoefle, A., Telles, V., Begum, K., Jiménez, F., Ahuja, S. S., & Ahuja, S. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009807200 · Cited by 104 · see citing works
An Immunoinhibitory Cell Wall Glycoprotein (Mannan) from Trichophyton rubrum
Blake, J. S., Dahl, M. V., Herron, M. J., & Nelson, R. D. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470582 · Cited by 93 · see citing works
Kan, V. L., & Bennett, J. E. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.2.407 · Cited by 78 · see citing works
HIV-1 transmission and cytokine-induced expression of DC-SIGN in human monocyte-derived macrophages
Chehimi, J., Luo, Q., Azzoni, L., Shawver, L., Ngoubilly, N., June, R., Jerandi, G., Farabaugh, M., & Montaner, L. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0503231 · Cited by 64 · see citing works
Geijtenbeek, T. B. H., van Vliet, S. J., van Duijnhoven, G. C. F., Figdor, C. G., & van Kooyk, Y. (2001) · Placenta · doi:10.1053/plac.2001.0674 · Cited by 51 · see citing works
Differences in the cell wall composition in the type species ofEupenicillium andTalaromyces
Go`mez-Miranda, B. ̃., Moya, A., & Leal, J. A. (1988) · Experimental Mycology · doi:10.1016/0147-5975(88)90040-0 · Cited by 39 · see citing works
Self-citationPersat, F., Noirey, N., DIANA, J., Gariazzo, M. ‐., Schmitt, D., Picot, S., & Vincent, C. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02222.x · Cited by 34 · see citing works
Ahrazem, O., Prieto, A., Leal, J. A., Jiménez‐Barbero, J., & Bernabé, M. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00293-8 · Cited by 21 · see citing works
Self-citationFrison, N., Taylor, M. E., Soilleux, E. J., Bousser, M.-T., Mayer, R., Monsigny, M. L. P., Drickamer, K., & Roche, A. (2003) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)83100-7 · Cited by 6 · see citing works
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Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species
Garcia-Rubio, R., de Oliveira, H. C., Rivera, J., & Trevijano-Contador, N. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02993 · Cited by 917 · see citing works
Luther, K., Torosantucci, A., Brakhage, A. A., Heesemann, J., & Ebel, F. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00796.x · Cited by 582 · see citing works
Martínez‐Pomares, L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512231 · Cited by 540 · see citing works
Medicinal importance of fungal β-(1→3), (1→6)-glucans
Chen, J., & Seviour, R. J. (2007) · Mycological Research · doi:10.1016/j.mycres.2007.02.011 · Cited by 519 · see citing works
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, C., Rapaka, R. R., Metz, A., Pop, S. M., Williams, D. L., Gordon, S., Kolls, J. K., & Brown, G. D. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010042 · Cited by 509 · see citing works
Aspergillus fumigatus morphology and dynamic host interactions
van de Veerdonk, F. L., Gresnigt, M. S., Romani, L., Netea, M. G., & Latgé, J.-P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.90 · Cited by 490 · see citing works
Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display
Hohl, T. M., Van Epps, H. L., Rivera, A., Morgan, L. A., Chen, P. L., Feldmesser, M., & Pamer, E. G. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010030 · Cited by 428 · see citing works
“ME), filtered through a 100-lm nylon mesh, and cultured in RP20 (20% FCS) supplemented with 30% (v/v) L929 cell supernatant (source of M-CSF) at a density of 0.25–0.5 3 106 cells/ml (in 100-mm cell culture dishes) for the generation of BMMØs or in RP10 and 2% (v/v) p815 cell supernatant (source of GMCSF) at a density…”
BackgroundInfluentialInnate Antifungal Immunity: The Key Role of Phagocytes
Brown, G. D. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101229 · Cited by 424 · see citing works
Martin, T. R., & Frevert, C. W. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200508-090js · Cited by 344 · see citing works
Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection
Hohl, T. M., Rivera, A., Lipuma, L., Gallegos, A., Shi, C., Mack, M., & Pamer, E. G. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.10.007 · Cited by 337 · see citing works
Gersuk, G. M., Underhill, D. M., Zhu, L., & Marr, K. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3717 · Cited by 334 · see citing works
C-type lectins and phagocytosis
Kerrigan, A. M., & Brown, G. D. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.003 · Cited by 325 · see citing works
Innate Immune Gene Polymorphisms in Tuberculosis
Azad, A. K., Sadée, W., & Schlesinger, L. S. (2012) · Infection and Immunity · doi:10.1128/iai.00443-12 · Cited by 306 · see citing works
Vermaelen, K. Y., & PAUWELS, R. A. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200410-1384so · Cited by 278 · see citing works
C-type lectin receptors in antifungal immunity
Willment, J. A., & Brown, G. D. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.10.012 · Cited by 268 · see citing works
Immune defence to invasive fungal infections: A comprehensive review
Pathakumari, B., Liang, G., & Liu, W. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110550 · Cited by 272 · see citing works
<i>Aspergillus fumigatus</i> : Principles of Pathogenesis and Host Defense
Hohl, T. M., & Feldmesser, M. (2007) · Eukaryotic Cell · doi:10.1128/ec.00274-07 · Cited by 237 · see citing works
Innate Immunity toAspergillusSpecies
Park, S. J., & Mehrad, B. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-09 · Cited by 230 · see citing works
Wüthrich, M., Deepe, G. S., & Klein, B. S. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074958 · Cited by 225 · see citing works
Pathogen Inhibition by Multivalent Ligand Architectures
Bhatia, S., Cuellar‐Camacho, J. L., & Haag, R. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b12950 · Cited by 194 · see citing works
Transepithelial Pathogen Uptake into the Small Intestinal Lamina Propria
Vallon-Eberhard, A., Landsman, L., Yogev, N., Verrier, B., & Jung, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2465 · Cited by 192 · see citing works
The innate immune response to Aspergillus fumigatus
Balloy, V., & Chignard, M. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.07.002 · Cited by 187 · see citing works
LeibundGut‐Landmann, S., Wüthrich, M., & Hohl, T. M. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.007 · Cited by 186 · see citing works
Torrelles, J. B., Azad, A. K., & Schlesinger, L. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1805 · Cited by 182 · see citing works
Dendritic Cells at the Oral Mucosal Interface
Cutler, C. W., & Jotwani, R. (2006) · Journal of Dental Research · doi:10.1177/154405910608500801 · Cited by 179 · see citing works
Lee, H.-J., Woo, Y., Hahn, T., Jung, Y. M., & Jung, Y. (2020) · Microorganisms · doi:10.3390/microorganisms8091298 · Cited by 172 · see citing works
Host–microbe interactions: innate pattern recognition of fungal pathogens
van de Veerdonk, F. L., Kullberg, B. J., van der Meer, J. W., Gow, N. A., & Netea, M. G. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.06.002 · Cited by 169 · see citing works
Pathogenesis of Respiratory Viral and Fungal Coinfections
Salazar, F., Bignell, E., Brown, G. D., Cook, P. C., & Warris, A. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00094-21 · Cited by 155 · see citing works
Vijayrajratnam, S., Nisha, N., Biswas, L., Kumar, V. A., & Biswas, R. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.02.005 · Cited by 153 · see citing works
Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact
Tefsen, B., Ram, A. F., van Die, I., & Routier, F. H. (2012) · Glycobiology · doi:10.1093/glycob/cwr144 · Cited by 149 · see citing works
Lionakis, M. S., Iliev, I. D., & Hohl, T. M. (2017) · JCI Insight · doi:10.1172/jci.insight.93156 · Cited by 153 · see citing works
Domínguez‐Soto, Á., Sierra‐Filardi, E., Puig‐Kröger, A., Pérez-Maceda, B. T., Gómez, F., Corcuera, M. T., Sánchez‐Mateos, P., & Corbí, A. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000475 · Cited by 147 · see citing works
Kyrmizi, I., Gresnigt, M. S., Akoumianaki, T., Samonis, G., Sidiropoulos, P., Boumpas, D., Netea, M. G., van de Veerdonk, F. L., Kontoyiannis, D. P., & Chamilos, G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300132 · Cited by 142 · see citing works
The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors
Goyal, S., Castrillón-Betancur, J. C., Klaile, E., & Slevogt, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01261 · Cited by 142 · see citing works
Immunocompromised Hosts: Immunopharmacology of Modern Antifungals
Ben‐Ami, R., Lewis, R. E., & Kontoyiannis, D. P. (2008) · Clinical Infectious Diseases · doi:10.1086/589290 · Cited by 140 · see citing works
Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection
Sáinz, J., Lupiañez, C. B., Segura-Catena, J., Vázquez, L., Ríos, R., Oyonarte, S., Hemminki, K., Försti, A., & Jurado, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032273 · Cited by 139 · see citing works
Ben‐Ami, R., Lewis, R. E., & Kontoyiannis, D. P. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08283.x · Cited by 132 · see citing works
The innate immune response to Aspergillus fumigatus at the alveolar surface
Margalit, A., & Kavanagh, K. A. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv018 · Cited by 129 · see citing works
Interference of Aspergillus fumigatus with the immune response
Heinekamp, T., Schmidt, H., Lapp, K., Pähtz, V., Shopova, I., Köster-Eiserfunke, N., Krüger, T., Kniemeyer, O., & Brakhage, A. A. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0465-1 · Cited by 123 · see citing works
Hohl, T. M., Feldmesser, M., Perlin, D. S., & Pamer, E. G. (2008) · The Journal of Infectious Diseases · doi:10.1086/589304 · Cited by 119 · see citing works
C-type lectins, fungi and Th17 responses
Vautier, S., Sousa, M. G. T., & Brown, G. D. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.001 · Cited by 111 · see citing works
Fungi in the cystic fibrosis lung: Bystanders or pathogens?
Chotirmall, S. H., & McElvaney, N. G. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.001 · Cited by 113 · see citing works
Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response
Chotirmall, S. H., Al‐Alawi, M., Mirković, B., Lavelle, G., Logan, P. M., Greene, C. M., & McElvaney, N. G. (2013) · BioMed Research International · doi:10.1155/2013/723129 · Cited by 109 · see citing works
Fungal glycans and the innate immune recognition
Barreto‐Bergter, E., & Figueiredo, R. T. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00145 · Cited by 110 · see citing works
C-type lectin receptors and cytokines in fungal immunity
Vautier, S., MacCallum, D. M., & Brown, G. D. (2011) · Cytokine · doi:10.1016/j.cyto.2011.08.031 · Cited by 104 · see citing works
Balloy, V., Sallenave, J.-M., Wu, Y., Touqui, L., Latgé, J.-P., Si-Tahar, M., & Chignard, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803149200 · Cited by 102 · see citing works
Immune Recognition of Fungal Polysaccharides
Snarr, B. D., Qureshi, S. T., & Sheppard, D. C. (2017) · Journal of Fungi · doi:10.3390/jof3030047 · Cited by 96 · see citing works
Slesiona, S., Gressler, M., Mihlan, M., Zaehle, C., Schaller, M., Barz, D., Hube, B., Jacobsen, I. D., & Brock, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031223 · Cited by 98 · see citing works
Mezger, M., Kneitz, S., Wozniok, I., Kurzai, O., Einsele, H., & Loeffler, J. (2008) · The Journal of Infectious Diseases · doi:10.1086/528694 · Cited by 97 · see citing works
Domínguez-Soto, A., Aragoneses‐Fenoll, L., Martín-Gayo, E., Martínez-Prats, L., Colmenares, M., Naranjo-Gómez, M., Borràs, F., Muñoz, P. M., Zubiaur, M., Toribio, M., et al. (2007) · Blood · doi:10.1182/blood-2006-09-048058 · Cited by 103 · see citing works
Anti-Immune Strategies of Pathogenic Fungi
Marcos, C. M., de Oliveira, H. C., Melo, W., da Silva, J. D. F., Assato, P. A., Scorzoni, L., Rossi, S. A., Silva, A. C. A. D. P. E., Mendes‐Giannini, M. J. S., & Fusco‐Almeida, A. M. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00142 · Cited by 94 · see citing works
The role of the cell wall in fungal pathogenesis
Arana, D. M., Prieto, D., Román, E., Nombela, C., Alonso‐Monge, R., & Pla, J. (2009) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00070.x · Cited by 92 · see citing works
Immune Correlates of Protection in Human Invasive Aspergillosis
Camargo, J. F., & Husain, S. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu337 · Cited by 91 · see citing works
Antifungal innate immunity: recognition and inflammatory networks
Becker, K. L., Ifrim, D. C., Quintin, J., Netea, M. G., & van de Veerdonk, F. L. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0467-z · Cited by 86 · see citing works
Fisher, C. E., Hohl, T. M., Fan, W., Storer, B. E., Levine, D., Zhao, L., Martin, P. J., Warren, E. H., Boeckh, M., & Hansen, J. A. (2017) · Blood · doi:10.1182/blood-2016-10-743294 · Cited by 87 · see citing works
Lambourne, J., Agranoff, D., Herbrecht, R., Troke, P. F., Buchbinder, A., Willis, F. M., Letscher‐Bru, V., Agrawal, S. G., Doffman, S. R., Johnson, E. M., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/644619 · Cited by 85 · see citing works
Ramirez‐Ortiz, Z. G., & Means, T. K. (2012) · Virulence · doi:10.4161/viru.22295 · Cited by 83 · see citing works
Victor, E. S., Karnam, A., Fontaine, T., Beauvais, A., Das, M., Hegde, P., Prakhar, P., Holla, S., Balaji, K. N., Kaveri, S. V., et al. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix469 · Cited by 84 · see citing works
Gafa, V., Lande, R., Gagliardi, M. C., Severa, M., Giacomini, E., Remoli, M. E., Nisini, R., Ramoni, C., Francesco, P. D., Aldebert, D., et al. (2006) · Infection and Immunity · doi:10.1128/iai.74.3.1480-1489.2006 · Cited by 82 · see citing works
Hohl, T. M., Rivera, A., & Pamer, E. G. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.05.003 · Cited by 80 · see citing works
Levels of complexity in pathogen recognition by C-type lectins
Cambi, A., & Figdor, C. G. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.05.011 · Cited by 75 · see citing works
DC-SIGN and mannosylated surface structures of Mycobacterium tuberculosis: a deceptive liaison.
Ehlers, S. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.10.004 · Cited by 72 · see citing works
Bonifazi, P., D'Angelo, C., Zagarella, S., Zelante, T., Bozza, S., LUCA, A. D., Giovannini, G., Moretti, S., Iannitti, R. G., Fallarino, F., et al. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.130 · Cited by 72 · see citing works
Morton, C. O., Varga, J. J., Hornbach, A., Mezger, M., Sennefelder, H., Kneitz, S., Kurzai, O., Krappmann, S., Einsele, H., Nierman, W. C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016016 · Cited by 67 · see citing works
Cellular immune reactions in the lung
Hasenberg, M., Stegemann‐Koniszewski, S., & Gunzer, M. (2012) · Immunological Reviews · doi:10.1111/imr.12020 · Cited by 65 · see citing works
DC-SIGN, DC-SIGNR and LSECtin: C-Type Lectins for Infection
Zhang, F., Ren, S., & Zuo, Y. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.834897 · Cited by 65 · see citing works
C-Type Lectin Receptors in Phagocytosis
Li, K., & Underhill, D. M. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_198 · Cited by 64 · see citing works
Chiodo, F., Marradi, M., Park, J., Ram, A. F. J., Penadés, S., van Die, I., & Tefsen, B. (2013) · ACS Chemical Biology · doi:10.1021/cb4008265 · Cited by 63 · see citing works
Serrano‐Gómez, D., Leal, J. A., & Corbí, A. L. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.011 · Cited by 62 · see citing works
Self-citationMacrophage Pattern Recognition Receptors in Immunity, Homeostasis and Self Tolerance
Mukhopadhyay, S., Plüddemann, A., & Gordon, S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0901-5_1 · Cited by 61 · see citing works
Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2
Hollmig, S. T., Ariizumi, K., & Cruz, P. D. (2009) · Glycobiology · doi:10.1093/glycob/cwp032 · Cited by 58 · see citing works
Fontaine, T., & Latgé, J. (2020) · Journal of Fungi · doi:10.3390/jof6040283 · Cited by 57 · see citing works
Park, S. J., Burdick, M. D., Brix, W. K., Stoler, M. H., Askew, D. S., Strieter, R. M., & Mehrad, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002064 · Cited by 57 · see citing works
Phagocyte responses towards Aspergillus fumigatus
Hasenberg, M., Behnsen, J., Krappmann, S., Brakhage, A. A., & Gunzer, M. (2011) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2011.04.012 · Cited by 56 · see citing works
The Role of CC Chemokine Receptor 6 in Host Defense in a Model of Invasive Pulmonary Aspergillosis
Phadke, A. P., Akangire, G. G., Park, S. J., Lira, S. A., & Mehrad, B. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-256oc · Cited by 56 · see citing works
Huston, S. M., Li, S. S., Stack, D., Timm-McCann, M., Jones, G. J., Islam, A., Berenger, B. M., Xiang, R. F., Colarusso, P., & Mody, C. H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202707 · Cited by 56 · see citing works
McCarthy, T. R., Torrelles, J. B., MacFarlane, A. S., Katawczik, M. L., Kutzbach, B., DesJardin, L. E., Clegg, S., Goldberg, J. B., & Schlesinger, L. S. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04862.x · Cited by 54 · see citing works
Park, S. J., Burdick, M. D., & Mehrad, B. (2012) · Infection and Immunity · doi:10.1128/iai.00097-12 · Cited by 51 · see citing works
Serrano‐Gómez, D., Sierra‐Filardi, E., Martínez-Nuñez, R. T., Caparrós, E., Delgado, R. B., Muñoz‐Fernández, M. Á., Abad, M. A., Jiménez‐Barbero, J., Leal, M., & Corbí, A. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706004200 · Cited by 46 · see citing works
Self and nonself recognition through C-type lectin receptor, Mincle
Miyake, Y., Ishikawa, E., Ishikawa, T., & Yamasaki, S. (2010) · Self/Nonself · doi:10.4161/self.1.4.13736 · Cited by 46 · see citing works
Guo, Y., Chang, Q., Cheng, L., Xiong, S., Jia, X., Lin, X., & Zhao, X. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800620 · Cited by 45 · see citing works
Role of the C-type lectins DC-SIGN and L-SIGN in Leishmania interaction with host phagocytes
Caparrós, E., Serrano‐Gómez, D., Puig‐Kröger, A., Riol‐Blanco, L., Lasala, F., Martinez, I. A., Vidal‐Vanaclocha, F., Delgado, R. B., Rodríguez‐Fernández, J. L., Rivas, L., et al. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.013 · Cited by 45 · see citing works
C-Type Lectin Receptors in Antifungal Immunity
Nikolakopoulou, C., Willment, J. A., & Brown, G. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1580-4_1 · Cited by 43 · see citing works
Analysis of DC-SIGN (CD209) Functional Variants in Patients with Tuberculosis
Gómez, L. M., Anaya, J., Sierra‐Filardi, E., Cadena, J., Corbí, A. L., & Martin, J. J. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.07.003 · Cited by 44 · see citing works
Santander, S. P., Aoki, M., Hernández, J. F., Pombo, M., Moins‐Teisserenc, H., Mooney, N., & Susana Fiorentino, G. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.01.006 · Cited by 43 · see citing works
Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!
Cavalheiro, M., Pais, P., Galocha, M., & Teixeira, M. C. (2018) · Genes · doi:10.3390/genes9070332 · Cited by 42 · see citing works
Fungal Surface and Innate Immune Recognition of Filamentous Fungi
Figueiredo, R., Carneiro, L., & Bozza, M. (2011) · Front. Microbio. · doi:10.3389/fmicb.2011.00248 · Cited by 42 · see citing works
Prospects of vaccines for medically important fungi
Feldmesser, M. (2005) · Medical Mycology · doi:10.1080/13693780500402138 · Cited by 39 · see citing works
C-Type Lectin Receptors Orchestrate Antifungal Immunity
Wevers, B. A., Geijtenbeek, T. B. H., & Gringhuis, S. I. (2013) · Future Microbiology · doi:10.2217/fmb.13.56 · Cited by 38 · see citing works
Karnam, A., Bonam, S. R., Rambabu, N., Wong, S. S. W., Aimanianda, V., & Bayry, J. (2021) · mBio · doi:10.1128/mbio.02824-21 · Cited by 38 · see citing works
Rapaka, R. R., & Kolls, J. K. (2008) · Medical Mycology · doi:10.1080/13693780802266777 · Cited by 38 · see citing works
Studies on galactofuranose-containing glycostructures of the pathogenic mold Aspergillus fumigatus
Heesemann, L., Kotz, A., Echtenacher, B., Broniszewska, M., Routier, F. H., Hoffmann, P., & Ebel, F. (2011) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2011.02.003 · Cited by 37 · see citing works
Characterisation of the phagocytic uptake of Aspergillus fumigatus conidia by macrophages
Luther, K., Rohde, M., Sturm, K., Kotz, A., Heesemann, J., & Ebel, F. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.11.001 · Cited by 37 · see citing works
Leal, J. A., Prieto, A., Bernabé, M., & Hawksworth, D. L. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00225.x · Cited by 37 · see citing works
Self-citationWong, S. S. W., Krylov, V. B., Argunov, D. A., Karelin, A. A., Bouchara, J.-P., Fontaine, T., Latgé, J., & Nifantiev, N. E. (2020) · mSphere · doi:10.1128/msphere.00688-19 · Cited by 36 · see citing works
Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors
Tang, C., Makusheva, Y., Sun, H., Han, W., & Iwakura, Y. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.2ri0119-031r · Cited by 35 · see citing works
Jiang, S., & Sun, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091848 · Cited by 34 · see citing works
Adjuvants and delivery systems for antifungal vaccines: Current state and future developments
Portuondo, D. L., Ferreira, L. S., Urbaczek, A. C., Batista-Duharte, A., & Carlos, I. Z. (2014) · Medical Mycology · doi:10.1093/mmy/myu045 · Cited by 33 · see citing works
Immune responses to airborne fungi and non-invasive airway diseases
Vacher, G., Niculita-Hirzel, H., & Roger, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0471-3 · Cited by 33 · see citing works
- Authors
- Serrano-Gómez, D., Domínguez-Soto, A., Ancochea, J., Jimenez-Heffernan, J. A., Leal, J. A., & Corbí, A. L.
- Affiliations
- Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cientificas , Madrid ,
- Hospital Universitario de La Princesa (ES)
- Servicio de Anatomía Patológica, Hospital General de Guadalajara , Guadalajara ,
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-01
- Volume
- 173
- Issue
- 9
- Pages
- 5635-5643
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1649649531
- Cited by
- 218
- References
- 47
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 16 · 2019: 7 · 2018: 8 · 2017: 10 · 2016: 6 · 2015: 7 · 2014: 16 · 2013: 9 · 2012: 19
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- DC-SIGN, Aspergillus fumigatus, dendritic cells, alveolar macrophages, C-type lectin receptors, galactomannan, pulmonary aspergillosis, invasive aspergillosis, fungal adhesion, monocyte-derived macrophages, IL-4
- MeSH terms
- Aspergillus fumigatus, Binding Sites, Binding, Competitive, Cell Differentiation, Cells, Cultured, Dendritic Cells, Galactose, Humans, Lung, Mannans, Monocytes, Receptors, Cell Surface, Spores, Fungal, Antigens, CD, Cell Adhesion Molecules, Macrophages, Alveolar, K562 Cells, Lectins, C-Type
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