Cited by 101Cell death mechanisms and regulationT-cell and B-cell ImmunologyRedox biology and oxidative stress

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Preferential Cell Death of CD8+ Effector Memory (CCR7−CD45RA−) T Cells by Hydrogen Peroxide-Induced Oxidative Stress

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Takahashi, Akihiro, Hanson, Mikael G V, Norell, Håkan R, Havelka, Aleksandra Mandic, Kono, Koji, Malmberg, Karl-Johan, Kiessling, Rolf V R·2005·The Journal of Immunology

DOI 10.4049/jimmunol.174.10.6080

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Abstract

T cells are used in many cell-based cancer treatments. However, oxidative stress that is induced during various chronic inflammatory conditions, such as cancer, can impair the immune system and have detrimental effects on T cell function. In this study, we have investigated the sensitivity of different human T cell subsets to H2O2-induced oxidative stress. We showed that central memory (CD45RA−CCR7+) and effector memory (CD45RA−CCR7−) T cells are more sensitive to H2O2 as compared with naive (CD45RA+CCR7+) T cells. Furthermore, the study showed that CD8+ effector memory T cells are more sensitive to low levels of H2O2 (5 μM) compared with other types of T cells investigated. H2O2-exposed CD45RO+ T cells showed mitochondrial depolarization prior to caspase 3 activity. Moreover, the pan-caspase inhibitor z-Val-Ala-Asp(OMe)-fluoromethylketone rescued cells from death. These experiments suggest that H2O2-induced cell death of CD45RO+ T cells acts via the mitochondrial pathway and that caspase involvement is needed. This study suggests that oxidative stress in cancer patients can be disadvantageous for T cell-based adoptive cell transfer therapies, since effector memory T cells are the primary phenotype of the cells administered.

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The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,410
Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer
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Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of t-cell function in advanced cancer patients.
Schmielau, J., & Finn, O. J. (2001) · PubMed · Cited by 867
Respiratory burst in human neutrophils
Dahlgren, C., & Karlsson, A. (1999) · Journal of Immunological Methods · doi:10.1016/s0022-1759(99)00146-5 · Cited by 810
The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x L
Chen, C., Edelstein, L. C., & Gélinas, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2687-2695.2000 · Cited by 760
The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosisPreprint
Zong, W.-X., Edelstein, L., Chen, C.-L., Bash, J., & Gélinas, C. (1999) · Genes & Development · doi:10.1101/gad.13.4.382 · Cited by 738
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Hampton, M. B., & Orrenius, S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01068-5 · Cited by 663

Flagged first, then by citations

Show all 62 references

Research works printed but not linked: 58

1979, Adv. Exp. Med. Biol., 53
1999, J. Immunol. Methods, 3
2003, Int. J. Obes. Relat. Metab. Disord., S12
1996, Neuron, 345
1995, Free Radical Res., 389
1994, J. Immunol., 4880
1998, Clin. Exp. Immunol., 242
1998, J. Immunol., 1354
2001, J. Immunol., 2595
2000, J. Immunol., 2170
1997, J. Immunol., 2973
2002, Antioxid. Redox Signal., 543
1997, Free Radical Biol. Med., 775
2001, Cancer Res., 4756
2004, Cancer Immunol. Immunother., 879
1995, J. Exp. Med., 1881
1996, Proc. Natl. Acad. Sci. USA, 13119
1996, Eur. J. Immunol., 1308
1996, J. Immunol., 42
1998, J. Immunol., 5729
1999, Nature, 708
2004, Annu. Rev. Immunol., 745
1999, Immunity, 735
2003, Diabetes, 1423
1998, Blood, 4808
1997, FEBS Lett., 552
1999, Oncogene, 747
1998, FEBS Lett., 351
1995, Biochim. Biophys. Acta, 139
2004, Cell Death Differ., 416
2002, Immunol. Lett., 107
1993, J. Exp. Med., 427
2002, Immunity, 759
1994, Eur. J. Immunol., 892
1999, J. Immunol., 4527
2000, J. Immunol., 3950
2000, Mol. Cell. Biol., 2687
1999, Genes Dev., 400
2000, J. Immunol., 1743
1999, Mol. Cell. Biol., 5923
1999, Genes Dev., 382
1998, Infect. Immun., 499
1998, Blood, 585
1993, Cancer Res., 5610
1995, Int. J. Cancer, 765
1996, Clin. Cancer Res., 161
1996, Clin. Cancer Res., 1825
1998, Int. J. Cancer, 16
1999, Clin. Cancer Res., 1263
2004, Clin. Cancer Res., 5101
2000, Clin. Cancer Res., 1351
1999, Cancer Res., 2950
2003, Nat. Immunol., 957
2000, Blood, 3838
2001, J. Immunol., 678
2002, Science, 850
2005, Blood, 241
2002, Clin. Cancer Res., 1772

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Authors: Takahashi, A., Hanson, M. G. V., Norell, H. R., Havelka, A. M., Kono, K., Malmberg, K.-J., & Kiessling, R. V. R.
Affiliations: Karolinska Institutet (SE)
Department of Oncology and Pathology, Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Institutet , Stockholm ,
University of Yamanashi (JP)
Karolinska University Hospital (SE)
Corresponding author: Takahashi, Akihiro
ORCID: Takahashi, Akihiro
Kono, Koji
Malmberg, Karl-Johan
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2005-05
Volume: 174
Issue: 10
Pages: 6080-6087
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.174.10.6080
OpenAlex: W2139536543
Cited by: 101
References: 62
Citations by year: 2026: 2 · 2025: 4 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 8
FWCI: 1.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Cancerfonden
Karolinska Institutet
National Institutes of Health
National Cancer Institute (R01CA102280, CA 102280)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: hydrogen peroxide, oxidative stress, T cell death, CD8+ effector memory T cells, central memory T cells, naive T cells, mitochondrial depolarization, caspase-3, z-VAD-fmk, adoptive cell transfer, T cell subsets, cancer immunotherapy
MeSH terms: Amino Acid Chloromethyl Ketones, Cells, Cultured, Cytotoxicity, Immunologic, Dose-Response Relationship, Immunologic, Growth Inhibitors, Humans, Hydrogen Peroxide, Immunologic Memory, Intracellular Membranes, Membrane Potentials, Mitochondria, Permeability, T-Lymphocytes, Cytotoxic, Cell Death, Leukocyte Common Antigens, Oxidative Stress, Receptors, Chemokine, Receptors, CCR7, Caspase Inhibitors

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Preferential Cell Death of CD8+ Effector Memory (CCR7−CD45RA−) T Cells by Hydrogen Peroxide-Induced Oxidative Stress

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