Cited by 365Extracellular vesicles in diseaseNeuroinflammation and Neurodegeneration MechanismsCellular transport and secretion

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Proteomic Analysis of Microglia-Derived Exosomes: Metabolic Role of the Aminopeptidase CD13 in Neuropeptide Catabolism

Potolicchio, Ilaria, Carven, Gregory J, Xu, Xiaonan, Stipp, Christopher, Riese, Richiard J, Stern, Lawrence J, Santambrogio, Laura·2005·The Journal of Immunology

DOI 10.4049/jimmunol.175.4.2237

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Abstract

Vesicle transport is a fundamental mechanism of communication in the CNS. In this study we characterized a novel type of vesicle released by murine brain microglial cells: microglial exosomes. Analysis of their protein content identified several enzymes, chaperones, tetraspanins, and membrane receptors previously reported in B cells and dendritic cell-derived exosomes. Additionally, microglia-derived exosomes expressed the aminopeptidase CD13 and the lactate transporter MCT-1. Exosomal CD13 was metabolically active in cleaving leucine- and methionine-enkephalins peptides by releasing the N-terminal tyrosine. Cleaved neuropeptides were unable to bind to the neuronal opioid receptor as assessed by cAMP response. Microglial exosomal vesicles may represent an important, previously unrecognized, cellular communication system in an organ in which cell motility is highly restricted.

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Authors: Potolicchio, I., Carven, G. J., Xu, X., Stipp, C., Riese, R. J., Stern, L. J., & Santambrogio, L.
Affiliations: Albert Einstein College of Medicine (US)
University of Massachusetts Chan Medical School (US)
Dana-Farber Cancer Institute (US)
Brigham and Women's Hospital (US)
ORCID: Carven, Gregory J
Stipp, Christopher
Stern, Lawrence J
Santambrogio, Laura
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2005-08
Volume: 175
Issue: 4
Pages: 2237-2243
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.175.4.2237
OpenAlex: W1524589668
Cited by: 365
References: 37
Citations by year: 2026: 11 · 2025: 6 · 2024: 18 · 2023: 22 · 2022: 32 · 2021: 31 · 2020: 30 · 2019: 29 · 2018: 16 · 2017: 18 · 2016: 29 · 2015: 13 · 2014: 16 · 2013: 14 · 2012: 22
FWCI: 3.39
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: National Institutes of Health (5k08ai001555-03)
National Cancer Institute (CA 86712, R01CA086712)
National Institute of Allergy and Infectious Diseases (K08AI01555, R01-AI38996, R01AI048832, R01AI038996)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: CD13, aminopeptidase, enkephalin, opioid receptors, MCT1, lactate transporters, tetraspanins, cell surface receptors, molecular chaperones
MeSH terms: Animals, Antigens, Differentiation, B-Lymphocyte, Histocompatibility Antigens Class II, Cathepsins, Cell Communication, Cell Line, Neuropeptides, Endosomes, Biomarkers, Microglia, CD13 Antigens, Proteome, Cytoplasmic Vesicles, Cell Line, Tumor, Mice

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Proteomic Analysis of Microglia-Derived Exosomes: Metabolic Role of the Aminopeptidase CD13 in Neuropeptide Catabolism

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