Proteomic Analysis of Microglia-Derived Exosomes: Metabolic Role of the Aminopeptidase CD13 in Neuropeptide Catabolism

Exosomes: composition, biogenesis and function

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B lymphocytes secrete antigen-presenting vesicles.

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Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles

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Molecular Characterization of Dendritic Cell-Derived Exosomes

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Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

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Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

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Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

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Basic principles of immunological surveillance of the normal central nervous system

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Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

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Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Membrane vesicles as conveyors of immune responses

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Extracellular vesicles: biology and emerging therapeutic opportunities

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Exosomes: Extracellular organelles important in intercellular communication

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Exosomes: proteomic insights and diagnostic potential

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Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

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Exosomes: secreted vesicles and intercellular communications

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Exosomes: A Common Pathway for a Specialized Function

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Microautophagy of Cytosolic Proteins by Late Endosomes

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Proteomic profiling of exosomes: Current perspectives

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Extracellular vesicles round off communication in the nervous system

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Tetraspanins: push and pull in suppressing and promoting metastasis

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Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

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Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

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Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

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Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

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Acid sphingomyelinase activity triggers microparticle release from glial cells

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Exosomes: immune properties and potential clinical implementations

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Extracellular Vesicles Produced by Cryptococcus neoformans Contain Protein Components Associated with Virulence

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Oligodendrocytes secrete exosomes containing major myelin and stress‐protective proteins: Trophic support for axons?

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Exosome mimetics: a novel class of drug delivery systems

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Proteomics, transcriptomics and lipidomics of exosomes and ectosomes

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Identification and proteomic profiling of exosomes in human cerebrospinal fluid

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Schwann cell‐derived exosomes enhance axonal regeneration in the peripheral nervous system

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Proteomic and immunologic analyses of brain tumor exosomes

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Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

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Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

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Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

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Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

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Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

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Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications

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Proteomics Analysis of Bladder Cancer Exosomes

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Extracellular vesicles as mediators of neuron-glia communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., & Krämer‐Albers, E. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00182 · Cited by 397

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

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Vesicular transport inHistoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes

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Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: A possible role in innate defense

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Tumor cell-derived exosomes: A message in a bottle

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Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

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Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

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Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies

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Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

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Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

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Understanding wiring and volume transmission

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Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

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Stimulation of P2 receptors causes release of IL-1β–loaded microvesicles from human dendritic cells

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CD8+ Dendritic Cells Use LFA-1 to Capture MHC-Peptide Complexes from Exosomes In Vivo

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Emerging roles of exosomes in neuron-glia communication

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Extracellular vesicles and intercellular communication within the nervous system

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Inhibition of γ‐secretase causes increased secretion of amyloid precursor protein C‐terminal fragments in association with exosomes

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Exosomal transfer of proteins and RNAs at synapses in the nervous system

Smalheiser, N. R. (2007) · Biology Direct · doi:10.1186/1745-6150-2-35 · Cited by 256

Exosomes are endogenous nanoparticles that can deliver biological information between cells

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Exosomes as nano-theranostic delivery platforms for gene therapy

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Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine?

Aryani, A., & Denecke, B. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9054-5 · Cited by 242

CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

Hornung, S., Dutta, S., & Bitan, G. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00038 · Cited by 244

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

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The role of exosomes in the processing of proteins associated with neurodegenerative diseases

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Extracellular vesicles as modulators of cell-to-cell communication in the healthy and diseased brain

Pegtel, D. M., Peferoen, L., & Amor, S. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0516 · Cited by 232

Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression

Fan, C., Li, Y., Lan, T., Wang, W., Long, Y., & Yu, S. Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2021.11.006 · Cited by 227

The role of extracellular vesicles in COVID-19 virus infection

Hassanpour, M., Rezaie, J., Nouri, M., & Panahi, Y. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104422 · Cited by 236

Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases

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Exosomes in stroke pathogenesis and therapy

Zhang, Z. G., & Chopp, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81133 · Cited by 228

Exosomes as Biomarker Enriched Microvesicles: Characterization of Exosomal Proteins Derived from a Panel of Prostate Cell Lines with Distinct AR Phenotypes

Beheshti, E. H., Pham, S., Adomat, H. H., Li, N., & Guns, E. S. T. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014845 · Cited by 224

Active endocannabinoids are secreted on extracellular membrane vesicles

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Exosomes as new diagnostic tools in CNS diseases

Kanninen, K. M., Korvenlaita, N., Koıstınaho, J., & Malm, T. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.09.020 · Cited by 226

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

Holm, M. M., Kaiser, J., & Schwab, M. E. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.006 · Cited by 213

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

Brites, D. M. T. O., & Vaz, A. R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00117 · Cited by 213

Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

von Bartheld, C. S., & Altick, A. L. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.003 · Cited by 207

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes

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Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

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Inflammation leads to distinct populations of extracellular vesicles from microglia

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Serum‐free culture alters the quantity and protein composition of neuroblastoma‐derived extracellular vesicles

Li, J., Lee, Y., Johansson, H. J., Mäger, I., Vader, P., Nordin, J. Z., Wiklander, O. P. B., Lehtiö, J., Wood, M. J. A., & Andaloussi, S. E. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26883 · Cited by 190

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

Koniusz, S., Andrzejewska, A., Muraca, M., Srivastava, A. K., Janowski, M., & Łukomska, B. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00109 · Cited by 191

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

Shi, M., Sheng, L., Stewart, T., Zabetian, C. P., & Zhang, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.005 · Cited by 181

BIN1 favors the spreading of Tau via extracellular vesicles

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Extracellular Vesicles and a Novel Form of Communication in the Brain

Basso, M., & Bonetto, V. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00127 · Cited by 161

Proteomics of MUC1‐containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF‐7

Staubach, S., Razawi, H., & Hanisch, F. (2009) · PROTEOMICS · doi:10.1002/pmic.200800793 · Cited by 175

Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications

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Microglial microvesicle secretion and intercellular signaling

Turola, E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00149 · Cited by 174

Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons.

Laulagnier, K., Javalet, C., Hemming, F. J., Chivet, M., Lachenal, G., Blot, B., Chatellard, C., & Sadoul, R. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2664-0 · Cited by 164

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

Silverman, J. M., Christy, D., Shyu, C. C., Moon, K., Fernando, S. M., Gidden, Z., Cowan, C. M., Ban, Y., Stacey, R. G., Grad, L. I., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004825 · Cited by 176

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

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Large Extracellular Vesicles: Have We Found the Holy Grail of Inflammation?

Słomka, A., Urban, S. K., Kornek, M., Żekanowska, E., & Kornek, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02723 · Cited by 165

Exosomes and stem cells in degenerative disease diagnosis and therapy

Chang, Y.-H., Wu, K.-C., Harn, H.-J., Lin, S.-Z., & Ding, D.-C. (2018) · Cell Transplantation · doi:10.1177/0963689717723636 · Cited by 159

Functions of p38 MAP Kinases in the Central Nervous System

Asih, P. R., Prikas, E., Stefanoska, K., Tan, A. R. P., Ahel, H. I., & Ittner, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.570586 · Cited by 163

Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro

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Exosomes as Novel Regulators of Adult Neurogenic Niches

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