The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Regulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell
Open accessAbstract
Elderly persons have a high incidence of lethal infections by encapsulated bacteria. However, mechanisms involved in their poor defense and maintenance of immunological memory have been poorly understood. The present study characterized the population of B cells known as IgM memory B cell compartment and their response by pneumococcal vaccine in elderly people. CD27+ memory B cells, particularly IgD+IgM+CD27+ IgM memory B cells, had dramatically declined in the aged. Their Ig syntheses by B cells and the differentiation into plasma cells were diminished in vitro compared with those in adults. A rise of anti-pneumococcal IgM in sera of elderly persons was found with lower levels compared with those in adults after pneumococcal vaccination. Although diminished function itself of aged B cells surely exist, decline of the IgM memory B cell pool is expected to result in a poor humoral immunity against pneumococcal infection in elderly people.
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“This decline is likely due to decreased numbers of IgM + memory and switched memory B cells, because the total number of naive B cells remains unchanged by aging (51,52).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [52]
In the citing paper
“Using these markers, it has been shown that the percentage of switched memory B cells, the predictors of optimal antibody responses [114], decreases with age [115, 116].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [116]
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Citations
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Cited by
Sorted by citations
Causes, consequences, and reversal of immune system aging
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Metadata
- Authors
- Shi, Y., Yamazaki, T., Okubo, Y., Uehara, Y., Sugane, K., & Agematsu, K.
- Affiliations
- Shinshu University (JP)
- Department of Infectious Immunology, Graduate School of Medicine , Matsumoto ,
- Kochi Medical School Hospital (JP)
- ORCID
- Yamazaki, Takashi
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-01
- Volume
- 175
- Issue
- 5
- Pages
- 3262-3267
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1539270061
- Cited by
- 229
- References
- 37
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 9 · 2015: 21 · 2014: 12 · 2013: 24 · 2012: 16
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- IgM memory B cells, aging, humoral immunity, pneumococcal infection, Streptococcus pneumoniae, pneumococcal vaccine, CD27+ memory B cells, immunosenescence, immunological memory, plasma cell differentiation, antibody production, encapsulated bacteria
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Antibodies, Bacterial, Antibody Formation, B-Lymphocytes, Female, Humans, Immunoglobulin D, Immunoglobulin M, Immunologic Memory, Male, Middle Aged, Streptococcus pneumoniae, Tumor Necrosis Factor Receptor Superfamily, Member 7, Pneumococcal Vaccines
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