Cited by 229T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunodeficiency and Autoimmune Disorders

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Regulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell

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Shi, Yuhui, Yamazaki, Takashi, Okubo, Yoshio, Uehara, Yoshio, Sugane, Kazuo, Agematsu, Kazunaga·2005·The Journal of Immunology

DOI 10.4049/jimmunol.175.5.3262

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Abstract

Elderly persons have a high incidence of lethal infections by encapsulated bacteria. However, mechanisms involved in their poor defense and maintenance of immunological memory have been poorly understood. The present study characterized the population of B cells known as IgM memory B cell compartment and their response by pneumococcal vaccine in elderly people. CD27+ memory B cells, particularly IgD+IgM+CD27+ IgM memory B cells, had dramatically declined in the aged. Their Ig syntheses by B cells and the differentiation into plasma cells were diminished in vitro compared with those in adults. A rise of anti-pneumococcal IgM in sera of elderly persons was found with lower levels compared with those in adults after pneumococcal vaccination. Although diminished function itself of aged B cells surely exist, decline of the IgM memory B cell pool is expected to result in a poor humoral immunity against pneumococcal infection in elderly people.

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Authors: Shi, Y., Yamazaki, T., Okubo, Y., Uehara, Y., Sugane, K., & Agematsu, K.
Affiliations: Shinshu University (JP)
Department of Infectious Immunology, Graduate School of Medicine , Matsumoto ,
Kochi Medical School Hospital (JP)
ORCID: Yamazaki, Takashi
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2005-09-01
Volume: 175
Issue: 5
Pages: 3262-3267
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.175.5.3262
OpenAlex: W1539270061
Cited by: 229
References: 37
Citations by year: 2026: 4 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 9 · 2015: 21 · 2014: 12 · 2013: 24 · 2012: 16
FWCI: 2.25
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: IgM memory B cells, aging, humoral immunity, pneumococcal infection, Streptococcus pneumoniae, pneumococcal vaccine, CD27+ memory B cells, immunosenescence, immunological memory, plasma cell differentiation, antibody production, encapsulated bacteria
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Antibodies, Bacterial, Antibody Formation, B-Lymphocytes, Female, Humans, Immunoglobulin D, Immunoglobulin M, Immunologic Memory, Male, Middle Aged, Streptococcus pneumoniae, Tumor Necrosis Factor Receptor Superfamily, Member 7, Pneumococcal Vaccines

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Regulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell

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