Cited by 117Cytokine Signaling Pathways and InteractionsImmune cells in cancerNF-κB Signaling Pathways

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The JNK Are Important for Development and Survival of Macrophages

Himes, S Roy, Sester, David P, Ravasi, Timothy, Cronau, Stephen L, Sasmono, Tedjo, Hume, David A·2006·The Journal of Immunology

DOI 10.4049/jimmunol.176.4.2219

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Abstract

We report in this study that activation of the JNK by the growth factor, CSF-1 is critical for macrophage development, proliferation, and survival. Inhibition of JNK with two distinct classes of inhibitors, the pharmacological agent SP600125, or the peptide D-JNKI1 resulted in cell cycle inhibition with an arrest at the G2/M transition and subsequent apoptosis. JNK inhibition resulted in decreased expression of CSF-1R (c-fms) and Bcl-xL mRNA in mature macrophages and repressed CSF-1-dependent differentiation of bone marrow cells to macrophages. Macrophage sensitivity to JNK inhibitors may be linked to phosphorylation of the PU.1 transcription factor. Inhibition of JNK disrupted PU.1 binding to an element in the c-fms gene promoter and decreased promoter activity. Promoter activity could be restored by overexpression of PU.1. A comparison of expression profiles of macrophages with 22 other tissue types showed that genes that signal JNK activation downstream of tyrosine kinase receptors, such as focal adhesion kinase, Nck-interacting kinase, and Rac1 and scaffold proteins are highly expressed in macrophages relative to other tissues. This pattern of expression may underlie the novel role of JNK in macrophages.

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Background
Lipopolysaccharide-dependent interaction between PU.1 and cJun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages
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Non-thermal plasma treatment induces MAPK signaling in human monocytes
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Background
The Mononuclear Phagocyte System of the Rat
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Deletion of JNK2 prevents vitamin-D-deficiency-induced hypertension and atherosclerosis in mice
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c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis
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Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
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Result
Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology
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Δ8-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: Involvement of cannabinoid receptor 2 and p38 MAPK
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Immuno-Modulatory Activity of Hot Water Extracts Isolated from Protaetia brevitarsis seulensis Larvae through MAPKs and NF-κB Pathways in Macrophages
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Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague
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“The JNK factor is known to play a role in cell survival [27].”
Background
Maraviroc Ameliorates the Increased Adipose Tissue Macrophage Recruitment Induced by a High-Fat Diet in a Mouse Model of Obesity
Pérez‐Matute, P., Pichel, J. G., Íñiguez, M., et al. (2016) · Antiviral Therapy · doi:10.3851/imp3099 · Cited by 13
“In addition, JNK are also important for the development and survival of macrophages [15].”
Background
The Spectrum of CAR Cellular Effectors: Modes of Action in Anti-Tumor Immunity
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“TRAF6 can also interact with IRF1, IRF5 and IRF7, leading to the transcription of TNF or type I IFN, and also links to the p38 and JNK pathway, inﬂuencing macrophage pro-or anti-inﬂammatory response, development, proliferation, and survival [159,161,162].”
Background
Early Activation of MAP Kinases by Influenza A Virus X-31 in Murine Macrophage Cell Lines
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Background
Tea Polyphenols Protects Tracheal Epithelial Tight Junctions in Lung during Actinobacillus pleuropneumoniae Infection via Suppressing TLR-4/MAPK/PKC-MLCK Signaling
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Activating Transcription Factor 3 Contributes to Toll-Like Receptor-Mediated Macrophage Survival via Repression of Bax and Bak
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Authors: Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A.
Affiliations: The University of Queensland (AU)
Cooperative Research Centre for Chronic Inflammatory Disease, Institute for Molecular Biosciences, University of Queensland , Brisbane ,
ORCID: Sester, David P
Ravasi, Timothy
Hume, David A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2006-02
Volume: 176
Issue: 4
Pages: 2219-2228
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.176.4.2219
OpenAlex: W1582648966
Cited by: 117
References: 69
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 5
FWCI: 3.24
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: JNK, macrophage development, macrophage survival, CSF-1, CSF-1 receptor, c-fms, Bcl-xL, apoptosis, cell cycle arrest, G2/M cell cycle arrest, PU.1, transcriptional regulation, macrophage differentiation, bone marrow, JNK inhibitor, SP600125, tyrosine kinase signaling, focal adhesion kinase, Rac1, scaffold proteins
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Cells, Cultured, DNA, Gene Expression Regulation, Macrophages, Phosphorylation, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins, RNA, Messenger, Signal Transduction, Trans-Activators, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, JNK Mitogen-Activated Protein Kinases, Mice

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The JNK Are Important for Development and Survival of Macrophages

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