Cited by 117Cytokine Signaling Pathways and InteractionsImmune cells in cancerNF-κB Signaling Pathways

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The JNK Are Important for Development and Survival of Macrophages

Himes, S Roy, Sester, David P, Ravasi, Timothy, Cronau, Stephen L, Sasmono, Tedjo, Hume, David A·2006·The Journal of Immunology

DOI 10.4049/jimmunol.176.4.2219

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Abstract

We report in this study that activation of the JNK by the growth factor, CSF-1 is critical for macrophage development, proliferation, and survival. Inhibition of JNK with two distinct classes of inhibitors, the pharmacological agent SP600125, or the peptide D-JNKI1 resulted in cell cycle inhibition with an arrest at the G2/M transition and subsequent apoptosis. JNK inhibition resulted in decreased expression of CSF-1R (c-fms) and Bcl-xL mRNA in mature macrophages and repressed CSF-1-dependent differentiation of bone marrow cells to macrophages. Macrophage sensitivity to JNK inhibitors may be linked to phosphorylation of the PU.1 transcription factor. Inhibition of JNK disrupted PU.1 binding to an element in the c-fms gene promoter and decreased promoter activity. Promoter activity could be restored by overexpression of PU.1. A comparison of expression profiles of macrophages with 22 other tissue types showed that genes that signal JNK activation downstream of tyrosine kinase receptors, such as focal adhesion kinase, Nck-interacting kinase, and Rac1 and scaffold proteins are highly expressed in macrophages relative to other tissues. This pattern of expression may underlie the novel role of JNK in macrophages.

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Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
Schreiber, E. H., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7686 · Cited by 2,679
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
Rogers, S. W., Wells, R., & Rechsteiner, M. (1986) · Science · doi:10.1126/science.2876518 · Cited by 2,541
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
Selective interaction of JNK protein kinase isoforms with transcription factors.
Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
Dai, X.-M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V., & Stanley, E. R. (2002) · Blood · doi:10.1182/blood.v99.1.111 · Cited by 1,184
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
Han, Z., Boyle, D. L., Chang, L., Bennett, B. L., Karin, M., Yang, L., Manning, A. M., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12466 · Cited by 797
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M., & Karin, M. (1991) · Nature · doi:10.1038/354494a0 · Cited by 789
c‐Jun regulates cell cycle progression and apoptosis by distinct mechanisms
Wisdom, R., Johnson, R. S., & Moore, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.188 · Cited by 687
A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse
Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., & Hume, D. A. (2003) · Blood · doi:10.1182/blood-2002-02-0569 · Cited by 662
Self-citation
Defective T Cell Differentiation in the Absence of Jnk1
Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J., & Flavell, R. A. (1998) · Science · doi:10.1126/science.282.5396.2092 · Cited by 579
Control of cell cycle progression by c-Jun is p53 dependentPreprint
Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Möhle-Steinlein, U., Tian, J., Karin, M., Angel, P., & Wagner, E. F. (1999) · Genes & Development · doi:10.1101/gad.13.5.607 · Cited by 576
Cell-Permeable Peptide Inhibitors of JNK
Bonny, C., Oberson, A., Negri, S., Sauser, C., & Schorderet, D. F. (2001) · Diabetes · doi:10.2337/diabetes.50.1.77 · Cited by 571
Statistical Issues in cDNA Microarray Data Analysis
Smyth, G. K., Yang, J. Y. H., & Speed, T. P. (2003) · Humana Press eBooks · doi:10.1385/1-59259-364-x:111 · Cited by 471
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
Hambleton, J., Weinstein, S. L., Lem, L., & DeFranco, A. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2774 · Cited by 471
Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2
Yang, D. D., Conze, D. B., Whitmarsh, A. J., Barrett, T., Davis, R. J., Rincón, M., & Flavell, R. A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80640-8 · Cited by 453
The Jun and Fos Protein Families Are Both Required for Cell Cycle Progression in Fibroblasts
Kovary, K., & Bravo, R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.9.4466 · Cited by 447
p110δ, a novel phosphoinositide 3-kinase in leukocytes
Vanhaesebroeck, B., Welham, M. J., Kotani, K., Stein, R. C., Warne, P. H., Zvelebil, M., Higashi, K., Volinia, S., Downward, J., & Waterfield, M. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4330 · Cited by 445
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor
Zhang, D.-E., Hetherington, C. J., Chen, H.-M., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.373-381.1994 · Cited by 411
Matrix Survival Signaling
Almeida, E. A. C., Ilić, D., Han, Q., Hauck, C. R., Jin, F., Kawakatsu, H., Schlaepfer, D. D., & Damsky, C. H. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.741 · Cited by 358
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism
Chen, J., Fujii, K., Zhang, L., Roberts, T. M., & Fu, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141224398 · Cited by 316
Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle
Oktay, M. H., Wary, K. K., Dans, M. J., Birge, R. B., & Giancotti, F. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1461 · Cited by 275
Transcription factors that regulate monocyte/macrophage differentiation
Valledor, A. F., Borràs, F. E., Cullell-Young, M., & Celada, A. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.4.405 · Cited by 215
MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival
Zheng, B., Fiumara, P. F., Li, Y. V., Georgakis, G. V., Snell, V., Younes, M., Vauthey, J., Carbone, A., & Younes, A. (2003) · Blood · doi:10.1182/blood-2002-11-3507 · Cited by 213
Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays
Miki, R., Kadota, K., Bono, H. U., Mizuno, Y., Tomaru, Y., Carninci, P., Itoh, M., Shibata, K., Kawai, J., Konno, H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041605498 · Cited by 200
Myeloid Development Is Selectively Disrupted in PU.1 Null Mice
Anderson, K. L., Smith, K. A., Conners, K., McKercher, S. R., Maki, R. A., & Torbett, B. E. (1998) · Blood · doi:10.1182/blood.v91.10.3702 · Cited by 193
The SH2 and SH3 Domain-Containing Nek Protein Is Oncogenic and a Common Target for Phosphorylation by Different Surface Receptors
Li, W., Hu, P. J., Skolnik, E. Y., Ullrich, A., & Schlessinger, J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5824 · Cited by 175
Survival signaling mediated by c-Jun NH2-terminal kinase in transformed B lymphoblasts
Hess, P., Pihan, G. A., Sawyers, C. L., Flavell, R. A., & Davis, R. J. (2002) · Nature Genetics · doi:10.1038/ng946 · Cited by 165
The transcription factor PU.1 is involved in macrophage proliferation.
Celada, A., Borràs, F. E., Soler, C., Lloberas, J., Klemsz, M., van Beveren, C., McKercher, S., & Maki, R. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.61 · Cited by 152 · cited 1×
“1 transcription factor has been shown to effect proliferation of BMMs in a CSF-1-dependent manner, and decreased proliferation of BMMs in response to JNK inhibition may partially occur through repression of c-fms gene expression (54) (Fig.”
Background
Mitogenic Signaling By Colony-Stimulating Factor 1 and ras Is Suppressed by the ets-2 DNA-Binding Domain and Restored by myc Overexpression
Langer, S. J., Bortner, D. M., Roussel, M. F., Sherr, C. J., & Ostrowski, M. C. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5355-5362.1992 · Cited by 146
Structural features of the colony‐stimulating factor 1 receptor that affect its association with phosphatidylinositol 3‐kinase.
Shurtleff, S. A., Downing, J. R., Rock, C. O., et al. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07417.x · Cited by 145
The Differential Time-course of Extracellular-regulated Kinase Activity Correlates with the Macrophage Response toward Proliferation or Activation
Valledor, A. F., Comalada, M., Xaus, J., & Celada, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.7403 · Cited by 135
Regulation of Urokinase-Type Plasminogen Activator Gene Transcription by Macrophage Colony-Stimulating Factor
Stacey, K. J., Fowles, L., Colman, M. S., Ostrowski, M. C., & Hume, D. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3430 · Cited by 128
Self-citation
Rescue of defective mitogenic signaling by D-type cyclins.
Roussel, M. F., Theodoras, A. M., Pagano, M., & Sherr, C. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6837 · Cited by 111
Persistent Activation of Mitogen-Activated Protein Kinases p42 and p44 and ets-2 Phosphorylation in Response to Colony-Stimulating Factor 1/c-fms Signaling
Fowles, L., Martin, M. L., Nelsen, L., Stacey, K. J., Redd, D., Clark, Y. M., Nagamine, Y., McMahon, M., Hume, D. A., & Ostrowski, M. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5148 · Cited by 104
Self-citation
The Ets2 Transcription Factor Inhibits Apoptosis Induced by Colony-Stimulating Factor 1 Deprivation of Macrophages through a Bcl-x L -Dependent Mechanism
Sevilla, L., Aperlo, C., Dulić, V., Chambard, J., Boutonnet, C., Pasquier, O., Pognonec, P., & Boulukos, K. E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2624 · Cited by 97
Cloning and Characterization of the Murine Genes for bHLH-ZIP Transcription Factors TFEC and TFEB Reveal a Common Gene Organization for All MiT Subfamily Members
Rehli, M., den Elzen, N. R., Cassady, A. I., Ostrowski, M. C., & Hume, D. A. (1999) · Genomics · doi:10.1006/geno.1998.5588 · Cited by 95
Self-citation
Isoforms of Jun Kinase Are Differentially Expressed and Activated in Human Monocyte/Macrophage (THP-1) Cells
Dreskin, S. C., Thomas, G. W., Dale, S. N., & Heasley, L. E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5646 · Cited by 95
Interleukin-3 Stimulation of mcl-1 Gene Transcription Involves Activation of the PU.1 Transcription Factor through a p38 Mitogen-Activated Protein Kinase-Dependent Pathway
Wang, J.-M., Lai, M.-Z., & Yang-Yen, H.-F. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.6.1896-1909.2003 · Cited by 90
Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle
Smith, M., & Prochownik, E. (1992) · Blood · doi:10.1182/blood.v79.8.2107.2107 · Cited by 84
Interaction between PU.1 and Another Ets Family Transcription Factor Promotes Macrophage-specific Basal Transcription Initiation
Ross, I. L., Xie, Y., Ostrowski, M. C., & Hume, D. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6662 · Cited by 79
Self-citation
A highly conserved c-fmsgene intronic element controls macrophage-specific and regulated expression
Himes, S. R., Tagoh, H., Goonetilleke, N., Sasmono, R. T., Oceandy, D., Clark, R. J., Bonifer, C., & Hume, D. A. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.5.812 · Cited by 79
Self-citation
ets-2 Is a Target for an Akt (Protein Kinase B)/Jun N-Terminal Kinase Signaling Pathway in Macrophages of motheaten-viable Mutant Mice
Smith, J. L., Schaffner, A. E., Hofmeister, J. K., Hartman, M. S., Guo, W., Forsthoefel, D. J., Hume, D. A., & Ostrowski, M. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8026-8034.2000 · Cited by 71
Self-citation
Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle
Smith, M., & Prochownik, E. (1992) · Blood · doi:10.1182/blood.v79.8.2107.bloodjournal7982107 · Cited by 64
Roles of the Mitogen-activated Protein Kinase Family in Macrophage Responses to Colony Stimulating Factor-1 Addition and Withdrawal
Jaworowski, A., Wilson, N. J., Christy, E., Byrne, R. A., & Hamilton, J. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15127 · Cited by 61
Bcl-xL Expression Correlates with Primary Macrophage Differentiation, Activation of Functional Competence, and Survival and Results from Synergistic Transcriptional Activation by Ets2 and PU.1
Sevilla, L., Zaldumbide, A., Carlotti, F., Dayem, M. A., Pognonec, P., & Boulukos, K. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008270200 · Cited by 60
EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-α-mediated apoptosis in epidermoid cancer cells
Caraglia, M., Tagliaferri, P., Marra, M., Giuberti, G., Budillon, A., Gennaro, E. D., Pepe, S., Vitale, G., Improta, S., Tassone, P., et al. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401131 · Cited by 59
Octamer Binding Factors and Their Coactivator Can Activate the Murine PU.1 (spi-1) Promoter
Chen, H.-M., Zhang, P., Radomska, H. S., Hetherington, C. J., Zhang, D.-E., & Tenen, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15743 · Cited by 59
c-Jun-NH2 Kinase (JNK) Contributes to the Regulation of c-Myc Protein Stability
Alarcon-Vargas, D., & Ronai, Z. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312054200 · Cited by 59
Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes.
Ross, I. L., Dunn, T. L., Yue, X., Himes, S. R., Barnett, C. J. K., & Hume, D. A. (1994) · PubMed · Cited by 57
Self-citation
Selective Involvement of p130Cas/Crk/Pyk2/c-Src in Endothelin-1-Induced JNK Activation
Kodama, H., Fukuda, K., Takahashi, E., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000069698.11814.f4 · Cited by 55
Colony‐stimulating factor‐1 receptor (c‐fms)
Sherr, C. J., Roussel, M. F., & Rettenmier, C. W. (1988) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240380305 · Cited by 55
A New Identity for MLK3 as an NIMA-related, Cell Cycle–regulated Kinase That Is Localized near Centrosomes and Influences Microtubule Organization
Swenson, K. I., Winkler, K. E., & Means, A. R. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0115 · Cited by 49
Differential phosphorylations of Spi-B and Spi-1 transcription factors.
Mao, C., Ray-Gallet, D., Tavitian, A., et al. (1996) · PubMed · Cited by 48
Alterations in Differentiation and Behavior of Monocytic Phagocytes in Transgenic Mice that Express Dominant Suppressors of ras Signaling
Jin, D. I., Jameson, S. B., Reddy, M. A., Schenkman, D., & Ostrowski, M. C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.693 · Cited by 47
Cell Cycle Regulation of c-Jun N-Terminal Kinase Activity at the Centrosomes
MacCorkle-Chosnek, R. A., VanHooser, A., Goodrich, D. W., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5948 · Cited by 38
A Scaffold Protein in the c-Jun N-terminal Kinase Signaling Pathway is Associated with Focal Adhesion Kinase and Tyrosine Phosphorylated
Takino, T., Yoshioka, K., Miyamori, H., et al. (2003) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 31
A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated
Takino, T., Yoshioka, K., Miyamori, H., Yamada, K. M., & Sato, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205840 · Cited by 31
The SH2 and SH3 Domain-Containing Nek Protein Is Oncogenic and a Common Target for Phosphorylation by Different Surface Receptors
Li, W., Hu, P. J., Skolnik, E. Y., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5824-5833.1992 · Cited by 30
Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor
Fowles, L., Stacey, K. J., Marks, D. C., HAMILTON, J. A., & Hume, D. A. (2000) · Biochemical Journal · doi:10.1042/bj3470313 · Cited by 20
Self-citation
Activation of c-Jun N-terminal Kinase by Human Granulocyte Macrophage-Colony Stimulating Factor in BA/F3 Cells
Liu, R., Itoh, T., Arai, K., & Watanabe, S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6643 · Cited by 16
Myeloid Development Is Selectively Disrupted in PU.1 Null Mice
Anderson, K. L., Smith, K. A., Conners, K., et al. (1998) · Blood · doi:10.1182/blood.v91.10.3702.3702_3702_3710 · Cited by 16
Regulation and functions of c-Jun N-terminal kinase/stress-activated protein kinase.
Wang, T. H., Wang, H. S., & Soong, Y. K. (2000) · PubMed · Cited by 11
Untitled work
(1997) · doi:10.1002/(sici)1098-2795(199701)46:1

Flagged first, then by citations

2 of the 69 references couldn’t be matched to a known paper.

Research works printed but not linked: 64

2000, J. Biol. Chem., 7403
1997, Biochem. Biophys. Res. Commun., 611
1998, Curr. Opin. Cell. Biol., 205
1996, EMBO J., 2760
1991, Nature, 494
1998, Immunity, 575
1998, Science, 2092
2000, Cell, 239
1996, Oncogene, 863
2000, Mol. Cell. Biol., 8026
1994, Mol. Cell. Biol., 373
1998, J. Leukocyte Biol., 405
1996, EMBO J., 5647
1997, Mol. Reprod. Dev., 4
1988, J. Cell. Biochem., 179
1990, EMBO J., 2415
1992, Mol. Cell. Biol., 5355
1995, Mol. Cell. Biol., 693
1999, Mol. Cell. Biol., 2624
2001, J. Clin. Invest., 73
2001, Diabetes, 77
2003, Blood, 1155
1989, Nucleic Acids Res., 6419
1998, J. Biol. Chem., 6662
2001, Proc. Natl. Acad. Sci. USA, 2199
2003, Methods Mol. Biol., 111
1999, J. Biol. Chem., 15127
1995, Proc. Natl. Acad. Sci. USA, 7686
1997, Proc. Natl. Acad. Sci. USA, 4330
1994, J. Biol. Chem., 5241
2003, Cell Death Differ., 218
2001, Proc. Natl. Acad. Sci. USA, 7783
2003, Blood, 1019
1999, Genomics, 111
2003, Mol. Cell. Biol., 1896
1986, Science, 364
1996, J. Biol. Chem., 15743
2001, J. Leukocyte Biol., 812
1994, Oncogene, 121
2001, J. Biol. Chem., 17800
2000, J. Cell Biol., 741
1999, J. Cell Biol., 1461
1992, Mol. Cell. Biol., 5824
1995, Mol. Cell. Biol., 3430
2000, Biochem. J., 313
1995, Proc. Natl. Acad. Sci. USA, 6837
1991, Mol. Cell. Biol., 4466
1992, Blood, 2107
1999, Genes Dev., 607
1999, EMBO J., 188
2004, J. Biol. Chem., 5008
2001, Biochem. Biophys. Res. Commun., 173
2003, Mol. Biol. Cell., 156
1996, J. Exp. Med., 61
1998, Mol. Cell. Biol., 5148
2000, Chang Gung Med. J., 57
1997, Mol. Reprod. Dev., 11
2002, Nat. Genet., 201
2003, Hypertension, 1372
2002, Oncogene, 6488
1998, Blood, 3702
2002, Blood, 111
1996, Proc. Natl. Acad. Sci. USA, 2774
2001, J. Immunol., 5646

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Authors: Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A.
Affiliations: The University of Queensland (AU)
Cooperative Research Centre for Chronic Inflammatory Disease, Institute for Molecular Biosciences, University of Queensland , Brisbane ,
ORCID: Sester, David P
Ravasi, Timothy
Hume, David A
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2006-02
Volume: 176
Issue: 4
Pages: 2219-2228
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.176.4.2219
OpenAlex: W1582648966
Cited by: 117
References: 69
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 11 · 2013: 9 · 2012: 5
FWCI: 3.24
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: JNK, macrophage development, macrophage survival, CSF-1, CSF-1 receptor, c-fms, Bcl-xL, apoptosis, cell cycle arrest, G2/M cell cycle arrest, PU.1, transcriptional regulation, macrophage differentiation, bone marrow, JNK inhibitor, SP600125, tyrosine kinase signaling, focal adhesion kinase, Rac1, scaffold proteins
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Bone Marrow Cells, Cell Differentiation, Cell Survival, Cells, Cultured, DNA, Gene Expression Regulation, Macrophages, Phosphorylation, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins, RNA, Messenger, Signal Transduction, Trans-Activators, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, JNK Mitogen-Activated Protein Kinases, Mice

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The JNK Are Important for Development and Survival of Macrophages

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