T Cell, Ig Domain, Mucin Domain-2 Gene-Deficient Mice Reveal a Novel Mechanism for the Regulation of Th2 Immune Responses and Airway Inflammation
Open accessAbstract
The development of asthma and other atopic diseases is influenced by cytokines produced by Th2 effector T cells. How effector T cell responses are regulated once these cell populations are established remains unclear. The recently described T cell and airway phenotype regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically associated with Th2 cytokine production and Th2-dependent immune responses. In this study, we report the phenotype of the TIM-2 gene-deficient mouse, and demonstrate exacerbated lung inflammation in an airway atopic response model. Immune responses in the TIM-2-deficient mouse reveal disregulated expression of Th2 cytokines, and adoptive transfer experiments show that the T cell compartment is responsible for the heightened inflammatory phenotype. These studies show that TIM-2 is a novel and critical regulator of effector T cell activity.
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An IRE is located at +51 to +94 from the 5′ cap in the 5′-UTR of Alzheimer amyloid precursor protein.
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From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [260]
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From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [260]
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- Authors
- Rennert, P. D., Ichimura, T., Sizing, I. D., Bailly, V., Li, Z., Rennard, R., McCoon, P., Pablo, L., Miklasz, S., Tarilonte, L., & Bonventre, J. V.
- Affiliations
- Biogen (United States) (US)
- Brigham and Women's Hospital (US)
- Biogen-Idec , Cambridge, MA 01746
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-01
- Volume
- 177
- Issue
- 7
- Pages
- 4311-4321
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2154455240
- Cited by
- 67
- References
- 25
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-72381, DK-39773, DK-46267, R01DK046267, R01DK072381)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th2 immune response, airway inflammation, asthma, atopic diseases, Th2 cytokines, effector T cells, adoptive transfer, gene-deficient mice, lung inflammation
- MeSH terms
- Animals, Asthma, Cell Differentiation, Disease Models, Animal, Flow Cytometry, Inflammation, Lung, Membrane Proteins, Mice, Inbred BALB C, Mice, Mutant Strains, Ovalbumin, Recombinant Fusion Proteins, T-Lymphocytes, Th2 Cells, Reverse Transcriptase Polymerase Chain Reaction, Mice, Rats
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