Cited by 149Respiratory viral infections researchImmunotherapy and Immune Responsesinterferon and immune responses

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Plasmacytoid Dendritic Cells Limit Viral Replication, Pulmonary Inflammation, and Airway Hyperresponsiveness in Respiratory Syncytial Virus Infection

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Wang, Hongwei, Peters, Nina, Schwarze, Jürgen·2006·The Journal of Immunology

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Abstract

Plasmacytoid dendritic cells (pDC), as major producers of IFN-α, are thought not only to be pivotal in antiviral immunity, but also to limit allergic inflammation. In this study, we delineate the role of pDC in a mouse model of respiratory syncytial virus (RSV)-induced airway inflammation. Bone marrow-derived pDC generated high levels of IFN-α upon RSV infection, and the percentage of pDC expressing MHC class II and maturation-associated costimulatory molecules was increased. However, their weak Ag-presenting capacity was not enhanced. Furthermore, pDC induced marked levels of IL-10 in T cell cultures irrespective of infection. In vivo, numbers of pDC in the lung increased early after RSV infection and remained elevated throughout the inflammatory phase and the resolution phase of infection. Depletion of pDC resulted in increases in peak RSV titers, pulmonary inflammation, and airway hyperresponsiveness. In contrast, adoptive transfer of activated pDC to the airways reduced RSV copy numbers. In conclusion, RSV infection induces activation of murine pDC with robust IFN-α production, limiting replication and accelerating elimination of RSV. In addition to this innate response, pDC also may play an immune regulatory role in reducing pulmonary inflammation and inhibiting the development of airway hyperresponsiveness.

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Authors: Wang, H., Peters, N., & Schwarze, J.
Affiliations: Imperial College London (GB)
Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, Imperial College London , London ,
ORCID: Wang, Hongwei
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2006-11-01
Volume: 177
Issue: 9
Pages: 6263-6270
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.177.9.6263
OpenAlex: W1661249704
Cited by: 149
References: 42
Citations by year: 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 5 · 2017: 12 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 11 · 2012: 9
FWCI: 9.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Amgen
Wellcome Trust (067454)
Topics: Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: plasmacytoid dendritic cells, respiratory syncytial virus, interferon-alpha, airway hyperresponsiveness, lung inflammation, viral replication, IL-10, dendritic cell maturation, MHC class II, antigen presentation, pDC depletion, adoptive transfer, innate immunity, immune regulation
MeSH terms: Animals, Dendritic Cells, Humans, Pneumonia, Viral, T-Lymphocytes, Virus Replication, Interferon-alpha, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, CD11c Antigen, Cell Proliferation, Mice

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Plasmacytoid Dendritic Cells Limit Viral Replication, Pulmonary Inflammation, and Airway Hyperresponsiveness in Respiratory Syncytial Virus Infection

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