The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis
Abstract
Though much is known about the function of T lymphocytes in the adaptive immune response against Mycobacterium tuberculosis, comparably little is understood regarding the corresponding role of B lymphocytes. Indicating B cells as components of lymphoid neogenesis during pulmonary tuberculosis, we have identified ectopic germinal centers (GCs) in the lungs of infected mice. B cells in these pulmonary lymphoid aggregates express peanut agglutinin and GL7, two markers of GC B cells, as well as CXCR5, and migrate in response to the lymphoid-associated chemokine CXCL13 ex vivo. CXCL13 is negatively regulated by the presence of B cells, as its production is elevated in lungs of B cell-deficient (B cell−/−) mice. Upon aerosol with 100 CFU of M. tuberculosis Erdman, B cell−/− mice have exacerbated immunopathology corresponding with elevated pulmonary recruitment of neutrophils. Infected B cell−/− mice show increased production of IL-10 in the lungs, whereas IFN-γ, TNF-α, and IL-10R remain unchanged from wild type. B cell−/− mice have enhanced susceptibility to infection when aerogenically challenged with 300 CFU of M. tuberculosis corresponding with elevated bacterial burden in the lungs but not in the spleen or liver. Adoptive transfer of B cells complements the phenotypes of B cell−/− mice, confirming a role for B cells in both modulation of the host response and optimal containment of the tubercle bacillus. As components of ectopic GCs, moderators of inflammatory progression, and enhancers of local immunity against bacterial challenge, B cells may have a greater role in the host defense against M. tuberculosis than previously thought.
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Cites
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Neutrophils and immunity: challenges and opportunities
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A chemokine-driven positive feedback loop organizes lymphoid follicles
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Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
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Lymphoid organ development: from ontogeny to neogenesis
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How can immunology contribute to the control of tuberculosis?
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Cited by
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
Ectopic lymphoid tissues and local immunity
Carragher, D. M., Rangel-Moreno, J., & Randall, T. D. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.12.004 · Cited by 274
Mycobacterial PE/PPE Proteins at the Host-Pathogen Interface
Sampson, S. L. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/497203 · Cited by 260
CD4 + T Cells: Guardians of the Phagosome
Tubo, N. J., & Jenkins, M. K. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00097-13 · Cited by 105
Metadata
- Authors
- Maglione, P. J., Xu, J., & Chan, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-06-01
- Volume
- 178
- Issue
- 11
- Pages
- 7222-7234
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1852410481
- Cited by
- 307
- References
- 45
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis. https://app.cochat.ai/papers/10.4049/jimmunol.178.11.7222
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- Maglione, P. J., Xu, J., & Chan, J. (2007). B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.11.7222
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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