The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Cutting Edge: Regulatory T Cells Prevent Efficient Clearance of Mycobacterium tuberculosis
Abstract
Mycobacterium tuberculosis remains one of the top microbial killers of humans causing ∼2 million deaths annually. More than 90% of the 2 billion individuals infected never develop active disease, indicating that the immune system is able to generate mechanisms that control infection. However, the immune response generally fails to achieve sterile clearance of bacilli. Using adoptive cell transfer into C57BL/6J-Rag1tm1Mom mice (Rag1−/−), we show that regulatory T cells prevent eradication of tubercle bacilli by suppressing an otherwise efficient CD4+ T cell response. This protective CD4+ T cell response was not correlated with increased numbers of IFN-γ- or TNF-α-expressing cells or general expression levels of IFN-γ or inducible NO synthase in infected organs compared with wild-type C57BL/6 animals. Furthermore, suppression of protection by cotransferred regulatory T cells was neither accompanied by a general increase of IL-10 expression nor by higher numbers of IL-10-producing CD4+ T cells.
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Cites
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Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
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CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
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Cited by
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Self-citationCell-Mediated Immune Responses in Tuberculosis
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The development and function of regulatory T cells
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Metadata
- Authors
- Kursar, M., Koch, M., Mittrücker, H.-W., Nouailles, G., Bonhagen, K., Kamradt, T., & Kaufmann, S. H. E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03-01
- Volume
- 178
- Issue
- 5
- Pages
- 2661-2665
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1744462629
- Cited by
- 290
- References
- 24
- FWCI
- 18.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kursar, M., Koch, M., Mittrücker, H.-W., Nouailles, G., Bonhagen, K., Kamradt, T., & Kaufmann, S. H. E. (2007). Cutting Edge: Regulatory T Cells Prevent Efficient Clearance of Mycobacterium tuberculosis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.5.2661
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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