The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice
Open accessAbstract
Boosting bacillus Calmette-Guérin (BCG)-primed mice with a recombinant adenovirus expressing Mycobacterium tuberculosis Ag 85A by different administration routes has very different effects on protection against aerosol challenge with M. tuberculosis. Mice boosted intradermally make very strong splenic CD4 and CD8 Th1 cytokine responses to Ag 85A, but show no change in lung mycobacterial burden over BCG primed animals. In contrast, intranasally boosted mice show greatly reduced mycobacterial burden and make a much weaker splenic response but a very strong lung CD4 and CD8 response to Ag 85A and an increased response to purified protein derivative. This effect is associated with the presence in the lung of multifunctional T cells, with high median fluorescence intensity and integrated median fluorescence intensity for IFN-γ, IL-2, and TNF. In contrast, mice immunized with BCG alone have few Ag-specific cells in the lung and a low proportion of multifunctional cells, although individual cells have high median fluorescence intensity. Successful immunization regimes appear to induce Ag-specific cells with abundant intracellular cytokine staining.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952 · cited 2×
“Abundant evidence indicates that tissue resident populations of T cells specific for other Ags have the properties of effector memory or activated effectors (21, 25, 26) and even central memory cells that enter the lung acquire effector memory phenotype and function (27).”
BackgroundHIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
Betts, M. R. (2006) · Blood · doi:10.1182/blood-2005-12-4818 · Cited by 1,826
Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel-Moreno, J., Cilley, G. E., Shen, F., Eaton, S. M., Gaffen, S. L., Swain, S. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1449 · Cited by 1,439
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Darrah, P. A., Patel, D. T., De Luca, P. M., Lindsay, R. W. B., Davey, D. F., Flynn, B. J., Hoff, S. T., Andersen, P., Reed, S. G., Morris, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1592 · Cited by 1,378
Mogues, T., Goodrich, M. E., Ryan, L., LaCourse, R., & North, R. J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.271 · Cited by 558
Goonetilleke, N. P., McShane, H., Hannan, C. M., Anderson, R. J., Brookes, R. H., & Hill, A. V. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1602 · Cited by 360
Self-citationWang, J., Thorson, L., Stokes, R. W., Santosuosso, M., Huygen, K., Zganiacz, A., Hitt, M., & Xing, Z. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6357 · Cited by 359
T-cell homing specificity and plasticity: new concepts and future challenges
Mora, J. R., & von Andrian, U. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.03.007 · Cited by 307
Cutting Edge: Regulatory T Cells Prevent Efficient Clearance of Mycobacterium tuberculosis
Kursar, M., Koch, M., Mittrücker, H.-W., Nouailles, G., Bonhagen, K., Kamradt, T., & Kaufmann, S. H. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2661 · Cited by 290
Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
Hinchey, J., Lee, S., Jeon, B. Y., Basaraba, R. J., Venkataswamy, M. M., Chen, B., Chan, J., Braunstein, M., Orme, I. M., Derrick, S. C., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31947 · Cited by 290
Cited by
Day, C. L., Abrahams, D. A., Lerumo, L., Janse van Rensburg, E., Stone, L., O’rie, T., Pienaar, B., de Kock, M., Kaplan, G., Mahomed, H., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101122 · Cited by 346
Ballester, M., Nembrini, C., Dhar, N., de Titta, A., de Piano, C., Pasquier, M., Simeoni, E., van der Vlies, A. J., McKinney, J. D., Hubbell, J. A., et al. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.07.039 · Cited by 130
Immune memory: the basics and how to trigger an efficient long-term immune memory
Beverley, P. C. L. (2010) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.09.008 · Cited by 4
Self-citation
Metadata
- Authors
- Forbes, E. K., Sander, C., Ronan, E. O., McShane, H., Hill, A. V. S., Beverley, P. C. L., & Tchilian, E. Z.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-01
- Volume
- 181
- Issue
- 7
- Pages
- 4955-4964
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2107876252
- Cited by
- 286
- References
- 28
- FWCI
- 17.05
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice. https://app.cochat.ai/papers/10.4049/jimmunol.181.7.4955
- The paper
- Forbes, E. K., Sander, C., Ronan, E. O., McShane, H., Hill, A. V. S., Beverley, P. C. L., & Tchilian, E. Z. (2008). Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice. The Journal of Immunology. https://doi.org/10.4049/jimmunol.181.7.4955
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
