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Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells
Open accessAbstract
TNFR2 is predominantly expressed by a subset of human and mouse CD4+CD25+FoxP3+ T regulatory cells (Tregs). In this study, we characterized the phenotype and function of TNFR2+ Tregs in peripheral lymphoid tissues of normal and tumor-bearing C57BL/6 mice. We found that TNFR2 was expressed on 30–40% of the Tregs of the peripheral activated/memory subset that were most highly suppressive. In contrast, TNFR2− Tregs exhibited the phenotype of naive cells and only had minimal suppressive activity. Although not typically considered to be Tregs, CD4+CD25−TNFR2+ cells nevertheless possessed moderate suppressive activity. Strikingly, the suppressive activity of TNFR2+ Tregs was considerably more potent than that of reportedly highly suppressive CD103+ Tregs. In the Lewis lung carcinoma model, more highly suppressive TNFR2+ Tregs accumulated intratumorally than in the periphery. Thus, TNFR2 identifies a unique subset of mouse Tregs with an activated/memory phenotype and maximal suppressive activity that may account for tumor-infiltrating lymphocyte-mediated immune evasion by tumors.
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Metadata
- Authors
- Chen, X., Subleski, J. J., Kopf, H., Howard, O. M. Z., Männel, D. N., & Oppenheim, J. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05
- Volume
- 180
- Issue
- 10
- Pages
- 6467-6471
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2162124617
- Cited by
- 335
- References
- 2
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Chen, X., Subleski, J. J., Kopf, H., Howard, O. M. Z., Männel, D. N., & Oppenheim, J. J. (2008). Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.180.10.6467
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