TNF and ROS crosstalk in inflammation

Blaser, Heiko; Dostert, Catherine; Mak, Tak W.; Brenner, Dirk

doi:10.1016/j.tcb.2015.12.002

Cited by 1,008Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNF-κB Signaling Pathways

TNF and ROS crosstalk in inflammation

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Blaser, Heiko, Dostert, Catherine, Mak, Tak W., Brenner, Dirk·2016·Trends in Cell Biology

DOI 10.1016/j.tcb.2015.12.002

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Abstract

Tumor necrosis factor (TNF) is tremendously important for mammalian immunity and cellular homeostasis. The role of TNF as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. Although these findings have revealed much about the direct impact of TNF on the regulation of NF-κB and JNK, there is now rising interest in understanding the emerging function of TNF as a regulator of the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In this review we summarize work aimed at defining the role of TNF in the control of ROS/RNS signaling that influences innate immune cells under both physiological and inflammatory conditions.

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Chronic inflammatory environment is also beneficial for the formation of free radicals such as reactive oxygen species (ROS), exacerbating β cells damage and yielding a positive feedback circle with the secretion of more detrimental cytokines to trigger further damage to β cells.
“Besides, chronic inflammatory environment is also beneficial for the formation of free radicals such as reactive oxygen species (ROS), exacerbating β cells damage and yielding a positive feedback circle with the secretion of more detrimental cytokines to trigger further damage to β cells (80).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [80]

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Redox Regulation of Tumor Necrosis Factor Signaling
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Authors: Blaser, H., Dostert, C., Mak, T. W., & Brenner, D.
Affiliations: University Health Network (CA)
Luxembourg Institute of Health (LU)
University of Southern Denmark (DK)
Corresponding author: Brenner, Dirk
ORCID: Mak, Tak W.
Brenner, Dirk
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2016-04
Volume: 26
Issue: 4
Pages: 249-261
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2015.12.002
OpenAlex: W2236270374
Cited by: 1,008
References: 131
Citations by year: 2026: 75 · 2025: 89 · 2024: 114 · 2023: 134 · 2022: 147 · 2021: 143 · 2020: 110 · 2019: 73 · 2018: 53 · 2017: 51 · 2016: 19
FWCI: 6.29
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: Fonds National de la Recherche Luxembourg (C15/BM/10355103)
Canadian Institutes of Health Research (S2B141816)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: TNF-α, reactive oxygen species, reactive nitrogen species, inflammation, innate immunity, NF-κB signaling, JNK signaling, apoptosis, necroptosis, cell survival, innate immune cells
MeSH terms: Animals, Cell Survival, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Inflammation, Lymphocytes, Necrosis, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Apoptosis, Reactive Oxygen Species, Reactive Nitrogen Species, MAP Kinase Kinase 4

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