Cited by 446T-cell and B-cell ImmunologyRheumatoid Arthritis Research and TherapiesPsoriasis: Treatment and Pathogenesis

TNF receptor 2 pathway: drug target for autoimmune diseases

Faustman, Denise, Davis, Miriam·2010·Nature Reviews Drug Discovery

Abstract

Although drug development has advanced for autoimmune diseases, many current therapies are hampered by adverse effects and the frequent destruction or inactivation of healthy cells in addition to pathological cells. Targeted autoimmune therapies capable of eradicating the rare autoreactive immune cells that are responsible for the attack on the body's own cells are yet to be identified. This Review presents a new emerging approach aimed at selectively destroying autoreactive immune cells by specific activation of tumour necrosis factor receptor 2 (TNFR2), which is found on autoreactive and normal T lymphocytes, with the potential of avoiding or reducing the toxicity observed with existing therapies.

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Crossref · 10.1038/nrd3030

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149 of 149 references verified0 citation errors · 0 not checkable

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  • Binding of TNFR1 induces apoptotic signaling, while TNFR2 activation results in nuclear entry of NF-kB and promotes transcription of pro-survival genes.

    “Binding of TNFR1 induces apoptotic signaling while TNFR2 activation results in nuclear entry of NF-kB and promotes transcription of pro-survival genes [140, 142].”

    From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [142]

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Authors
Faustman, D., & Davis, M.
Affiliations
Harvard University (US)
Corresponding author
Faustman, Denise
Venue
Nature Reviews Drug Discovery
Published
2010-05-21
Volume
9
Issue
6
Pages
482-493
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W2038729399
Cited by
446
References
149
Citations by year
2026: 17 · 2025: 28 · 2024: 23 · 2023: 20 · 2022: 28 · 2021: 33 · 2020: 24 · 2019: 33 · 2018: 27 · 2017: 29 · 2016: 28 · 2015: 39 · 2014: 33 · 2013: 34 · 2012: 22
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
TNF receptor 2, autoimmune disease, autoreactive T cells, targeted immunotherapy, therapeutic target, T cell activation
MeSH terms
Autoimmune Diseases, Humans, Signal Transduction, NF-kappa B, CD3 Complex, Receptor Cross-Talk, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II

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