TNF receptor 2 pathway: drug target for autoimmune diseases
Abstract
Although drug development has advanced for autoimmune diseases, many current therapies are hampered by adverse effects and the frequent destruction or inactivation of healthy cells in addition to pathological cells. Targeted autoimmune therapies capable of eradicating the rare autoreactive immune cells that are responsible for the attack on the body's own cells are yet to be identified. This Review presents a new emerging approach aimed at selectively destroying autoreactive immune cells by specific activation of tumour necrosis factor receptor 2 (TNFR2), which is found on autoreactive and normal T lymphocytes, with the potential of avoiding or reducing the toxicity observed with existing therapies.
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Binding of TNFR1 induces apoptotic signaling, while TNFR2 activation results in nuclear entry of NF-kB and promotes transcription of pro-survival genes.
“Binding of TNFR1 induces apoptotic signaling while TNFR2 activation results in nuclear entry of NF-kB and promotes transcription of pro-survival genes [140, 142].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [142]
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532 · see citing works
Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis
Lipsky, P. E., van der Heijde, D. M. F. M., Clair, E. W. S., Fürst, D. E., Breedveld, F. C., Kalden, J. R., Smolen, J. S., Weisman, M. H., Emery, P., Feldmann, M., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011303432202 · Cited by 2,990 · see citing works
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793 · see citing works
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738 · see citing works
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,486 · see citing works
The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,024 · see citing works
Tumour necrosis factor and cancer
Balkwill, F. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2628 · Cited by 1,925 · see citing works
Breedveld, F. C., Weisman, M. H., Kavanaugh, A. F., Cohen, S. B., Pavelká, K., van Vollenhoven, R., Sharp, J. T., Perez, J. L., & Spencer-Green, G. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21519 · Cited by 1,786 · see citing works
Klareskog, L., van der Heijde, D., de Jager, J. P., Gough, A., Kalden, J., Malaise, M., Mola, E. M., Pavelka, K., Sany, J., Settas, L., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15640-7 · Cited by 1,751 · see citing works
Etanercept Therapy in Rheumatoid Arthritis
Moreland, L. W., Schiff, M. H., Baumgartner, S. W., Tindall, E. A., Fleischmann, R. M., Bulpitt, K. J., Weaver, A. L., Keystone, E. C., Furst, D. E., Mease, P. J., et al. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00004 · Cited by 1,403 · see citing works
Grell, M., Douni, E. K., Wajant, H., Löhden, M., Clauss, M. A., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G. A., Pfizenmaier, K., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90192-2 · Cited by 1,328 · see citing works
A novel domain within the 55 kd TNF receptor signals cell death
Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290 · see citing works
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222 · see citing works
INFLIXIMAB AND METHOTREXATE IN THE TREATMENT OF RHEUMATOID ARTHRITIS
Ipsky, P. E. E. L., Illiam, E. W., Urst, D. A. E. F., Reedveld, C. B., Oachim, J., Alden, R. K., Osef, J., Molen, S. S., Eisman, M. I. W., Mery, P. A. E., et al. (2000) · Cited by 1,155 · see citing works
Induction of apoptosis in mature T cells by tumour necrosis factor
Zheng, L., Fisher, G. H., Miller, R. E., Peschon, J. J., Lynch, D. H., & Lenardo, M. J. (1995) · Nature · doi:10.1038/377348a0 · Cited by 1,116 · see citing works
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
Keymeulen, B., Vandemeulebroucke, E., Ziegler, A. G., Mathieu, C., Kaufman, L., Hale, G., Gorus, F., Goldman, M., Walter, M., Candon, S., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043980 · Cited by 1,099 · see citing works
Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994) · Cell · doi:10.1016/0092-8674(94)90532-0 · Cited by 1,054 · see citing works
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40
Rothe, M., Sarma, V. J., Dixit, V. M., & Goeddel, D. V. (1995) · Science · doi:10.1126/science.7544915 · Cited by 1,050 · see citing works
lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis
Lenardo, M. J. (1991) · Nature · doi:10.1038/353858a0 · Cited by 1,021 · see citing works
TNFα promotes proliferation of oligodendrocyte progenitors and remyelination
Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works
The role of TNF superfamily members in T-cell function and diseases
Croft, M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2526 · Cited by 924 · see citing works
Circuitry of nuclear factor κB signaling
Hoffmann, A., & Baltimore, D. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00375.x · Cited by 907 · see citing works
Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial
Chaudhari, U., Romano, P., Mulcahy, L., Dooley, L. T., Dg, B., & Gottlieb, A. B. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04954-0 · Cited by 888 · see citing works
McCoy, M. K., & Tansey, M. G. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-45 · Cited by 843 · see citing works
NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses
Watanabe, T., Kitani, A., Murray, P. J., & Strober, W. (2004) · Nature Immunology · doi:10.1038/ni1092 · Cited by 839 · see citing works
<i>TRAF1–C5</i> as a Risk Locus for Rheumatoid Arthritis — A Genomewide Study
Plenge, R. M., Seielstad, M., Padyukov, L., Lee, A. T., Remmers, E. F., Ding, B., Liew, A., Khalili, H., Chandrasekaran, A., Davies, L. R. L., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073491 · Cited by 823 · see citing works
The two different receptors for tumor necrosis factor mediate distinct cellular responses.
Tartaglia, L. A., Weber, R. F., Figari, I. S., Reynolds, C. P., Palladino, M. A., & Goeddel, D. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9292 · Cited by 792 · see citing works
Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing
Maeda, S., Hsu, L.-C., Liu, H., Bankston, L. A., Iimura, M., Kagnoff, M. F., Eckmann, L., & Karin, M. (2005) · Science · doi:10.1126/science.1103685 · Cited by 748 · see citing works
Herold, K. C., Gitelman, S. E., Masharani, U. B., Hagopian, W., Bisikirska, B. C., DONALDSON, D. L., Rother, K. I., Diamond, B. E., Harlan, D. M., & Bluestone, J. A. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1763 · Cited by 631 · see citing works
Small-Molecule Inhibition of TNF-α
He, M. M., Stroustrup, A., Oslob, J. D., Flanagan, W. M., Braisted, A. C., Whitty, A., Cancilla, M. T., Wang, J., Lugovskoy, A. A., Yoburn, J. C., et al. (2005) · Science · doi:10.1126/science.1116304 · Cited by 626 · see citing works
Fontaine, V. K., Mohand‐Saïd, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., & Eisel, U. L. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-j0001.2002 · Cited by 587 · see citing works
Death receptor signal transducers: nodes of coordination in immune signaling networks
Wilson, N., Dixit, V., & Ashkenazi, A. (2009) · Nature Immunology · doi:10.1038/ni.1714 · Cited by 569 · see citing works
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Li, X., Yang, Y., & Ashwell, J. D. (2002) · Nature · doi:10.1038/416345a · Cited by 452 · see citing works
Wong, F. S., Karttunen, J. T., Dumont, C., Li, W., Visintin, I., Pilip, I. M., Shastri, N., Pamer, E. G., & Janeway, C. A. (1999) · Nature Medicine · doi:10.1038/12465 · Cited by 427 · see citing works
Christianson, S. W., Shultz, L. D., & Leiter, E. H. (1993) · Diabetes · doi:10.2337/diab.42.1.44 · Cited by 427 · see citing works
Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., & Eisel, U. L. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311766200 · Cited by 424 · see citing works
The RIP kinases: crucial integrators of cellular stress
Meylan, E., & Tschopp, J. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.01.003 · Cited by 383 · see citing works
Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.
Engelmann, H., Holtmann, H., Brakebusch, C., Avni, Y. S., SAROV, I., Nophar, Y., Hadas, E., Leitner, O., & Wallach, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77330-4 · Cited by 374 · see citing works
Abbott, D. W., Wilkins, A., Asara, J. M., & Cantley, L. C. (2004) · Current Biology · doi:10.1016/j.cub.2004.12.032 · Cited by 374 · see citing works
Irwin, M. W., Mak, S. S., Mann, D. L., Qu, R., Penninger, J. M., Yan, A. T.-K., Dawood, F., Wen, W.-H., Shou, Z., & Liu, P. J. (1999) · Circulation · doi:10.1161/01.cir.99.11.1492 · Cited by 368 · see citing works
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice
Kodama, S., Kühtreiber, W. M., Fujimura, S., Dale, E. A., & Faustman, D. L. (2003) · Science · doi:10.1126/science.1088949 · Cited by 356 · see citing works
Self-citationDorman, J. S., LaPorte, R. E., Kuller, L. H., Cruickshanks, K. J., Orchard, T. J., Wagener, D. K., Becker, D. J., CAVENDER, D. E., & Drash, A. L. (1984) · Diabetes · doi:10.2337/diab.33.3.271 · Cited by 350 · see citing works
[Etanercept for therapy of rheumatoid arthritis].
Miyasaka, N. (2005) · PubMed · Cited by 345 · see citing works
Cope, A. P., Gibbons, D. L., Brennan, F. M., Feldmann, M., Aderka, D., Doherty, M., Jones, A. C., Engelmann, H., Wallach, D. S., & Maini, R. N. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780351008 · Cited by 337 · see citing works
Chen, X., Subleski, J. J., Kopf, H., Howard, O. M. Z., Männel, D. N., & Oppenheim, J. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6467 · Cited by 336 · see citing works
Karban, A. S., Okazaki, T., Panhuysen, C. I. M., Gallegos, T. F., Potter, J. J., Wilson, J., Silverberg, M. S., Duerr, R. H., Cho, J. H., Gregersen, P. K., et al. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddh008 · Cited by 335 · see citing works
Vermeire, S., Noman, M., Van Assche, G., Baert, F., Van Steen, K., Esters, N., Joossens, S., Bossuyt, X., & Rutgeerts, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00701-7 · Cited by 327 · see citing works
Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis
Diez‐Ruiz, A., Tilz, G. P., Zangerle, R., Baier‐Bitterlich, G., WACHTER, H., & Fuchs, D. (1995) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1995.tb01618.x · Cited by 306 · see citing works
Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells
Chen, L. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i20.3016 · Cited by 298 · see citing works
van Heel, D. A. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1281 · Cited by 296 · see citing works
TNF receptor superfamily‐induced cell death: redox‐dependent execution
Shen, H., & Pervaiz, S. (2006) · The FASEB Journal · doi:10.1096/fj.05-5603rev · Cited by 288 · see citing works
Fotin‐Mleczek, M., Henkler, F., Samel, D., Reichwein, M., Haußer, A., Parmryd, I., Scheurich, P., Schmid, J. A., & Wajant, H. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.13.2757 · Cited by 284 · see citing works
Regulated Commitment of TNF Receptor Signaling
Pimentel‐Muiños, F. X., & Seed, B. (1999) · Immunity · doi:10.1016/s1074-7613(00)80152-1 · Cited by 282 · see citing works
Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes
Pinkse, G. G. M., Tysma, O. M. H., van Bergen, C. A. M., Kester, M. G. D., OSSENDORP, F. A., van Veelen, P. A., Keymeulen, B., Pipeleers, D., Drijfhout, J. W., & Roep, B. O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508621102 · Cited by 277 · see citing works
TRAIL/Apo-2-ligand-induced apoptosis in human T cells
Jeremias, I., Herr, I., Böhler, T., & Debatin, K. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199801)28:01 · Cited by 265 · see citing works
Development of glomerulonephritis during anti-TNF-α therapy for rheumatoid arthritis
Stokes, M. B., Foster, K. W., Markowitz, G. S., Ebrahimi, F., Hines, W. H., Kaufman, D., Moore, B., Wolde, D. J., & D’Agati, V. D. (2005) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfh832 · Cited by 264 · see citing works
Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences
Dembić, Z., Loetscher, H., Gubler, U., et al. (1990) · Cytokine · doi:10.1016/1043-4666(90)90022-l · Cited by 263 · see citing works
Flendrie, M., Vissers, W. H. P. M., Creemers, M. C. W., et al. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1724 · Cited by 259 · see citing works
Yang, L., Lindholm, K., Konishi, Y., Li, R., & Shen, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03025.2002 · Cited by 255 · see citing works
Gabay, C., Çakır, N., Moral, F., Roux-Lombard, P., Meyer, O., Dayer, J. M., VISCHER, T. L., Yazici, H., & Guerne, P. (1997) · PubMed · Cited by 230 · see citing works
Herold, K. C., Gitelman, S., Greenbaum, C., Puck, J., Hagopian, W., Gottlieb, P., Sayre, P., Bianchine, P., Wong, E., Seyfert-Margolis, V., et al. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.04.007 · Cited by 219 · see citing works
Linkage of Faulty Major Histocompatibility Complex Class I to Autoimmune Diabetes
Faustman, D. L., Li, X., Lin, H. Y.-F., et al. (1991) · Science · doi:10.1126/science.1763324 · Cited by 214 · see citing works
Self-citationLoetscher, H., Stueber, D., Banner, D. W., Mackay, F., & Lesslauer, W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74322-1 · Cited by 202 · see citing works
Xanthoulea, S., Pasparakis, M., Kousteni, S., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040435 · Cited by 199 · see citing works
NOD2 and Crohn’s Disease: Loss or Gain of Function?
Eckmann, L., & Karin, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.004 · Cited by 185 · see citing works
Weiss, T., Grell, M., Hessabi, B., Bourteele, S., Müller, G., Scheurich, P., & Wajant, H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2398 · Cited by 184 · see citing works
Satoh, J., Seino, H., Abo, T., Tanaka, S., Shintani, S., Ohta, S., Tamura, K., Sawai, T., Nobunaga, T., & Oteki, T. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114304 · Cited by 180 · see citing works
Mechanisms of T regulatory cell function
Askenasy, N., Kaminitz, A., & Yarkoni, S. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.03.001 · Cited by 175 · see citing works
Ware, C. F., Crowe, P. D., VanArsdale, T. L., Andrews, J. L., Grayson, M. H., Jerzy, R., Smith, C. A., & Goodwin, R. G. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.12.4229 · Cited by 174 · see citing works
Anti-tumor necrosis factor-alpha therapy-induced vasculitis: case series.
Jarrett, S. J., Cunnane, G., Conaghan, P. G., Bingham, S. J., Buch, M. H., Quinn, M. A., & Emery, P. (2003) · PubMed · Cited by 174 · see citing works
Lantz, M., Malik, S., Slevin, M. L., & Olsson, I. (1990) · Cytokine · doi:10.1016/1043-4666(90)90048-x · Cited by 170 · see citing works
Reversal of established autoimmune diabetes by restoration of endogenous β cell function
Ryu, S., Kodama, S., Ryu, K., Schoenfeld, D., & Faustman, D. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12335 · Cited by 167 · see citing works
Self-citationChristen, U., Wolfe, T., Möhrle, U., Hughes, A., Rodrigo, E., Green, E. A., Flavell, R., & von Herrath, M. (2001) · Journal of Immunology · doi:10.4049/jimmunol.166.12.7023 · Cited by 161 · see citing works
Sheehan, K. C. F., Pinckard, J. K., Arthur, C. D., Dehner, L. P., Goeddel, D. V., & Schreiber, R. D. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.607 · Cited by 158 · see citing works
Grewal, I. S., Grewal, K. D., Wong, F. S., Picarella, D., Janeway, C. A., & Flavell, R. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1963 · Cited by 158 · see citing works
Sashio, H., Tamura, K., Ito, R., et al. (2002) · Immunogenetics · doi:10.1007/s00251-001-0423-7 · Cited by 153 · see citing works
Monden, Y., Kubota, T., Inoue, T., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00166.2007 · Cited by 151 · see citing works
Nagar, M., Jacob‐Hirsch, J., Vernitsky, H., Berkun, Y., Ben‐Horin, S., Amariglio, N., Bank, I., Kloog, Y., Rechavi, G., & Goldstein, I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902070 · Cited by 150 · see citing works
Pierik, M. J., Vermeire, S., Steen, K. V., Joossens, S. B. A., Claessens, G., VLIETINCK, R. F., & Rutgeerts, P. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01946.x · Cited by 149 · see citing works
Yagi, H., Matsumoto, M., Kunimoto, K., et al. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220931 · Cited by 143 · see citing works
Gehr, G., Gentz, R., Brockhaus, M., Loetscher, H., & Lesslauer, W. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.3.911 · Cited by 142 · see citing works
Weiß, T., Grell, M., Siemienski, K., Mühlenbeck, F., Dürkop, H., Pfizenmaier, K., Scheurich, P., & Wajant, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.3136 · Cited by 134 · see citing works
Requirement for TNF-α and IL-1α in Fetal Thymocyte Commitment and Differentiation
Zúñiga‐Pflücker, J. C., Jiang, D., & Lenardo, M. J. (1995) · Science · doi:10.1126/science.7541554 · Cited by 130 · see citing works
NOD Mice Are Defective in Proteasome Production and Activation of NF-κB
Hayashi, T., & Faustman, D. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8646 · Cited by 127 · see citing works
Self-citationDouni, E. K., & Kollias, G. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1343 · Cited by 127 · see citing works
Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism
Ban, L., Zhang, J. Y., Wang, L., Kühtreiber, W. M., Burger, D., & Faustman, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803429105 · Cited by 127 · see citing works
Self-citationKary, S., Worm, M., Audring, H., Huscher, D., Renelt, M., Sörensen, H., Ständer, E., Maaß, U., Lee, H., Sterry, W., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.037424 · Cited by 125 · see citing works
Leukocytoclastic vasculitis due to etanercept.
Galaria, N. A., Werth, V. P., & Schumacher, H. R. (2000) · PubMed · Cited by 123 · see citing works
Komata, T., Tsuchiya, N., Matsushita, M., Hagiwara, K., & Tokunaga, K. (1999) · Tissue Antigens · doi:10.1034/j.1399-0039.1999.530602.x · Cited by 123 · see citing works
PKC Phosphorylation of TRAF2 Mediates IKKα/β Recruitment and K63-Linked Polyubiquitination
Li, S., Wang, L., & Dorf, M. E. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.11.023 · Cited by 116 · see citing works
Tumor necrosis factor activities and cancer therapy — A perspective
Sidhu, R. S., & Bollon, A. P. (1993) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(93)90037-e · Cited by 114 · see citing works
Function and Regulation of Tumor Necrosis Factor Receptor Type 2
Carpentier, I., Coornaert, B., & Beyaert, R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364694 · Cited by 112 · see citing works
Reversal of Diabetes in Non-Obese Diabetic Mice Without Spleen Cell-Derived ß Cell Regeneration
Chong, A. S., Shen, J., Tao, J., et al. (2006) · Science · doi:10.1126/science.1123510 · Cited by 111 · see citing works
Nishio, J., Gaglia, J. L., Turvey, S. E., et al. (2006) · Science · doi:10.1126/science.1124004 · Cited by 111 · see citing works
IKK-2 is required for TNF-α-induced invasion and proliferation of human mesenchymal stem cells
Böcker, W., Docheva, D., Prall, W. C., Egea, V., Pappou, E. P., Roßmann, O., Popov, C., Mutschler, W., Ries, C., & Schieker, M. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0378-3 · Cited by 107 · see citing works
Psoriasiform Eruption Induced by Infliximab
Verea, M. M., del Pozo, J., Yebra-Pimentel, M. T., Porta, A., & Fonseca, E. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1c477 · Cited by 103 · see citing works
Immunological Reversal of Autoimmune Diabetes Without Hematopoietic Replacement of ß Cells
Suri, A., Calderón, B., Esparza, T. J., et al. (2006) · Science · doi:10.1126/science.1123500 · Cited by 101 · see citing works
Shen, Y., Li, R., & Shiosaki, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3550 · Cited by 99 · see citing works
Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer
Kretschmer, K., Apostolou, I., Jaeckel, E., et al. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00411.x · Cited by 98 · see citing works
Kodama, S., Davis, M., & Faustman, D. L. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5022-6 · Cited by 96 · see citing works
Self-citationKrippner‐Heidenreich, A., Tübing, F., Bryde, S., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207399200 · Cited by 94 · see citing works
Deng, G. Y., MUIR, A. B., Maclaren, N. K., et al. (1995) · PubMed · Cited by 88 · see citing works
Till, A., Rosenstiel, P. C., Krippner‐Heidenreich, A., Mascheretti-Croucher, S., Croucher, P. J. P., Schäfer, H., Scheurich, P., Seegert, D., & Schreiber, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411541200 · Cited by 86 · see citing works
TNF signaling: early events and phosphorylation.
Ihnatko, R., & Kubes, M. (2007) · PubMed · Cited by 85 · see citing works
Tumor Necrosis Factor for the Treatment of Malignancies
Hieber, U., & Heim, M. (2009) · Oncology · doi:10.1159/000227329 · Cited by 82 · see citing works
Miterski, B., Böhringer, S., Klein, W., Sindern, E., Haupts, M. R., Schimrigk, S., & Epplen, J. T. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363846 · Cited by 82 · see citing works
Pustular psoriasis induced by infliximab.
Thurber, M., Feasel, A. M., Stroehlein, J., et al. (2004) · PubMed · Cited by 78 · see citing works
Dieudé, P., Petit, É., Cailleau‐Moindrault, S., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10101 · Cited by 78 · see citing works
AIMP2 promotes TNFα-dependent apoptosis via ubiquitin-mediated degradation of TRAF2
Choi, J. W., Kim, D. G., Park, M., Um, J. Y., Han, J. M., Park, S. G., Choi, E., & Kim, S. (2009) · Journal of Cell Science · doi:10.1242/jcs.049767 · Cited by 78 · see citing works
Milani, D., Zauli, G., Rimondi, E., Celeghini, C., Marmiroli, S., Narducci, P., Capitani, S., & Secchiero, P. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01805.x · Cited by 77 · see citing works
Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant
Sadelain, M., Qin, H.-Y., SUMOSKI, W., Parfrey, N. A., Singh, B., & Rabinovitch, A. (1990) · Journal of Autoimmunity · doi:10.1016/s0896-8411(05)80034-4 · Cited by 77 · see citing works
In vivo apoptosis of diabetogenic T cells in NOD mice by IFN- /TNF-
Qin, H. (2004) · International Immunology · doi:10.1093/intimm/dxh173 · Cited by 75 · see citing works
Mukai, Y., Shibata, H., Nakamura, T., Yoshioka, Y., Abe, Y., Nomura, T., Taniai, M., Ohta, T., Ikemizu, S., Nakagawa, S., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.053 · Cited by 71 · see citing works
Psoriatic lesions induced by antitumour necrosis factor-alpha treatment: two cases
Dereure, O., Guillot, B., Jørgensen, C., Cohen, J.-D., Combes, B., & Guilhou, J. J. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06107.x · Cited by 71 · see citing works
Hayashi, T., & Faustman, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5238 · Cited by 70 · see citing works
Self-citationC3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L
Fournel, S., Wieckowski, S., Sun, W., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio746 · Cited by 69 · see citing works
Polymorphisms in TNFA and TNFR2 affect outcome of unrelated bone marrow transplantation
Ishikawa, Y., Kashiwase, K., Akaza, T., et al. (2002) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703409 · Cited by 61 · see citing works
Mechanisms of Sex Differences in TNFR2-Mediated Cardioprotection
Wang, M., Crisostomo, P. R., Markel, T. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.756890 · Cited by 60 · see citing works
Dopp, J. M., Sarafian, T. A., Spinella, F. M., Kahn, M. A., Shau, H., & de Vellis, J. (2002) · Neurochemical Research · doi:10.1023/a:1021608724117 · Cited by 57 · see citing works
Welborn, M. B., Zee, K. V., Edwards, P. D., Pruitt, J. H., Kaibara, A., Vauthey, J., Rogy, M. A., Castleman, W. L., Lowry, S. F., Kenney, J. S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.1.165 · Cited by 56 · see citing works
Study of functional variants of the BANK1 gene in rheumatoid arthritis
Orozco, G., Abelson, A.-K., González-Gay, M. Á., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24244 · Cited by 55 · see citing works
Tack, C. J., Kleijwegt, F. S., van Riel, P. L. C. M., & Roep, B. O. (2009) · Diabetologia · doi:10.1007/s00125-009-1381-0 · Cited by 54 · see citing works
Krause, S., Kuckelkorn, U., Dörner, T., et al. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.045930 · Cited by 54 · see citing works
Levine, A., Shamir, R., Wine, E., Weiss, B., Karban, A. S., Shaoul, R. R., Reif, S. S., Yakir, B., Friedlander, M., Kaniel, Y., et al. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41737.x · Cited by 53 · see citing works
NFκB Polymorphisms and susceptibility to type 1 diabetes
Hegazy, D., O'Reilly, D. D., Yang, B. M., et al. (2001) · Genes and Immunity · doi:10.1038/sj.gene.6363776 · Cited by 51 · see citing works
Vercammen, D., Vandenabeele, P., Declercq, W., de Craen, M. V., Grooten, J., & Fiers, W. C. (1995) · Cytokine · doi:10.1006/cyto.1995.0063 · Cited by 48 · see citing works
Yan, G., Fu, Y., & Faustman, D. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.6.3068 · Cited by 47 · see citing works
Self-citationGrech, A. P., Gardam, S., Chan, T. D., Quinn, R., Gonzales, R., Basten, A., & Brink, R. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504849200 · Cited by 47 · see citing works
Chatzikyriakidou, A., Georgiou, I. A., Voulgari, P. V., et al. (2009) · PubMed · Cited by 41 · see citing works
Reversal of Sjögren's-like syndrome in non-obese diabetic mice
Tran, S. D., Kodama, S., Lodde, B. M., Szalayova, I., Key, S., Khalili, S., Faustman, D. L., & Mezey, É. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.064030 · Cited by 39 · see citing works
Self-citationSempowski, G. D., Rhein, M. E., Scearce, R. M., & Haynes, B. F. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200211)32:11 · Cited by 38 · see citing works
The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies
Faustman, D. L., & Davis, M. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0516-6 · Cited by 38 · see citing works
Self-citationReply to 'LMP2 expression and proteasome activity in NOD mice'
Hayashi, T., Kodama, S., & Faustman, D. L. (2000) · Nature Medicine · doi:10.1038/80353 · Cited by 35 · see citing works
Self-citationJansen, J., van der Poll, T., Levi, M. M., et al. (1995) · Journal of Clinical Immunology · doi:10.1007/bf01489489 · Cited by 35 · see citing works
Antigen Processing and Autoimmunity: Evaluation of mRNA Abundance and Function of HLA‐linked Genesa
Fu, Y., Yan, G., Shi, L., et al. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09642.x · Cited by 35 · see citing works
Increased CD8+ T Cell Apoptosis in Scleroderma Is Associated with Low Levels of NF-κB
Kessel, A., Rosner, I., Rozenbaum, M., et al. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000018060.36183.bb · Cited by 30 · see citing works
Samira, S., Ferrand, C., Peled, A., et al. (2004) · Stem Cells · doi:10.1634/stemcells.22-6-1085 · Cited by 28 · see citing works
Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse.
Li, F., Guo, J., Fu, Y., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11128 · Cited by 27 · see citing works
Rodriguez, M., Zoecklein, L. J., Papke, L. M., Gamez, J. D., Đenić, A., Macura, S. I., & Howe, C. L. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00151.x · Cited by 26 · see citing works
Linseman, D. A., McClure, M. L., Bouchard, R. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201098200 · Cited by 25 · see citing works
Biological Agents for Rheumatoid Arthritis
Klinkhoff, A. (2012) · Drugs · doi:10.2165/00003495-200464120-00001 · Cited by 22 · see citing works
Selected Contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis
Hayashi, T., & Faustman, D. L. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2804 · Cited by 17 · see citing works
Self-citationAblamunits, V. G., & Herold, K. C. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.08.290 · Cited by 16 · see citing works
Abnormal T Lymphocyte Signal Transduction in Systemic Lupus Erythematosus
Kammer, G. M., & Tsokos, G. C. (2001) · KARGER eBooks · doi:10.1159/000060555 · Cited by 15 · see citing works
Mukai, Y., Nakamura, T., Yoshioka, Y., et al. (2009) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309109004461 · Cited by 15 · see citing works
Ding, H., Cheng, H., Fu, Z., et al. (2001) · PubMed · Cited by 14 · see citing works
Warrington (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200101)44:1 · Cited by 2 · see citing works
Nagar, M., Jacob‐Hirsch, J., Vernitsky, H., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.supp.89.27 · Cited by 1 · see citing works
Shigeyama (2000) · doi:10.1002/1529-0131(200011)43:11
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Blaser, H., Dostert, C., Mak, T. W., & Brenner, D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.12.002 · Cited by 1,008 · see citing works
Regulation of tumour necrosis factor signalling: live or let die
Brenner, D., Blaser, H., & Mak, T. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3834 · Cited by 998 · see citing works
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Ward-Kavanagh, L. K., Lin, W. W., Šedý, J. R., & Ware, C. F. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.019 · Cited by 463 · see citing works
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Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409 · see citing works
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Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333 · see citing works
Bower, J. E., Greendale, G., Crosswell, A. D., Garet, D., Sternlieb, B., Ganz, P. A., Irwin, M. R., Olmstead, R., Arevalo, J., & Cole, S. W. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.019 · Cited by 283 · see citing works
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Mbalaviele, G., Novack, D. V., Schett, G., & Teitelbaum, S. L. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93356 · Cited by 251 · see citing works
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Purkayastha, S., Zhang, G., & Cai, D. (2011) · Nature Medicine · doi:10.1038/nm.2372 · Cited by 220 · see citing works
TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer
Gong, K., Guo, G., Gerber, D. E., Gao, B., Peyton, M., Huang, C., Minna, J. D., Hatanpaa, K. J., Kernstine, K., Cai, L., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96148 · Cited by 98 · see citing works
- Authors
- Faustman, D., & Davis, M.
- Affiliations
- Harvard University (US)
- Corresponding author
- Faustman, Denise
- ORCID
- Faustman, Denise
- Venue
- Nature Reviews Drug Discovery
- Published
- 2010-05-21
- Volume
- 9
- Issue
- 6
- Pages
- 482-493
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2038729399
- Cited by
- 446
- References
- 149
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 23 · 2023: 20 · 2022: 28 · 2021: 33 · 2020: 24 · 2019: 33 · 2018: 27 · 2017: 29 · 2016: 28 · 2015: 39 · 2014: 33 · 2013: 34 · 2012: 22
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- TNF receptor 2, autoimmune disease, autoreactive T cells, targeted immunotherapy, therapeutic target, T cell activation
- MeSH terms
- Autoimmune Diseases, Humans, Signal Transduction, NF-kappa B, CD3 Complex, Receptor Cross-Talk, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II
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