CoChat
Sign Up
Cited by 127Blood Coagulation and Thrombosis MechanismsRespiratory Support and MechanismsInflammation biomarkers and pathways

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

C5a and TNF-α Up-Regulate the Expression of Tissue Factor in Intra-Alveolar Neutrophils of Patients with the Acute Respiratory Distress Syndrome

Open access
Kambas, Konstantinos, Markiewski, Maciej M, Pneumatikos, Ioannis A, Rafail, Stavros S, Theodorou, Vassiliki, Konstantonis, Dimitrios, Kourtzelis, Ioannis, Doumas, Michael N, Magotti, Paola, DeAngelis, Robert A, Lambris, John D, Ritis, Konstantinos D·2008·The Journal of Immunology
DOI 10.4049/jimmunol.180.11.7368PMC PMC2673518
Open this paper in CoChat — free accountOpen PDF

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by the presence of fibrin-rich inflammatory exudates in the intra-alveolar spaces and the extensive migration of neutrophils into alveoli of the lungs. Tissue factor (TF)-dependent procoagulant properties of bronchoalveaolar lavage fluid (BALF) obtained from ARDS patients favor fibrin deposition, and are likely the result of cross-talk between inflammatory mediators and hemostatic mechanisms. However, the regulation of these interactions remains elusive. Prompted by previous findings suggesting that neutrophils, under certain inflammatory conditions, can express functional TF, we investigated the contribution of intra-alveolar neutrophils to the procoagulant properties of BALF from patients with ARDS. Our results confirm that the procoagulant properties of BALF from ARDS patients are the result of TF induction, and further indicate that BALF neutrophils are a main source of TF in intra-alveolar fluid. We also found that BALF neutrophils in these patients express significantly higher levels of TF than peripheral blood neutrophils. These results suggest that the alveolar microenvironment contributes to TF induction in ARDS. Additional experiments indicated that the ability of BALF to induce TF expression in neutrophils from healthy donors can be abolished by inhibiting C5a or TNF-α signaling, suggesting a primary role for these inflammatory mediators in the up-regulation of TF in alveolar neutrophils in ARDS. This cross-talk between inflammatory mediators and the induction of TF expression in intra-alveolar neutrophils may be a potential target for novel therapeutic strategies to limit ARDS-associated disturbances of coagulation.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4049/jimmunol.180.11.7368

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 55 references

Research works printed but not linked: 50

  1. 2004, Curr. Opin. Crit. Care, 1
  2. 2000, N. Engl. J. Med., 1301
  3. 1994, New Horiz., 566
  4. 2000, N. Engl. J. Med., 1334
  5. 2000, Am. J. Respir. Crit. Care Med., 454
  6. 2002, N. Engl. J. Med., 1281
  7. 1989, J. Clin. Invest., 695
  8. 1999, Proc. Natl. Acad. Sci. USA, 2311
  9. 2005, Circ. Res., 1233
  10. 2003, Crit. Care Med., S195
  11. 2004, Crit. Care, 453
  12. 2005, Am. J. Physiol., L807
  13. 1982, Clin. Chest Med., 35
  14. 1986, Crit. Care Clin., 405
  15. 2006, J. Immunol., 4794
  16. 1986, Am. Rev. Respir. Dis., 218
  17. 1999, Chest, 1709
  18. 1987, Am. Rev. Respir. Dis., 651
  19. 2006, Nat. Med., 682
  20. 1994, Am. J. Respir. Crit. Care Med., 818
  21. 1997, Am. J. Respir. Crit. Care Med., 945
  22. 1978, J. Clin. Invest., 649
  23. 1981, J. Exp. Med., 892
  24. 1977, J. Clin. Invest., 549
  25. 2001, J. Immunol., 6341
  26. 2001, J. Immunol., 2479
  27. 2003, Nat. Med., 458
  28. 2005, J. Am. Coll. Cardiol., 1081
  29. 2001, Methods, 402
  30. 1984, J. Histochem. Cytochem., 219
  31. 2007, Trends Immunol., 184
  32. 2007, Blood, 2423
  33. 2004, J. Pathol., 145
  34. 1995, J. Leukocyte Biol., 820
  35. 1986, N. Engl. J. Med., 547
  36. 2002, Crit. Care Med., 781
  37. 1996, J. Immunol., 4609
  38. 1981, J. Clin. Invest., 1253
  39. 1982, J. Clin. Invest., 1126
  40. 2007, Am. J. Pathol., 715
  41. 2005, Br. J. Surg., 1227
  42. 1996, J. Clin. Invest., 503
  43. 1992, Am. Rev. Respir. Dis., 1016
  44. 1995, Chest, 1303
  45. 2005, J. Immunol., 262
  46. 2000, Immunol. Rev., 195
  47. 2008, PLoS ONE, e1527
  48. 2006, PLoS ONE, e108
  49. 2003, Crit. Care Med., 1442
  50. 2003, Shock, 559

Cited by

Sorted by citations

Items 101–127 of 127

Related

See all

Metadata

Authors
Kambas, K., Markiewski, M. M., Pneumatikos, I. A., Rafail, S. S., Theodorou, V., Konstantonis, D., Kourtzelis, I., Doumas, M. N., Magotti, P., DeAngelis, R. A., Lambris, J. D., & Ritis, K. D.
Affiliations
  • Democritus University of Thrace (GR)
  • University of Pennsylvania (US)
Corresponding author
  • Kambas, Konstantinos
  • Kourtzelis, Ioannis
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2008-06-01
Volume
180
Issue
11
Pages
7368-7375
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.180.11.7368
PMC
PMC2673518
OpenAlex
W2132616983
Cited by
127
References
55
Citations by year
2026: 2 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 11 · 2021: 18 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 6 · 2013: 8 · 2012: 4
FWCI
5.63
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (AI068730)
  • National Institute of General Medical Sciences (GM-62134, R01GM062134)
  • National Institute of Allergy and Infectious Diseases (AI 068730, P01AI068730)
Topics
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
acute respiratory distress syndrome, tissue factor, neutrophils, C5a, TNF-α, procoagulant activity, bronchoalveolar lavage fluid, fibrin deposition, alveolitis, coagulation, complement signaling, inflammatory mediators
MeSH terms
Adult, Aged, Bronchoalveolar Lavage Fluid, Fibrin, Humans, Middle Aged, Neutrophils, Respiratory Distress Syndrome, Thromboplastin, Tumor Necrosis Factor-alpha, Complement C5a, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review