Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells
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Th cells can be subdivided into IFN-γ-secreting Th1, IL-4/IL-5-secreting Th2, and IL-17-secreting Th17 cells. We have evaluated the capacity of fully differentiated Th1, Th2, and Th17 cells derived from a mouse bearing a transgenic TCR specific for the gastric parietal cell antigen, H+K+-ATPase, to induce autoimmune gastritis after transfer to immunodeficient recipients. We have also determined the susceptibility of the disease induced by each of the effector T cell types to suppression by polyclonal regulatory T cells (Treg) in vivo. Each type of effector cell induced autoimmune gastritis with distinct histological patterns. Th17 cells induced the most destructive disease with cellular infiltrates composed primarily of eosinophils accompanied by high levels of serum IgE. Polyclonal Treg could suppress the capacity of Th1 cells, could moderately suppress Th2 cells, but could suppress Th17-induced disease only at early time points. The major effect of the Treg was to inhibit the expansion of the effector T cells. However, effector cells isolated from protected animals were not anergic and were fully competent to proliferate and produce effector cytokines ex vivo. The strong inhibitory effect of polyclonal Treg on the capacity of some types of differentiated effector cells to induce disease provides an experimental basis for the clinical use of polyclonal Treg in the treatment of autoimmune disease in humans.
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These observations suggest a role for Th17-cells following TGN1412-induced CRS, and are consistent with other reports of irAEs due to immunotherapy.
“These observations suggest a role for Th17-cells following TGN1412-induced CRS, and are consistent with other reports of irAEs due to immunotherapy [23, 35, 36].”
From Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm (2021) · cites this paper as [36]
The Results section ('In vitro differentiated Th1, Th2 and Th17 effectors induce AIG'; page not provided) shows that transferred Th17 cells induced autoimmune gastritis in mice, supporting a general role for Th17 cells in inflammatory disease. The paper does not study TGN1412-induced cytokine release syndrome or report immune-related adverse events caused by immunotherapy, so it cannot support those specific comparisons. (LLM, conf=0.82)
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- Authors
- Stummvoll, G. H., DiPaolo, R. J., Huter, E. N., Davidson, T. S., Glass, D., Ward, J. M., & Shevach, E. M.
- Affiliations
- Laboratory of Immunology, Cellular Immunology Section
- National Institutes of Health (US)
- Corresponding author
- Glass, Deborah
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-08-01
- Volume
- 181
- Issue
- 3
- Pages
- 1908-1916
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC2561289
- OpenAlex
- W2161329415
- Cited by
- 170
- References
- 38
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 14
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (Z01AI000224)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- autoimmune gastritis, Th1 cells, Th2 cells, Th17 cells, regulatory T cells, T cell-mediated autoimmunity, H+/K+-ATPase, transgenic T cells, eosinophilic inflammation, serum IgE, Treg suppressive function, effector T cell expansion
- MeSH terms
- Animals, Autoimmune Diseases, Cell Differentiation, Cell Separation, Cells, Cultured, Disease Susceptibility, Female, Gastric Mucosa, Gastritis, T-Lymphocytes, Helper-Inducer, Immunoglobulin G, Lymph Nodes, Mice, Inbred BALB C, Mice, Nude, Interleukin-17, T-Lymphocytes, Regulatory, Mice
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