The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells
Abstract
Enhanced secondary Ab responses are a vital component of adaptive immunity, yet little is understood about the intrinsic and extrinsic regulators of naive and memory B cells that result in differences in their responses to Ag. Microarray analysis, together with surface and intracellular phenotyping, revealed that memory B cells have increased expression of members of the TNF receptor, SLAM (signaling lymphocytic activation molecule), B7, and Bcl2 families, as well as the TLR-related molecule CD180 (RP105). Accordingly, memory B cells exhibited enhanced survival, proliferation, and Ig secretion, and they entered division more rapidly than did naive B cells in response to both T cell-dependent and T cell-independent stimuli. Furthermore, both IgM and isotype-switched memory B cells, but not naive B cells, costimulated CD4+ T cells in vitro through a mechanism dependent on their constitutive expression of CD80 and CD86. This study demonstrates that up-regulation of genes involved in activation, costimulation, and survival provides memory B cells with a unique ability to produce enhanced immune responses and contributes to the maintenance of the memory B cell pool.
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Regulation of plasma-cell development
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Cited by
Griffin, D. O., Holodick, N. E., & Rothstein, T. L. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101499 · Cited by 615
Sanz, I., Wei, C., Jenks, S. A., Cashman, K. S., Tipton, C., Woodruff, M. C., Hom, J., & Lee, F. E.-H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02458 · Cited by 569
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Mcl-1 is essential for the survival of plasma cells
Peperzak, V., Vikström, I., Walker, J., Glaser, S. P., LePage, M., Coquery, C. M., Erickson, L. D., Fairfax, K., Mackay, F., Strasser, A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2527 · Cited by 320
Human peripheral blood B‐cell compartments: A crossroad in B‐cell traffic
Perez‐Andres, M., Paiva, B., Nieto, W. G., Caraux, A., Schmitz, A., Almeida, J., Vogt, R. F., Marti, G. E., Rawstron, A. C., Van Zelm, M. C., et al. (2010) · Cytometry Part B: Clinical Cytometry · doi:10.1002/cyto.b.20547 · Cited by 270
Metadata
- Authors
- Good, K. L., Avery, D. T., & Tangye, S. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 182
- Issue
- 2
- Pages
- 890-901
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1550073790
- Cited by
- 279
- References
- 57
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Good, K. L., Avery, D. T., & Tangye, S. G. (2009). Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.182.2.890
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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