The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
ANTIGEN-SPECIFIC MEMORY B CELL DEVELOPMENT
Abstract
▪ Abstract Helper T (Th) cell–regulated B cell immunity progresses in an ordered cascade of cellular development that culminates in the production of antigen-specific memory B cells. The recognition of peptide MHC class II complexes on activated antigen-presenting cells is critical for effective Th cell selection, clonal expansion, and effector Th cell function development (Phase I). Cognate effector Th cell–B cell interactions then promote the development of either short-lived plasma cells (PCs) or germinal centers (GCs) (Phase II). These GCs expand, diversify, and select high-affinity variants of antigen-specific B cells for entry into the long-lived memory B cell compartment (Phase III). Upon antigen rechallenge, memory B cells rapidly expand and differentiate into PCs under the cognate control of memory Th cells (Phase IV). We review the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo.
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Multiple layers of B cell memory with different effector functions
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Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
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CD8 + T‐cell memory in tumor immunology and immunotherapy
Klebanoff, C. A., Gattinoni, L., & Restifo, N. P. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00391.x · Cited by 511
Metadata
- Authors
- McHeyzer-Williams, L. J., & McHeyzer-Williams, M. G.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2005-04-01
- Volume
- 23
- Issue
- 1
- Pages
- 487-513
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2148759300
- Cited by
- 725
- References
- 9
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
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