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Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis

Lu, Xinyan, Zhang, Yuanlin, Liu, Feng, Wang, Lu·2020·The Journal of Immunology
DOI 10.4049/jimmunol.1901494
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Abstract

The caudal hematopoietic tissue in zebrafish, the equivalent to the fetal liver in mammals, is an intermediate hematopoietic niche for the maintenance and differentiation of hematopoietic stem and progenitor cells before homing to the thymus and kidney marrow. As one of the ultimate hematopoietic organs, the thymus sustains T lymphopoiesis, which is essential for adaptive immune system. However, the mechanism of prethymic T lymphoid progenitors migrating to the thymus remains elusive. In this study, we identify an Rho GTPase Rac2 as a modulator of T lymphoid progenitor homing to the thymus in zebrafish. rac2-Deficient embryos show the inability of T lymphoid progenitors homing to the thymus because of defective cell–autonomous motility. Mechanistically, we demonstrate that Rac2 regulates homing of T lymphoid progenitor through Pak1-mediated AKT pathway. Taken together, our work reveals an important function of Rac2 in directing T lymphoid progenitor migration to the thymus during zebrafish embryogenesis.

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Cited by

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Metadata

Authors
Lu, X., Zhang, Y., Liu, F., & Wang, L.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2020-05-01
Volume
204
Issue
9
Pages
2447-2454
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1901494
Cited by
21
References
4
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Funders
  • Ministry of Science and Technology of China (2018YFA0801200, 2018YFA0800200)
  • National Natural Science Foundation of China (31271570, 31425016, 81530004, 31771604)

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