Neuroprotective effect of L-theanine on Aβ-induced neurotoxicity through anti-oxidative mechanisms in SK-N-SH and SK-N-MC cells
Open accessAbstract
Amyloid beta ( $A{\beta}$ )-induced neurotoxicity is a major pathological mechanism of Alzheimer's disease (AD). In this study, we investigated the inhibitory effect of L-theanine, a component of green tea (Camellia sinensis) on $A{\beta}_{1-42}$ -induced neurotoxicity and oxidative damages of macromolecules. L-theanine inhibited $A{\beta}_{1-42}$ -induced generation of reactive oxygen species, and activation of extracellular signal-regulated kinase and p38 mitogenic activated protein kinase as well as the activity of nuclear factor kappa-B. L-theanine also signifi cantly reduced oxidative protein and lipid damage, and elevated glutathione level. Consistent with the reduced neurotoxic signals, L-theanine (10-50 ${\mu}g$ /ml) concomitantly attenuated $A{\beta}_{1-42}$ (5 ${\mu}M$ )-induced neurotoxicity in SK-N-MC and SK-N-SH human neuroblastoma cells. These data indicate that L-theanine on $A{\beta}$ -induced neurotoxicity prevented oxidative damages of neuronal cells, and may be useful in the prevention and treatment of neurodegenerative disease like AD.
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Theanine protects neural damage and improves function by reducing cerebral infarction through inhibiting catalase, superoxide dismutase, and succinate dehydrogenase activity, thus reducing GSH and oxidative damage of neuronal cells.
“Theanine helps to protect neural damage and improve function by reduction of cerebral infarction by inhibiting different neurological functions like catalase, superoxide dismutase, and succinate dehydrogenase (SDH) activity, thus reduces GSH and oxidative damage of neuronal cells [36][37][38] .”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [37]
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- Yamada et al., 2008). To further confi rm whether the anti-oxidant property of L-theanine is signifi cant for neuroprotective effects in neuro- nal cells, we investigated the inhibitory effect of L-theanine on Original Article Biomol Ther 19(3), 288-295 (2011) www.biomolther.org
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l -theanine: A potential multifaceted natural bioactive amide as health supplement
Adhikary, R., & Mandal, V. (2017) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2017.08.005 · Cited by 55 · see citing works
- Authors
- Jo, M.-R., Park, M.-H., Choi, D.-Y., Yuk, D.-Y., Lee, Y.-M., Lee, J.-M., Jeong, J.-H., Oh, K.-W., Lee, M.-S., Han, S.-B., & Hong, J.-T.
- Affiliations
- Chungbuk National University (KR)
- Chungbuk Provincial College (KR)
- Venue
- Biomolecules and Therapeutics
- Published
- 2011-07-31
- Volume
- 19
- Issue
- 3
- Pages
- 288-295
- ISSN
- 1976-9148 (ISSN-L)
- OpenAlex
- W2021734110
- Cited by
- 18
- References
- 43
- Citations by year
- 2024: 1 · 2022: 4 · 2021: 1 · 2020: 3 · 2018: 3 · 2017: 2 · 2016: 3
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomolecules & Therapeutics (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Education, Science and Technology (2010-0029709)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Keywords
- theanine, amyloid-beta 42, neurotoxicity, Alzheimer's disease, neuroprotection, oxidative stress, reactive oxygen species, ERK, p38 MAPK, NF-κB, glutathione, oxidative protein damage, lipid peroxidation, SK-N-SH cells, SK-N-MC cells, green tea
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