Protective Effect of Different Antioxidant Agents in UVB-Irradiated Keratinocytes
Open accessAbstract
Skin cells can respond to UVB-induced damage either by tolerating it, or restoring it through antioxidant activation and DNA repair mechanisms or, ultimately, undergoing programmed cell death, when damage is massive. Nutritional factors, in particular, food antioxidants, have attracted much interest because of their potential use in new preventive, protective, and therapeutic strategies for chronic degenerative diseases, including skin inflammation and cancer. Some polyphenols, present in virgin olive oil, well tolerated by organism after oral administration, show a variety of pharmacological and clinical benefits such as anti-oxidant, anti-cancer, anti-inflammatory, and neuro-protective activities. Here, the protective effects of antioxidant compounds against UV-induced apoptosis have been described in HaCat cell line. Human keratinocytes were pre-treated with antioxidants before UVB exposure and their effects have been evaluated by means of ultrastructural analyses. After UVB radiation, a known cell death trigger, typical apoptotic features, absent in control condition and in antioxidant alone-treated cells, appear. An evident numerical decrease of ultrastructural apoptotic patterns and TUNEL positive nuclei can be observed when natural antioxidants were supplied before cell death induction. These data have been confirmed by molecular investigation of caspase activity. In conclusion, this paper highlights antioxidant compound ability to prevent apoptotic cell death in human keratinocytes exposed to UVB, suggesting, for these molecules, a potential role in preventing skin damage.
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Polyphenols contribute to prevention of muscle atrophy.
“Polyphenols, a large family of naturally occurring organic compounds characterized by multiples of phenol units, contribute to the prevention of muscle atrophy [82].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [82]
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Cites
Nichols, J. A., & Katiyar, S. K. (2010) · Archives of Dermatological Research · doi:10.1007/s00403-009-1001-3 · Cited by 1,103 · see citing works
Pillai, S., Oresajo, C., & Hayward, J. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.00241.x · Cited by 706 · see citing works
Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541 · see citing works
The cutaneous serotoninergic/melatoninergic system: securing a place under the sun
Slominski, A., Wortsman, J., & Tobin, D. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2079rev · Cited by 402 · see citing works
Skin DNA photodamage and its biological consequences
Marrot, L., & Meunier, J.-R. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.12.007 · Cited by 343 · see citing works
Serotoninergic and melatoninergic systems are fully expressed in human skin
Slominski, A. T., Pisarchik, A. V., Semak, I. V., Sweatman, T. W., Wortsman, J., Szczesniewski, A., Slugocki, G., McNulty, J. A., Kauser, S., Tobin, D. J., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0952fje · Cited by 285 · see citing works
On the Role of Melatonin in Skin Physiology and Pathology
Slominski, A. T., Fischer, T. W., Zmijewski, M. A., Wortsman, J., Semak, I. V., Zbytek, B., Slominski, R. M., & Tobin, D. J. (2005) · Endocrine · doi:10.1385/endo:27:2:137 · Cited by 265 · see citing works
Melatonin as an antioxidant: physiology versus pharmacology
Reiter, R. J., Tan, D. X., & y Aibar, M. D. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00261.x · Cited by 232 · see citing works
Sestili, P., Martinelli, C., Colombo, E., Barbieri, E., Potenza, L., Sartini, S., & Fimognari, C. (2011) · Amino Acids · doi:10.1007/s00726-011-0875-5 · Cited by 200 · see citing works
Hydroxytyrosol and Its Potential Therapeutic Effects
Hu, T., He, X., Jiang, J., & Xu, X.-L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405820v · Cited by 192 · see citing works
Phenolic compounds and antioxidant capacity of virgin olive oil
Franco, M. N., Díaz, T. G., López, Ó., Fernández‐Bolaños, J. G., Sánchez, J., Miguel, C. D., Gil, M. V., & Martín‐Vertedor, D. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.04.091 · Cited by 184 · see citing works
Strozyk, E. A., & Kulms, D. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815260 · Cited by 160 · see citing works
Fischer, T. W., Zmijewski, M. A., Wortsman, J., & Slominski, A. T. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00542.x · Cited by 128 · see citing works
Melatonin, Immune Function and Cancer
Srinivasan, V., Pandi-Perumal, S. R., Brzezinski, A., Bhatnagar, K. P., & Cardinali, D. P. (2011) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221411799015408 · Cited by 109 · see citing works
Gallagher, R. P., Lee, T. K., Bajdik, C. D., & Borugian, M. (2010) · Chronic Diseases and Injuries in Canada · doi:10.24095/hpcdp.29.s1.04 · Cited by 103 · see citing works
New Lipophilic Tyrosyl Esters. Comparative Antioxidant Evaluation with Hydroxytyrosyl Esters
Mateos, R., Trujillo, M., Pereira‐Caro, G., Madrona, A., Cert, A., & Espartero, J. L. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8020267 · Cited by 101 · see citing works
Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways
Slominski, A. T., Zmijewski, M. A., Semak, I. V., Zbytek, B., Pisarchik, A. V., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990308 · Cited by 91 · see citing works
Sestili, P., Barbieri, E., Martinelli, C., Battistelli, M., Guescini, M., Vallorani, L., Casadei, L., D'Emilio, A., Falcieri, E., Piccoli, G., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800504 · Cited by 84 · see citing works
Melatonin prevents apoptosis induced by UV‐B treatment in U937 cell line
Luchetti, F., Canonico, B., Curci, R., Battistelli, M., Mannello, F., Papa, S., Tarzia, G., & Falcieri, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00293.x · Cited by 73 · see citing works
Tyrosol prevents apoptosis in irradiated keratinocytes
Salucci, S., Burattini, S., Battistelli, M., Buontempo, F., Canonico, B., Martelli, A. M., Papa, S., & Falcieri, E. (2015) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2015.07.002 · Cited by 69 · see citing works
Anti-apoptotic activity of hydroxytyrosol and hydroxytyrosyl laurate
Burattini, S., Salucci, S., Baldassarri, V., Accorsi, A., Piatti, E., Madrona, A., Espartero, J. L., Candiracci, M., Zappia, G., & Falcieri, E. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.049 · Cited by 64 · see citing works
Antioxidants in the prevention of UVB-induced keratynocyte apoptosis
Salucci, S., Burattini, S., Curzi, D., Buontempo, F., Martelli, A. M., Zappia, G., Falcieri, E., & Battistelli, M. (2014) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2014.09.004 · Cited by 51 · see citing works
Starting and propagating apoptotic signals in UVB irradiated keratinocytes
Laethem, A. V., Garmyn, M., & Agostinis, P. (2009) · Photochemical & Photobiological Sciences · doi:10.1039/b813346h · Cited by 49 · see citing works
Lipophilic Hydroxytyrosol Esters: Fatty Acid Conjugates for Potential Topical Administration
Procopio, A., Celia, C., Nardi, M., Oliverio, M., Paolino, D., & Sindona, G. (2011) · Journal of Natural Products · doi:10.1021/np200405s · Cited by 41 · see citing works
Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line
Luchetti, F., Canonico, B., Mannello, F., Masoni, C., D'Emilio, A., Battistelli, M., Papa, S., & Falcieri, E. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.08.003 · Cited by 40 · see citing works
The Circadian Control of Skin and Cutaneous Photodamage†
Desotelle, J. A., Wilking, M. J., & Ahmad, N. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01099.x · Cited by 35 · see citing works
Choi, Y. J., Uehara, Y., Park, J. Y., Kim, S., Kim, S. R., Lee, H. W., Moon, H. R., & Chung, H. Y. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.01.040 · Cited by 33 · see citing works
Gallagher, R. P., Lee, T. K., Bajdik, C. D., & Borugian, M. J. (2010) · PubMed · Cited by 31 · see citing works
HaCaT Cell Proliferation Influenced by Melatonin
Hipler, U. ‐., Fischer, T. W., & Elsner, P. U. (2003) · Skin Pharmacology and Physiology · doi:10.1159/000072933 · Cited by 29 · see citing works
Park, G., Kim, H. G., Hong, S., Kim, S. Y., & Oh, M. S. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000354917 · Cited by 29 · see citing works
Scheuer, C., Pommergaard, H., Rosenberg, J., & Gögenür, I. (2013) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12080 · Cited by 29 · see citing works
Cell death in human articular chondrocyte: a morpho-functional study in micromass model
Battistelli, M., Salucci, S., Olivotto, E., Facchini, A., Minguzzi, M., Guidotti, S., Pagani, S., Flamigni, F., Borzı̀, R. M., Facchini, A., et al. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1017-9 · Cited by 25 · see citing works
Lahtz, C., Kim, S., Bates, S., Li, A. X., Wu, X., & Pfeifer, G. P. (2013) · F1000Research · doi:10.12688/f1000research.2-45.v1 · Cited by 25 · see citing works
Melatonin Prevents Chemical-Induced Haemopoietic Cell Death
Salucci, S., Burattini, S., Battistelli, M., Baldassarri, V., Curzi, D., Valmori, A., & Falcieri, E. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046625 · Cited by 23 · see citing works
Huynh, T. T., Chan, K. S., & Piva, T. J. (2009) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2009.00395.x · Cited by 19 · see citing works
Salamanna, F., Frizziero, A., Pagani, S., Giavaresi, G., Curzi, D., Falcieri, E., Marini, M., Abruzzo, P. M., Martini, L., & Fini, M. (2014) · Connective Tissue Research · doi:10.3109/03008207.2014.979166 · Cited by 18 · see citing works
Crystal Structures of Substrate-Free and Nitrosyl Cytochrome P450cin: Implications for O2 Activation
Madrona, Y., Tripathi, S. M., Li, H., & Poulos, T. L. (2012) · Biochemistry · doi:10.1021/bi300666u · Cited by 16 · see citing works
[The protective role of melatonin in the course of UV exposure].
Iżykowska, I., Piotrowska, A., Podhorska‐Okołów, M., Cegielski, M., Zabel, M., & Dzięgiel, P. (2008) · PubMed · Cited by 10 · see citing works
Skeletal Muscle Cell Behavior After Physical Agent Treatments
Battistelli, M., Salucci, S., Guescini, M., Curzi, D., Stocchi, V., & Falcieri, E. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150122123412 · Cited by 10 · see citing works
Canonico, B., Luchetti, F., Ambrogini, P., Arcangeletti, M., Betti, M., Cesarini, E., Lattanzi, D., Ciuffoli, S., Palma, F., Cuppini, R., et al. (2013) · Cell Biology International · doi:10.1002/cbin.10030 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [18]Sestili P Barbieri E Martinelli C Battistelli M Guescini M Vallorani L Creatine supplementation prevents the inhibition of myogenic differentiation in oxidatively injured C2C12 murine myoblasts. Mol Nutr Food Res 2009; 53: 1187- 204. 19653222
Cited by
Sorted by citations
Polyphenols and Their Potential Role in Preventing Skeletal Muscle Atrophy
Salucci, S., & Falcieri, E. (2020) · Nutrition Research · doi:10.1016/j.nutres.2019.11.004 · Cited by 83 · see citing works
Chondrocyte death involvement in osteoarthritis
Salucci, S., Falcieri, E., & Battistelli, M. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03639-4 · Cited by 63 · see citing works
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
Molagoda, I. M. N., Lee, K. T., Choi, Y. H., & Kim, G. (2020) · Antioxidants · doi:10.3390/antiox9010042 · Cited by 57 · see citing works
Challenges and opportunities on vegetable oils derived systems for biomedical applications
Ribeiro, A. R., Silva, S. S., & Reis, R. L. (2022) · Biomaterials Advances · doi:10.1016/j.msec.2022.112720 · Cited by 48 · see citing works
Salesa, B., Serra, R. S. I., & Serrano‐Aroca, Á. (2021) · Biology · doi:10.3390/biology10111072 · Cited by 45 · see citing works
Antioxidant and Cytoprotective Effects of (−)-Epigallocatechin-3-(3″-O-methyl) Gallate
Kim, E., Han, S. Y., Hwang, K., Kim, D., Kim, E., Hossain, M. A., Kim, J., & Cho, J. Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163993 · Cited by 43 · see citing works
Andreani, C., Bartolacci, C., Guescini, M., Battistelli, M., Stocchi, V., Orlando, F., Provinciali, M., Amici, A., Marchini, C., Tiano, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8936251 · Cited by 37 · see citing works
Self-citationKarunarathne, W. A. H. M., Molagoda, I. M. N., Lee, K. T., Choi, Y. H., Yu, S., Kang, C., & Kim, G. (2021) · Antioxidants · doi:10.3390/antiox10040584 · Cited by 29 · see citing works
Bolotta, A., Battistelli, M., Falcieri, E., Ghezzo, A., Manara, M. C., Manfredini, S., Marini, M., Posar, A., Visconti, P., & Abruzzo, P. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6430601 · Cited by 24 · see citing works
Biological effects of the olive tree and its derivatives on the skin
Melguizo‐Rodríguez, L., González‐Acedo, A., Montes, R. I., García‐Recio, E., Ramos‐Torrecillas, J., Costela-Ruiz, V. J., & García‐Martínez, O. (2022) · Food & Function · doi:10.1039/d2fo01945k · Cited by 26 · see citing works
Luangpraditkun, K., Tissot, M., Joompang, A., Charoensit, P., Grandmottet, F., Viyoch, J., & Viennet, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5067957 · Cited by 17 · see citing works
Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy
Adamiak, K., Gaida, V. A., Schäfer, J. A., Bosse, L., Diemer, C., Reiter, R. J., Slominski, A. T., Steinbrink, K., Sionkowska, A., & Kleszczyński, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094858 · Cited by 16 · see citing works
Traditionally Used Natural Products in Preventing Ionizing Radiation-Induced
Baliga, M. S., Kalekhan, F. M., Kudva, A. K., Raghu, S. V., Rao, S., Hegde, S. K., & Simon, P. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210405093236 · Cited by 15 · see citing works
The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent
Mahendra, C. K., Tan, L. T. H., Mahendra, C. K., Ser, H.-L., Pusparajah, P., Htar, T. T., Chuah, L.-H., Yap, W. H., Tang, S. Y., Ming, L. C., et al. (2021) · Cosmetics · doi:10.3390/cosmetics8030079 · Cited by 14 · see citing works
Diet Modulation Restores Autophagic Flux in Damaged Skeletal Muscle Cells
Giordano, F. M., Burattini, S., Buontempo, F., Canonico, B., Martelli, A. M., Papa, S., Sampaolesi, M., Falcieri, E., & Salucci, S. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1245-3 · Cited by 13 · see citing works
Ke, J., Wang, J., Wu, X., & Yan, Y. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s367233 · Cited by 11 · see citing works
Penna, I., Albanesi, E., Bertorelli, R., Bandiera, T., & Russo, D. (2018) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1722 · Cited by 12 · see citing works
A literature-based phytochemical evidence and biological activities of Trichosanthes dioica Roxb
Islam, M. T. (2018) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-018-0305-2 · Cited by 10 · see citing works
Abotorabi, Z., Khorashadizadeh, M., Arab, M., Fard, M. H., & Zarban, A. (2020) · PubMed Central · doi:10.22038/ajp.2019.14078 · Cited by 10 · see citing works
Al‐Shudiefat, A. A., Alzyoud, J. A. M., Najjar, S. A. A., Talat, S., Bustanji, Y. K., & Abu‐Irmaileh, B. (2022) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2022.103391 · Cited by 10 · see citing works
Woo, S. M., Choi, W. R., Lee, D., Kim, H., Yi, C., Kim, K., Kim, H. L., Cheng, J., Le, B., Yang, S. H., et al. (2018) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2018.10.013 · Cited by 5 · see citing works
Pellicciari, C. (2018) · European Journal of Histochemistry · doi:10.4081/ejh.2018.3006 · Cited by 5 · see citing works
Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb
Burattini, S., Gianfanti, F., Onesimo, F., Zeppa, S. D., Canonico, B., Montanari, M., Panza, G., Lopez, D., Annibalini, G., Fanelli, F., et al. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106699 · Cited by 4 · see citing works
Morpho-Functional Analyses Demonstrate That Tyrosol Rescues Dexamethasone-Induced Muscle Atrophy
Salucci, S., Burattini, S., Versari, I., Bavelloni, A., Bavelloni, F., Curzi, D., Battistelli, M., Gobbi, P., & Faenza, I. (2024) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk9030124 · Cited by 4 · see citing works
Garcia‐Merino, J. A., Carrabs, V., Ferrini, F., Salucci, S., Battistelli, M., Burattini, S., Luchetti, F., Nasoni, M. G., Annibalini, G., Micucci, M., et al. (2024) · Microscopy Research and Technique · doi:10.1002/jemt.24755 · Cited by 3 · see citing works
Food Waste to Wellness: A Grape Pomace Blend in Gastric Cancer Prevention
Micucci, M., Battistelli, M., Burattini, S., Mari, M., Retini, M., Osman, R., Versari, I., Stella, A. B., Gianfanti, F., Okeke, U. J., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70350 · Cited by 3 · see citing works
Smeriglio, A., Mangano, M., Ingegneri, M., Neve, A. L., Brenna, C., Mastracci, L., Merlino, F., Tonon, G., Bosco, D., & Trombetta, D. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1744377 · Cited by 2 · see citing works
Soltan, H. R., El-Megeed, F. A. A., & Mustafa, F. I. (2026) · International Journal of Tropical Insect Science · doi:10.1007/s42690-026-01790-x · Cited by 1 · see citing works
TEM: A precious evergreen approach to cell biology and pathology
Burattini, S., & Falcieri, E. (2020) · AIP conference proceedings · doi:10.1063/5.0024496 · Cited by 1 · see citing works
Program and Book of the 15th Interuniversity Institute of Myology Meeting - Assisi (Italy), 2018
Editors, T. L. O. (2018) · European Journal of Translational Myology · doi:10.4081/ejtm.2018.7927 · Cited by 1 · see citing works
Combination of PDTC and GBE Could Better Alleviate the Damage to HaCaT Cells Caused by UVB.
Xu, F., Hou, B. L., Wang, Y., Meng, F. Z., Zhuang, C. N., Pan, Q. Z., & Ren, S. P. (2019) · PubMed · doi:10.3967/bes2019.097 · Cited by 1 · see citing works
- Authors
- Salucci, S., Burattini, S., Buontempo, F., Martelli, A. M., Falcieri, E., & Battistelli, M.
- Affiliations
- University of Urbino (IT)
- University of Bologna (IT)
- Corresponding author
- Salucci, Sara
- Burattini, Sabrina
- Buontempo, Francesca
- Martelli, Alberto Maria
- Falcieri, Elisabetta
- Battistelli, Michela
- ORCID
- Venue
- European Journal of Histochemistry
- Publisher
- PAGEPress Publications
- Published
- 2017-09-18
- Volume
- 61
- Issue
- 3
- Pages
- 2784-2784
- ISSN
- 1121-760X (ISSN-L)
- 2038-8306
- PMC
- PMC5617901
- OpenAlex
- W2755502476
- Cited by
- 32
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 7
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- European Journal of Histochemistry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion, cc-by-nc-nd)
- Funders
- Università degli Studi di Urbino Carlo Bo
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- UV-B radiation, keratinocytes, antioxidants, apoptosis, HaCaT keratinocytes, caspase activity, TUNEL, skin damage prevention, DNA repair, programmed cell death
- MeSH terms
- Antioxidants, Cells, Cultured, Enzyme Activation, Humans, Microscopy, Electron, Scanning, Ultraviolet Rays, Blotting, Western, Keratinocytes, Apoptosis, Caspase 1
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