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The Epidemiology of DSM-5 Nicotine Use Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III
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OBJECTIVE: To present nationally representative information on the prevalence, correlates, psychiatric comorbidity, and treatment of DSM-5 nicotine use disorder (NUD) and the public health burden of US cigarette consumption among adults with NUD and other psychiatric disorders. METHODS: Using data from the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions-III (N = 36,309), we conducted weighted cross-tabulations and multivariate logistic regression analyses to estimate prevalences and examine comorbidity of NUD. RESULTS: Prevalences of 12-month and lifetime DSM-5 NUD were 20.0% and 27.9%, respectively. Nicotine use disorder was more frequent among men, non-Hispanic whites, younger individuals, the previously married, those with less education and lower incomes, and those residing in rural areas. Adjusting for sociodemographic characteristics and additional psychiatric comorbidity, 12-month NUD and lifetime NUD were significantly associated with other substance use and antisocial personality disorders (odds ratios [ORs] = 1.5-5.1, 12-month; 1.5-5.6, lifetime). Twelve-month severe NUD was generally associated with major depressive, bipolar I, bipolar II, panic, generalized anxiety, posttraumatic stress, and schizotypal, borderline, and antisocial personality disorders (ORs = 1.3-2.5). Individuals with current NUD and at least 1 psychiatric disorder comprised 11.1% of US adults but smoked 53.6% of total cigarettes consumed. Treatment was utilized by 20.3% of respondents with 12-month and 18.8% with lifetime NUD. CONCLUSIONS: Findings underscore the need to address nicotine use in clinical settings. Recognition of psychiatrically vulnerable subpopulations may inform etiologic research, prevention, and treatment of NUD.
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“Although SUDs remain more prevalent in men than in women, the gender gap has been narrowing 150,328- 330 , possibly in part due to changes in gender roles 331 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [329]
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“For lifetime NUD, figures were 1.57 (CI: 1.29–1.90) for BD-I and 1.22 (CI: 0.77–1.95) for BD-II, respectively.”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [15]
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“Chou and colleagues (15) reported adjusted odds ratios for 12-month DSM-5 NUD of 1.93 (CI: 1.49–2.50) for BD-I, and 1.05 (CI: 0.67–1.64) for BD-II.”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [15]
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“Looking into severe NUD as defined by DSM-5 only, 12-month DSM-5 NUD adjusted odds ratio was 2.53 (CI:1.87–3.42) for BD-I, and 1.85 (CI:1.07–3.21) for BD-II.”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [15]
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Koob, G. F., Kandel, D. B., Baler, R., & Volkow, N. D. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_29 · Cited by 1
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Metadata
- Authors
- Chou, S. P., Goldstein, R. B., Smith, S. M., Huang, B., Ruan, W. J., Zhang, H., Jung, J., Saha, T. D., Pickering, R. P., & Grant, B. F.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2016-04-26
- Volume
- 77
- Issue
- 10
- Pages
- 1404-1412
- ISSN
- 0160-6689 (ISSN-L)
- PMC
- PMC8154113
- OpenAlex
- W2345309666
- Cited by
- 106
- References
- 44
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 18 · 2019: 18 · 2018: 17 · 2017: 2 · 2016: 1
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99‐AA999999)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Keywords
- nicotine use disorder, DSM-5, prevalence, psychiatric comorbidity, substance use disorders, antisocial personality disorder, major depressive disorder, bipolar disorder, anxiety disorders, post-traumatic stress disorder, schizotypal personality disorder, borderline personality disorder, smoking, public health burden, treatment utilization, sociodemographic factors
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Alcoholism, Mental Disorders, Cross-Sectional Studies, Female, Health Surveys, Humans, Male, Middle Aged, Risk Factors, Smoking, Statistics as Topic, Tobacco Use Disorder, United States, Comorbidity, Smoking Cessation, Diagnostic and Statistical Manual of Mental Disorders, Young Adult
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