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Cited by 121Suicide and Self-Harm StudiesAutism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study

Chen, Mu-Hong, Pan, Tai-Long, Lan, Wen-Hsuan, Hsu, Ju-Wei, Huang, Kai-Lin, Su, Tung-Ping, Li, Cheng-Ta, Lin, Wei-Chen +3 more·2017·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.16m11100
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Abstract

BACKGROUND: Previous studies reported a high prevalence of depression among patients with autism spectrum disorder (ASD) and suggested a relationship between ASD and suicidality. However, whether ASD independently increases the risk of attempted suicide regardless of depression has not been determined. METHODS: Using the Taiwan National Health Insurance Research Database, 5,618 adolescents aged 12-17 years and young adults aged 18-29 years with ASD (ICD-9-CM code: 299) and 22,472 age- and sex-matched controls were enrolled between 2001 and 2009 and followed to the end of 2011. Any suicide attempt was identified during the follow-up period. RESULTS: Patients with ASD had a higher incidence of suicide attempts (3.9% vs 0.7%, P < .001) than did those without ASD. Both adolescents (HR = 5.79; 95% CI, 3.98-8.41) and young adults (HR = 5.38; 95% CI, 3.58-8.06) with ASD were more likely to attempt suicide in later life after adjusting for demographic data and psychiatric comorbidities. Sensitivity analyses after excluding the first year (HR = 4.52; 95% CI, 3.39-6.03) or first 3 years (HR = 3.36; 95% CI, 2.40-4.70) of observation showed consistent findings. CONCLUSIONS: Patients with ASD had an increased risk of suicide attempts compared with those without ASD. ASD was an independent risk factor of attempted suicide. Further studies are needed to clarify the underlying pathophysiology between ASD and suicidality and to elucidate whether prompt intervention for ASD may reduce this risk.

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  • ASC diagnosis has recently been found to be an independent risk marker for suicide attempts independent of demographic characteristics and co-occurring diagnoses.

    “ASC diagnosis has also recently been found to be an independent risk marker for suicide attempts independent of demographic characteristics and co-occurring diagnoses [19].”

    From Risk markers for suicidality in autistic adults (2018) · cites this paper as [19]

  • ASC diagnosis is an independent risk marker for suicide attempts when controlling for a range of demographics and co-occurring diagnoses.

    “This is consistent with research showing that ASC diagnosis is an independent risk marker for suicide attempts when controlling for a range of demographics and co-occurring diagnoses [19].”

    From Risk markers for suicidality in autistic adults (2018) · cites this paper as [19]

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Authors
Chen, M.-H., Pan, T.-L., Lan, W.-H., Hsu, J.-W., Huang, K.-L., Su, T.-P., Li, C.-T., Lin, W.-C., Wei, H.-T., Chen, T.-J., & Bai, Y.-M.
Affiliations
  • Taipei Veterans General Hospital (TW)
  • Chang Gung University (TW)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2017-12-27
Volume
78
Issue
9
Pages
e1174-e1179
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.16m11100
OpenAlex
W2747034110
Cited by
121
References
0
Citations by year
2026: 8 · 2025: 18 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 16 · 2020: 15 · 2019: 14 · 2018: 3
FWCI
10.85
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
autism spectrum disorder, suicide attempts, suicidality, adolescents, young adults, depression, psychiatric comorbidity, risk factors
MeSH terms
Autism Spectrum Disorder, Adolescent, Adult, Child, Follow-Up Studies, Humans, Longitudinal Studies, Risk Factors, Suicide, Attempted, Taiwan, Case-Control Studies, Young Adult

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