It is time to address the crisis in the pharmacotherapy of posttraumatic stress disorder: A consensus statement of the PTSD psychopharmacology working group

Krystal, John H.; Davis, Lori L.; Neylan, Thomas C.; A. Raskind, Murray; Schnurr, Paula P.; Stein, Murray B.; Vessicchio, Jennifer; Shiner, Brian; Gleason, Theresa D.; Huang, Grant D.

doi:10.1016/j.biopsych.2017.03.007

Cited by 269Posttraumatic Stress Disorder ResearchSleep and related disordersMigration, Health and Trauma

It is time to address the crisis in the pharmacotherapy of posttraumatic stress disorder: A consensus statement of the PTSD psychopharmacology working group

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Krystal, John H., Davis, Lori L., Neylan, Thomas C., A. Raskind, Murray, Schnurr, Paula P., Stein, Murray B., Vessicchio, Jennifer, Shiner, Brian +2 more·2017·Biological Psychiatry

DOI 10.1016/j.biopsych.2017.03.007

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Increasing evidence suggests that these circuitry treatment effects are mediated by changes in synaptic plasticity in key areas of the circuitry.
“Increasing evidence suggests that these circuitry treatment effects are mediated by changes in synaptic plasticity in key areas of the circuitry (Krystal et al., 2017;Luchkina & Bolshakov, 2018;Mahan & Ressler, 2012;Mansson et al., 2016;Mansson et al., 2017).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Krystal et al., 2017
Patients with an anxiety disorder display abnormal levels of glutamate and glutamate receptors.
“and, indeed, patients with an anxiety disorder display abnormal levels of glutamate and glutamate receptors (Krystal et al., 2017).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Krystal et al., 2017
Stress considered a risk factor in the development of anxiety disorders alters levels of glutamate in rodents.
“Stress that is considered a risk factor in the development of anxiety disorders alters levels of glutamate in rodents, and, indeed, patients with an anxiety disorder display abnormal levels of glutamate and glutamate receptors (Krystal et al., 2017).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Krystal et al., 2017

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The PTSD Psychopharmacology Working Group: Two Suggestions
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Response to the Consensus Statement of the PTSD Psychopharmacology Working Group
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Reply to: It Is Time to Look for New Treatments for Posttraumatic Stress Disorder: Can Sympathetic System Modulation Be an Answer?
Krystal, J. H., Davis, L. L., Neylan, T. C., Raskind, M. A., Schnurr, P. P., Stein, M. B., Vessicchio, J. C., Shiner, B. R., Gleason, T., & Huang, G. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.031 · Cited by 1 · see citing works
Self-citation

Authors: Krystal, J. H., Davis, L. L., Neylan, T. C., A. Raskind, M., Schnurr, P. P., Stein, M. B., Vessicchio, J., Shiner, B., Gleason, T. D., & Huang, G. D.
Affiliations: Yale University (US)
University of Alabama (US)
San Francisco VA Medical Center (US)
National Center for Post Traumatic Stress Disorder (US)
University of California San Diego (US)
VA Connecticut Healthcare System (US)
United States Department of Veterans Affairs (US)
Corresponding author: Krystal, John H.
ORCID: Krystal, John H.
Davis, Lori L.
Neylan, Thomas C.
Schnurr, Paula P.
Stein, Murray B.
Shiner, Brian
Huang, Grant D.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2017-10
Volume: 82
Issue: 7
Pages: e51-e59
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2017.03.007
OpenAlex: W2598895258
Cited by: 265
References: 61
Citations by year: 2026: 15 · 2025: 33 · 2024: 26 · 2023: 31 · 2022: 30 · 2021: 41 · 2020: 30 · 2019: 26 · 2018: 26 · 2017: 6
FWCI: 28.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 335 d)
Locations: Biological Psychiatry (acceptedVersion)
PubMed (publishedVersion)
Funders: VA Office of Research and Development Clinical Science Research & Development Service and Cooperative Studies Program
National Institutes of Health
Pfizer
AstraZeneca
National Institute on Alcohol Abuse and Alcoholism
National Institute of Mental Health
Department of Veterans Affairs
Department of Defense
Lilly Pharmaceuticals
VA Health Services Research and Development Career Development Award
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
Keywords: post-traumatic stress disorder, pharmacotherapy, psychopharmacology, treatment gap, veterans, military personnel, Department of Veterans Affairs, Department of Defense
MeSH terms: Animals, Clinical Trials as Topic, Humans, Psychopharmacology, Psychotropic Drugs, Stress Disorders, Post-Traumatic

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