Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management: (Academic Highlights)

Culpepper, Larry; Lam, Raymond W.; McIntyre, Roger S.

doi:10.4088/jcp.tk16043ah5c

Cited by 211Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesDementia and Cognitive Impairment Research

Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management: (Academic Highlights)

Culpepper, Larry, Lam, Raymond W., McIntyre, Roger S.·2017·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.tk16043ah5c

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Abstract

Article Abstract †‹†‹ Click to enlarge page Cognitive impairment is a common, often persistent, symptom of major depressive disorder (MDD) that is disproportionately represented in patients who have not returned to full psychosocial functioning. The ultimate goal of treatment in depression is full functional recovery, and assessing patients for cognitive impairment and selecting treatments that address cognitive dysfunction should lead to improved functional outcomes. Unfortunately, many clinicians use screening and assessment tools that are not suited for measuring cognitive impairment in patients with depression. The new THINC-it assessment tool is the first instrument that provides objective and subjective data on dysfunction in all the cognitive domains commonly affected by depression. In regard to treatment, several pharmacologic and nonpharmacologic interventions have been investigated as treatments for cognitive dysfunction in individuals with MDD. However very few studies of treatments for cognitive function in patients with MDD have been adequate, in terms of sample size and study methods, to guide clinical practice. The best evidence supports the moderate efficacy of some antidepressants, cognitive-behavioral therapy, and exercise. From the Department of Family Medicine, Boston University, Massachusetts (Dr Culpepper); the Department of Mood and Anxiety Disorders, The University of British Columbia, Vancouver, Canada (Dr Lam); and the Mood Disorders Psychopharmacology Unit, University of Toronto, Ontario, Canada (Dr McIntyre). †‹†‹†‹†‹

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Objective measures of neuro-cognition are impacted in depression.
“Additionally, we used a multidimensional approach to evaluate trial outcomes; symptom assessments were complemented with evaluation of change in subjective mental health behaviors and quality of life, as well as change in objective measures of neuro-cognition that are impacted in depression [31–37].”
From Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study (2026) · cites this paper as [37]
Depression can be associated with cognitive deficits.
“Notably, while depression can be associated with cognitive deficits [31–37]”
From Personalized machine learning guided intervention for optimizing lifestyle behaviors in depression: a pilot study (2026) · cites this paper as [37]
Depressed people often have impaired cognition.
“depressed people often have impaired cognition [42–44].”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [42]

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Background
Prevalence and clinical correlates of thyroid dysfunction in first-episode and drug-naïve major depressive disorder patients with metabolic syndrome
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“However, most existed articles have focused on specific types of cognitive impairment [8–10], yet few have concentrated on the current general research pro-ceedings of this field.”
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Contreras-Osorio, F., Ramírez‐Campillo, R., Cerda-Vega, E., Campos-Jara, R., Martínez‐Salazar, C., Reigal, R. E., Morales‐Sánchez, V., Araya-Sierralta, S., & Campos‐Jara, C. (2022) · Sustainability · doi:10.3390/su142215158 · Cited by 10 · see citing works
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Neurocognitive outcomes of HIV-associated tuberculous meningitis
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Authors: Culpepper, L., Lam, R. W., & McIntyre, R. S.
Affiliations: Boston University (US)
University of British Columbia (CA)
University of Toronto (CA)
ORCID: Culpepper, Larry
Lam, Raymond W.
McIntyre, Roger S.
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2017-12-27
Volume: 78
Issue: 9
Pages: 1383-1394
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.tk16043ah5c
OpenAlex: W2776397410
Cited by: 211
References: 0
Citations by year: 2026: 23 · 2025: 33 · 2024: 38 · 2023: 34 · 2022: 35 · 2021: 21 · 2020: 14 · 2019: 8 · 2018: 5
FWCI: 5.16
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: cognitive impairment, major depressive disorder, cognitive screening, antidepressants, cognitive behavioral therapy, physical activity, functional recovery, treatment selection
MeSH terms: Antidepressive Agents, Major Depressive Disorder, Humans, Cognitive Dysfunction

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Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management: (Academic Highlights)

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