The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Clinical Relevance of Adipokines
Open accessAbstract
The incidence of obesity has increased dramatically during recent decades. Obesity increases the risk for metabolic and cardiovascular diseases and may therefore contribute to premature death. With increasing fat mass, secretion of adipose tissue derived bioactive molecules (adipokines) changes towards a pro-inflammatory, diabetogenic and atherogenic pattern. Adipokines are involved in the regulation of appetite and satiety, energy expenditure, activity, endothelial function, hemostasis, blood pressure, insulin sensitivity, energy metabolism in insulin sensitive tissues, adipogenesis, fat distribution and insulin secretion in pancreatic β-cells. Therefore, adipokines are clinically relevant as biomarkers for fat distribution, adipose tissue function, liver fat content, insulin sensitivity, chronic inflammation and have the potential for future pharmacological treatment strategies for obesity and its related diseases. This review focuses on the clinical relevance of selected adipokines as markers or predictors of obesity related diseases and as potential therapeutic tools or targets in metabolic and cardiovascular diseases.
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Cites
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Self-citationSerum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
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Cited by
Adipokines in health and disease
Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050
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Adipocyte dysfunction, inflammation and metabolic syndrome
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Self-citationAdipose tissue dysfunction contributes to obesity related metabolic diseases
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Self-citationAdipose tissue and its role in organ crosstalk
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Metadata
- Authors
- Blüher, M.
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2012
- Volume
- 36
- Issue
- 5
- Pages
- 317
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- OpenAlex
- W2097335715
- Cited by
- 200
- References
- 16
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- gold
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