Cited by 142Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

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Probiotics as Complementary Treatment for Metabolic Disorders

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Le Barz, Mélanie, Anhê, Fernando F., Varin, Thibaut V., Desjardins, Yves, Levy, Emile, Roy, Denis, Urdaci, Maria C., Marette, André·2015·Diabetes & Metabolism Journal

DOI 10.4093/dmj.2015.39.4.291PMC PMC4543192

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Abstract

Recent studies have demonstrated beneficial effects of specific probiotics on alleviating obesity-related disorders.Here we aimed to identify probiotics with potential antiobesity activity among 88 lactic acid bacterial strains via in vitro screening assays, and a Lactobacillus plantarum strain K21 was found to harbor abilities required for hydrolyzing bile salt, reducing cholesterol, and inhibiting the accumulation of lipid in 3T3-L1 preadipocytes.Furthermore, effects of K21 on diet-induced obese (DIO) mice were examined.Male C57Bl/6J mice received a normal diet, high-fat diet (HFD), or HFD with K21 administration (10 9 CFU in 0.2 mL PBS/day) for eight weeks.Supplementation of K21, but not placebo, appeared to alleviate body weight gain and epididymal fat mass accumulation, reduce plasma leptin levels, decrease cholesterol and triglyceride levels, and mitigate liver damage in DIO mice.Moreover, the hepatic expression of peroxisome proliferator-activated receptor-𝛾 (PPAR-𝛾) related to adipogenesis was significantly downregulated in DIO mice by K21 intervention.We also found that K21 supplementation strengthens intestinal permeability and modulates the amount of Lactobacillus spp., Bifidobacterium spp., and Clostridium perfringens in the cecal contents of DIO mice.In conclusion, our results suggest that dietary intake of K21 protects against the onset of HFD-induced obesity through multiple mechanisms of action.

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Authors: Le Barz, M., Anhê, F. F., Varin, T. V., Desjardins, Y., Levy, E., Roy, D., Urdaci, M. C., & Marette, A.
Affiliations: Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Québec, QC, Canada.
Institut universitaire de cardiologie et de pneumologie de Québec (CA)
Université Laval (CA)
Centre Hospitalier Universitaire Sainte-Justine (CA)
University of Bordeaux, UMR 5248, CBMN, Bordeaux, France.
Corresponding author: Marette, André
ORCID: Anhê, Fernando F.
Desjardins, Yves
Levy, Emile
Roy, Denis
Marette, André
Venue: Diabetes & Metabolism Journal
Publisher: Korean Diabetes Association
Published: 2015
Volume: 39
Issue: 4
Pages: 291
ISSN: 2233-6079 (ISSN-L)
2233-6087
DOI: 10.4093/dmj.2015.39.4.291
PMC: PMC4543192
OpenAlex: W2167419149
Cited by: 142
References: 61
Citations by year: 2026: 8 · 2025: 18 · 2024: 10 · 2023: 9 · 2022: 14 · 2021: 7 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 15 · 2016: 15 · 2015: 3
FWCI: 2.01
Type: journal article
Language: en
Update notices: erratum (2015-10-22)
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (tdm)
Locations: Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, Lactobacillus plantarum, anti-obesity, diet-induced obesity, high-fat diet, bile salt hydrolysis, cholesterol lowering, leptin, hepatic steatosis, PPARγ, intestinal permeability, gut microbiota, 3T3-L1 preadipocytes, metabolic disorders

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Probiotics as Complementary Treatment for Metabolic Disorders

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