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The limbic system

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RajMohan, V, Mohandas, E·2007·Indian Journal of Psychiatry
DOI 10.4103/0019-5545.33264PMC PMC2917081
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Abstract

“The hypothalamus, the anterior thalamic nucleus, the cingulate gyrus, the hippocampus and their interconnections, constitute a harmonious mechanism which may elaborate the functions of central emotion as well as participate in the emotional expression.” James Papez, 1937 The limbic system consists of the phylogenetically old limbic lobe and other subcortical structures and their connections. Although not empirically proven, the limbic system is a functional concept which may be employed to explain various brain functions.[1] HISTORY Paul Pierre Broca in 1878 spoke of ‘le grand lobe limbique’ or the great limbic lobe and applied the term “limbic” (from the Latin limbus for border) to the curved rim of the cortex which incudes the cingulate and the parahippocampal gyri. However, its putative role in emotion was elaborated by the American physician, James Papez in 1937 in the seminal paper titled ‘A proposed mechanism of emotion’. This anatomical model is referred to as the Papez circuit.[2] Yakovlev in 1948 proposed Yakovlev's circuit in the control of emotion involving the orbitofrontal, insular and anterior temporal lobe cortex, the amygdala and the dorsomedial nucleus of thalamus.[3] In 1952, Paul D. MacLean coined the term “limbic system” to describe Broca's limbic lobe and related subcortical nuclei as the collective neural substrate for emotion.[1] MacLean was also instrumental in proposing and defining the Triune concept of the brain. MacLean's evolutionary “Triune brain theory” proposed that the human brain was in reality three brains in one: the R-complex (reptilian complex), the limbic system and the neocortex.[4] The concept of the limbic system has since been further expanded and developed by Nauta, Heimer and others. COMPONENTS OF THE LIMBIC SYSTEM There is no universal agreement on the total list of structures, which comprise the limbic system. The brain regions that constitute the limbic system are: Limbic cortex Cingulate gyrus Parahippocampal gyrus Hippocampal formation The dentate gyrus Hippocampus Subicular Complex Amygdala Septal area Hypothalamus These structures form a complex network for controlling emotion.[5] Limbic lobe The limbic lobe situated at the inferomedial aspect of the cerebral hemispheres, consists of two concentric gyri surrounding the corpus callosum. Broca proposed that the larger outer gyrus be named “limbic gyrus” and the smaller inner one “the intralimbic gyrus”. The limbic gyrus (limbic lobe) consists of the isthmus of the cingulate gyrus, the parahippocampal gyrus (both of which are continuous via a bundle of white matter called “cingulum”) and the subcallosal area.[6] The cingulate gyrus (Latin = Belt ridge) dorsal to the corpus callosum is heavily interconnected with the association areas of the cerebral cortex. The parahippocampal gyrus in the medial temporal lobe contains several distinct regions, the most important being the entorhinal cortex (ERC). The ERC funnels highly processed cortical information to the hippocampal formation and serves as its major output pathway.[5] The hippocampal formation Hippocampal formation in the temporal lobe has three distinct zones: The dentate gyrus The hippocampus proper The subiculum Embryologically, the hippocampal formation is an extension of the medial edge of the temporal lobe. The entire hippocampal formation has a length of about 5 cm from its anterior end at the amygdala to its tapering posterior end near the splenium of the corpus callosum.[5] Dentate gyrus The dentate gyrus is composed of three layers: an outer acellular molecular layer, a granular middle layer and an inner polymorphic layer. Hippocampus The word hippocampus means “Sea Horse” in Greek. Hippocampus is a trilaminate structure with an outer molecular layer, a middle pyramidal layer and an inner polymorphic layer. On the basis of differences in cytoarchitecture and connectivity, the hippocampus has four fields (named by Lorente de No in 1934): CA1, CA2, CA3 and CA4 (CA: Cornu Ammonis). To embryologic enthusiasts, CA4 is not part of the Cornu Ammonis but is a separate structure—the dentate hilus. The thin layer of fibers adjacent to the polymorphic layer of the hippocampus is known as the alveus. These fibres coalesce to form the fimbria and subsequently, the crura of the fornix (main efferent pathway of the hippocampal formation). The crura of the fornix converge to form the body of the fornix, which later forms the columns of the fornix and pass through the hypothalamus into the mammillary bodies.[57] Subicular complex The subicular complex has three components: the presubiculum, the parasubiculum and subiculum. Subiculum is the transitional zone between the six-layered, entorhinal cortex and the three-layered hippocampus.[5] Amygdala Identified by Burdach in the early 19th century, amygdala, an almond-shaped structure deep within the temporal lobe, is a collection of nuclei lying beneath the uncus. Lying at the anterior end of the hippocampal formati

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Figures

Figure 1 Papez circuit
Figure 1 Papez circuitCC BY · PubMed Central
Figure 2 Internal circuit of hippocampal formation
Figure 2 Internal circuit of hippocampal formationCC BY · PubMed Central
Figure 3 Connections of the hippocampal formation (F: Fornix, MTT: Mammilothalamic tract)
Figure 3 Connections of the hippocampal formation (F: Fornix, MTT: Mammilothalamic tract)CC BY · PubMed Central
Figure 4 Amygdalo-septal pathway, S: Stria terminalis, V: Ventral amygdalofugal pathway
Figure 4 Amygdalo-septal pathway, S: Stria terminalis, V: Ventral amygdalofugal pathwayCC BY · PubMed Central
Figure 5 Amygdala basal ganglia circuit
Figure 5 Amygdala basal ganglia circuitCC BY · PubMed Central
Figure 6 Basolateral circuit
Figure 6 Basolateral circuitCC BY · PubMed Central
Figure 7 Olfactory role of limbic system
Figure 7 Olfactory role of limbic systemCC BY · PubMed Central
Figure 8 Limbic system and autonomic and endocrine responses
Figure 8 Limbic system and autonomic and endocrine responsesCC BY · PubMed Central
Figure 9 Neural Circuit of Male Sexual Behavior CTF: Central Tegmental Field, MeA: Medial Amygdala, BNST: Bed Nucleus of Stria Terminalis, VTA: Ventral Tegmental Area, MPOA: Medial Preoptic Area
Figure 9 Neural Circuit of Male Sexual Behavior CTF: Central Tegmental Field, MeA: Medial Amygdala, BNST: Bed Nucleus of Stria Terminalis, VTA: Ventral Tegmental Area, MPOA: Medial Preoptic AreaCC BY · PubMed Central
Figure 10 Pathway for motivated or goal directed behavior(modified from Kalivas and Volkow)[21]
Figure 10 Pathway for motivated or goal directed behavior(modified from Kalivas and Volkow)[21]CC BY · PubMed Central
Figure 11 Anterior Limbic Network: PFC: Prefrontal Cortex, PHG: Parahippocampal Gyrus, BA: Broadman area (adapted from Strakowsky et al.[30])
Figure 11 Anterior Limbic Network: PFC: Prefrontal Cortex, PHG: Parahippocampal Gyrus, BA: Broadman area (adapted from Strakowsky et al.[30])CC BY · PubMed Central

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Citations

Cites

Show all 24 references

Research works printed but not linked: 7

  1. Maclean PD. The triune brain in evolution: Role in paleocerebral functions. Plenum Press: New York; 1990.
  2. Pierri JN, Lewis DA. Functional neuroanatomy. In : Kaplan and Sadock′s Comprehensive textbook of psychiatry, 8 th ed. Sadock BJ, Sadock VA, editor. Lippincott William and Wilkins: Phildelphia; p. 3-33.
  3. Ganong WF. Smell and taste. In : review of medical physiology. 21 st ed. McGraw Hill Companies Inc: 2003. p. 188-91.
  4. Ganong WF. Neural basis of instinctual behavior and emotions. In Review of Medical Physiology. 21 st ed. McGraw Hill Companies Inc: 2003. p. 260-9.
  5. Benca RM, Cirelli C, Rattenborg MC, Tononi G. Basic science of sleep. In : Kaplan and Sadock′s Comprehensive textbook of psychiatry, 8 th ed. Sadock BJ, Sadock VA, editors. Lippincott William and Wilkins: Phildelphia; p. 280-95.
  6. Paller KA, Squire LR. Biology of memory. In : Kaplan and Sadock′s Comprehensive textbook of psychiatry, 8 th ed. Sadock BJ, Sadock VA, editor. Lippincott William and Wilkins: Phildelphia; p. 553-66.
  7. Hechtman L. Attention-deficit/hyperactivity disorder. In : Kaplan and Sadock′s Comprehensive textbook of psychiatry, 8 th ed. Sadock BJ, Sadock VA, editor. Lippincott William and Wilkins: Phildelphia; p. 3183-97.

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Metadata

Authors
RajMohan, V, & Mohandas, E.
Venue
Indian Journal of Psychiatry
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007
Volume
49
Issue
2
Pages
132
ISSN
0019-5545 (ISSN-L)
DOI
10.4103/0019-5545.33264
PMC
PMC2917081
OpenAlex
W1968677514
Cited by
342
References
24
Citations by year
2026: 18 · 2025: 38 · 2024: 45 · 2023: 55 · 2022: 41 · 2021: 31 · 2020: 31 · 2019: 33 · 2018: 14 · 2017: 12 · 2016: 9 · 2015: 5 · 2014: 3 · 2012: 3
FWCI
0.50
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Indian Journal of Psychiatry (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
limbic system, Papez circuit, emotions, limbic lobe, cingulate gyrus, parahippocampal gyrus, hippocampus, amygdala, hypothalamus, septal area, triune brain theory, limbic cortex

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