The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.
The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: A randomized, double-blind placebo-controlled study
Open accessAbstract
BACKGROUND: Finding an effective treatment for acne that is well tolerated by the patients is a challenge. One study has suggested the efficacy of tea tree oil in treatment of the acne vulgaris. AIM: To determine the efficacy of tea tree oil in mild to moderate acne vulgaris. METHODS: This was a randomized double-blind clinical trial performed in 60 patients with mild to moderate acne vulgaris. They were randomly divided into two groups and were treated with tea tree oil gel (n=30) or placebo (n=30). They were followed every 15 days for a period of 45 days. Response to treatment was evaluated by the total acne lesions counting (TLC) and acne severity index (ASI). The data was analyzed statistically using t-test and by SPSS program. RESULTS: There were no significant differences regarding demographic characteristics between the two groups. There was a significant difference between tea tree oil gel and placebo in the improvement of the TLC and also regarding improvement of the ASI. In terms of TLC and ASI, tea tree oil gel was 3.55 times and 5.75 times more effective than placebo respectively. Side-effects with both groups were relatively similar and tolerable. CONCLUSION: Topical 5% tea tree oil is an effective treatment for mild to moderate acne vulgaris.
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“The study design was a randomized, double‐blind, placebo‐controlled trial, which is considered Level 2b evidence according to the Oxford evidence hierarchy.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [18]
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Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris.
White, G. M. (1998) · Journal of American Academy of Dermatology · doi:10.1016/s0190-9622(98)70442-6 · Cited by 341 · cited 1×
“There are States of America indicated that the prevalence of acne in the age group 12-24 was 85%.([1]) Even in its mild form, acne can have lingering impacts on mental health (e.”
BackgroundEady, E. A., Cove, J. H., Holland, K. T., & Cunliffe, W. J. (1989) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1989.tb01399.x · Cited by 279
Propionibacterium acnes resistance to antibiotics in acne patients.
Leyden, J., Mcginley, K., Cavalieri, S., et al. (1983) · Journal of American Academy of Dermatology · doi:10.1016/s0190-9622(83)70005-8 · Cited by 234
Tea tree oil reduces histamine-induced skin inflammation
Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05034.x · Cited by 185
Evandri, M. G., Battinelli, L., Daniele, C., Mastrangelo, S., Bolle, P., & Mazzanti, G. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.03.013 · Cited by 181
Antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage.
Eady, E., Jones, C. E., Tipper, J., et al. (1993) · British medical journal · doi:10.1136/bmj.306.6877.555 · Cited by 164
Antimicrobial activity of the essential oil of Melaleuca alternifolia
Carson, C., & Riley, T. V. (1993) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.1993.tb00340.x · Cited by 160
Jandourek, A., Vaishampayan, J. K., & Vázquez, J. (1998) · AIDS (London) · doi:10.1097/00002030-199809000-00011 · Cited by 98
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Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929
Guidelines of care for the management of acne vulgaris
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.037 · Cited by 1,597
“COMPLEMENTARY/ALTERNATIVE THERAPIES Two clinical trials have shown that topical tea tree oil is effective for the treatment of acne.(150,151) In 1 study, it was comparable to BP but better tolerated.”
Williams, H. C., Dellavalle, R. P., & Garner, S. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60321-8 · Cited by 1,126
Essential Oils and Their Single Compounds in Cosmetics—A Critical Review
Sarkic, A., & Stappen, I. (2018) · Cosmetics · doi:10.3390/cosmetics5010011 · Cited by 340
“Applying 5% of tea tree gel to acne lesions was more than threefold as effective in reducing the number of lesions than a placebo [68].”
BackgroundDraelos, Z. D. (2007) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2007.00144.x · Cited by 390
Metadata
- Authors
- Jooya, A., Siadat, A., Iraji, F., & Enshaieh, S.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- ORCID
- Iraji, Fariba
- Venue
- Indian Journal of Dermatology, Venereology and Leprology
- Publisher
- Scientific Scholar
- Published
- 2007
- Volume
- 73
- Issue
- 1
- Pages
- 22
- ISSN
- 0378-6323 (ISSN-L)
- OpenAlex
- W2018583838
- Cited by
- 165
- References
- 9
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 13
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Indian Journal of Dermatology Venereology and Leprology (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Bioline International (Bioline International) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- tea tree oil, topical gel, acne, mild to moderate acne, herbal medicine, treatment efficacy, tolerability
- MeSH terms
- Acne Vulgaris, Administration, Topical, Adolescent, Adult, Anti-Infective Agents, Local, Double-Blind Method, Female, Gels, Humans, Male, Severity of Illness Index, Treatment Outcome, Tea Tree Oil
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