The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.
The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: A randomized, double-blind placebo-controlled study
Open accessAbstract
BACKGROUND: Finding an effective treatment for acne that is well tolerated by the patients is a challenge. One study has suggested the efficacy of tea tree oil in treatment of the acne vulgaris. AIM: To determine the efficacy of tea tree oil in mild to moderate acne vulgaris. METHODS: This was a randomized double-blind clinical trial performed in 60 patients with mild to moderate acne vulgaris. They were randomly divided into two groups and were treated with tea tree oil gel (n=30) or placebo (n=30). They were followed every 15 days for a period of 45 days. Response to treatment was evaluated by the total acne lesions counting (TLC) and acne severity index (ASI). The data was analyzed statistically using t-test and by SPSS program. RESULTS: There were no significant differences regarding demographic characteristics between the two groups. There was a significant difference between tea tree oil gel and placebo in the improvement of the TLC and also regarding improvement of the ASI. In terms of TLC and ASI, tea tree oil gel was 3.55 times and 5.75 times more effective than placebo respectively. Side-effects with both groups were relatively similar and tolerable. CONCLUSION: Topical 5% tea tree oil is an effective treatment for mild to moderate acne vulgaris.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The study design was a randomized, double‐blind, placebo‐controlled trial, which is considered Level 2b evidence according to the Oxford evidence hierarchy.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [18]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recent findings in the epidemiologic evidence, classification, and subtypes of acne vulgaris.
White, G. M. (1998) · Journal of American Academy of Dermatology · doi:10.1016/s0190-9622(98)70442-6 · Cited by 341 · cited 1×
“There are States of America indicated that the prevalence of acne in the age group 12-24 was 85%.([1]) Even in its mild form, acne can have lingering impacts on mental health (e.”
BackgroundEady, E. A., Cove, J. H., Holland, K. T., & Cunliffe, W. J. (1989) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1989.tb01399.x · Cited by 279
Propionibacterium acnes resistance to antibiotics in acne patients.
Leyden, J., Mcginley, K., Cavalieri, S., et al. (1983) · Journal of American Academy of Dermatology · doi:10.1016/s0190-9622(83)70005-8 · Cited by 234
Tea tree oil reduces histamine-induced skin inflammation
Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.05034.x · Cited by 185
Evandri, M. G., Battinelli, L., Daniele, C., Mastrangelo, S., Bolle, P., & Mazzanti, G. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.03.013 · Cited by 181
Antibiotic resistant propionibacteria in acne: need for policies to modify antibiotic usage.
Eady, E., Jones, C. E., Tipper, J., et al. (1993) · British medical journal · doi:10.1136/bmj.306.6877.555 · Cited by 164
Antimicrobial activity of the essential oil of Melaleuca alternifolia
Carson, C., & Riley, T. V. (1993) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.1993.tb00340.x · Cited by 160
Jandourek, A., Vaishampayan, J. K., & Vázquez, J. (1998) · AIDS (London) · doi:10.1097/00002030-199809000-00011 · Cited by 98
Cited by
Sorted by citations
Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929
Guidelines of care for the management of acne vulgaris
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.037 · Cited by 1,597
“COMPLEMENTARY/ALTERNATIVE THERAPIES Two clinical trials have shown that topical tea tree oil is effective for the treatment of acne.(150,151) In 1 study, it was comparable to BP but better tolerated.”
Williams, H. C., Dellavalle, R. P., & Garner, S. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60321-8 · Cited by 1,126
Essential Oils and Their Single Compounds in Cosmetics—A Critical Review
Sarkic, A., & Stappen, I. (2018) · Cosmetics · doi:10.3390/cosmetics5010011 · Cited by 340
“Applying 5% of tea tree gel to acne lesions was more than threefold as effective in reducing the number of lesions than a placebo [68].”
BackgroundDraelos, Z. D. (2007) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2007.00144.x · Cited by 390
Fox, L. T., Csongradi, C., Aucamp, M. E., du Plessis, J., & Gerber, M. (2016) · Molecules · doi:10.3390/molecules21081063 · Cited by 339
“[93] showed that a topical gel containing 5% tea tree oil was effective in treating mild-to-moderate Acne vulgaris when compared to the placebo, i.”
BackgroundCommercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases
Orchard, A., & van Vuuren, S. F. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/4517971 · Cited by 282
A review of applications of tea tree oil in dermatology
Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2012.05654.x · Cited by 252
A review of diagnosis and treatment of acne in adult female patients
Tan, A. U., Schlosser, B. J., & Paller, A. S. (2017) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2017.10.006 · Cited by 263
“These complementary and alternative therapies include tea tree oil (Bassett et al., 1990; Bowe and Shalita, 2008; Enshaieh et al., 2007; Hammer, 2015; Sharquie et al., 2006), niacinamide (Draelos et al.”
BackgroundPhytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria
Khameneh, B., Eskin, N. A. M., Iranshahy, M., & Bazzaz, B. S. F. (2021) · Antibiotics · doi:10.3390/antibiotics10091044 · Cited by 217
Tea tree oil: contact allergy and chemical composition
de Groot, A. C., & Schmidt, E. (2016) · Contact Dermatitis · doi:10.1111/cod.12591 · Cited by 180
Botanicals in Dermatology: An Evidence-Based Review
Reuter, J., Merfort, I., & Schempp, C. M. (2010) · American Journal of Clinical Dermatology · doi:10.2165/11533220-000000000-00000 · Cited by 176
Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care
Kokoška, L., Klouček, P., Leuner, O., & Nový, P. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180831144344 · Cited by 165
Giornale italiano di Dermatologia e Venereologia
Ribero, S., Quaglino, P., Sanlorenzo, M., Osella‐Abate, S., Marenco, F., Fierro, M. T., & Bernengo, M. G. (2012) · Institutional Research Information System University of Turin (University of Turin) · Cited by 155
Plants of theMelaleucaGenus as Antimicrobial Agents: From Farm to Pharmacy
Sharifi‐Rad, J., Salehi, B., Varoni, E. M., Sharopov, F. S., Yousaf, Z., Ayatollahi, S. A., Kobarfard, F., Sharifi‐Rad, M., Afdjei, M. H., Sharifi‐Rad, M., et al. (2017) · Phytotherapy Research · doi:10.1002/ptr.5880 · Cited by 152
“5% TTO gel showed to ameliorate acne lesions, although the onset of action in the case of TTO was slower (Enshaieh et al., 2007; Feinblatt, 1960).”
BackgroundResultTisserand, R., & Young, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06241-4.00013-8 · Cited by 162
α-Terpinene, an Antioxidant in Tea Tree Oil, Autoxidizes Rapidly to Skin Allergens on Air Exposure
Rudbäck, J., Bergström, M. A., Börje, A., et al. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200486f · Cited by 140
Taleb, M. H., Abdeltawab, N. F., Shamma, R. N., Abdelgayed, S. S., Mohamed, S. S., Farag, M. A., & Ramadan, M. A. (2018) · Molecules · doi:10.3390/molecules23092164 · Cited by 147
“Thus, in this study, the anti‐acne effects of oregano EO surpassed that of other EOs evaluated including commercialized over‐the‐counter acne treatment tea tree EO [15,16].”
BackgroundACNE VULGARIS TREATMENT: THE CURRENT SCENARIO
Rathi, S. (2011) · Indian Journal of Dermatology · doi:10.4103/0019-5154.77543 · Cited by 134
“[42] Picolinic acid gel 10%: It is an intermediate metabolite of the amino acid, tryptophan.”
Hammer, K. A. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.10.011 · Cited by 132
“Enshaieh et al. (2007) conducted a double-blinded placebocontrolled trial of the efficacy of 5% tea tree oil gel in patients (30 per group) with mild-to-moderate acne [17].”
Mastrofrancesco, A., Ottaviani, M., Aspite, N., Cardinali, G., Izzo, E., Graupe, K., Zouboulis, C. C., Camera, E., & Picardo, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01107.x · Cited by 131
Plant essential oils and their constituents in coping with multidrug-resistant bacteria
Kon, K. V., & Rai, M. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.57 · Cited by 115
Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences
Nasri, H., Bahmani, M., Shahinfard, N., نافچی, ع. م., Saberianpour, S., & Rafieian‐Kopaei, M. (2015) · Jundishapur Journal of Microbiology · doi:10.5812/jjm.25580 · Cited by 116
“Some plants, especially the roots of mountain grapes, tea tree oil, Saccharomyces, and perhaps Ocimum basilicum due to their effectiveness and safety can be compared to alternative treatments with synthetic drugs for mild to moderate acne (74-76).”
BackgroundNew Perspectives on Antiacne Plant Drugs: Contribution to Modern Therapeutics
Sinha, P., Srivastava, S., Mishra, N., & Yadav, N. P. (2014) · BioMed Research International · doi:10.1155/2014/301304 · Cited by 99
“From a study of 60 patients with mild to moderate acne, tea tree oil in terms of total acne lesion count and acne severity index was found to be highly effectual in treating acne [78].”
BackgroundA review of phytotherapy of acne vulgaris: Perspective of new pharmacological treatments
Azimi, H., Fallah-Tafti, M., Khakshur, A. A., et al. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.03.026 · Cited by 90
Weber, N., Biehler, K., Schwabe, K., Haarhaus, B., Quirin, K.-W., Frank, U., Schempp, C. M., & Wölfle, U. (2019) · Molecules · doi:10.3390/molecules24020223 · Cited by 89
“This result was confirmed in a vehicle-controlled randomized double-blind study over 45 days in 60 acne-prone patients [43,44].”
ResultNew Herbal Biomedicines for the Topical Treatment of Dermatological Disorders
Hoffmann, J., Gendrisch, F., Schempp, C. M., & Wölfle, U. (2020) · Biomedicines · doi:10.3390/biomedicines8020027 · Cited by 88
“- Gel containing 5% Melaleuca alternifolia oil applied topically for 3 months B [95] Tea tree (Melaleuca alternifolia (Maiden & Betche) Cheel) Tea tree oil - Gel containing 5% Melaleuca alternifolia oil applied twice daily for 45 days A [96]”
MethodComplementary therapies for acne vulgaris
Cao, H., Yang, G., Wang, Y., Liu, J., Smith, C. A., Luo, H., & Liu, Y. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009436.pub2 · Cited by 89
Amer, S. S., Nasr, M., Abdel-Aziz, R. T. A., Moftah, N. H., ElShaer, A., Polycarpou, E., Mamdouh, W., & Sammour, O. A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119092 · Cited by 78
Kairey, L., Agnew, T., Bowles, E. J., Barkla, B. J., Wardle, J., & Lauche, R. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1116077 · Cited by 75
“…to 2022, and conducted in Australia (Bassett et al., 1990; Satchell et al., 2002a), Germany (Beikert et al., 2013; Rothenberger et al., 2016), Iran (Enshaieh et al., 2007; Beheshti Roy et al., 2014; Najafi-Taher et al., 2022), Brazil (Hugo Infante et al., 2023), or Korea (Cho and Choi, 2017),…”
BackgroundMethodInfluentialTea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review
Nascimento, T., Gomes, D., Simões, R., & Miguel, M. G. (2023) · Antioxidants · doi:10.3390/antiox12061264 · Cited by 84
“, 2007 [154] RCT double-blind Intervention group (n = 30): TTO 5% carbomer gel.”
BackgroundInfluentialNovel vesicular and particulate drug delivery systems for topical treatment of acne
Goulart, G. A. C., & Ferreira, L. A. M. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.6.665 · Cited by 69
Reuter, J., Wölfle, U., Weckesser, S., & Schempp, C. M. (2010) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07496.x · Cited by 70
Mazzarello, V., Donadu, M., Ferrari, M., et al. (2018) · Clinical Pharmacology : Advances and Applications · doi:10.2147/cpaa.s180474 · Cited by 63
Aromatherapy, botanicals, and essential oils in acne
Winkelman, W. J. (2018) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2018.03.004 · Cited by 63
Sinha, P., Srivastava, S., Mishra, N., et al. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2016.1141931 · Cited by 61
Amer, S. S., Mamdouh, W., Nasr, M., ElShaer, A., Polycarpou, E., Abdel-Aziz, R. T. A., & Sammour, O. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121309 · Cited by 60
Tea tree oil gel for mild to moderate acne; a 12 week uncontrolled, open‐label phase II pilot study
Malhi, H. K., Tu, J., Riley, T. V., Kumarasinghe, S. P., & Hammer, K. A. (2016) · Australasian Journal of Dermatology · doi:10.1111/ajd.12465 · Cited by 49
Kwon, H. H., Yoon, J. Y., Park, S. Y., Min, S., & Suh, D. H. (2014) · Dermatology · doi:10.1159/000362491 · Cited by 48
Dermocosmetics: beneficial adjuncts in the treatment of acne vulgaris
Araviiskaia, E., Lopez Estebaranz, J. L., & Pincelli, C. (2021) · Journal of Dermatological Treatment · doi:10.1080/09546634.2019.1628173 · Cited by 47
Mazzarello, V., Gavini, E., Rassu, G., et al. (2020) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s236956 · Cited by 46
“The effective essential oils for acne treatment so far have been Tea tree oil, Lavender oil and Ocimum gratissimum and Ramulusmori.(7,9,10,12,15,16) In a previous paper, we also demonstrated the anti-acne efficacy of an essential oil, associated with 2 plant extracts, Table 2 Demographic Characteristics of Patients”
BackgroundEssential oils as topical anti-infective agents: A systematic review and meta-analysis
Deyno, S., Mtewa, A. G., Abebe, A., Hymete, A., Makonnen, E., Bazira, J., & Alele, P. E. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102224 · Cited by 47
Botanical and Phytochemical Therapy of Acne: A Systematic Review
Fisk, W. A., Lev‐Tov, H. A., & Sivamani, R. K. (2014) · Phytotherapy Research · doi:10.1002/ptr.5125 · Cited by 44
Najafi-Taher, R., Kohneloo, A. J., Farsani, V. E., Rayeni, N. M., Moghimi, H. R., Ehsani, A. H., & Amani, A. (2021) · Archives of Dermatological Research · doi:10.1007/s00403-021-02267-2 · Cited by 39
“On the tolerability aspect of tea tree oil, Enshaieh reported that ~ 10% patients reported minimal pruritus ~ 3% little burning and ~ 3% minimal scaling after 6 weeks treatment of patients with tea tree oil gel [23].”
BackgroundMethodEfficacy of 2% metronidazole gel in moderate acne vulgaris
Fouladi, R., Nojookambari, N. Y., Amirnia, M., et al. (2012) · Indian Journal of Dermatology · doi:10.4103/0019-5154.97666 · Cited by 38
Proença, A. C., Luís, Â., & Duarte, A. P. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2011945 · Cited by 43
Jones, V., Patel, P. M., Wilson, C., Wang, H., & Ashack, K. A. (2020) · JAAD International · doi:10.1016/j.jdin.2020.11.001 · Cited by 40
Different approaches of alternative medicines in acne vulgaris treatment
Ghosh, V. K., Nagore, D. H., Kadbhane, K. P., et al. (2011) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-011-0006-6 · Cited by 37
“The study revealed that both the formulations have very good effect in acne treatment by reducing the inflamed and non-inflamed lesions although onset of action in case of tee tree oil was found to be slow (Enshaieh et al. 2007).”
BackgroundDiagnosis and treatment of acne.
Titus, S. J., & Hodge, J. (2012) · PubMed · Cited by 68
Over-the-counter Acne Treatments: A Review.
Decker, A., & Graber, E. (2012) · Europe PMC (PubMed Central) · Cited by 63
Agrawal, R., Jurel, P., Deshmukh, R., Harwansh, R. K., Garg, A., Kumar, A., Singh, S. K., Guru, A., Kumar, A., & Kumarasamy, V. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16070869 · Cited by 35
Lam, N. S. K., Long, X. X., Griffin, R. C., Chen, M.-K., & Doery, J. C. G. (2018) · Parasitology · doi:10.1017/s0031182018000495 · Cited by 34
The Art and Science of New Advances in Cosmeceuticals
Draelos, Z. D. (2011) · Clinics in Plastic Surgery · doi:10.1016/j.cps.2011.02.002 · Cited by 31
Wiatrak, K., Morawiec, T., Rój, R., Kownacki, P., Nitecka-Buchta, A., Niedzielski, D., Wychowański, P., Machorowska-Pieniążęk, A., Cholewka, A., Baldi, D., et al. (2021) · Molecules · doi:10.3390/molecules26134071 · Cited by 31
Harnessing the Power of Crowds
Armstrong, A. W., Cheeney, S., Wu, J., Harskamp, C. T., & Schupp, C. W. (2012) · American Journal of Clinical Dermatology · doi:10.2165/11634040-000000000-00000 · Cited by 31
Emerging Insights into the Applicability of Essential Oils in the Management of Acne Vulgaris
Bungău, A. F., Radu, A.-F., BUNGAU, S. G., Vesa, C. M., Ţiţ, D. M., Purza, A. L., & Endres, L. M. (2023) · Molecules · doi:10.3390/molecules28176395 · Cited by 34
“Results indicated that tea tree oil gel demonstrated significant improvement over placebo in terms of total acne lesion count and acne severity index [74].”
BackgroundMicroencapsulation ofMelaleuca alternifolia(Tea Tree) Oil as Biocide for Footwear Applications
Sánchez-Navarro, M. M., Cuesta-Garrote, N., Arán‐Aís, F., & Orgilés‐Barceló, C. (2011) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2011.616126 · Cited by 30
(2013) · Europe PMC (PubMed Central) · Cited by 29
Self-citationOrchard, A., van Vuuren, S. F., Viljoen, A. M., & Kamatou, G. (2018) · International Journal of Cosmetic Science · doi:10.1111/ics.12456 · Cited by 30
Cha, H., Kim, S.-K., Kook, M., & Yi, T. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102243 · Cited by 28
Ramsis, T. M., Selim, H. M. R. M., Elseedy, H. A., & Fayed, E. A. (2024) · RSC Advances · doi:10.1039/d4ra03865g · Cited by 28
Dontje, A. E. W. K., Schuiling‐Veninga, C. C. M., van Hunsel, F. P. A. M., Ekhart, C., Demi̇rci̇, F., & Woerdenbag, H. J. (2024) · Pharmaceuticals · doi:10.3390/ph17050571 · Cited by 25
Lubtikulthum, P., Kamanamool, N., & Udompataikul, M. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12962 · Cited by 23
Tea Tree Oil as a Novel Antipsoriasis Weapon
Pazyar, N., & Yaghoobi, R. (2012) · Skin Pharmacology and Physiology · doi:10.1159/000337936 · Cited by 23
Raut, C., & Sethi, K. (2016) · Contemporary Clinical Dentistry · doi:10.4103/0976-237x.188572 · Cited by 23
“The gel was sterilized in the autoclave at 110°C for 20 min.[16] Placebo gel The placebo gel preparation was same as that of tea‐tree oil gel preparation except for the addition of tea‐tree oil.”
Principles of herbal pharmacology
(2013) · Elsevier eBooks · doi:10.1016/b978-0-443-06992-5.00002-5 · Cited by 27
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23
Abrha, S., Tesfaye, W. H., Christenson, J. K., Carson, C. F., & Thomas, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14081587 · Cited by 20
Acne Vulgaris Topical Therapies: Application of Probiotics as a New Prevention Strategy
Dapkevicius, I., Romualdo, V., Marques, A. C., Lopes, C. M., & Amaral, M. H. (2023) · Cosmetics · doi:10.3390/cosmetics10030077 · Cited by 21
Bisht, A., Hemrajani, C., Upadhyay, N. K., et al. (2021) · Therapeutic Delivery · doi:10.4155/tde-2021-0059 · Cited by 19
Kon, K. V., & Rai, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-398539-2.00010-0 · Cited by 19
Abrha, S., Tesfaye, W. H., & Thomas, J. (2020) · Antibiotics · doi:10.3390/antibiotics9120909 · Cited by 18
Efficacy of Topical Timolol 0.5% in the Treatment of Acne and Rosacea: A Multicentric Study.
Mokadem, S. M. A. E. F. A., Ibrahim, A. M., & Sayed, A. M. E. (2020) · PubMed · Cited by 18
Characterization and Efficacy of Essential Oil-Based Cosmetic Formulations for Acne-Prone Skin
Infante, V. H. P., Darvin, M. E., & Campos, P. M. B. G. M. (2023) · Cosmetics · doi:10.3390/cosmetics10060158 · Cited by 17
Waranuch, N., Phimnuan, P., Yakaew, S., et al. (2019) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s200564 · Cited by 17
“The number of subjects enrolled was 60 (30 per arm).(16,17)”
BackgroundMethodLiposomes as topical drug delivery systems: State of the arts
Rahman, M., Alam, K., Beg, S., et al. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816506-5.00004-8 · Cited by 17
Nanotools as potential approach in effective management of acne
Darvishi, M., Khan, M. S., Mohapatra, S., Singh, M., Ali, A., Rajabalizadeh, S., Rahman, H., Iqbal, Z., & Mirza, M. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106380 · Cited by 16
Pezantes-Orellana, C., Bermúdez, F. G., Montalvo, J. L., Packer, T., & Orellana‐Manzano, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1589691 · Cited by 23
Case Reports of Acne and Homeopathy
Nwabudike, L. C. (2018) · Complementary Medicine Research · doi:10.1159/000486309 · Cited by 16
ACNE-CAUSES AND AMAZING REMEDIAL MEASURES FOR ACNE
Ravisankar, P., Koushik, O. S., Himaja, V., Ramesh, J., & Pragna, P. (2015) · Indo American Journal of Pharmaceutical Research · Cited by 15
Essential oils in cosmetics: Antioxidant properties and advancements through nanoformulations
Reddy, B. H. V., Hussain, S. M. S., Hussain, M. S., Kumar, R. N., & Gupta, J. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100192 · Cited by 13
Garcinia mangostana hydrogel patch
Phumlek, K., Itharat, A., Pongcharoen, P., et al. (2022) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.355195 · Cited by 13
“Moreover, tea tree oil products, one of the popular topical anti-acne, also reported ACD (42) and side effects of treatment with minimal pruritus, burning, and scaling (43).”
BackgroundAn overview on the anti-acne properties of herbal essential oils
Asnaashari, S., Kazemnezhad, M., Masoud, F., et al. (2023) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2023.100642 · Cited by 13
Cosmetic Industry: Natural Secondary Metabolites for Beauty and Aging
Saraiva, S. M., Miguel, S. P., Araújo, A. R. T. S., Rodrigues, M., Ribeiro, M. P., & Coutinho, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_27 · Cited by 16
Exploiting Medicinal Plants as Possible Treatments for Acne Vulgaris
Lambrechts, I. A., Canha, M. N. D., & Lall, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812475-8.00004-4 · Cited by 13
External Application of Herbal Medicines for Acne Vulgaris: A Systematic Review and Meta Analysis
Sung, S.-H., Choi, G.-H., Lee, N.-W., & Shin, B. (2020) · Journal of pharmacopuncture · doi:10.3831/kpi.2020.23.002 · Cited by 11
A review on efficacy and tolerability of tea tree oil for acne
Ahmad, S., Afsana, & Popli, H. (2019) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v9i3.2838 · Cited by 11
A review of phytotherapy of Acne vulgaris
Dodov, M. G., & Kulevanova, S. (2009) · Macedonian Pharmaceutical Bulletin · doi:10.33320/maced.pharm.bull.2009.55.001 · Cited by 10
“Few years ago, Enshaieh et al. (2007) confirmed the efficacy of 5% topical TTO gel in treatment of moderate acne vulgaris in a randomized, double-blind placebo-controlled study.”
BackgroundEpidemiology and Management of Acne in Adult Women
Fisk, W. A., Lev‐Tov, H. A., & Sivamani, R. K. (2014) · Current Dermatology Reports · doi:10.1007/s13671-014-0071-4 · Cited by 10
Yılmaz, U., Coşkun, A. G., Özel, Y., Ünlü, M., & Ünlü, G. V. (2024) · Journal of Applied Microbiology · doi:10.1093/jambio/lxae090 · Cited by 10
Phytochemicals as emerging therapeutics for acne vulgaris: a comprehensive review
El‐Shiekh, R. A., Merghany, R. M., Fayez, N., Hassan, M., Bakr, A. F., Eid, O., Ali, D. E., & Sweilam, S. H. (2025) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-025-00842-2 · Cited by 9
Tabasum, H., Ahmad, T., Anjum, F., et al. (2016) · Journal of Pakistan Association of Dermatologists · doi:10.66344/jpad.v24i4.220 · Cited by 9
Yapar, E. A., Gokce, E. H., Şahiner, A., et al. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105811 · Cited by 7
Cruz, R. D., Nguyen, R., Chen, P. G., Kérob, D., Gebauer, K., Willems, A., Tong, P. L., & Lee, M. (2025) · Australasian Journal of Dermatology · doi:10.1111/ajd.14447 · Cited by 7
Gurnee, E. A., Kamath, S., & Kruse, L. L. (2019) · Pediatric Dermatology · doi:10.1111/pde.13904 · Cited by 6
Abrha, S., Christenson, J. K., McEwen, J., Tesfaye, W. H., Nery, S. V., Chang, A. Y., Spelman, T. D., Kosari, S., Kigen, G., Carroll, S., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-047380 · Cited by 6
Laboratory Evaluation of Safety and Efficacy for Melafix (Melaleuca cajuputi Extract)
Shivappa, R. B., Christian, L. S., Noga, E. J., et al. (2015) · Journal of Exotic Pet Medicine · doi:10.1053/j.jepm.2015.04.020 · Cited by 6
Over‐the‐Counter Acne Treatments
Graber, E., & Thiboutot, D. M. (2010) · Cosmetic Dermatology · doi:10.1002/9781444317657.ch60 · Cited by 6
Herbal medicine and common dermatologic diseases
Ünlü, B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90572-5.00019-6 · Cited by 5
Volatile Oil Containing Plants as Phytopharmaceuticals to Treat Psoriasis: A Review
Vyas, P. J., Wagh, S. S., Kalaskar, M. G., Patil, K. R., Sharma, A., Kazmi, I. A., Al-Abbasi, F. A., Alzarea, S. I., Afzal, O., Altamimi, A. S. A., et al. (2023) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201024666230607140404 · Cited by 5
Metadata
- Authors
- Jooya, A., Siadat, A., Iraji, F., & Enshaieh, S.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- ORCID
- Iraji, Fariba
- Venue
- Indian Journal of Dermatology, Venereology and Leprology
- Publisher
- Scientific Scholar
- Published
- 2007
- Volume
- 73
- Issue
- 1
- Pages
- 22
- ISSN
- 0378-6323 (ISSN-L)
- OpenAlex
- W2018583838
- Cited by
- 165
- References
- 9
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 11 · 2012: 13
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Indian Journal of Dermatology Venereology and Leprology (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Bioline International (Bioline International) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- tea tree oil, topical gel, acne, mild to moderate acne, herbal medicine, treatment efficacy, tolerability
- MeSH terms
- Acne Vulgaris, Administration, Topical, Adolescent, Adult, Anti-Infective Agents, Local, Double-Blind Method, Female, Gels, Humans, Male, Severity of Illness Index, Treatment Outcome, Tea Tree Oil
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
