The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

Natural products as sources of new drugs over the last 25 years

Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517 · see citing works

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works

Therapeutic potential of resveratrol: the in vivo evidence

Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works

SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE

DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works

Natural products as sources of new drugs over the period 1981–2002

Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082 · see citing works

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

Epstein, F. H., Lipton, S. A., & Rosenberg, P. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403033300907 · Cited by 2,644 · see citing works

Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030

Dorsey, E. R., Constantinescu, R., Thompson, J. P., Biglan, K., Holloway, R. G., Kieburtz, K. D., Marshall, F. J., Ravina, B. M., Schifitto, G., Siderowf, A. D., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000247740.47667.03 · Cited by 2,479 · see citing works

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

Olney, J. (1969) · Science · doi:10.1126/science.164.3880.719 · Cited by 1,885 · see citing works

Medicinal natural products: A biosynthetic approach

(2001) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(01)01302-2 · Cited by 1,698 · see citing works

Biological effects of resveratrol

Frémont, L. (2000) · Life Sciences · doi:10.1016/s0024-3205(99)00410-5 · Cited by 1,663 · see citing works

Natural Products in Drug Discovery and Development

Cragg, G. M. L., Newman, D. J., & Snader, K. M. (1997) · Journal of Natural Products · doi:10.1021/np9604893 · Cited by 1,589 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · see citing works

The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease

Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380 · see citing works

MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits

Kaminska, B. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.08.017 · Cited by 1,285 · see citing works

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,256 · see citing works

Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works

Diagnosis and Treatment of Alzheimer Disease and Related Disorders

Small, G. W. (1997) · JAMA · doi:10.1001/jama.1997.03550160083043 · Cited by 984 · see citing works

A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia

Le Bars, P. L. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03550160047037 · Cited by 966 · see citing works

Central Nervous System

Peters, A., & Vaughan, D. W. (1981) · Springer eBooks · doi:10.1007/978-1-4684-3929-8_1 · Cited by 900 · see citing works

Review on some plants of Indian traditional medicine with antioxidant activity

Scartezzini, P., & Speroni, E. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00213-0 · Cited by 818 · see citing works

Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP

Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803 · see citing works

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial

Freund-Levi, Y., Eriksdotter-Jönhagen, M., Cederholm, T., Basun, H., Faxén-Irving, G., Garlind, A., Vedin, I., Vessby, B., Wahlund, L.-O., & Palmblad, J. (2006) · Archives of Neurology · doi:10.1001/archneur.63.10.1402 · Cited by 751 · see citing works

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

Marambaud, P., Zhao, H., & Davies, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508246200 · Cited by 750 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Missing pieces in the Parkinson's disease puzzle

Obeso, J. A., Rodríguez‐Oroz, M., Goetz, C. G., Marin, C. A., Kordower, J. H., Rodrı́guez, M., Hirsch, É. C., Farrer, M. J., Schapira, A. H. V., & Halliday, G. M. (2010) · Nature Medicine · doi:10.1038/nm.2165 · Cited by 737 · see citing works

Neurotransmitter enzyme abnormalities in senile dementia

Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90073-9 · Cited by 724 · see citing works

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

Newman, D. J. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm0704090 · Cited by 716 · see citing works

β-Amyloid-mediated vasoactivity and vascular endothelial damage

Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703 · see citing works

Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets

Ramassamy, C. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.025 · Cited by 680 · see citing works

Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease

Schapira, A. H. V., Mann, V. M., Cooper, J. A. D., Dexter, D. T., Daniel, S. E., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb05809.x · Cited by 673 · see citing works

Ginkgo biloba for Prevention of Dementia A Randomized Controlled Trial

DeKosky, S. T. (2008) · JAMA · doi:10.1001/jama.2008.683 · Cited by 671 · see citing works

Characteristics of the Inhibition of NADPH Oxidase Activation in Neutrophils by Apocynin, a Methoxy-Substituted Catechol

Stolk, J. N., Hiltermann, T. J. N., Dijkman, J. H., & Verhoeven, A. J. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.1.8018341 · Cited by 650 · see citing works

Diagnosis and treatment of Parkinson disease: molecules to medicine

Savitt, J. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29178 · Cited by 649 · see citing works

Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial

Wilcock, G. K., Lilienfeld, S., & Gaens, E. (2000) · BMJ · doi:10.1136/bmj.321.7274.1445 · Cited by 623 · see citing works

Environmental risk factors and Parkinson's disease

Liou, H., Tsai, M.-C., Chen, C., Jeng, J., Chang, Y. C., Chen, S. Y., & Chen, R.-T. (1997) · Neurology · doi:10.1212/wnl.48.6.1583 · Cited by 616 · see citing works

Antioxidant activities of polyphenols from sage (Salvia officinalis)

Lu, Y., & Foo, L. Y. (2001) · Food Chemistry · doi:10.1016/s0308-8146(01)00198-4 · Cited by 591 · see citing works

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587 · see citing works

The Efficacy of Ginkgo biloba on Cognitive Function in Alzheimer Disease

Oken, B., Storzbach, D. M., & Kaye, J. A. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1409 · Cited by 585 · see citing works

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein

Selkoe, D. J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3111 · Cited by 538 · see citing works

Resveratrol protects against global cerebral ischemic injury in gerbils

Wang, Q., Xu, J., Rottinghaus, G. E., Simonyi, Á., Lubahn, D. E., Sun, G. Y., & Sun, A. Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03543-6 · Cited by 528 · see citing works

Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area.

Orgogozo, J. M., Dartigues, J. F., Lafont, S., Letenneur, L., Commenges, D., Salamon, R., Renaud, S., & Breteler, M. M. B. (1997) · PubMed · Cited by 525 · see citing works

Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica

Brinkhaus, B., Lindner, M., Schuppan, D., & Hahn, E. G. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80065-3 · Cited by 525 · see citing works

Recent Natural Products Based Drug Development: A Pharmaceutical Industry Perspective

Shu, Y. (1998) · Journal of Natural Products · doi:10.1021/np9800102 · Cited by 518 · see citing works

The Nigrostriatal Dopaminergic System as a Preferential Target of Repeated Exposures to Combined Paraquat and Maneb: Implications for Parkinson's Disease

Thiruchelvam, M. J., Richfield, E. K., Baggs, R. B., Tank, A. W., & Cory‐Slechta, D. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09207.2000 · Cited by 471 · see citing works

A Hundred Years of Alzheimer's Disease Research

Hardy, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.016 · Cited by 467 · see citing works

In-vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes

Perry, N. S. L., Houghton, P. J., Theobald, A. E., Jenner, P. G., & Perry, E. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774598 · Cited by 458 · see citing works

Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function

Howes, M. R., & Houghton, P. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00128-x · Cited by 443 · see citing works

Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases

Mandel, S. A., & Youdim, M. B. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.012 · Cited by 443 · see citing works

Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons

Gao, H., Hong, J., Zhang, W., & Liu, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00782.2002 · Cited by 439 · see citing works

Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss

Brooks, A. I., Chadwick, C. A., Gelbard, H. A., Cory‐Slechta, D. A., & Federoff, H. J. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01192-5 · Cited by 425 · see citing works

Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders

Howes, M. R., Perry, N. S. L., & Houghton, P. J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1280 · Cited by 418 · see citing works

Advances in the treatment of Parkinson's disease

Singh, N., Pillay, V., & Choonara, Y. E. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.11.009 · Cited by 396 · see citing works

Mutational analysis of the glycine-binding site of the NMDA receptor: Structural similarity with bacterial amino acid-binding proteins

Kuryatov, A. (1994) · Neuron · doi:10.1016/0896-6273(94)90445-6 · Cited by 385 · see citing works

Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial

Perry, N. S. L., Bollen, C. S. C., Perry, E. K., & Ballard, C. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00108-4 · Cited by 384 · see citing works

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases

Mandel, S. A., Weinreb, O., Amit, T., & Youdim, M. B. H. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02291.x · Cited by 379 · see citing works

The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β‐amyloid

Bastianetto, S., Ramassamy, C., Doré, S., Christen, Y., Poirier, J., & Quirion, R. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00069.x · Cited by 378 · see citing works

Proof of Efficacy of the Ginkgo Biloba Special Extract EGb 761 in Outpatients Suffering from Mild to Moderate Primary Degenerative Dementia of the Alzheimer Type or Multi-infarct Dementia

Kanowski, S., Herrmann, W., Stephan, K., Wierich, W., & Hörr, R. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979544 · Cited by 369 · see citing works

Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil

Savelev, S. U., Okello, E. J., Perry, N. S. L., Wilkins, R. M., & Perry, E. K. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00125-4 · Cited by 366 · see citing works

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

Murakami, M., Shimbara, S., Kambe, T., Kuwata, H., Winstead, M. V., Tischfield, J. A., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14411 · Cited by 366 · see citing works

NADPH Oxidases of the Brain: Distribution, Regulation, and Function

Infanger, D. W., Sharma, R. V., & Davisson, R. L. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1583 · Cited by 362 · see citing works

Plant-insect coevolution and inhibition of acetylcholinesterase

Ryan, M. F., & Byrne, O. (1988) · Journal of Chemical Ecology · doi:10.1007/bf01013489 · Cited by 357 · see citing works

Plants and the central nervous system

Carlini, E. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00112-6 · Cited by 357 · see citing works

Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats

Sinha, K., Chaudhary, G., & Gupta, Y. K. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01691-0 · Cited by 356 · see citing works

Multifunctional Activities of Green Tea Catechins in Neuroprotection

Mandel, S. A., Avramovich‐Tirosh, Y., Reznichenko, L., Zheng, H., Weinreb, O., Amit, T., & Youdim, M. B. H. (2005) · Neurosignals · doi:10.1159/000085385 · Cited by 347 · see citing works

Inflammaging as a prodrome to Alzheimer's disease

Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327 · see citing works

Expression of Concern: Antioxidant compounds have potent anti‐fibrillogenic and fibril‐destabilizing effects for α‐synuclein fibrils in vitro

Ono, K., & Yamada, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03707.x · Cited by 320 · see citing works

Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase

Brown, G. C. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351119 · Cited by 315 · see citing works

Neurotoxicant-induced animal models of Parkinson?s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration

Uversky, V. N. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0937-z · Cited by 312 · see citing works

The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review

Miquel, J., Bernd, A., Sempere, J. M., Dı́az-Alperi, J., & Ramı́rez, A. (2002) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00194-7 · Cited by 309 · see citing works

Metabolism of 20(S)- and 20(R)-Ginsenoside Rg3 by Human Intestinal Bacteria and Its Relation to in Vitro Biological Activities.

Bae, E., Han, M. J., Choo, M., Park, S., & Kim, D. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.58 · Cited by 307 · see citing works

Oxidative and Inflammatory Pathways in Parkinson’s Disease

Miller, R. L., James-Kracke, M., Sun, G. Y., & Sun, A. Y. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9656-2 · Cited by 306 · see citing works

Critical role of microglial NADPH oxidase‐derived free radicals in the in vitro MPTP model of Parkinson's disease

Gao, H., Liu, B., Zhang, W., & Hong, J. (2003) · The FASEB Journal · doi:10.1096/fj.03-0109fje · Cited by 306 · see citing works

The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers

Wesnes, K. A., Ward, T., McGinty, A., & Petrini, O. (2000) · Psychopharmacology · doi:10.1007/s002130000533 · Cited by 305 · see citing works

Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I–III from Curcuma longa

Ramsewak, R. S., DeWitt, D. L., & Nair, M. G. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80048-3 · Cited by 302 · see citing works

Neuroprotective effects of resveratrol against β‐amyloid‐induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

Han, Y.-S., Zheng, W., Bastianetto, S., Chabot, J., & Quirion, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705688 · Cited by 300 · see citing works

Moderate consumption of Cabernet Sauvignon attenuates A� neuropathology in a mouse model of Alzheimer's disease

Wang, J., Ho, L., Zhao, Z., Seror, I., Humala, N., Dickstein, D. L., Thiyagarajan, M., Percival, S. S., Talcott, S. T., & Pasinetti, G. M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6281com · Cited by 299 · see citing works

Antidepressant activity of aqueous extracts of Curcuma longa in mice

Yu, Z. F., Kong, L., & Chen, Y. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00211-8 · Cited by 293 · see citing works

Antioxidant Action of Ginkgo Biloba Extract (EGB 761)

Packer, L. (1997) · Springer eBooks · doi:10.1007/978-1-4899-1837-6_7 · Cited by 291 · see citing works

Signal integration between IFNγ and TLR signalling pathways in macrophages

Schroder, K., Sweet, M. J., & Hume, D. A. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.05.007 · Cited by 288 · see citing works

A Reassessment of the Low Molecular Weight Phospholipase A2 Gene Family in Mammals

Tischfield, J. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17247 · Cited by 284 · see citing works

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A 2 in cortical neurons

Shelat, P. B., Chalimoniuk, M., Wang, J., Strosznajder, J. B., Lee, J. C., Sun, A. Y., Simonyi, Á., & Sun, G. Y. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05347.x · Cited by 283 · see citing works

Discovery of Natural Products from Curcuma longa that Protect Cells from Beta-Amyloid Insult: A Drug Discovery Effort against Alzheimer's Disease

Park, S., & Kim, D. S. H. L. (2002) · Journal of Natural Products · doi:10.1021/np010039x · Cited by 278 · see citing works

Mitochondrial Dysfunction and Oxidative Damage in Alzheimer's and Parkinson's Diseases and Coenzyme Q10 as a Potential Treatment

Beal, M. F. (2004) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000041772.74810.92 · Cited by 276 · see citing works

Parkinson's disease

Semchuk, K. M., Love, E. J., & Lee, R. G. (1993) · Neurology · doi:10.1212/wnl.43.6.1173 · Cited by 275 · see citing works

Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia

Bi, X. L., Yang, J., Dong, Y. X., Wang, J., Cui, Y. H., Ikeshima, T., Zhao, Y. Q., & Wu, C. F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.08.008 · Cited by 274 · see citing works

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Radad, K., Gille, G., Liu, L., & Rausch, W. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05010x · Cited by 268 · see citing works

Oxidative and Antioxidative Potential of Brain Microglial Cells

Dringen, R. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1223 · Cited by 266 · see citing works

Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from βA(1–42) insult

Kim, D. S. H. L., Park, S., & Kim, J.-Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01677-9 · Cited by 262 · see citing works

Dopaminergic cell death induced by MPP+, oxidant and specific neurotoxicants shares the common molecular mechanism

Chun, H. S., Gibson, G. E., DeGiorgio, L. A., Zhang, H., Kidd, V. J., & Son, J. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00096.x · Cited by 256 · see citing works

The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers

Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2000) · Psychopharmacology · doi:10.1007/s002130000501 · Cited by 255 · see citing works

Synergistic Dopaminergic Neurotoxicity of the Pesticide Rotenone and Inflammogen Lipopolysaccharide: Relevance to the Etiology of Parkinson's Disease

Gao, H., Hong, J., Zhang, W., & Liu, B. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01228.2003 · Cited by 251 · see citing works

Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.

Bores, G. M., Huger, F. P., Petko, W. W., Mutlib, A. E., Camacho, F., Rush, D. K., Selk, D. E., Wolf, V., Kosley, R. W., Davis, L., et al. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12928-5 · Cited by 249 · see citing works

Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory

Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.ft-8 · Cited by 245 · see citing works

Ginseng: potential for the enhancement of cognitive performance and mood

Kennedy, D. O., & Scholey, A. B. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00126-6 · Cited by 245 · see citing works

Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes

Liu, G.-T., Zhang, T., Wang, B.-E., & Wang, Y. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90271-j · Cited by 244 · see citing works

Cardioprotective and Anti-oxidant Effects of the Terpenoid Constituents ofGinkgo bilobaExtract (EGb 761)

Pietri, S., Maurelli, E., Drieu, K., & Culcasi, M. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0316 · Cited by 236 · see citing works

Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence

DeVries, T. A., Neville, M. C., & Reyland, M. E. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf606 · Cited by 236 · see citing works

Chemical Constituents of Polygonaceous Plants. I

Nonomura, S., Kanagawa, H., & Makimoto, A. (1963) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.83.10_988 · Cited by 233 · see citing works

Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor α in mice

Inoue, H., Jiang, X., Katayama, T., Osada, S., Umesono, K., & Namura, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.001 · Cited by 232 · see citing works

Pesticides and Risk of Parkinson Disease

Firestone, J. A., Smith‐Weller, T., Franklin, G. M., Swanson, P. D., Longstreth, W. T., Jr., & Checkoway, H. (2005) · Archives of Neurology · doi:10.1001/archneur.62.1.91 · Cited by 232 · see citing works

Botanical Phenolics and Brain Health

Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8052-z · Cited by 225 · see citing works

The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

Hirai, H., Kirsch, J., Laube, B., Betz, H., & Kuhse, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6031 · Cited by 223 · see citing works

The Ginkgo biloba Extract (EGb 761) Protects and Rescues Hippocampal Cells Against Nitric Oxide‐Induced Toxicity

Bastianetto, S., Zheng, W., & Quirion, R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0742268.x · Cited by 222 · see citing works

Determination of Stilbenes (trans-Astringin,cis- andtrans-Piceid, andcis- andtrans-Resveratrol) in Portuguese Wines

Lima, T., Waffo‐Téguo, P., Teissèdre, P., Pujolas, A., Vercauteren, J., Cabanis, J. C., & Mérillon, J. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9900884 · Cited by 220 · see citing works

Neuroprotection by resveratrol against traumatic brain injury in rats

Ateş, Ö., Cayli, S. R., Altınöz, E., Gürses, İ., Yücel, N., Sener, M., Koçak, A., & Yoloğlu, S. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9253-0 · Cited by 219 · see citing works

Caspase-3-Dependent Proteolytic Cleavage of Protein Kinase Cδ Is Essential for Oxidative Stress-Mediated Dopaminergic Cell Death after Exposure to Methylcyclopentadienyl Manganese Tricarbonyl

Anantharam, V., Kitazawa, M., Wagner, J. R., Kaul, S., & Kanthasamy, A. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01738.2002 · Cited by 219 · see citing works

Mechanisms of MAPK signalling specificity

Bardwell, L. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340837 · Cited by 213 · see citing works

Inhibition of Acetylcholinesterase Activity by Monoterpenoids with a p-Menthane Skeleton

Miyazawa, M., Watanabe, H., & Kameoka, H. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf960398b · Cited by 210 · see citing works

Curcumin (diferuloylmethane), a singlet oxygen (1O2) quencher

Das, K. C., & Das, C. K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00633-2 · Cited by 208 · see citing works

Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells

Chanvitayapongs, S., Draczynska‐Lusiak, B., & Sun, A. Y. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00035 · Cited by 206 · see citing works

A mechanism of paraquat toxicity involving nitric oxide synthase

Day, B. J., Patel, M., Calavetta, L., Chang, L.-Y., & Stamler, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12760 · Cited by 206 · see citing works

Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets

Srivastava, K. C., Bordia, A., & Verma, S. K. (1995) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(95)90040-3 · Cited by 204 · see citing works

Microglia Proliferation Is Regulated by Hydrogen Peroxide from NADPH Oxidase

Mander, P. K., Jekabsone, A., & Brown, G. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1046 · Cited by 198 · see citing works

Determination of biologically active constituents in Centella asiatica

Inamdar, P. K., Yeole, R. D., Ghogare, A. B., & SOUZA, N. J. D. (1996) · Journal of Chromatography A · doi:10.1016/0021-9673(96)00237-3 · Cited by 197 · see citing works

Scavenging effects of salvia miltiorrhiza on free radicals and its protection for myocardial mitochondrial membranes from ischemia-reperfusion injury.

Zhao, B., Jiang, W., Zhao, Y., Hou, J. W., & Xin, W. J. (1996) · PubMed · Cited by 193 · see citing works

Anti-anxiety studies on extracts of Passiflora incarnata Linneaus

Dhawan, K., Kumar, S., & Sharma, A. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00339-7 · Cited by 192 · see citing works

Appearance of Compound K, a Major Metabolite of Ginsenoside Rb1 by Intestinal Bacteria, in Rat Plasma after Oral Administration. Measurement of Compound K by Enzyme Immunoassay.

Akao, T., Kanaoka, M., & Kobashi, K. (1998) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.21.245 · Cited by 189 · see citing works

Resveratrol: A Natural Compound with Pharmacological Potential in Neurodegenerative Diseases

Rocha-­González, H. I., Ambriz‐Tututi, M., & Granados‐Soto, V. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2008.00045.x · Cited by 187 · see citing works

Determination of the Phytoalexin Resveratrol (3,5,4‘-Trihydroxystilbene) in Peanuts and Pistachios by High-Performance Liquid Chromatographic Diode Array (HPLC-DAD) and Gas Chromatography−Mass Spectrometry (GC-MS)

Tokuşoğlu, Ö., Ünal, M. K., & Yemiş, F. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050496+ · Cited by 183 · see citing works

A Randomized, Double-Blind, Placebo-Controlled Trial of Two Doses of Ginkgo Biloba Extract in Dementia of the Alzheimers Type

Schneider, L. S., DeKosky, S. T., Farlow, M. R., Tariot, P. N., Hoerr, R., & Kieser, M. (2005) · Current Alzheimer Research · doi:10.2174/156720505774932287 · Cited by 182 · see citing works

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands

Yao, Z., Drieu, K., & Papadopoulos, V. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03131-0 · Cited by 181 · see citing works

In vitro andin vivo activity of eugenol on human herpesvirus

Benencia, F., & Courr�ges, M. C. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200011)14:7 · Cited by 181 · see citing works

Free Radical Reactions of Curcumin in Membrane Models

Priyadarsini, K. I. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00026-9 · Cited by 174 · see citing works

Amyloid β-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

Butterfield, D. A., Griffin, S. T., Münch, G. W., & Pasinetti, G. M. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4309 · Cited by 174 · see citing works

Os produtos naturais e a química medicinal moderna

Viegas, C., Bolzani, V. D. S., & Barreiro, E. J. (2006) · Química Nova · doi:10.1590/s0100-40422006000200025 · Cited by 173 · see citing works

Protein Kinase Cδ Is Required for p47phox Phosphorylation and Translocation in Activated Human Monocytes

Bey, E. A., Xu, B., Bhattacharjee, A., Oldfield, C. M., Zhao, X., Li, Q., Subbulakshmi, V., Feldman, G. M., Wientjes, F. B., & Cathcart, M. K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5730 · Cited by 172 · see citing works

Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice

Rajeswari, A., & Sabesan, M. (2008) · Inflammopharmacology · doi:10.1007/s10787-007-1614-0 · Cited by 170 · see citing works

The pharmacology of galanthamine and its analogues

Harvey, A. L. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02002-0 · Cited by 169 · see citing works

Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms

Kumar, P., Padi, S. S., Naidu, P. S., & Kumar, A. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00014 · Cited by 167 · see citing works

Evaluation In Vitro of Plant Essential Oils as Natural Antioxidants

Dorman, H. J. D., Deans, S. G., Noble, R. C., & Surai, P. F. (1995) · Journal of Essential Oil Research · doi:10.1080/10412905.1995.9700520 · Cited by 166 · see citing works

Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse

Soulimani, R., Younos, C., Jarmouni, I. S., Bousta, D., Misslin, R., & Mortier, F. (1997) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(97)00042-1 · Cited by 165 · see citing works

A 26-Week Analysis of a Double-Blind, Placebo-Controlled Trial of the Ginkgo biloba Extract EGb 761® in Dementia

Bars, P. L. L., Kieser, M., & Itil, K. Z. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017242 · Cited by 164 · see citing works

Membrane Phospholipid Alterations In Alzheimer's Disease: Deficiency of Ethanolamine Plasmalogens

Farooqui, A. A., Rapoport, S. I., & Horrocks, L. A. (1997) · Neurochemical Research · doi:10.1023/a:1027380331807 · Cited by 163 · see citing works

Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms

Barbieri, S. S., Cavalca, V., Eligini, S., Brambilla, M., Caiani, A., Tremoli, E., & Colli, S. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.020 · Cited by 161 · see citing works

Superoxide Dismutase/Catalase Mimetics Are Neuroprotective against Selective Paraquat-mediated Dopaminergic Neuron Death in the Substantial Nigra

Peng, J., Stevenson, F. F., Doctrow, S. R., & Andersen, J. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500984200 · Cited by 159 · see citing works

In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease

Perry, N. S. L., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis‐Balchin, M., Hoult, J. R. S., Evans, P., Jenner, P. G., Milligan, S. R., et al. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011777846 · Cited by 159 · see citing works

Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline

Casarejos, M. J., Menéndez, J., Solano, R. M., Rodríguez‐Navarro, J. A., de Yébenes, J. G., & Mena, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03777.x · Cited by 156 · see citing works

Flavonoid‐mediated presenilin‐1 phosphorylation reduces Alzheimer's disease β‐amyloid production

Rezai-Zadeh, K. P., Shytle, R. D., Bai, Y., Tian, J., Hou, H., Mori, T., Zeng, J., Obregon, D. F., Town, T., & Tan, J. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00344.x · Cited by 153 · see citing works

Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults

Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00665-0 · Cited by 150 · see citing works

Resistance to Endotoxic Shock in Endothelial Nitric-oxide Synthase (eNOS) Knock-out Mice

Connelly, L., Madhani, M., & Hobbs, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411991200 · Cited by 149 · see citing works

Studies on Absorption, Distribution, Excretion and Metabolism of Ginseng Saponins. VII. Comparison of the Decomposition Modes of Ginsenoside-Rb1 and -Rb2 in the Digestive Tract of Rats.

Karikura, M., Miyase, T., Tanizawa, H., TANIYAMA, T., & Takino, Y. (1991) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.39.2357 · Cited by 148 · see citing works

Gingko Biloba: A Case Report of Herbal Medicine and Bleeding Postoperatively from a Laparoscopic Cholecystectomy

Fessenden, J., Wittenborn, W., & Clarke, L. E. (2001) · The American Surgeon · doi:10.1177/000313480106700108 · Cited by 147 · see citing works

Neuroprotective Effects of Resveratrol against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress in Rats

Kumar, A., Naidu, P. S., Seghal, N., & Padi, S. S. V. (2006) · Pharmacology · doi:10.1159/000097511 · Cited by 147 · see citing works

Mechanism of inhibition of cholinesterases by huperzine A

Ashani, Y., Peggins, J. O., & Doctor, B. P. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90649-6 · Cited by 144 · see citing works

A double-blind, placebo controlled study of Ginkgo biloba extract (‘Tanakan’) in elderly outpatients with mild to moderate memory impairment

S, G., Shovlin, C. L., & Wesnes, K. A. (1991) · Current Medical Research and Opinion · doi:10.1185/03007999109111504 · Cited by 144 · see citing works

Novel Anticholinesterase and Antiamnesic Activities of Dehydroevodiamine, a Constituent ofEvodia rutaecarpa

Park, C., Kim, S., Choi, W., Lee, Y. J., Kim, J., Kang, S. S., & Sun, Y. (1996) · Planta Medica · doi:10.1055/s-2006-957926 · Cited by 143 · see citing works

HPLC Separation and Quantitative Determination of Ginsenosides from Panax ginseng, Panax quinquefolium and from Ginseng Drug Preparations

Soldati, F., & Sticher, O. (1980) · Planta Medica · doi:10.1055/s-2008-1074929 · Cited by 140 · see citing works

Quality of life and parkinson's disease: Translation and validation of the US Parkinson's Disease Questionnaire (PDQ-39)

Bushnell, D. M., & Martin, M. L. (1999) · Quality of Life Research · doi:10.1023/a:1008979705027 · Cited by 139 · see citing works

Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats

Shimizu, K., Matsubara, K., Ohtaki, K., Fujimaru, S., Saito, O., & Shiono, H. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02750-1 · Cited by 139 · see citing works

Dose Dependent Changes in Cognitive Performance and Mood following Acute Administration ofGinsengto Healthy Young Volunteers

Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2001) · Nutritional Neuroscience · doi:10.1080/1028415x.2001.11747370 · Cited by 138 · see citing works

NADPH oxidase is required for NMDA receptor‐dependent activation of ERK in hippocampal area CA1

Kishida, K. T., Pao, M., Holland, S. M., & Klann, E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03189.x · Cited by 135 · see citing works

The efficacy of EGb 761 in patients with senile dementia of the alzheimer type, a double‐blind, placebo‐controlled study on different levels of investigation

Hofferberth, B. (1994) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470090308 · Cited by 134 · see citing works

Antioxidant property of Celastrus paniculatus Willd.: A possible mechanism in enhancing cognition

Kumar, M. H. V., & Gupta, Y. K. (2002) · Phytomedicine · doi:10.1078/0944-7113-00136 · Cited by 133 · see citing works

Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT‐11

Park, C. H., Choi, S. H., Koo, J., Seo, J., Kim, H., Jeong, S., & Suh, Y. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10429 · Cited by 131 · see citing works

Antioxidant Activity of Leaves of Salvia Species in Enzyme-Dependent and Enzyme-Independent Systems of Lipid Peroxidation and their Phenolic Constituents

Zupkó, I., Hohmann, J., Rédei, D., Falkay, G., Janicsák, G., & Máthé, I. (2001) · Planta Medica · doi:10.1055/s-2001-14327 · Cited by 129 · see citing works

Resveratrol reduces the elevated level of MMP-9 induced by cerebral ischemia–reperfusion in mice

Gao, D., Zhang, X., Jiang, X., Peng, Y., Huang, W., Cheng, G. S., & Song, L. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.030 · Cited by 129 · see citing works

Ginkgo Biloba Extract (EGb 761) Independently Improves Changes in Passive Avoidance Learning and Brain Membrane Fluidity in the Aging Mouse

Stoll, S., Scheuer, K., Pohl, O., & Müller, W. E. G. (2007) · Pharmacopsychiatry · doi:10.1055/s-2007-979561 · Cited by 128 · see citing works

Manganese-Induced Dopaminergic Neurodegeneration: Insights into Mechanisms and Genetics Shared with Parkinson’s Disease

Benedetto, A., Au, C., & Aschner, M. (2009) · Chemical Reviews · doi:10.1021/cr800536y · Cited by 127 · see citing works

Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba

GALLUZZI, S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.5.679a · Cited by 125 · see citing works

Synergistic protection of PC12 cells from β-amyloid toxicity by resveratrol and catechin

Conte, A., Pellegrini, S., & Tagliazucchi, D. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.08.001 · Cited by 124 · see citing works

Cohort analysis of Parkinson's syndrome

Poskanzer, D. C., & Schwab, R. S. (1963) · Journal of Chronic Diseases · doi:10.1016/0021-9681(63)90098-5 · Cited by 122 · see citing works

Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia

Wen, T., Yoshimura, H., Matsuda, S., Lim, J.-H., & Sakanaka, M. (1995) · Acta Neuropathologica · doi:10.1007/s004010050387 · Cited by 122 · see citing works

Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

Moreira, P. I., Siedlak, S. L., Aliev, G., Zhu, X., Cash, A., Smith, M. A., & Perry, G. L. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0242-8 · Cited by 116 · see citing works

Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate

Ved, H. S., Koenig, M. L., Dave, J. R., & Doctor, B. P. (1997) · Neuroreport · doi:10.1097/00001756-199703030-00029 · Cited by 116 · see citing works

Protein kinase C isoforms as therapeutic targets in nervous system disease states

Battaini, F. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0893 · Cited by 115 · see citing works

Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia

Chandrasekaran, K., Mehrabian, Z., Spinnewyn, B., Drieu, K., & Fiskum, G. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03188-2 · Cited by 112 · see citing works

Unique Properties of Polyphenol Stilbenes in the Brain: More than Direct Antioxidant Actions; Gene/Protein Regulatory Activity

Doré, S. (2005) · Neurosignals · doi:10.1159/000085386 · Cited by 112 · see citing works

The Bipyridyl Herbicide Paraquat Produces Oxidative Stress-Mediated Toxicity in Human Neuroblastoma SH-SY5Y Cells: Relevance to the Dopaminergic Pathogenesis

Yang, W., & Tiffany‐Castiglioni, E. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390500226987 · Cited by 112 · see citing works

Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence.

Zandi, P., & Breitner, J. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00297-4 · Cited by 112 · see citing works

Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?

Maguire‐Zeiss, K. A., Short, D. W., & Federoff, H. J. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.09.014 · Cited by 111 · see citing works

Improvement in organically disturbed behavior with trazodone treatment.

Simpson, D. M., & Foster, D. (1986) · PubMed · Cited by 108 · see citing works

Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)

Schindowski, K., Leutner, S., Kressmann, S., Eckert, A., & Müller, W. E. G. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170016 · Cited by 106 · see citing works

Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats

Chopin, P., & Briley, M. (1992) · Psychopharmacology · doi:10.1007/bf02253584 · Cited by 105 · see citing works

Anti-inflammatory and analgesic effects of magnolol

Wang, J.-P., Hsu, M., Raung, S.-Z., Chen, C., Kuo, J., & Teng, C. (1992) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00168746 · Cited by 103 · see citing works

Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cells

Miloso, M., Bertelli, A. A. E., Nicolini, G., & Tredici, G. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00194-9 · Cited by 101 · see citing works

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3

Uhlik, M. T., Abell, A. N., Cuevas, B. D., Nakamura, K., & Johnson, G. L. (2004) · Biochemistry and Cell Biology · doi:10.1139/o04-114 · Cited by 101 · see citing works

Differential, Dose Dependent Changes in Cognitive Performance Following Acute Administration of aGinkgo biloba/Panax ginsengCombination to Healthy Young Volunteers

Kennedy, D. O., Scholey, A. B., & Wesnes, K. A. (2001) · Nutritional Neuroscience · doi:10.1080/1028415x.2001.11747376 · Cited by 100 · see citing works

Evaluation of Commercial Ginseng Products

Liberti, L. E., & Marderosian, A. D. (1978) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600671050 · Cited by 100 · see citing works

Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine

Lee, M. K., Kang, S. J., Poncz, M., Song, K., & Park, K. S. (2007) · Experimental & Molecular Medicine · doi:10.1038/emm.2007.42 · Cited by 99 · see citing works

Neuropathology of Parkinson’s Disease and Related Syndromes

Gibb, W. R. G. (1992) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30215-9 · Cited by 99 · see citing works

Cognitive Improving and Cerebral Protective Effects of Acylated Oligosaccharides in Polygala tenuifolia

Ikeya, Y., Takeda, S., Tunakawa, M., Karakida, H., Toda, K., Yamaguchi, T., & Aburada, M. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.1081 · Cited by 98 · see citing works

Mitogen-activated protein kinase (MAPK)

Cuschieri, J., & Maier, R. V. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000191714.39495.a6 · Cited by 96 · see citing works

Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition

Bickel, U., Thomsen, T., Weber, W., Fischer, J. P., Bachus, R., Nitz, M., & Kewitz, H. (1991) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1991.159 · Cited by 94 · see citing works

Comparative analysis of the effects of resveratrol in two apoptotic models: Inhibition of complex I and potassium deprivation in cerebellar neurons

Alvira, D., Yeste‐Velasco, M., Folch, J., Verdaguer, E., Canudas, A. M., Pallàs, M., & Camins, A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.029 · Cited by 93 · see citing works

Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat

Topic, B., Tani, E., Tsiakitzis, K. C., Kourounakis, P. N., Dere, E., Hasenöhrl, R. U., Häcker, R., Mattern, C., & Huston, J. P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00241-x · Cited by 90 · see citing works

Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury

Xiao, X., Yang, J., & Tang, X. C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00695-3 · Cited by 90 · see citing works

Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture

Shimizu, K., Matsubara, K., Ohtaki, K., & Shiono, H. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00163-9 · Cited by 89 · see citing works

Tenuigenin treatment decreases secretion of the Alzheimer’s disease amyloid β-protein in cultured cells

Jia, H., Jiang, Y., Ruan, Y., Zhang, Y., Ma, X., Zhang, J., Beyreuther, K. T., Tu, P., & Zhang, D. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.093 · Cited by 88 · see citing works

Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in β-amyloid-treated C6 glioma cells

Kim, Y., Lim, S., Rhee, S., Park, K., Kim, C., Choi, B., Lee, S. J., Park, Y., & Choi, Y. H. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.17.6.1069 · Cited by 88 · see citing works

857-860Anti-inflammatory Effect of Magnolol, Isolated from Magnolia officinalis , on A23187-induced Pleurisy in Mice

Wang, J.-P., Ho, T., Chang, L., & Chen, C. (1995) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1995.tb05754.x · Cited by 85 · see citing works

Current Treatment and Recent Clinical Research in Alzheimer's Disease

Neugroschl, J. A., & Sano, M. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20165 · Cited by 83 · see citing works

Lipid peroxide, phospholipids, glutathione levels and superoxide dismutase activity in rat brain after ischaemia: Effect of ginkgo biloba extract

Seif-El-Nasr, M., & ABDELFATTAH, A. (1995) · Pharmacological Research · doi:10.1016/s1043-6618(05)80014-3 · Cited by 82 · see citing works

Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice

Gravel, M., Polo, A. D., Valera, P. B., & Braun, P. E. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980815)53:4 · Cited by 82 · see citing works

Pharmacologic treatment of Alzheimer's disease: an update.

DeLaGarza, V. W. (2003) · PubMed · Cited by 82 · see citing works

Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats

Wang, L., Han, Y., & Tang, X. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00291-0 · Cited by 81 · see citing works

Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats

Nalini, K., Karanth, K. S., Rao, A., & Aroor, A. R. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)01264-e · Cited by 81 · see citing works

Cerebral Protective and Cognition-Improving Effects of Sinapic Acid in Rodents

Karakida, F., Ikeya, Y., 綱川, 光., Yamaguchi, T., Ikarashi, Y., Takeda, S., & Aburada, M. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.514 · Cited by 78 · see citing works

Cholinesterase inhibition by galanthamine and lycoramine

Irwin, R. L., & Smith, H. J. (1960) · Biochemical Pharmacology · doi:10.1016/0006-2952(60)90030-7 · Cited by 78 · see citing works

Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives

Dutra, R. C., Campos, M. M., Santos, A. R. S., & Calixto, J. Β. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.021 · Cited by 439 · see citing works

Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Makhoba, X. H., Viegas, C., Mosa, R. A., Viegas, F. P. D., & Pooe, O. J. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s257494 · Cited by 333 · see citing works

Neuroprotective Herbs for the Management of Alzheimer’s Disease

Gregory, J., Vengalasetti, Y. V., Bredesen, D. E., & Rao, R. V. (2021) · Biomolecules · doi:10.3390/biom11040543 · Cited by 238 · see citing works

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

Dey, A., Bhattacharya, R., Mukherjee, A., & Pandey, D. K. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.005 · Cited by 232 · see citing works

Parkinson’s Disease: A Review from Pathophysiology to Treatment

Marino, B. L. B., de Souza, L. R., Sousa, K. P. A., Ferreira, J. V., Padilha, E. C., da Silva, C. H. T. D. P., Taft, C. A., & Hage-Melim, L. I. D. S. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666191104110908 · Cited by 228 · see citing works

Ayurvedic medicinal plants for Alzheimer’s disease: A review

Rao, R. V., Descamps, O., John, V., & Bredesen, D. E. (2012) · Alzheimer's Research & Therapy · doi:10.1186/alzrt125 · Cited by 213 · see citing works

Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects

Ma, H., Johnson, S. L., Liu, W., DaSilva, N. A., Meschwitz, S. M., Dain, J. A., & Seeram, N. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020461 · Cited by 179 · see citing works

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease

Dias, K. S. T., & Viegas, C. (2014) · Current Neuropharmacology · doi:10.2174/1570159x1203140511153200 · Cited by 174 · see citing works

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Ahmad, R. S., Hussain, M. B., Sultan, M. T., Arshad, M. S., Waheed, M., Shariati, M. A., Plygun, S., & Hashempur, M. H. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/7656919 · Cited by 166 · see citing works

Coumarins as cholinesterase inhibitors: A review

de Souza, L. G., Rennó, M. N., & Figueroa‐Villar, J. D. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.05.001 · Cited by 162 · see citing works

Cordycepin protects PC12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties

Olatunji, O. J., Feng, Y., Olatunji, O. O., Tang, J., Ouyang, Z., & Su, Z. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.03.009 · Cited by 114 · see citing works

Natural Products As A Rich Source Of Tau-Targeting Drugs For Alzheimer’s Disease

Calcul, L., Zhang, B., Jinwal, U. K., Dickey, C. A., & Baker, B. J. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.124 · Cited by 107 · see citing works

Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera

Jung, H. A., Ali, M. Y., Choi, R. J., Jeong, H. O., Chung, H. Y., & Choi, J. S. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.01.014 · Cited by 99 · see citing works

Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer’s disease?

Aalinkeel, R., Kutscher, H. L., Singh, A. K., Cwiklinski, K., Khechen, N., Schwartz, S. A., Prasad, P. N., & Mahajan, S. D. (2017) · Journal of drug targeting · doi:10.1080/1061186x.2017.1354002 · Cited by 97 · see citing works

Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus.

Sadeghnia, H. R., Kamkar, M., Assadpour, E., Boroushaki, M. T., & Ghorbani, A. (2013) · Europe PMC (PubMed Central) · Cited by 96 · see citing works

Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway

Dong, H., Li, R., Yu, C., Xu, T., Zhang, X., & Dong, M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.008 · Cited by 92 · see citing works

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease

Chen, Y., Zhang, D.-Q., Liao, Z., Wang, B., Gong, S., Wang, C., Zhang, M.-Z., Wang, G., Cai, H., Liao, F., et al. (2015) · Molecular Neurodegeneration · doi:10.1186/1750-1326-10-4 · Cited by 93 · see citing works

The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth

More, S. V., Koppula, S., Kim, I., Kumar, H., Kim, B.-W., & Choi, D. (2012) · Molecules · doi:10.3390/molecules17066728 · Cited by 89 · see citing works

Therapeutic Potential of Phytoconstituents in Management of Alzheimer’s Disease

Singh, S. P., Nand, S., Maurya, A., Mishra, G., Awasthi, R., Shakya, A., Chellappan, D. K., Dua, K., Vamanu, E., Chaudhary, S. K., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5578574 · Cited by 75 · see citing works

Amyloid beta (Aβ) peptide modulators and other current treatment strategies for Alzheimer’s disease (AD)

Lukiw, W. J. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.672559 · Cited by 74 · see citing works

The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis

Azizi, G., & Mirshafiey, A. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2012.705292 · Cited by 72 · see citing works

Rutin protects Huntington's disease through the insulin/IGF1 (IIS) signaling pathway and autophagy activity: Study in Caenorhabditis elegans model

Cordeiro, L. M., Machado, M. L., da Silva, A. F., Baptista, F. B. O., da Silveira, T. L., Soares, F. A. A., & Arantes, L. P. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111323 · Cited by 69 · see citing works

Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity

Zhang, S., Shao, S.-Y., Song, X., Xia, C., Yang, Y., Zhang, P., & Chen, N. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.09.009 · Cited by 68 · see citing works

Crocin protects PC12 cells against MPP+-induced injury through inhibition of mitochondrial dysfunction and ER stress

Zhang, G.-F., Zhang, Y., & Zhao, G. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.011 · Cited by 67 · see citing works

Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer’s Disease Immunotherapy

Liu, J., Yang, B., Ke, J., Li, W., & Suen, W.-C. (2016) · Drugs & Aging · doi:10.1007/s40266-016-0406-x · Cited by 67 · see citing works

Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective

Priglinger, E., Urmann, C., Steffenhagen, C., Bieler, L., Brunner, D., Furtner, T., Humpel, C., Bäumer, B. E., Bandtlow, C. E., Couillard‐Després, S., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.06.005 · Cited by 65 · see citing works

Salvianolic Acid B Attenuates Toxin-Induced Neuronal Damage via Nrf2-Dependent Glial Cells-Mediated Protective Activity in Parkinson’s Disease Models

Zhou, J., Qu, X., Li, Z., Wei-Ji, Liu, Q., Ma, Y., & He, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101668 · Cited by 62 · see citing works

Docking Studies for Multi-Target Drugs

Scotti, L., Mendonça, F. J. B., Ishiki, H. M., Ribeiro, F. F., Singla, R. K., Barbosa‐Filho, J. M., da Silva, M. S., & Scotti, L. (2015) · Current Drug Targets · doi:10.2174/1389450116666150825111818 · Cited by 58 · see citing works

Pharmacological exploration of traditional plants for the treatment of neurodegenerative disorders

Wahid, M., Ali, A., Saqib, F., Aleem, A., Bibi, S., Afzal, K., Ali, A., Baig, A., Khan, S. A., & Asad, M. H. H. B. (2020) · Phytotherapy Research · doi:10.1002/ptr.6742 · Cited by 60 · see citing works

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity

Hu, Z., Wang, W., Jing, L., & Jiang, C. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0264-9 · Cited by 50 · see citing works

Herbal Medicines for Parkinson's Disease: A Systematic Review of Randomized Controlled Trials

Kim, T., Cho, K., Jung, W., & Lee, M. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035695 · Cited by 49 · see citing works

Macromolecular and small-molecule modulation of intracellular Aβ42 aggregation and associated toxicity

Chakrabortee, S., Liu, Y., Zhang, L., Matthews, H. R., Zhang, H., Pan, N., Cheng, C., Guan, S., Guo, D., Huang, Z., et al. (2011) · Biochemical Journal · doi:10.1042/bj20111661 · Cited by 48 · see citing works

An Antioxidant Dietary Supplement Improves Brain-Derived Neurotrophic Factor Levels in Serum of Aged Dogs: Preliminary Results

Sechi, S., Chiavolelli, F., Spissu, N., Cerbo, A. D., Canello, S., Guidetti, G., Fiore, F., & Cocco, R. (2015) · Journal of Veterinary Medicine · doi:10.1155/2015/412501 · Cited by 45 · see citing works

Interaction of Aβ(25–35) fibrillation products with mitochondria: Effect of small‐molecule natural products

Ghobeh, M., Ahmadian, S., Meratan, A. A., Ebrahim‐Habibi, A., Ghasemi, A., Shafizadeh, M., & Nemat‐Gorgani, M. (2014) · Biopolymers · doi:10.1002/bip.22572 · Cited by 45 · see citing works

Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants

Arora, N., Shah, K., & Rai, S. P. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0829-y · Cited by 44 · see citing works

Cucurbitacin E Has Neuroprotective Properties and Autophagic Modulating Activities on Dopaminergic Neurons

Arel-Dubeau, A.-M., Longpré, F., Bournival, J., Tremblay, C., Demers-Lamarche, J., Hašková, P., Attard, E., Germain, M., & Martinoli, M. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/425496 · Cited by 43 · see citing works

Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma

Kwon, K. J., Bae, S., Kim, K., An, I. S., Ahn, K. J., An, S., & Cha, H. J. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2159 · Cited by 43 · see citing works

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

Yang, A., Liu, C., Wu, J., Kou, X., & Shen, R. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173950 · Cited by 40 · see citing works

Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer’s Disease

Chakraborty, B., Mukerjee, N., Maitra, S., Zehravi, M., Mukherjee, D., Ghosh, A., Massoud, E. E. S., & Rahman, M. H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6873874 · Cited by 42 · see citing works

Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells

Weng, J., Yen, M., & Lin, W. (2013) · Phytochemistry · doi:10.1016/j.phytochem.2013.05.022 · Cited by 38 · see citing works

Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases

Franco, G. D. R. R., Smid, S. D., & Viegas, C. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200720172624 · Cited by 36 · see citing works

Ziyuglycoside II induces caspases-dependent and caspases-independent apoptosis in human colon cancer cells

Lkhagvasuren, K., & Kim, J. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.04.028 · Cited by 34 · see citing works

The Rational Discovery of a Tau Aggregation Inhibitor

Baggett, D. W., & Nath, A. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00581 · Cited by 34 · see citing works

Recent Advancement in Clinical Application of Nanotechnological Approached Targeted Delivery of Herbal Drugs

Javed, M. N., Dahiya, E. S., Ibrahim, A. M., Alam, M. S., Khan, F. A., & Pottoo, F. H. (2020) · Springer eBooks · doi:10.1007/978-981-15-4909-0_9 · Cited by 30 · see citing works

The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment

Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works

Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission

Chae, U., Min, J., Leem, H. H., Lee, H., Lee, H. J., Lee, S., & Lee, D. (2017) · Pharmacology · doi:10.1159/000477814 · Cited by 28 · see citing works

Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm

Baradaran, S., Moghaddam, A. H., & Ghasemi‐Kasman, M. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.07.001 · Cited by 28 · see citing works

Verbascoside promotes the regeneration of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra

He, J., Liang, J., Wang, L., & Hua, X.-D. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.175053 · Cited by 27 · see citing works

Flavonoids with Potential Anti-Amyloidogenic Effects as Therapeutic Drugs for Treating Alzheimer’s Disease

Wang, Q., Dong, X., Zhang, R., & Zhao, C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210735 · Cited by 27 · see citing works

Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer’s disease

Kumar, A., Sharma, V., Singh, V. P., Kaundal, M., Gupta, M., Bariwal, J. B., & Deshmukh, R. R. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.05.009 · Cited by 27 · see citing works

Neurotropic and neuroprotective activities of the earthworm peptide Lumbricusin

Kim, D. H., Lee, I. H., Nam, S. T., Hong, J., Zhang, P., Hwang, J. S., Seok, H., Choi, H., Lee, D. G., Kim, J. I., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.105 · Cited by 25 · see citing works

Phytochemical composition, antioxidant and cytoprotective activities of essential oil of Salvia lavandulifolia Vahl

Porres-Martínez, M., González‐Burgos, E., Accame, M. E. C., & Gómez-Serranillos, M. P. (2013) · Food Research International · doi:10.1016/j.foodres.2013.07.029 · Cited by 24 · see citing works

In silico development of new acetylcholinesterase inhibitors

Pascoini, A. L., Federico, L. B., Arêas, A. L. F., Verde, B., de Freitas, P. G., & Camps, I. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1447513 · Cited by 24 · see citing works

Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions

Panwar, S., Uniyal, P., Kukreti, N., Hashmi, A., Verma, S., Arya, A., & Joshi, G. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14515 · Cited by 23 · see citing works

Novel multi-target therapeutic potential of the genus Inula: Advances and opportunities for neuroprotection

Talebi, M., Khoramjouy, M., Feizi, A., Ali, Z., Khan, I. A., Ayatollahi, N. A., Ayatollahi, S. A., & Faizi, M. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100263 · Cited by 22 · see citing works

Recent Advances in Drug Delivery Systems Targeting Insulin Signalling for the Treatment of Alzheimer’s Disease

Sachdeva, P., Narayanan, K. B., Sinha, J. K., Gupta, S. K., Ghosh, S., Singh, D. K. K., Bhaskar, R., Almutary, A. G., Zothantluanga, J. H., Kotta, K. K., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231181 · Cited by 22 · see citing works

An Insight in Pathophysiological Mechanism of Alzheimer’s Disease and its Management Using Plant Natural Products

Firdaus, Z., & Singh, T. D. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666200730155928 · Cited by 22 · see citing works

Effects of triphala and guggul aqueous extracts on inhibition of protein fibrillation and dissolution of preformed fibrils

Save, S. N., & Choudhary, S. (2017) · RSC Advances · doi:10.1039/c6ra28440j · Cited by 21 · see citing works

Forestalling the Epidemics of Parkinson's Disease Through Plant-Based Remedies

Banjari, I., Marček, T., Tomić, S., & Waisundara, V. Y. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00095 · Cited by 21 · see citing works

Diphenyl diselenide protects a Caenorhabditis elegans model for Huntington’s disease by activation of the antioxidant pathway and a decrease in protein aggregation

Baptista, F. B. O., Arantes, L. P., Machado, M. L., da Silva, A. F., Cordeiro, L. M., da Silveira, T. L., & Soares, F. A. A. (2020) · Metallomics · doi:10.1039/d0mt00074d · Cited by 20 · see citing works

Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation

Abed, D. A., Lee, S., Wen, X., Ali, A. R., Mangipudy, V. S., Aleksunes, L. M., & Hu, L. (2021) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2021.116300 · Cited by 19 · see citing works

Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

Viegas, F. P. D., Gontijo, V. S., Silva, M. D. F., Ortiz, C. J. C., Franco, G. D. R. R., Ernesto, J. T., Damásio, C. M., Silva, I. M. F., Campos, T. G., & Viegas, C. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210712152532 · Cited by 20 · see citing works

Myelophil ameliorates brain oxidative stress in mice subjected to restraint stress

Lee, J., Kim, H.-G., Han, J., Lee, J.-S., Son, S., Ahn, Y., & Son, C. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.006 · Cited by 19 · see citing works

Cholinesterases inhibition studies of biological active compounds from the rhizomes of Alpinia officinarum Hance and in silico molecular dynamics

Lee, J. S., Kim, J. H., Han, Y. K., Yeul, J., Kim, Y. H., Li, W., & Yang, S. Y. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.09.014 · Cited by 19 · see citing works

Behavioral and molecular effects of intrahippocampal infusion of auraptene, resveratrol, and curcumin on H-89-induced deficits on spatial memory acquisition and retention in Morris water maze

Tabrizian, K., Musavi, S., Rigi, M., Hosseindadi, F., Kordi, S., Shamshirgaran, F., Bazı, A., Shahraki, J., Rezaee, R., & Hashemzaei, M. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119839160 · Cited by 19 · see citing works

Insect peptide CopA3-induced protein degradation of p27Kip1 stimulates proliferation and protects neuronal cells from apoptosis

Nam, S. T., Kim, D. H., Lee, M. B., Nam, H. J., Kang, J. K., Park, M. J., Lee, I. H., Seok, H., Lee, D. G., Hwang, J. S., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.031 · Cited by 17 · see citing works

Insights on the Neuromodulatory Propensity of Selaginella (Sanjeevani) and its Potential Pharmacological Applications

., M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660188 · Cited by 17 · see citing works

Evaluation of antioxidant, anti-inflammatory, anticancer activities and molecular docking of Moringa oleifera seed oil extract against experimental model of Ehrlich ascites carcinoma in Swiss female albino mice

Aldayel, T. S., El-Hak, H. N. G., Nafie, M. S., Saad, R., Abdelrazek, H. M. A., & Kilany, O. E. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04279-z · Cited by 16 · see citing works

Docking of Natural Products against Neurodegenerative Diseases: General Concepts

Ribeiro, F. F., Mendonça, F. J. B., Ghasemi, J. B., Ishiki, H. M., Scotti, L., & Scotti, L. (2018) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207321666180313130314 · Cited by 16 · see citing works

Centella asiatica promotes early differentiation, axodendritic maturation and synaptic formation in primary hippocampal neurons

Hannan, M. A., Haque, M. N., Munni, Y. A., Oktaviani, D. F., Timalsina, B., Dash, R., Afrin, T., & Moon, I. S. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104957 · Cited by 15 · see citing works

Natural Phytoestrogens

Morissette, M., Litim, N., & Paolo, T. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809593-5.00002-1 · Cited by 14 · see citing works

Glaucocalyxin A as a natural product increases amyloid β clearance and decreases tau phosphorylation involving the mammalian target of rapamycin signaling pathway

Zhou, T., Zhuang, J., Wang, Z., Zhou, Y., Li, W., Wang, Z., & Zhu, Z. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001202 · Cited by 14 · see citing works

Cutaneous mucinosis associated with thyroid dysfunction.

Schaeffer, D., Bruce, S., & Rosén, T. (1983) · PubMed · Cited by 14 · see citing works

Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions

Verma, H., Kaur, S., Kaur, S., Gangwar, P., Dhiman, M., & Mantha, A. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04053-3 · Cited by 11 · see citing works

Nine Steps to Discover New Medicines from Traditional Sources: The Example of Persian Medicine

Mozaffarpur, S. A., Naseri, M., Kamalinejad, M., Shams, M. A., Memariani, Z., Moeini, R., Gorji, N., Farahani, A. M., & Shirafkan, H. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2019.0377 · Cited by 11 · see citing works

Liver CEBPβ Modulates the Kynurenine Metabolism and Mediates the Motility for Hypoxia-Induced Central Fatigue in Mice

Yang, F., Zhou, L., Song, J., WangJinMei, A., Yang, Y., Tang, Z.-W., & Huang, Q. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00243 · Cited by 11 · see citing works

Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

Pirolla, N. F. F., Batista, V. S., Viegas, F. P. D., Gontijo, V. S., McCarthy, C. R., Viegas, C., & Nascimento-Júnior, N. M. (2020) · Current Drug Targets · doi:10.2174/1389450121999200819144544 · Cited by 11 · see citing works

Effect of Lycoris chejuensis and Its Active Components on Experimental Models of Alzheimer’s Disease

Kim, J., Park, Y., Chun, Y. S., Cha, J. W., Kwon, H. C., Oh, M. S., Chung, S., & Yang, H. O. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00889 · Cited by 11 · see citing works

Dehydroabietylamine derivatives as multifunctional agents for the treatment of Alzheimer's disease

Cao, Y., Wang, L., Lin, Z., Liang, F., Pei, Z., Xu, J., & Gu, Q. (2014) · MedChemComm · doi:10.1039/c4md00305e · Cited by 10 · see citing works

Pharmacognostical Sources of Popular Medicine To Treat Alzheimer’s Disease

Kalász, H., Ojha, S. K., Tekes, K., Szőke, É., Rajesh, M., Fahim, M. F. M., Adeghate, E. A., & Adem, A. (2018) · The Open Medicinal Chemistry Journal · doi:10.2174/1874104501812010023 · Cited by 10 · see citing works

7-Deoxy-trans-dihydronarciclasine Reduces β-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer’s Disease

Chun, Y. S., Zhang, L., Li, H., Park, Y., Chung, S., & Yang, H. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1023-y · Cited by 10 · see citing works

Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease

Ortiz, C. J. C., Silva, M. D. F., Gontijo, V. S., Viegas, F. P. D., Dias, K. S. T., & Viegas, C. (2018) · Methods in pharmacology and toxicology · doi:10.1007/7653_2018_2 · Cited by 9 · see citing works

Biotechnological Approaches to Medicinal Plants of Aravalli Hills: Conservation and Scientific Validation of Biological Activities

Goyal, S., Arora, J., & Ramawat, K. G. (2014) · Sustainable development and biodiversity · doi:10.1007/978-3-319-09381-9_11 · Cited by 9 · see citing works

Centella asiatica (Gotu kola) leaves

Thakurdesai, P. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00021-5 · Cited by 8 · see citing works

The Contribution of Studies with Canabidiol and Synthetic Analogues in the Design of New Drug Candidates for Neuropsychiatric Disorders and Neurodegenerative Diseases

Franco, G. R. R., & Viegas, C. (2017) · Revista Virtual de Química · doi:10.21577/1984-6835.20170103 · Cited by 7 · see citing works

Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease

Choubdar, N., & Avizheh, S. (2019) · Nanoscience &amp Nanotechnology-Asia · doi:10.2174/2210681209666190228143636 · Cited by 7 · see citing works

Molecular characterization of neuroprotective activities of plant based products could revive their utilization and lead discovery of new drug candidates for brain diseases

Hegde, M. (2014) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.129168 · Cited by 6 · see citing works

Neuropharmacological and Cognitive Effects of Celastrus paniculatus – A Comprehensive Review

Bhagya, V. R., & Jaideep, S. (2020) · International Journal of Pharmaceutical Sciences Review and Research · doi:10.47583/ijpsrr.2020.v65i01.013 · Cited by 6 · see citing works

Attenuation of Oxidative Stress and Cognitive Impairment in Cadmium Chloride-Exposed Wistar Rats Pre-treated with Ethanolic Turmeric Root Extract

Enogieru, A. B., & Inegbedion, G. O. (2022) · The Journal of Phytopharmacology · doi:10.31254/phyto.2022.11212 · Cited by 6 · see citing works

Celastrus paniculatus

Maurya, H., Arya, R. K. K., Belwal, T., Rana, M. D., & Kumar, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00036-0 · Cited by 6 · see citing works

Proposed remedies for some developmental disorders

Ibrahim, K. S., & El-Sayed, E. M. (2012) · Toxicology and Industrial Health · doi:10.1177/0748233711433937 · Cited by 6 · see citing works

Implications of phytochemicals as disease-modifying agents against Huntington's disease (HD): Bioactivity, animal models and transgenics, synergism and structure–activity studies

Dey, A., Nanda, B., Nandy, S., Mukherjee, A., & Pandey, D. K. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819483-6.00002-3 · Cited by 6 · see citing works

Neuroprotective and Antiapoptotic Effects of Allopregnanolone and Curcumin on Arsenic-Induced Toxicity in SH-SY5Y Dopaminergic Human Neuroblastoma Cells

Khodadadi, H., Jahromi, G. P., Zaeinalifard, G., Fasihi‐Ramandi, M., Esmaeili, M. A., & Shahriary, A. (2020) · Neurophysiology · doi:10.1007/s11062-020-09861-6 · Cited by 6 · see citing works

Innate antiviral immunity of human PBLs and immunoregulatory activity of EGb 761

Sochocka, M., Taboł, A., Sobczyński, M., Zaczyńska, E., Czarny, A., & Leszek, J. (2013) · Open Life Sciences · doi:10.2478/s11535-013-0278-6 · Cited by 6 · see citing works

Isolation and Characterization of NP‐POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease

Lemieszewska, M., Polanowski, A., Wilusz, T., Sokołowska, A., Zambrowicz, A., Mikołajewicz, K., Macała, J., Rymaszewska, J., & Zabłocka, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3760124 · Cited by 6 · see citing works

Quinazoline-2,4(1H,3H)-dione modulates STAT3 and FOXO3a signaling in HepG2 cells

Manoharan, S., Murugesan, K., Gunasekaran, S., Vedagiri, H., & Perumal, E. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108304 · Cited by 5 · see citing works

Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy

Malik, J., & Choudhary, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-8127-4_50 · Cited by 5 · see citing works

CADD Studies Applied to Secondary Metabolites in the Anticancer Drug Research

Scotti, L., Yarla, N. S., Mendonça, F. J. B., Barbosa‐Filho, J. M., da Silva, M. S., Tavares, J. F., & Scotti, L. (2018) · Springer eBooks · doi:10.1007/978-981-10-8417-1_9 · Cited by 5 · see citing works

Potential Treatment Strategies of Dementia With Ayurvedic Medicines

Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00009-x · Cited by 4 · see citing works

The Effects of Aqueous Leave Extract of Moringa oleifera on the Hippocamppal Histology of Aluminium Chloride-Induced Alzheimer’s Disease in Adult Wistar Rats

Ozor, I. I., Agwag, Z. N., Finbarrs-Bello, E., Ozioko, O. M., Ozioko, U. S., & Iruka, N. C. (2020) · International Journal of Neurologic Physical Therapy · doi:10.11648/j.ijnpt.20200602.12 · Cited by 4 · see citing works

Role of natural products for the treatment of Alzheimer’s disease

Noori, T., Dehpour, A. R., Sureda, A., Sobarzo-Sanchez, E., & Shirooie, S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173974 · Cited by 141 · see citing works

Selected Natural Products in Neuroprotective Strategies for Alzheimer’s Disease—A Non-Systematic Review

Wojtunik‐Kulesza, K. A., Oniszczuk, T., Mołdoch, J., Kowalska, I., Szponar, J., & Oniszczuk, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031212 · Cited by 15 · see citing works

Exploring the efficacy of natural products in alleviating Alzheimer’s disease

Singh, A., Deshpande, P., & Gogia, N. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.253509 · Cited by 108 · see citing works

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works

A Systematic Review on the Role of Natural Products in Modulating the Pathways in Alzheimer’s Disease

Auti, S. T., & Kulkarni, Y. A. (2017) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000405 · Cited by 16 · see citing works