Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models An experimental study
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BACKGROUND: In the traditional system of medicine, the roots and rhizomes of Glycyrrhiza glabra (Gg) (family: Leguminosae) have been studied for their ability to improve a variety of health ailments. AIMS: The present study was designed to investigate the beneficial effects of Gg root extract on learning and memory in 1-month-old male Wistar albino rats. Four doses (75, 150, 225, and 300 mg/kg) of aqueous extract of root of Gg was administered orally for six successive weeks. MATERIALS AND METHODS: The aqueous extracts were evaluated for their effect on spatial learning and memory in rats using the elevated plus maze, Hebb-William maze, and Morris water maze tests which served as the exteroceptive behavioral model. Diazepam-induced amnesia served as the interoceptive behavioral model. RESULTS: Results showed that all the doses of aqueous root extract of Gg significantly enhanced the memory; however, in the doses of 150 and 225 mg/kg, it showed a significant (P < 0.01) enhancement in learning and memory. Furthermore, Diazepam-induced amnesia was reversed by the aqueous root extract of Gg (150 and 225 mg/kg, p.o.). CONCLUSION: These findings suggest that the memory enhancement effects of Gg may be mediated by its antioxidant and anti-inflammatory activities. Thus, Gg appears to be a promising drug for improving memory in the management of impaired learning, dementia, Alzheimer's disease, and other neurodegenerative disorders.
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Experimental results of glycyrrhiza glabra plant extract administered orally to a 1-month-old albino rat for 6 weeks showed improved memory and learning capacity.
“Experimental results of the glycyrrhiza glabra plant extract administered orally to a 1-month-old albino rat for 6 weeks showed improved memory and learning capacity [54] .”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [54]
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Mridula, M., Ansary, P. Y., Oommen, S. M., Shincymol, V. V., & Sethu, R. (2022) · International Research Journal of Ayurveda & Yoga · doi:10.47223/irjay.2022.5119
Öztürk, M., Altay, V., Hakeem, K. R., & Akçiçek, E. (2018) · Liquorice · doi:10.1007/978-3-319-74240-3_8 · Cited by 43 · see citing works
“An application of 150 and 225 mg/kg doses significantly enhance learning as well as memory (Chakravarthi and Avadhani 2013).”
BackgroundHerbal Medicines and Supplements
Caritá, E. (2022) · Springer eBooks · doi:10.1007/978-3-030-94383-7_7
Traditional Herbs With Potential Wound Healing Properties
Babu, N., Singh, A., & Navneet (2021) · IGI Global eBooks · doi:10.4018/978-1-6684-3546-5.ch012
Arumugam, S., Suba Malani, S., Arumugam, B., & Srirangaramasamy, J. (2023) · Journal of chemical health risks · doi:10.53555/jchr.v13.i6.2293
Herbal Plants for Mental Disorders in Sri Lanka
Senarathne, R. N., Jayasuriya, B. N., & Gunawardana, S. L. A. (2024) · Future Integrative Medicine · doi:10.14218/fim.2024.00024 · Cited by 1 · see citing works
Traditional Therapies for Alzheimer’s Disease
Gobinath, M., Dwarampudi, L. P., Roychowdhury, P., Yamuna, K., Dutta, S., & Shanmugam, R. (2024) · Springer eBooks · doi:10.1007/978-981-96-0259-9_10
Natural Medicines (Phytoconstituents) and Probiotics as the Future of Alzheimer’s Disease
Vishwas, S., Gulati, M., Singh, S. K., Bashir, B., Kumar, R., Gupta, G., & Dua, K. (2024) · Springer eBooks · doi:10.1007/978-981-96-0259-9_20
Ayurvedic Supplements for Healthy Brain and Longevity
Yadav, H., Thapliyal, A., Maurya, S. K., & Mishra, R. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_10
Sawai, K., Todoroki, Y., Nakamukai, S., Matsuzawa, Y., Noguchi, K., Kato, T., Mori, T., Rai, A., Hirai, M. Y., & Tsugawa, H. (2026) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6c00565
Neuroprotective potential of natural products in dementia: Mechanisms and clinical evidence
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- Authors
- Chakravarthi, K., & Avadhani, R.
- Affiliations
- Yenepoya University (IN)
- Venue
- Journal of Natural Science Biology and Medicine
- Publisher
- Manuscript Technomedia LLP
- Published
- 2013
- Volume
- 4
- Issue
- 2
- Pages
- 420
- ISSN
- 0976-9668 (ISSN-L)
- PMC
- PMC3783792
- OpenAlex
- W2021459668
- Cited by
- 87
- References
- 8
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 13 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 9 · 2015: 7 · 2014: 1 · 2013: 2
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Journal of Natural Science Biology and Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- licorice, licorice extract, aqueous root extract, learning and memory, spatial learning, Morris water maze, elevated plus maze, diazepam-induced amnesia, neuroprotection, antioxidant activity, anti-inflammatory activity, dementia, Alzheimer's disease, neurodegenerative diseases
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