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Cited by 20Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration MechanismsGlioma Diagnosis and Treatment

Progenies of NG2 glia: what do we learn from transgenic mouse models ?

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Huang, Wenhui, Guo, Qilin, Scheller, Anja·2021·Neural Regeneration Research
DOI 10.4103/1673-5374.286950PMC PMC7818854
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Abstract

In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain, whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence. This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development. We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential. We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies.

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  • Neuroplasticity is a fundamental principle of neuroscience and underlies learning, memory, and resilience to injury.

    “Neuroplasticity, the brain’s ability to adapt its structural and functional properties in response to intrinsic and extrinsic stimuli, is a fundamental principle of neuroscience and underlies learning, memory, and resilience to injury [79].”

    From Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses (2026) · cites this paper as [79]

    The section on spatiotemporally controlled generation of oligodendrocytes discusses adult myelin remodeling, and the Conclusion addresses NG2 glial cell fate. Neither states that neuroplasticity underlies learning, memory, and resilience to injury; searches for those terms and for adaptive plasticity found no supporting passage in our copy. No page numbers were available for these passages. (LLM, conf=0.72)

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Cited by

Sorted by citations

Authors
Huang, W., Guo, Q., & Scheller, A.
Affiliations
Saarland University (DE)
Corresponding author
Huang, Wenhui
ORCID
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2021
Volume
16
Issue
1
Pages
43
ISSN
1673-5374 (ISSN-L)
DOI
10.4103/1673-5374.286950
PMC
PMC7818854
OpenAlex
W3048505733
Cited by
20
References
11
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2021: 6
FWCI
0.98
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords
NG2 glia, oligodendrocyte progenitors, neurogenesis, glial differentiation, central nervous system development, ventral forebrain, transgenic mouse model, Cre-loxP system, lineage tracing

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