Embryonic origin of postnatal neural stem cells
Open accessAbstract
Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally. Using a retroviral library carrying over 100,000 genetic tags, we found that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but this lineage relationship is lost before E15.5. The regional specification of B1 cells is evident as early as E11.5 and is spatially linked to the production of neurons that populate different areas of the forebrain. This study reveals an early embryonic regional specification of postnatal neural stem cells and the lineage relationship between them and embryonic progenitor cells.
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Adult V-SVZ NSCs are set aside during embryogenesis and remain largely quiescent until adulthood.
“Adult V-SVZ NSCs are set aside during embryogenesis, remaining largely quiescent until adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and reside in a complex microenvironment comprising diverse cell types and local and long-range signals (Silva-Vargas et al., 2013).”
From Single-Cell Analysis of Regional Differences in Adult V-SVZ Neural Stem Cell Lineages (2019) · cites this paper as Fuentealba et al., 2015
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ResultA Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
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“To study the lineage of single RG cells, we have previously used a library of retroviruses (QmGFP-OL), each encoding a unique 24-base pair DNAsequence, or”barcode” (Cepkoetal., 1995,1998; Golden et al., 1995; Fuentealba et al., 2015).”
BackgroundMethodInfluentialIdentification of quiescent and spatially restricted mammary stem cells that are hormone responsive
Fu, N. Y., Rios, A. C., Pal, B., Law, C. W., Jamieson, P. R., Liu, R., Vaillant, F., Jackling, F. C., Liu, K. H., Smyth, G. K., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3471 · Cited by 134 · see citing works
Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt, M., Clavreul, S., Lalioti, M., Taraviras, S. L., Hippenmeyer, S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.051 · Cited by 134 · see citing works
“, although B1 astrocytes are reactivable quiescent neuronal progenitors, multiciliated ependymal cells are postmitotic throughout life (Fuentealba et al., 2015; Furutachi et al., 2015; Shah et al., 2018; Spassky et al., 2005).”
Mechanisms of radial glia progenitor cell lineage progression
Beattie, R., & Hippenmeyer, S. (2017) · FEBS Letters · doi:10.1002/1873-3468.12906 · Cited by 127 · see citing works
Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone
Engler, A., Rolando, C., Giachino, C., Saotome, I., Erni, A., Brien, C., Zhang, R., Zimber-Strobl, U., Radtke, F., Artavanis-Tsakonas, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.094 · Cited by 125 · see citing works
“In these distinct neurogenic niches, adult neural stem cells (NSCs) remain active and drive neurogenesis in rodents, non-human primates, and humans into adulthood (Doetsch, 2003; Doetsch et al., 1999; Ernst et al., 2014; Fuentealba et al., 2015; Furutachi et al., 2015; Spalding et al., 2013).”
Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., Hippenmeyer, S., & Fishell, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.011 · Cited by 113 · see citing works
“high complexity of the library, and the relatively low number of clones, cells sharing the same barcode are almost certainly siblings (Golden et al., 1995; Fuentealba et al., 2015).”
Gorabi, A. M., Kiaie, N., Barreto, G. E., Read, M. I., Tafti, S. H. A., & Sahebkar, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01663-0 · Cited by 120 · see citing works
Bi- and uniciliated ependymal cells define continuous floor-plate-derived tanycytic territories
Mirzadeh, Z., Kusne, Y. N., Duran‐Moreno, M., Cabrales, E., Gil‐Perotín, S., Ortiz, C., Chen, B., García‐Verdugo, J. M., Sanai, N., & Álvarez-Buylla, A. (2017) · Nature Communications · doi:10.1038/ncomms13759 · Cited by 121 · see citing works
Neural stem cells: developmental mechanisms and disease modeling
Zhao, X., & Moore, D. L. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2738-1 · Cited by 117 · see citing works
“During development, a subset of slowly-dividing NSCs are set aside to be the NSCs of the SVZ in the postnatal and adult brain (Fuentealba et al. 2015; Furutachi et al. 2015).”
BackgroundRoles of mitochondria in neuronal development
Son, G., & Han, J. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.11.226 · Cited by 117 · see citing works
“regions of the brain and maintained as adult NSCs (40,41).”
BackgroundNeural stem cell niche heterogeneity
Andreotti, J. P., da Silva, W. N., Costa, A. C., Picoli, C. C., Bitencourt, F. C. O., Coimbra-Campos, L. M. C., Resende, R. R., Magno, L. A. V., Romano‐Silva, M. A., Mintz, A., et al. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.005 · Cited by 115 · see citing works
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
Zhou, Y. F., Bond, A. M., Shade, J. E., Zhu, Y., Davis, C.-H. O., Wang, X., Su, Y., Yoon, K., Phan, A. T., Chen, W. J., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.005 · Cited by 112 · see citing works
“Neural stem cells that will populate the adult SVZ are set aside and remain quiescent during development (Fuentealba et al., 2015; Furutachi et al., 2015).”
The emergence of the stem cell niche
Hicks, M. R., & Pyle, A. D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.07.003 · Cited by 112 · see citing works
“The brain houses at least two well-studied neural stem cell (NSC) niches in the subgranular zone in the hippocampal dentate gyrus and the subventricular zone around the lateral ventricles [6,7].”
Wide dispersion and diversity of clonally related inhibitory interneurons
Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.030 · Cited by 106 · see citing works
“To directly determine the clonal relationship of clustered interneurons, we utilized an EnvA-pseudotyped retrovirus library carrying oligonucleotide sequence tags or barcodes (Cepko et al., 1995; Fuentealba et al., 2015; Jiang et al., 2013;WalshandCepko, 1992) (Figure3A).”
Matarredona, E. R., & Pastor, Á. M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00779 · Cited by 109 · see citing works
Falk, S., & Götz, M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.025 · Cited by 99 · see citing works
Therapeutic Plasticity of Neural Stem Cells
Ottoboni, L., von Wunster, B., & Martino, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00148 · Cited by 98 · see citing works
“Thus, adult SVZ NSCs are regionally specified during the early embryonic stage and remain largely quiescent until, post-natally, they are re-activated (46, 47); they have intrinsic temporal programs linked to their positional characteristics (dorsal-ventral, rostral-caudal) (48) that guide differentiation in a cell-au…”
BackgroundTong, C. K., Fuentealba, L. C., Shah, J. K., Lindquist, R. A., Ihrie, R. A., Guinto, C. D., Rodas-Rodriguez, J. L., & Álvarez-Buylla, A. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.08.013 · Cited by 99 · see citing works
“The V-SVZ is an extensive germinal layer on the walls of the lateral ventricles that includes components derived from the MGE, LGE, septum, and cortex (Merkle et al., 2007; Alvarez-Buylla et al., 2008; Fuentealba et al., 2015).”
BackgroundPotential Therapies by Stem Cell‐Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
Luarte, A., Bátiz, L. F., Wyneken, Ú., & Lafourcade, C. (2016) · Stem Cells International · doi:10.1155/2016/5736059 · Cited by 99 · see citing works
“[173] L.”
Zhang, Y., Liu, G., Guo, T., Liang, X. G., Du, H., Yang, L., Bhaduri, A., Li, X., Xu, Z., Zhang, Z., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.027 · Cited by 84 · see citing works
“A recent lineage analysis using barcoded virus libraries confirmed this result and revealed that individual early cortical RGCs generate both PyNs and OB-INs in vivo (Fuentealba et al., 2015).”
Current Understanding of the Neural Stem Cell Niches
Llorente, V., Velarde, P., Desco, M., & Gómez‐Gaviro, M. V. (2022) · Cells · doi:10.3390/cells11193002 · Cited by 94 · see citing works
Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Niche
Chang, E. H., Adorján, I., Mundim, M. V., Sun, B., Dizon, M. L. V., & Szele, F. G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00332 · Cited by 92 · see citing works
Regulation of active and quiescent somatic stem cells by Notch signaling
Sueda, R., & Kageyama, R. (2019) · Development Growth & Differentiation · doi:10.1111/dgd.12626 · Cited by 88 · see citing works
“It has been shown that some neural stem cells become slowly dividing or quiescent during embryonic stages and remain as adult neural stem cells (Fuentealba et al., 2015; Furutachi et al., 2015) while others be‐ come quiescent postnatally (Berg et al., 2019).”
BackgroundChavali, M., Klingener, M., Kokkosis, A. G., Garkun, Y., Felong, S., Maffei, A., & Aguirre, A. A. (2017) · Nature Communications · doi:10.1038/s41467-017-02440-0 · Cited by 85 · see citing works
Raj, B., Gagnon, J. A., & Schier, A. F. (2018) · Nature Protocols · doi:10.1038/s41596-018-0058-x · Cited by 85 · see citing works
Bifari, F., Decimo, I., Pino, A., Llorens-Bobadilla, E., Zhao, S., Lange, C. M., Panuccio, G., Boeckx, B., Thienpont, B., Vinckier, S., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.10.020 · Cited by 85 · see citing works
Regulation of neurogenesis in the adult and aging brain
Katsimpardi, L., & Lledo, P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.07.006 · Cited by 85 · see citing works
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
Berg, D. A., Bond, A. M., Ming, G.-L., & Song, H. (2018) · F1000Research · doi:10.12688/f1000research.12684.1 · Cited by 89 · see citing works
Vascular Influence on Ventral Telencephalic Progenitors and Neocortical Interneuron Production
Tan, X., Liu, W. A., Zhang, X., Shi, W., Ren, S., Li, Z., Brown, K. N., & Shi, S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.02.023 · Cited by 83 · see citing works
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript insights into the embryonic origin and distinct properties of adult neural stem cells (Fuentealba et al., 2015).”
BackgroundStorer, M. A., Gallagher, D., Fatt, M. P., Simonetta, J. V., Kaplan, D. R., & Miller, F. D. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.03.008 · Cited by 82 · see citing works
“We propose that these different long-term outcomes result fromdifferences in neural precursor cell-cycle state since, at the time of the IL-6 surge, embryonic NSCs were actively proliferating while post-natal NSCs were quiescent (Fuentealba et al., 2015; Furutachi et al., 2015; Yuzwa et al., 2017).”
BackgroundThe aged brain: genesis and fate of residual progenitor cells in the subventricular zone
Capilla‐González, V., Herranz‐Pérez, V., & García‐Verdugo, J. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00365 · Cited by 82 · see citing works
“It is known that NSCs within the SVZ derive from embryonic radial glia cells (Merkle et al., 2004; Kriegstein and Alvarez-Buylla, 2009; Morrens et al., 2012; Fuentealba et al., 2015).”
BackgroundMorizur, L., Chicheportiche, A., Gauthier, L., Daynac, M., Boussin, F. D., & Mouthon, M. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.005 · Cited by 81 · see citing works
“In contrast to their progeny, most adult NSCs are quiescent and a tight regulation of the balance between their quiescent and proliferative states appears essential for their long-term maintenance in neurogenic niches (Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundGengatharan, A., Bammann, R. R., & Saghatelyan, A. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00149 · Cited by 81 · see citing works
New neurons in adult brain: distribution, molecular mechanisms and therapies
Pino, A., Fumagalli, G. F., Bifari, F., & Decimo, I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.003 · Cited by 78 · see citing works
Stem cells in tissues, organoids, and cancers
Wang, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03199-x · Cited by 77 · see citing works
Adult Neurogenesis and the Promise of Adult Neural Stem Cells
Ghosh, H. S. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519856876 · Cited by 77 · see citing works
Development of the mammalian main olfactory bulb
Tufo, C., Poopalasundaram, S., Dorrego-Rivas, A., Ford, M. C., Graham, A., & Grubb, M. S. (2022) · Development · doi:10.1242/dev.200210 · Cited by 75 · see citing works
“Cre-lox fate mapping of telencephalic neuroepithelium has revealed that the postnatal SVZ is populated by a heterogeneous pool of stem cells, derived from the MGE, LGE and embryonic cortex, which remain quiescent until activated in adulthood (Fuentealba et al., 2015; Young et al., 2007).”
BackgroundLepko, T., Pusch, M., Müller, T., Schulte, D., Ehses, J., Kiebler, M. A., Hasler, J., Huttner, H. B., Vandenbroucke, R. E., Vandendriessche, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100481 · Cited by 72 · see citing works
“Lifelong neurogenesis in the adult brain relies on a population of qNSCs set apart during development (Fuentealba et al , 2015; Furutachi et al , 2015; Falk et al , 2017).”
Cerrato, V., Parmigiani, E., Figueres‐Oñate, M., Betizeau, M., Aprato, J., Nanavaty, I. N., Berchialla, P., Luzzati, F., de’Sperati, C., López‐Mascaraque, L., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005513 · Cited by 64 · see citing works
Notch signaling as a master regulator of adult neurogenesis
Lampada, A., & Taylor, V. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1179011 · Cited by 72 · see citing works
“5 and remain quiescent through the late stages of embryogenesis until postnatal and adult stages of life (Merkle et al., 2004; Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundAlonso, S. B., Reinert, J. K., Marichal, N., Massalini, S., Berninger, B., Kuner, T., & Calegari, F. (2019) · The EMBO Journal · doi:10.15252/embj.201798791 · Cited by 69 · see citing works
“Specifically, slowly dividing progenitors of embryonic origin (Fuentealba et al , 2015; Furutachi et al , 2015) become activated NSC (B1 cells) of the adult SVZ and give rise to intermediate progenitors (C cells) that produce neuroblasts (A cells) migrating through the rostral migratory stream…”
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62 · see citing works
Quiescent Neural Stem Cells for Brain Repair and Regeneration: Lessons from Model Systems
Otsuki, L., & Brand, A. H. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.02.002 · Cited by 68 · see citing works
Nucleotides in neuroregeneration and neuroprotection
Miras‐Portugal, M. T., Gómez‐Villafuertes, R., Gualix, J., Díaz‐Hernandéz, J. I., Artalejo, A. R., Ortega, F., Delicado, E. G., & Pérez‐Sen, R. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.002 · Cited by 70 · see citing works
“The diverse and fine-tuned molecular and biochemical properties of stem cell types are essential for specific neurorepair, but it is also part of the difficulty for a feasible clinical application (Fuentealba et al., 2015; Merkle et al., 2014).”
BackgroundHu, X.-L., Chen, G., Zhang, S., Zheng, J., Wu, J., Bai, Q., Wang, Y., Li, J., Wang, H., Han, F., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.047 · Cited by 66 · see citing works
Borrett, M. J., Innes, B. T., Jeong, D., Tahmasian, N., Storer, M. A., Bader, G. D., Kaplan, D. R., & Miller, F. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108022 · Cited by 69 · see citing works
Neurogenesis From Embryo to Adult – Lessons From Flies and Mice
Mira, H., & Morante, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00533 · Cited by 64 · see citing works
Boareto, M., Iber, D., & Taylor, V. (2017) · Development · doi:10.1242/dev.152520 · Cited by 65 · see citing works
“In the peak neurogenic period, a few NSCs exit the cell cycle and become quiescent (qNSCs) (Furutachi et al., 2013, 2015; Fuentealba et al., 2015). qNSCs are only reactivated in the adult neurogenic niches.”
BackgroundInfluentialTranslating neural stem cells to neurons in the mammalian brain
Zahr, S. K., Kaplan, D. R., & Miller, F. D. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0411-9 · Cited by 63 · see citing works
Carradori, D., Eyer, J., Saulnier, P., Véronique Préat, A., & Rieux, A. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.032 · Cited by 63 · see citing works
“Adult SGZ-NSC could originate from the ventral hippocampus during the late fetal stage [21], while adult SVZ-NSC are regionally specified at an early embryonic stage [22,23].”
Mizrak, D., Bayin, N. S., Yuan, J., Liu, Z., Suciu, R. M., Niphakis, M. J., Ngo, N., Lum, K. M., Cravatt, B. F., Joyner, A. L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107805 · Cited by 59 · see citing works
“, 2014), with intrinsic regional identities defined during embryogenesis (Fuentealba et al., 2015), generating different olfactory bulb (OB) interneuron subtypes or glia depending on their location (Brill et al.”
Adult Neural Stem Cells: Born to Last
Morales, A. V., & Mira, H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00096 · Cited by 59 · see citing works
Neural crest lineage analysis: from past to future trajectory
Tang, W., & Bronner-Fraser, M. E. (2020) · Development · doi:10.1242/dev.193193 · Cited by 59 · see citing works
Regulation of CNS precursor function by neuronal chemokines
Watson, A. E. S., Goodkey, K., Footz, T. K., & Voronova, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134533 · Cited by 57 · see citing works
Harada, Y., Yamada, M., Imayoshi, I., Kageyama, R., Suzuki, Y., Kuniya, T., Furutachi, S., Kawaguchi, D., & Gotoh, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-26605-0 · Cited by 56 · see citing works
Cole, A., Murray, S. S., & Xiao, J. (2016) · Stem Cells International · doi:10.1155/2016/9260592 · Cited by 56 · see citing works
“5 in murine embryogenesis [9].”
How a radial glial cell decides to become a multiciliated ependymal cell
Kyrousi, C., Lygerou, Z., & Taraviras, S. L. (2017) · Glia · doi:10.1002/glia.23118 · Cited by 57 · see citing works
“…embryonic stages, suggesting that RGCs committed to aNSCs are separated from the common pool of embryonic neural progenitor cells before E15 dpc. Interestingly, this pool of progenitors is maintained quiescent throughout embryogenesis and generates the majority of aNSCs (Fuentealba et al., 2015).”
BackgroundLineage hierarchies and stochasticity ensure the long-term maintenance of adult neural stem cells
Than‐Trong, E., Kiani, B., Dray, N., Ortica, S., Simons, B. D., Rulands, S., Alunni, A., & Bally‐Cuif, L. (2020) · Science Advances · doi:10.1126/sciadv.aaz5424 · Cited by 55 · see citing works
Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation
Ribeiro, M. F., Santos, A. A., Afonso, M. B., Rodrigues, P., Santos, S. S., Castro, R., Rodrigues, C., & Solá, S. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa165 · Cited by 53 · see citing works
Cascade diversification directs generation of neuronal diversity in the hypothalamus
Zhang, Y.-H., Xu, M., Shi, X., Sun, X., Mu, W., Wu, H., Wang, J., Li, S., Su, P., Gong, L., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.020 · Cited by 52 · see citing works
Targeting Adult Neurogenesis for Poststroke Therapy
Lu, J., Manaenko, A., & Hu, Q. (2017) · Stem Cells International · doi:10.1155/2017/5868632 · Cited by 54 · see citing works
“NSCs from medial wall produce calretinin (CalR) GCs and CalR PGCs [21] (Figure 1).”
BackgroundZimmermann, T., Maroso, M., Beer, A., Baddenhausen, S., Ludewig, S., Fan, W., Vennin, C., Loch, S., Berninger, B., Hofmann, C., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy258 · Cited by 52 · see citing works
“Even if adult NSCs and progenitors in the DG and SVZ share some cellular characteristics reflected by the expression of common specific transcription factors, they are clearly of different embryonic origin (Fuentealba et al. 2015; Berg et al. 2018) and are equipped with distinct transcriptional profiles (Hsieh 2012).”
BackgroundThyroid hormone regulation of neural stem cell fate: From development to ageing
Gothié, J. M., Vancamp, P., DEMENEIX, B. A., & Remaud, S. (2019) · Acta Physiologica · doi:10.1111/apha.13316 · Cited by 51 · see citing works
McLean, W. J., McLean, D. T., Eatock, R. A., & Edge, A. S. B. (2016) · Development · doi:10.1242/dev.139840 · Cited by 52 · see citing works
“*Authors for correspondence (eatock@uchicago.edu; albert_edge@meei.harvard.edu) A.S.B.E., 0000-0001-8641-755X D E V E LO P M E N T remained unresolved in several neural and non-neural stem cell compartments (Fuentealba et al., 2015).”
BackgroundNeural Stem Cell Regulation by Adhesion Molecules Within the Subependymal Niche
Morante‐Redolat, J. M., & Porlan, E. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00102 · Cited by 50 · see citing works
“Notwithstanding their potential for generating differentiated progeny, NSC display a functional quiescence in adulthood (Fuentealba et al., 2015; Furutachi et al., 2015), and in contrast to other tissues, adult NSC can be found at different states of activation (Daynac et al.”
BackgroundEffects of Radiation Therapy on Neural Stem Cells
Michaelidesova, A. J., Konířová, J., Bartůněk, P., & Zı́ková, M. (2019) · Genes · doi:10.3390/genes10090640 · Cited by 51 · see citing works
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Neural stem cell metabolism revisited: a critical role for mitochondria
Scandella, V., Petrelli, F., Moore, D. L., Braun, S. M. G., & Knobloch, M. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.05.008 · Cited by 53 · see citing works
“In both niches, NSCs that remain in adulthood originate from embryonic NSCs, which are set aside during embryonic and early postnatal development [20–22].”
BackgroundSabelström, H., Petri, R., Shchors, K., Jandial, R., Schmidt, C., Sacheva, R., Masic, S., Yuan, E., Fenster, T., Martinez, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.071 · Cited by 49 · see citing works
“Ventricularsubventricular zone (V-SVZ) stem cells expressing glial fibrillary acidic protein (GFAP) line the lateral ventricles and give rise to normal constituents, including doublecortin (DCX)-expressing neuroblasts that migrate along the rostral migratory stream and differentiate into olfactory bulb interneurons an…”
BackgroundBast, L., Calzolari, F., Strasser, M. K., Hasenauer, J., Theis, F. J., Ninkovic, J., & Marr, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.088 · Cited by 50 · see citing works
“, 2016), possibly since late embryonic times (Falk et al., 2017; Fuentealba et al., 2015; Furutachi et al., 2015).”
BackgroundBalakrishnan, J., Kannan, S., & Govindasamy, A. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.12.003 · Cited by 50 · see citing works
Mercury Toxicity and Neurogenesis in the Mammalian Brain
Abbott, L. C., & Nigussie, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147520 · Cited by 49 · see citing works
“Some of the radial glial cells that are formed in early development become quiescent as the brain continues to develop and eventually form postnatal and adult NSCs in the subventricular zone (SVZ), located along the edges of the lateral ventricles [23,24].”
Background
- Authors
- Fuentealba, L. C., Rompani, S. B., Parraguez, J. I., Obernier, K., Romero, R., Cepko, C. L., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1644-1655
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4475276
- OpenAlex
- W1617074755
- Cited by
- 488
- References
- 55
- Citations by year
- 2026: 22 · 2025: 38 · 2024: 29 · 2023: 43 · 2022: 43 · 2021: 51 · 2020: 62 · 2019: 58 · 2018: 45 · 2017: 47 · 2016: 35 · 2015: 15
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Helen Hay Whitney Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R37NS028478, NS-28478, R01NS028478)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD32116, R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neural stem cells, neural progenitor cells, olfactory bulb, lateral ventricle, embryonic origin, regional specification, lineage tracing, quiescence, forebrain development, striatum, septum, cortex
- MeSH terms
- Animals, Embryo, Mammalian, Olfactory Bulb, Prosencephalon, Cell Lineage, Mice, Adult Stem Cells, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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